1 0 0 0 岩波動物学辞典
- 著者
- 谷津直秀, 岡田弥一郎 編
- 出版者
- 岩波書店
- 巻号頁・発行日
- 1935
1 0 0 0 岩波動物学辞典
- 著者
- 谷津直秀, 岡田弥一郎 共編
- 出版者
- 岩波書店
- 巻号頁・発行日
- 1935
1 0 0 0 無脊椎動物系統學概論
- 著者
- Shigehiro Yanagihara Yuya Taniguchi Mareto Hosono Eiji Yoshioka Rika Ishikawa Yoshihiro Shimada Toshihiko Kadoya Kazuhiro Kutsukake
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.33, no.9, pp.1596-1599, 2010-09-01 (Released:2010-09-01)
- 参考文献数
- 22
- 被引用文献数
- 10 11
Assessment of biological potency and its comparison with clinical effects are important in the quality control of therapeutic glycoproteins. Animal models are usually used for evaluating bioactivity of these compounds. However, alternative methods are required to simplify the bioassay and avoid ethical issues associated with animal studies. Negatively charged sialic acid residues are known to be critical for in vivo bioactivity of recombinant human erythropoietin (rhEPO). In this study, we used capillary zone electrophoresis, a charge-based separation method, to estimate the sialic acid content for predicting in vivo bioactivity of rhEPO. In vivo bioactivities of rhEPO subfractions were measured and compared with sialylation levels. The results obtained indicated that in vivo bioactivity of rhEPO is not simply correlated with the sialylation level, which suggests that it is difficult to predict biological potency from the sialic acid content alone. N-Glycan moieties as well as sialic acid residues may have a significant impact on in vivo bioactivity of rhEPO.
- 著者
- 石川千代松[著] . 早田文藏[著] .
- 出版者
- 岩波書店
- 巻号頁・発行日
- 1931
1 0 0 0 OA アメーバから人間まで
1 0 0 0 五十年前の日本の動物學
- 著者
- 石川 千代松
- 出版者
- 社団法人日本動物学会
- 雑誌
- 動物学雑誌 (ISSN:00445118)
- 巻号頁・発行日
- vol.41, no.490, pp.349-358, 1929-09-15
1 0 0 0 ホィットマン先生
- 著者
- 石川 千代松
- 出版者
- 社団法人日本動物学会
- 雑誌
- 動物学雑誌 (ISSN:00445118)
- 巻号頁・発行日
- vol.23, no.269, pp.146-150, 1911-03-15