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252 0 0 0 Collective dynamics of small-world networks

著者: WATTS D. J.
雑誌: Nature
巻号頁・発行日: vol.393, pp.440-442, 1998
被引用文献数: 265 29714

2017-08-18 12:54:12
251 CiteULike
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128 0 0 0 Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

著者: ALTSCHUL S. F.
雑誌: Nucleic Acids Res.
巻号頁・発行日: vol.25, no.17, pp.3389-3402, 1997
被引用文献数: 549 55977

2016-11-30 09:25:36
127 CiteULike
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66 0 0 0 CLUSTAL W:improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice

著者: THOMPSON J. D.
雑誌: Nucleic Acids Res.
巻号頁・発行日: vol.22, pp.4673-4680, 1994
被引用文献数: 1465 48540

2015-06-17 22:40:23
65 CiteULike
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37 0 0 0 IR Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

著者: TAKAHASHI K
出版者: Elsevier Inc.
雑誌: Cell (ISSN:00928674)
巻号頁・発行日: vol.126, no.4, pp.663-676, 2006-08-25
被引用文献数: 157 19928

This article is related to the Nobel Prize in Physiology or Medicine 2012Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors.

2018-12-21 03:52:11
36 CiteULike
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109 0 0 0 OA Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

著者: Takahashi Kazutoshi Yamanaka Shinya
出版者: Elsevier Inc.
雑誌: Cell (ISSN:00928674)
巻号頁・発行日: vol.126, no.4, pp.663-676, 2006-08-25
被引用文献数: 19928

This article is related to the Nobel Prize in Physiology or Medicine 2012

34 0 0 0 Factor graphs and the sum-product algorithm

著者: KSCHISCHANG F. R.
雑誌: IEEE Transactions on Information Theory
巻号頁・発行日: vol.47, pp.498-519, 2001
被引用文献数: 104 4290

2018-04-09 23:01:33
33 CiteULike
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32 0 0 0 IR Mersenne Twister: A 623-Dimensionally Equidistributed Uniform Pseudo-Random Number Generator

著者: Matsumoto Makoto Nishimura Takuji
出版者: ACM
雑誌: ACM Transactions on Modeling and Computer Simulation (ISSN:10493301)
巻号頁・発行日: vol.8, no.1, pp.3-30, 1998-01
被引用文献数: 131 3916

A new algorithm called Mersenne Twister (MT) is proposed for generating uniform pseudorandom numbers. For a particular choice of parameters, the algorithm provides a super astronomical period of 219937 - 1 and 623-dimensional equidistribution up to 32-bit accuracy, while using a working area of only 624 words. This is a new variant of the previously proposed generators, TGFSR, modified so as to admit a Mersenne-prime period. The characteristic polynomial has many terms. The distribution up to v bits accuracy for 1 ≤ v ≤ 32 is also shown to be good. An algorithm is also given that checks the primitivity of the characteristic polynomial of MT with computational complexity O(p2) where p is the degree of the polynomial. We implemented this generator in portable C-code. It passed several stringent statistical tests, including diehard. Its speed is comparable to other modern generators. Its merits are due to the efficient algorithms that are unique to polynomial calculations over the two-element field.

2016-08-12 13:44:24
31 CiteULike
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64 0 0 0 IR Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

著者: Takahashi Kazutoshi Tanabe Koji Ohnuki Mari Narita Megumi Ichisaka Tomoko Tomoda Kiichiro Yamanaka Shinya
出版者: Elsevier B.V.
雑誌: Cell (ISSN:00928674)
巻号頁・発行日: vol.131, no.5, pp.861-872, 2007-11-30
被引用文献数: 207 15752

Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Human iPS cells were similar to human embryonic stem (ES) cells in morphology, proliferation, surface antigens, gene expression, epigenetic status of pluripotent cell-specific genes, and telomerase activity. Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts.