著者

山下 裕司 下郡 博明 菅原 一真 広瀬 敬信

出版者

山口大学

雑誌

基盤研究(C)

巻号頁・発行日

2012-04-01

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本研究の目的は,生活習慣病であるメタボリック症候群が聴覚に及ぼす影響について明らかにし,その予防方法を開発,将来の臨床応用に発展させることである。そのためにモデルマウスTSODを用いて研究を行った。結果としてメタボリック症候群モデル動物は,加齢に伴い出現する難聴が対照動物に比べてより早期に出現することが明らかになった。組織学的検討からは内耳の血管に動脈硬化が生じ,内耳の血流が減少することが原因のひとつであると考えられた。また,発現遺伝子の検討からは,多くの種類の成長因子が減少していることが明らかになった。これらの結果は新しい難聴予防の方法の開発につながると考える。

著者

近藤 真前 清水 謙祐 五島 史行 北原 糺 今井 貴夫 橋本 誠 下郡 博明 池園 哲郎 中山 明峰

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.75, no.6, pp.489-497, 2016-12-31 (Released:2017-02-01)

参考文献数

29

被引用文献数

2 2

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Introduction: The vertigo symptom scale-short form (VSS-sf), which has three factors, the vestibular-balance symptom with long duration, the vestibular-balance symptom with short duration, and the autonomic symptom, was developed for measurement of the therapeutic effect in vestibular diseases. However, clinical use of the VSS-sf has not been reported in Japan, and there are very few analyses using scores of the factors or each item of the VSS-sf. The aims of this study is to report both clinical use of the VSS-sf in Japan and analyses using scores of the factors or each item of the VSS-sf. Methods: Participants included both adult inpatients and outpatients with either non-central dizziness/vertigo or vertebrobasilar insufficiency which occurred more than one month before, diagnosed by expert neuro-otologists. Participants completed three questionnaires: the VSS-sf, the dizziness handicap inventory, and the hospital anxiety and depression scale (HADS). We conducted a multiple regression analysis with the scores of the three factors of the VSS-sf, to evaluate how much influence there was from vestibular and autonomic symptoms on any handicap due to dizziness. We analyzed the scores of each item of the VSS-sf to examine profiles of the symptoms in major vestibular diseases. Results: The results of 159 participants were analyzed. Standard partial regression coefficients of anxiety, depression, and the vestibular-balance symptom with long duration were significant, however, those of the vestibular-balance symptom with short duration and the autonomic symptom were not. Most frequent autonomic symptoms were headache, chill/flashes, and palpitation in Ménière's disease, benign paroxysmal positional vertigo, vestibular neuronitis, and psychogenic dizziness. Conclusion: The VSS-sf can be conducted without major problems in Japan, and may be useful for patients with vestibular diseases, not only to measure therapeutic effect but also to analyze the influence of, or relation between the vestibular-balance symptom/autonomic symptoms and other clinical variables.

著者

下郡 博明

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.114, no.1, pp.65-69, 2021 (Released:2021-01-01)

参考文献数

13

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This study was performed to analyze the characteristics of patients with a definitive diagnosis of mumps outside the sentinel surveillance population. Patients aged 15 years or older who visited the otolaryngology department of Yamaguchi Rosai Hospital between October 2015 and April 2017 were included. A definitive diagnosis of mumps was obtained in 8 patients, based on the detection of mumps-specific IgM antibody in the blood. There were 4 male and 4 female patients, ranging in age from 16 to 44 years, with a mean age of 31.4 years. None of the 8 patients had received mumps vaccination. In regard to the swelling of the salivary glands, a single swelling was observed in 4 patients and multiple swellings in the remaining 4 patients. The most commonly affected salivary gland was the left parotid gland (7/8 patients; 87.5%). The complications included hearing loss in 2 of 8 patients, and vertigo and orchitis in one patient each. There were no significant differences in the peripheral blood white blood cell count, serum CRP level, or antibody index between the patients with and without complications. However, the serum amylase level was statistically significantly higher in patients with complications than in those without complications, suggesting the possibility that elevated serum amylase may be marker of the development of complications.