- 著者
- 甲田 雅一 福原 淳子 竹内 美香 大川原 正文 松崎 廣子 遠井 初子 古畑 紀子 丸山 美樹 佐々木 希実 沢辺 悦子 池田 昭 鈴木 ツル 佐藤 仁美 高橋 一郎 木村 冨美子 野村 久子 小野 恵美
- 出版者
- 公益財団法人 日本感染症医薬品協会
- 雑誌
- The Japanese Journal of Antibiotics (ISSN:03682781)
- 巻号頁・発行日
- vol.52, no.6, pp.458-468, 1999
<I>Pseudomonas aeruginosa</I>に対する各種抗生物質の抗菌力は分離施設の使用抗生物質の種類や量により影響されることが多く, ある施設で有効とされる抗生物質が他の施設でも有効とは限らない。真に抗菌力に優れる抗生物質とはMICが低く, 薬剤耐性が進行し難い薬剤であり, そのような抗生物質こそ, どの施設からの分離菌に対しても有効と言えるであろう。著者らは薬剤耐性が進行し易い抗生物質ではMICの施設間差が大きいと考え, 6施設から分離した<I>P.aeruginosa</I>に対する各種抗生物質のMICとMICの施設間差を調査し, その結果をスコア化して, 総合的に抗菌力を評価する試みを行った。その結果, 真に<I>P.aeruginosa</I>に対する抗菌力に優れる抗生物質はimipenem, cefozopran, ceftazidime, cefsulodin, amikacinなどであると考えられた。本報告で提案した解析方法は, 入院患者の細菌感染症に対する優れた抗生物質の評価のための一方法になり得ると考える。
- 著者
- 三橋 博 金子 光 佐々木 希吉
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.10, no.11, pp.1119-1122, 1962
- 被引用文献数
- 1
It was shown that DL-phenylalanine [2-<SUP>14</SUP>C] was incorporated into C-3 of two kinds of isoflavone, formononetin and genistein, by <I>Trifolium pratense</I> sp., <I>in vivo</I>.<BR>These results indicate that the aryl group undergoes a migration within the C<SUB>6</SUB>-C-C-C fragment, and this observation agrees with Grisebach's experimental data.
- 著者
- 本間 秀彰 橋本 義人 宮崎 信義 松本 隆亜 佐々木 希吉
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.33, no.5, pp.457-462, 2007-05-10
- 参考文献数
- 24
- 被引用文献数
- 3 5
To ascertain the use of health foods by patients and the associated problems, we asked 364 patients who brought prescriptions to our pharmacy to fill out a questionnaire. The questions asked aimed to determine the percentage of patients using health foods, the purpose of using them and the kinds of health foods used as well as the period, the frequency, amounts, and the effects of using them. Other questions concerned the person advising them on the use of health foods, the side effects of health foods, and the awareness of patients regarding the interactions between drugs and health foods. The knowledge obtained from the responses received should enable us to provide better pharmaceutical care to patients.
1 0 0 0 OA 14 イソプレノイドキノン類の合成
- 著者
- 川松 豊 杉原 弘貞 佐々木 希吉 森本 浩
- 出版者
- 天然有機化合物討論会
- 雑誌
- 天然有機化合物討論会講演要旨集
- 巻号頁・発行日
- no.13, pp.99-106, 1969-09-01
I. Synthesis of 2,3-dialkoxy-5-alkyl-1,4-benzoquinone a) 4a and 4b obtained from 1 were oxidized with organic peracids to give 2,3-dimethoxy-(5a) and 2,3-diethoxy-5-methyl-1,4-benzoquinone (5b). b) 9a and 9b obtained from 6 were oxidized in a similar manner to give 5a and 10. II. Synthesis of isoprenoid quinones The authors found two new condensation methods. a) Method using an N-sulfinylamine. A solution of hydroquinone (12), methyl N-sulfinylanthranilate (14) and phytol (13) in dioxane was heated and oxidized with ferric chloride to give 2,3-dimethoxy-5-methyl-6-phytyl-1,4-benzoquinone (15) as well as by-products 16 and 17. The structures of 16 and 17 were made clear and the reaction mechanism was discussed. The results are shown in Table 1. b) Method using a metal. A solution of 5a and X-CH_2-CH=C-CH_3-CH_2-R in petroleum ether was treated with slightly an excess amount of amalgamated zinc at the room temperature to give 18. The product 18 was obtained also from hydroquinone (12). The reaction mechanism and the results are shown in Table 2. III. Stereochemistry of isoprenoid quinones It has been so far known that the steric configuration of the side chain of naturally occurring isoprenoid quinones is all-trans, but synthesized isoprenoid quinones inevitably contain a small amount of the cis-isomer. Then, the authors separated these isomers by the column chromatography to confirm their yields and to compare their NMR spectra with each other. The relationship between the structures of the quinones and the biological activity is also mentioned.
1 0 0 0 14 イソプレノイドキノン類の合成
- 著者
- 川松 豊 杉原 弘貞 佐々木 希吉 森本 浩
- 出版者
- 天然有機化合物討論会実行委員会
- 雑誌
- 天然有機化合物討論会講演要旨集
- 巻号頁・発行日
- vol.13, pp.99-106, 1969
I. Synthesis of 2,3-dialkoxy-5-alkyl-1,4-benzoquinone a) 4a and 4b obtained from 1 were oxidized with organic peracids to give 2,3-dimethoxy-(5a) and 2,3-diethoxy-5-methyl-1,4-benzoquinone (5b). b) 9a and 9b obtained from 6 were oxidized in a similar manner to give 5a and 10. II. Synthesis of isoprenoid quinones The authors found two new condensation methods. a) Method using an N-sulfinylamine. A solution of hydroquinone (12), methyl N-sulfinylanthranilate (14) and phytol (13) in dioxane was heated and oxidized with ferric chloride to give 2,3-dimethoxy-5-methyl-6-phytyl-1,4-benzoquinone (15) as well as by-products 16 and 17. The structures of 16 and 17 were made clear and the reaction mechanism was discussed. The results are shown in Table 1. b) Method using a metal. A solution of 5a and X-CH_2-CH=C-CH_3-CH_2-R in petroleum ether was treated with slightly an excess amount of amalgamated zinc at the room temperature to give 18. The product 18 was obtained also from hydroquinone (12). The reaction mechanism and the results are shown in Table 2. III. Stereochemistry of isoprenoid quinones It has been so far known that the steric configuration of the side chain of naturally occurring isoprenoid quinones is all-trans, but synthesized isoprenoid quinones inevitably contain a small amount of the cis-isomer. Then, the authors separated these isomers by the column chromatography to confirm their yields and to compare their NMR spectra with each other. The relationship between the structures of the quinones and the biological activity is also mentioned.
- 著者
- 南部 泰士 佐々木 希 南部 美由紀 佐々木 英行 桐原 優子 月澤 恵子 今野谷 美名子 高橋 俊明
- 出版者
- THE JAPANESE ASSOCIATION OF RURAL MEDICINE
- 雑誌
- 日本農村医学会雑誌 (ISSN:04682513)
- 巻号頁・発行日
- vol.60, no.2, pp.76-84, 2011
秋田県南部前期高齢者女性の介護予防基本チェックリストと骨密度の関連を明らかにし,今後の介護予防支援事業における基礎情報の提供を目的に調査を行なった。基本チェックリスト『口腔』の症状がある前期高齢者女性は骨密度が低かった。また,特定高齢者判定基準で『口腔』に該当している前期高齢者女性は,『運動』,『うつ』の生活機能が低下していた。<br> 骨密度は前期高齢者女性の要介護リスクを判断する指標となることから,骨密度の維持および向上を図る,骨粗鬆症検診の受診率を向上させる必要がある。
- 著者
- 三橋 博 金子 光 佐々木 希吉
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chemical & pharmaceutical bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.10, no.11, pp.1119-1122, 1962-11-25
It was shown that DL-phenylalanine [2-^<14>C] was incorporated into C-3 of two kinds of isoflavone, formononetin and genistein, by Trifolium pratense sp., in vivo. These results indicate that the aryl group undergoes a migration within the C_6-C-C-C fragment, and this observation agrees with Grisebach's experimental data.
- 著者
- 三橋 博 佐々木 希吉 清水 譲
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chemical & pharmaceutical bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.11, no.11, pp.1452-1455, 1963-11-25
The whole plant of Perugularia extensa N. E. Br. was proved to contain a glycoside mixture which showed strong Keller-Kiliani reaction, suggesting the presence of a 2-deoxy-sugars in the sugar part. The sugar fraction obtained by acid hydrolysis was found to contain D-cymarose, D-sarmentose, L-oleandrose, and D-glucose by a paper chromatographic comparison with authentic specimens. Uzarigenin and a new glycoside (m.p. 244〜248°) were found.