著者

本間 義治 古川原 芳明

出版者

日本セトロジー研究会

雑誌

日本セトロジー研究 (ISSN:18813445)

巻号頁・発行日

no.17, pp.1-4, 2007 (Released:2019-12-04)

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1994年以来続けてきた佐渡海峡の新潟~両津間における佐渡汽船ジェットフォイル並びにカーフェリーによる鯨類目撃記録を、2005年分も整理してみた。22回目撃されたが、1頭のみのことが多く、6回がカーフェリー、16回がジェットフォイルで、例年の記録より少なかった。目撃数は5月が最多で、4月、3月と続き、従来と異ならなかった。時間帯は午前は8時前後、午後は2時頃が多かった。同一日における複数目撃は、2回のみであった。浮遊物との接触事故は、2005年11月19日にジェットフォイルが1回起こしたのみで、軽度なため人身事故に至らなかった。本邦のみならず世界的に高速船の衝突事故が増えてきているので、接触回避策などについて議論した。

著者

石井 明子 橋井 則貴 松本 真理子 香取 典子 新井 進 粟津 洋寿 磯野 哲也 井上 友美 永座 明 大山 幸仁 奥村 剛宏 梶原 大介 田熊 晋也 丹下 浩一 塚原 正義 筒井 麻衣子 寺島 伊予 中川 泰志郎 服部 秀志 林 慎介 原 芳明 松田 博行 村上 聖 矢野 高広 巌倉 正寛 大政 健史 川崎 ナナ 広瀬 明彦

出版者

一般社団法人日本PDA製薬学会

雑誌

日本PDA学術誌 GMPとバリデーション (ISSN:13444891)

巻号頁・発行日

vol.19, no.2, pp.15-29, 2017 (Released:2017-12-21)

参考文献数

17

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The use of single-use systems has been getting more popular in biologics manufacturing. Utilization of this novel technology enables the efficient manufacturing, including prevention of cross contamination, flexibility to manufacture multiple products, and elimination of the need for cleaning and steam sterilization including those validations. In order to ensure the quality and stable supply of biologics, appropriate risk management considering the characteristics of the system is necessary. However, there is no regulatory document describing the examples or recommendations on it. In 2015, we published the White paper of “Approaches to Quality Risk Management When Using Single-Use Systems in the Manufacture of Biologics” in AAPS PharmSciTech, which was a fruit of discussion in the research group consisting of Japanese pharmaceutical manufacturers, single-use suppliers, academia and regulatory agencies. This review introduces the contents of the White paper with some revision reflecting the comments on it as well as the discussion in our research group after publishing the paper. The basic concept is consistent with ICH guideline on quality risk management. Here we describe the points to consider in risk assessment as well as in risk control when single-use systems are used in biologics manufacturing.

著者

菅原 芳明 井浦 良枝 青井 紀子 住廣 紗奈美 北山 一郎

出版者

日本官能評価学会

雑誌

日本官能評価学会誌 (ISSN:1342906X)

巻号頁・発行日

vol.9, no.2, pp.101-107, 2005-10-15 (Released:2013-07-11)

参考文献数

11

被引用文献数

1

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In order to elucidate the deodorizing efficacy of a titanium oxide-type deodorant, perceived changes in refrigerator odors were assessed by subjects using 13 contrasting pairs of adjectives on an 11-point scale (from −5 to +5). This assessment by inquiry was conducted three times: once immediately before placing the deodorant in the refrigerator, again after keeping it in the refrigerator for one week, and lastly at one week after removing it from the refrigerator. The obtained sensory evaluation spectrum corresponding to the changes of scores between the first inquiry and the second inquiry (second minus first) showed an upward tendency with a positive value in terms of the 13 descriptors. This implies that the odors were lessened by the use of the deodorant. The respective spectrum (third minus first) at the removal was just the reverse. This implies that the odors were intensified by removing the deodorant. Here, the sensory evaluation spectrum was represented by a bar graph, in which the mean of the foregoing impression difference was plotted against the descriptors. When the statistical significance of each of the 13 descriptors was assessed by Student's t-test, 11 or more of the descriptors were regarded as significant among 13 descriptors at a probability value of p<0.05.

著者

四釜 慶治 松岡 有樹 菅原 芳明

出版者

一般社団法人日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.41, no.2, pp.74-79, 2001-03-25

被引用文献数

4

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The reversible and stable binding of dioxygen to the heme iron (II) is the basis of myoglobin and hemoglobin functions. During reversible oxygen binding, however, the oxygenated form of myoglobin or hemoglobin is oxidized easily to the ferric (III) met-form with generation of the superoxide anion. Thus, stability property of each oxygenated form is of particular importance in vivo, since the iron (III) species cannot bind dioxygen and is therefore physiologically inactive. With special emphasis on the possible roles of the distal histidine, this overview represents a compendium for the molecular mechanism of autoxidation for myoglobin and hemoglobin molecules.