著者

堤 大輔 倉本 到 渋谷 雄 辻野 嘉宏

出版者

一般社団法人情報処理学会

雑誌

情報処理学会論文誌 (ISSN:18827764)

巻号頁・発行日

vol.48, no.12, pp.4064-4075, 2007-12-15

被引用文献数

4

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本論文では,既存のスケジューラシステムがかかえる問題を解消するため,ユーザが自由に使用できる時間である「空き時間」の概念を導入したタスク・スケジュール管理,タスクの階層構造と実行順序関係からなる「タスク間関係」に基づいたタスク管理の2 つの手法を提案した.そして,2 つの提案手法の機能を付加したスケジューラシステム「タイムラインナビ」を設計・実装し,提案手法の有用性を評価するための実験を行った.その結果,空き時間表示がユーザのスケジューリングを効率的かつ容易にし,タスク間関係に対応したタスク管理が,かかえているタスクの現在の状態をより把握しやすくすることが分かった.In general scheduler systems, tasks and schedules are managed independently though they are actually related. So it is difficult for users to notice that their scheduling is overbooked. In addition, users cannot explicitly grasp a state of their tasks, such as a progress of each task because they have no chance to know such state with the scheduler systems. In order to solve these problems, we propose a task-and-schedule management method based on the amount of free time and a task management method based on the relationship among tasks. Furthermore a scheduler system with the proposed methods, named "Time Line Navi", was implemented and evaluated experimentally. The results show that the free time is useful for the user's scheduling and the relationship among tasks enable users to manage tasks clearly and effectively.

著者

飯塚 俊介 葉山 達也 内池 明博 堤 大輔 小田桐 功武 中山 敏光 早坂 正敏 村松 高 橋本 修 吉田 善一

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.43, no.3, pp.145-153, 2017-03-10 (Released:2018-03-10)

参考文献数

21

被引用文献数

1

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The absorption of gefitinib is dependent on gastric pH. However, an increase in gastric pH via the use of antacids such as proton pump inhibitors (PPI) and histamine H2 receptor antagonists may reduce the bioavailability and efficacy of gefitinib.In this study, we report the influence of the concurrent use of antacids with gefitinib on the efficacy in epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). Our subjects were 68 patients with NSCLC who were treated with gefitinib at our hospital between 2008 and 2015.In the study, we compared time to treatment failure (TTF), overall survival (OS), response rate, disease control rate and adverse effect rates in patients receiving antacids in combination as well as (AC; n = 29) with those only receiving gefitinib (no AC; n = 34).The patients in the AC group exhibited a significant difference in TTF (409 days (95%CI: 1.00-4.22) vs 901 days (95%CI: 0.24-0.99), P = 0.0492) as compared to the no AC group. But then the OS, response rate, disease control rate and adverse effects rate were not significant between each group. Therefore, this study suggests that, as long as the combination of gefitinib with antacids is avoided, the combination with antacids should not impair the clinical efficacy of gefitinib. From the results of the sub-analysis, this study suggests that, in particular men, less than 75 years old, PS≧2, pulmonary metastasis, it is preferable to avoid the combination of gefitinib and antacids.

著者

堤 大輔

出版者

教育哲学会

雑誌

教育哲学研究 (ISSN:03873153)

巻号頁・発行日

vol.2000, no.81, pp.75-91, 2000-05-10 (Released:2010-05-07)

参考文献数

41

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In this paper the author will elucidate the merits and demerits of “analysis” as a commonly used method in educational theory. To make an appropriate assessment and utilization of “analysis”, he will examine the concept through the following steps, a procedure which has not been taken explicitly so far : First, two ways of conceptualizing “analysis” in educational theory are identified, which the author names “analysis-1” and “analysis-2” respectively;'analysis-1' is conceived of as an aggregation of procedures good for checking argumentation or explicating meanings (and configuration) of concepts used in a theory. (Hiroshi Usami's view exemplifies this.) 'analysis-2' is conceived of as transforming data in an explicitly defined and orderly manner. (Seiji Tsuruta's view exemplifies this.) Second, the author will show that many of those characteristics which are commonly alleged of “analysis” such as “tendency for truth” shall be properly attributed to “Analysis-1” only; and that many others such as objectivity, critical power, and an attribute which is isomorphic with “analyticity”, to “analysis-2” only.Third, he will argue that many of the actual cases of “analysis” fall under “analysis-1” only; and that many others fall under “analysis-2” only.Consequently, one can naturally expect that an actual case of “analysis” does not necessarily have those merits or demerits which are inherent to “analysis-1” when it is in fact a case of “analysis-2” and vice versa.

著者

堤 大輔 Tsutsumi Daisuke

出版者

育英短期大学

雑誌

育英短期大学研究紀要 (ISSN:09143351)

巻号頁・発行日

no.28, pp.33-46, 2011-02