著者

吉田 善一 小田 良平

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.9, no.11, pp.230-235, 1951-11-30 (Released:2010-10-20)

参考文献数

70

被引用文献数

2 2

著者

吉田 善一

出版者

東洋大学井上円了研究センター

雑誌

井上円了センタ一年報 = Annual Report of the Inoue Enryo Center (ISSN:13427628)

巻号頁・発行日

vol.30, 2022-03

著者

入口 慎史 今井 徹 吉田 善一 折井 孝男

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.135, no.5, pp.745-751, 2015 (Released:2015-05-01)

参考文献数

32

被引用文献数

2 6

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Therapeutic drug monitoring (TDM) of vancomycin (VCM) is recommended to minimize its nephrotoxicity and maximize efficacy. Recently, the concept of systemic inflammatory response syndrome (SIRS) has been introduced to describe a clinical state resulting from the actions of complex intrinsic mediators in an acute-phase systemic response. However, there are few reports on the pharmacokinetics of VCM in patients with SIRS. This study investigated the effect of SIRS on the pharmacokinetics of VCM by analyzing the predictability of TDM and pharmacokinetic parameters in 31 non-SIRS patients and 52 SIRS patients, with stratification by SIRS score. The mean prediction error (ME) and mean absolute prediction error in SIRS score 2 and 3 patients differed from those in non-SIRS patients. The ME in the score 4 group showed a negative value. In the comparison of pharmacokinetic parameters by SIRS score, a significantly lower CLvcm value was observed at score 4 compared with scores 2 and 3, a higher Vd value was observed at score 4 compared with non-SIRS and at score 3, and a longer T1/2 was observed at score 2. In the comparison of patient characteristics by SIRS score, albumin, aspartate aminotransferase, and alanine aminotransferase levels showed differences among the scores. However, no correlation was observed between VCM pharmacokinetics and these three laboratory parameters. These findings suggest that the pharmacokinetics of VCM may be affected by the pathology of SIRS rather than by patient characteristics.

著者

今井 徹 吉田 善一

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.7, pp.967-972, 2016 (Released:2016-07-01)

参考文献数

7

被引用文献数

1

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Emergency and critical care centers provide multidisciplinary therapy for critically ill patients by centralizing the expertise and technology of many medical professionals. Because the patients' conditions vary, different drug treatments are administered along with surgery. Therefore, the role of pharmacists is important. Critically ill patients who receive high-level invasive treatment undergo physiological changes differing from their normal condition along with variable therapeutic effects and pharmacokinetics. Pharmacists are responsible for recommending the appropriate drug therapy using their knowledge of pharmacology and pharmacokinetics. Further, pharmacists need to determine the general condition of patients by understanding vital signs, blood gas analysis results, etc. It is therefore necessary to conduct consultations with physicians and nurses. The knowledge required for emergency medical treatment is not provided during systematic training in pharmaceutical education, meaning that pharmacists acquire it in the clinical setting through trial and error. To disseminate the knowledge of emergency medical care to pharmacy students, emergency care training has been started in a few facilities. I believe that medical facilities and universities need to conduct joint educational sessions on emergency medical care. Moreover, compared with other medical fields, there are fewer studies on emergency medical care. Research-oriented pharmacists must resolve this issue. This review introduces the work conducted by pharmacists for clinical student education and clinical research at the Emergency and Critical Care Center of Nihon University Itabashi Hospital and discusses future prospects.

著者

菊池 憲和 今井 徹 中馬 真幸 鏑木 盛雄 吉田 善一

出版者

一般社団法人 日本臨床救急医学会

雑誌

日本臨床救急医学会雑誌 (ISSN:13450581)

巻号頁・発行日

vol.19, no.1, pp.46-51, 2016-02-29 (Released:2016-02-29)

参考文献数

7

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目的:救急認定薬剤師の現状と今後の課題を把握するために,救急認定薬剤師の業務実態と展望を調査した。方法:2014年4月1日時点で日本臨床救急医学会により認定を受けた救急認定薬剤師に択一選択および自由記述の調査用紙を郵送した。結果:調査用紙の回収率は75%,所属施設の病床数は平均649床,救急・集中治療業務への従事率は77%であった。現在の業務内容として,処方提案,注射薬の監査,麻薬等の管理,投与速度の算出,治療薬物モニタリング(therapeutic drug monitoring; TDM),持参薬の確認については80%以上が行っており,救急認定薬剤師が精通している領域は,救急医療が最も多かった。今後実施したいと考えている業務は初療が60%,今後の展望として,業務のガイドライン作成が73%と最も多かった。考察:救急認定薬剤師が大小さまざまな施設で救急・集中治療に従事しており,今後は初療に関与してゆくことが課題であり,早急に業務ガイドラインの作成を行う必要があると考える。

著者

寺田 信幸 山田 博之 吉田 善一

出版者

公益社団法人 日本生体医工学会

雑誌

生体医工学 (ISSN:1347443X)

巻号頁・発行日

vol.43, no.4, pp.785-789, 2005 (Released:2007-01-19)

参考文献数

5

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Many studies have been carried out in order to understand the real effects of space environment on the human body. Our aim is to create a very small, energy-saving vital signs monitoring device capable of facilitating simple and precise blood tests in an orbiting vehicle where harsh technical conditions experienced. The device also has the potential to be used portable and ubiquitous diagnostics systems for medical care at home or bedside. In this study, we developed a micro-fluid device using laser-processing and resin-lamination methods. A number of heat-hardening resin films are layered on a soda glass. A laser is used to fabricate part of the channel on each film for every lamination. The channels are 45 μm in depth and 50-150 μm in width. The components we have currently produced were : 1) a trident channel structure ; 2) a solid-body flow channel with a micro-pipe, both of which were designed to make blood cells flow in a single line in the channel for cell counting ; and 3) a micro-flow channel simulating a capillary vessel for measuring blood coagulation, platelet aggregation, and transformation of red blood cells. We have successfully observed blood cells flowing in these micro-fluid devices.

著者

吉田 善一

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.40, no.11, pp.1076-1081, 1982-11-01 (Released:2009-11-13)

参考文献数

12

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Biomimetic chemistry, particularly in Japan, is reviewed based on the special project research “Biomimetic Chemistry” supported by Ministry of Education, Science and Culture. Emphasis is made on the synthetic applications and the future aspects of this field.

著者

飯塚 俊介 葉山 達也 内池 明博 堤 大輔 小田桐 功武 中山 敏光 早坂 正敏 村松 高 橋本 修 吉田 善一

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.43, no.3, pp.145-153, 2017-03-10 (Released:2018-03-10)

参考文献数

21

被引用文献数

1

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The absorption of gefitinib is dependent on gastric pH. However, an increase in gastric pH via the use of antacids such as proton pump inhibitors (PPI) and histamine H2 receptor antagonists may reduce the bioavailability and efficacy of gefitinib.In this study, we report the influence of the concurrent use of antacids with gefitinib on the efficacy in epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). Our subjects were 68 patients with NSCLC who were treated with gefitinib at our hospital between 2008 and 2015.In the study, we compared time to treatment failure (TTF), overall survival (OS), response rate, disease control rate and adverse effect rates in patients receiving antacids in combination as well as (AC; n = 29) with those only receiving gefitinib (no AC; n = 34).The patients in the AC group exhibited a significant difference in TTF (409 days (95%CI: 1.00-4.22) vs 901 days (95%CI: 0.24-0.99), P = 0.0492) as compared to the no AC group. But then the OS, response rate, disease control rate and adverse effects rate were not significant between each group. Therefore, this study suggests that, as long as the combination of gefitinib with antacids is avoided, the combination with antacids should not impair the clinical efficacy of gefitinib. From the results of the sub-analysis, this study suggests that, in particular men, less than 75 years old, PS≧2, pulmonary metastasis, it is preferable to avoid the combination of gefitinib and antacids.

著者

吉田 善一

出版者

公益社団法人 日本分析化学会

雑誌

分析化学 (ISSN:05251931)

巻号頁・発行日

vol.17, no.7, pp.871-878, 1968-07-05 (Released:2009-06-30)

参考文献数

29

著者

吉田 善一 アベリャナ バルジリオ バダナ ジェレミア

出版者

公益社団法人 日本工学教育協会

雑誌

工学教育研究講演会講演論文集 (ISSN:21898928)

巻号頁・発行日

vol.2015, pp.380-381, 2015

著者

山岸 光 吉田 善一 坂上 榮松 守屋 俊浩 増澤 恒明 矢島 正男 池田 博通 尾坂 一 小口 京吾 若林 優治

出版者

公益社団法人 精密工学会

雑誌

精密工学会学術講演会講演論文集

巻号頁・発行日

vol.2008, pp.955-956, 2008

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超精密微細な表面構造を持つ光学部品や、マイクロ医療用デバイスなどの加工を実現するために、ミリメートルからセンチメートルサイズの面積を、ナノメートルからマイクロメートオーダーで加工できる「レーザー・集束イオンビーム複合加工機」を開発した。この加工機は、FIBと3種類のレーザー、そしてAFMを有し、工作物の着脱無しで機上計測しながら、デバイス形状の全体に亘り、超精密微細三次元構造を加工できる。

著者

吉田 善一

出版者

社団法人日本化学会

雑誌

化学と教育 (ISSN:03862151)

巻号頁・発行日

vol.36, no.2, 1988-04-20