著者

石原 優 戸田 光 砂金 信義 太田 隆文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.131, no.5, pp.679-684, 2011-05-01 (Released:2011-05-01)

参考文献数

21

被引用文献数

5 6

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Furanocoumarins (FCs) such as bergamottin (BG) and 6′,7′-dihydroxybergamottin (DHBG) contained in grapefruits are known to be cytochrome P450 3A4 (CYP3A4) inhibitors. These are contained in larger quantity in peel than in pulp, and therefore, processed peel products possibly have strong CYP3A4 inhibitory activity. The CYP3A4 inhibitory potency of these processed peel products, however, remains to be elucidated. The FC content and CYP3A inhibitory activities of various processed fruit peel products were investigated. CYP3A inhibitory activities of crystallized grapefruit peel, grapefruit marmalade, lemon peel and bitter orange slice were close to that of 100% grapefruit juice, while the activities of yuzu slice, pomelo (buntan) marmalade and crystallized iyokan peel were very weak, 1/8-1/20 of 100% grapefruit juice. The maximum BG content was 5.6 μg/g in lemon peel. The maximum DHBG content was 7.2 μg/g in crystallized grapefruit peel, about 1/30 that of raw peel. Grapefruit marmalade and crystallized grapefruit peel contained similar amounts of FCs to 100% grapefruit juice, but FCs were not detected in pomelo (buntan) marmalade or crystallized iyokan peel. Good correlation (r=0.78) was observed between the FC contents of these peel products and those CYP3A inhibitory activities. Preparation of homemade grapefruit marmalade and crystallized peel revealed that considerably lower DHBG content in these products and lower CYP3A inhibitory activity than anticipated were attributable to outflow of DHBG to broth during boiling of the raw peel.

著者

太田 隆文 倉持 剛 柳浦 麻未 上村 直樹 金澤 幸江 杉浦 邦夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.1, pp.47-53, 2014-01-10 (Released:2015-01-10)

参考文献数

12

被引用文献数

1 5

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Polystyrene sulfonate drugs (PSS) are likely to adsorb coadministered drugs through ionic and hydrophobic interactions because of their chemical structures. Nine drugs frequently dispensed at our 3 pharmacies to administer with PSS concurrently were selected and examined for their adsorption in vitro to Kalimate® powder in pH 6.8.Cationic drugs in the solution, amlodipine besylate and dilazep hydrochloride hydrate were adsorbed almost totally, while anionic drugs, aspirin, furosemide and losartan potassium were only adsorbed in 0-15%. Non-ionic drugs, allopurinol, nifedipine and prednisolone were adsorbed to different extents, 9, 59 and 84%, respectively in proportion to their hydrophobicity (XLogP3). These data clearly indicate that cationic drugs and highly hydrophobic non-ionic drugs are susceptible to be adsorbed by PSS.The dissolution test of Adalat® L at pH 6.8, pH 4.5 and pH 1.2 in the presence of Argamate® Jelly showed that release of nifedipine was apparently depressed markedly at any pH.We propose that a description directing attention to the interaction with a wide range of drugs is added in the package inserts of PSS to avoid the occurrence of drug interactions.

著者

小合 由起 砂金 信義 太田 隆文 宇留野 強

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.125, no.12, pp.1009-1011, 2005-12-01 (Released:2005-12-01)

参考文献数

2

被引用文献数

6 7

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This study aimed to examine the effects of banana juice on levodopa bioavailability in rats. When a levodopa preparation (EC-Doparl tablets) was orally administered with banana juice made by mixing with a fresh banana and water, there were significant decreases in Cmax (17.4±2.5 vs. 8.6±3.1 μg/ml; α=0.05) and AUC (1882.8±49.2 vs. 933.5±286.6 μg•min/ml; α=0.05) for levodopa. On the other hand, administration of the levodopa preparation with a commercial beverage containing 10% banana juice resulted in no significant change in Cmax or AUC. These results indicate that concomitant intake of levodopa preparations with banana juice, but not with a commercial banana beverage, may cause a drug-food interaction reducing levodopa bioavailability, and we should pay attention to such interactions during levodopa therapy for patients with Parkinson's disease.

著者

小合 由起 砂金 信義 太田 隆文 宇留野 強

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.125, no.12, pp.1009-1011, 2005-12-01

被引用文献数

7

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This study aimed to examine the effects of banana juice on levodopa bioavailability in rats. When a levodopa preparation (EC-Doparl tablets) was orally administered with banana juice made by mixing with a fresh banana and water, there were significant decreases in C_<max>(17.4±2.5vs.8.6±3.1μg/ml;α=0.05) and AUC(1882.8±49.2vs.933.5±286.6μg・min/ml;α=0.05) for levodopa. On the other hand, administration of the levodopa preparation with a commercial beverage containing 10% banana juice resulted in no significant change in C_<max> or AUC. These results indicate that concomitant intake of levodopa preparations with banana juice, but not with a commercial banana beverage, may cause a drug-food interaction reducing levodopa bioavailability, and we should pay attention to such interactions during levodopa therapy for patients with Parkinson's disease.

著者

砂金 信義 小合 由起 太田 隆文 宇留野 強

出版者

日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集

巻号頁・発行日

vol.16, 2006-09-01

著者

飯田 淳子 砂金 信義 田中 裕子 太田 隆文

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集 17 (ISSN:24242470)

巻号頁・発行日

pp.367, 2007-09-01 (Released:2019-01-19)