著者

横山 徹 南 浩一郎 上田 陽 岡本 隆史

出版者

自治医科大学

雑誌

基盤研究(C)

巻号頁・発行日

2008

---

腰痛をはじめとする疼痛機序解明を目的にTRPチャネルを中心に細胞内痛みセンサーの解析を行った。皮膚や脊髄などでは、痛み刺激に反応するTRPV1やTRPA1が中枢神経系では、水分調節に関係する視索上核の存在するバゾプレッシン産生細胞に興奮性に作用することをはじめて見出した。また、下肢の痛みなどではバゾプレッシンの分泌が増加し、痛みとバゾプレッシンに密接な関係がある可能性を明らかにした。

著者

松下 宗洋 宮地 元彦 川上 諒子 岡本 隆史 塚本 浩二 中田 由夫 荒尾 孝 澤田 亨

出版者

一般社団法人日本体力医学会

雑誌

体力科学 (ISSN:0039906X)

巻号頁・発行日

vol.62, no.5, pp.375-381, 2013-10-01 (Released:2013-10-19)

参考文献数

29

---

Several studies have shown that low cardiorespiratory fitness (CRF) or heavy alcohol consumption is risks of total or certain types of cancer death. However, the combined influence of CRF and drinking habits on total cancer mortality is not clear. The purpose of this study was to investigate the joint effect of CRF and drinking habits on total cancer mortality among Japanese men. We evaluated the CRF and drinking habits on risk of total cancer mortality in 8,760 Japanese men (age: 19-59 yr) who were given a submaximal exercise test, a medical examination test, and questionnaires on their health habits. CRF was measured using a cycle ergometer test, and the men were classified into two categories by CRF levels based on the reference value of CRF (R-CRF) in “Physical Activity Reference for Health Promotion 2013” (Under R-CRF and Over R-CRF). Also, the men were assigned to Non Drinking, Moderate Drinking, and Heavy Drinking categories. There were 178 cancer deaths during the 20-yr follow-up period. Relative risk and 95% confidence intervals for total cancer mortality were obtained using the Cox proportional hazards model while adjusting for age, body mass index, systolic blood pressure, and smoking habits. Using the Under R-CRF & Heavy Drinking group as reference, the relative risk and 95% confidence intervals were 0.37 (0.16–0.85) for the Over R-CRF & Non Drinking group. This result suggests that Japanese male with a high CRF and a low drinking habit have a lower risk of total cancer mortality.