著者

小池 麻由 大津 史子 榊原 仁作 後藤 伸之

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.14, no.4, pp.134-143, 2013-02-28 (Released:2013-03-06)

参考文献数

20

被引用文献数

12

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Objective: Recently, use of health foods and supplements, as well as the amount of information available about them, has been steadily increasing.  Therefore, a noticeable increase in adverse drug reactions caused by health foods and supplements has also been seen.  The purpose of this study was to clarify the current status and backgrounds of patients with health food- or supplement-related adverse health effects.Methods: We selected the cases of health food- or supplement-related adverse health effects from the Case Reports of Adverse Drug Reactions and Poisoning Information System (CARPIS) database, which contains over 57,000 case reports of adverse drug reactions.  We investigated the background, suspected products and adverse events in each case and conducted univariate logistic regression analysis to determine significance.Results: We obtained a total of 327 cases consisting of 103 causative products.  Women comprised 66% of study subjects and had a significant association with dietary supplements.  Patients with a history of liver disease had a significant association with liver damage caused by “Ukon,” a drink made from turmeric root and sold as an anti-hangover remedy in Japan.Conclusion: The causative products had several unique features.  This information should be utilized to prevent health food- and supplement-related adverse health effects in the future.

著者

掛谷 雅之 大津 史子 矢野 玲子 榊原 仁作 後藤 伸之

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.16, no.2, pp.70-80, 2014 (Released:2014-09-06)

参考文献数

23

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Objective: The present study investigated risk factors and subjective symptoms associated with drug-induced thrombocytopenia.Methods: We selected 361 patients with drug-induced thrombocytopenia from the Case Reports of Adverse Drug Reactions and Poisoning Information System (CARPIS) database of over 65,000 case reports of adverse drug reactions and assigned these patients to a case group.  We also randomly selected 794 cases of adverse drug reactions not associated with thrombocytopenia as a control group.Results: Data were compared between the case and control groups, and results were analyzed using logistic regression analysis.  We identified type of infection (non-viral) and renal failure as risk factors for drug-induced thrombocytopenia.  In addition, administration of carbamazepine, methotrexate, interferon alpha, ticlopidine or valproic acid significantly increased the risk of drug-induced thrombocytopenia.  Significant associations were also found between drug-induced thrombocytopenia and purpura, fever, and mucosal bleeding.Conclusion: These findings provide helpful information for early detection and prevention of thrombocytopenia as a serious adverse drug reaction.

著者

榊原 仁作 永井 慎一 森 淳 竹谷 和視 堀田 芳弘

出版者

日本生薬学会

雑誌

生薬学雑誌 (ISSN:00374377)

巻号頁・発行日

vol.40, no.3, pp.p317-324, 1986-09

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20R-Dihydroouabain (20R-DHO) and 20S-dihydroouabain (20S-DHO) were synthesized by reduction of ouabain (G-strophanthin) and separated by reversed phase high performance liquid chromatography. The relationships between the stereochemical structures and pharmacological activities of 20R- and 20S-DHO were studied by the use of isolated guinea-pig papillary muscle and renal Na^+, K^+-ATPase. 20S-DHO was more inotropic (pD_2: 5.0, 100% increase in contractile force at 3.0 x 10^<-5> M) and more inhibitory (pIC_<50>: 5.9) than 20R-DHO (pD_2: 4.6, 100% increase in contractile force at 1.0 × 1O^<-4> M, pIC_<50>: 5.5). On the other hand, both R and S compounds inhibited the positive inotropic effect of their parent compound ouabain; the potency of inhibition by 20S-DHO was greater than that by 20R-DHO. These results suggest that the pharmacological differences in 20R- and 20S-DHO may depend on the strength of hydrogen bond between the carbonyl oxygen and Na^+, K^+-ATPase receptor.

著者

内藤 俊一 橋本 庸平 百瀬 雄章 榊原 仁作

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.15, no.9, pp.773-778, 1979-09-01 (Released:2018-08-26)

著者

小林 和弘 織田 範一 榊原 仁作

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.103, no.2, pp.165-172, 1983-02-25 (Released:2008-05-30)

参考文献数

16

被引用文献数

1 1

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Ethyl 5-hydroxybenzo [α] phenazine-6-carboxylates (IIa, b) were prepared by the condensation of ethyl 1, 4-dihydro-1, 4-dioxo-3-methoxy-2-naphthoate (I) with o-phenylene-diamines. Acylations and alkylations of IIa, b gave the corresponding o-acyl and alkyl compounds (IIIa-k). The reaction of IIa, b with ethanolamine gave β-hydroxyethyl-carboxamides (Va, b). Compound Va was converted into β-chlorinated compound (VIa), whose chlorine was substituted by dialkylamines to give ethylenediamine-type amides (VIIa, b, c). Compounds VIId and VIIe were obtained by the reaction of IIb with dialkylalkylenediamines. Oxidation of IIa, b afforded N-oxides (IXa, b). The antimicrobial activities of all synthetic compounds were tested by paper discagar diffusion assay. Compounds IIId, e, g, VIIa and IXa showed inhibitory activities to T. interdigitale and IXa to C. albicans.

著者

小林 和弘 織田 範一 榊原 仁作

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.103, no.4, pp.473-479, 1983-04-25 (Released:2008-05-30)

参考文献数

8

被引用文献数

1 1

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Ethyl 1, 4-dihydro-1, 4-dioxo-3-methoxy-2-naphthoate (I) is condensed with amidines, 2-aminopyridines and 3-aminopyrazole, to give new tetracyclic quinones (IIIa-c and VI) containing nitrogen atom and hydrogenation of IIIa and IIIb over Pd-C or Raney-Ni afforded 1, 2, 3, 4-tetrahydro (IXa, b) or 1, 2, 3, 4, 7, 8, 9, 10-octahydrobenzo[g]pyrido[2, 1-b]quinazoline (Xa), respectively. Benzo[g]pyrido[2, 1-b]quinazoline derivatives except for Xa showed inhibitory activities to S. aureus and T. interdigitale.

著者

小林 和弘 織田 範一 榊原 仁作

出版者

公益社団法人日本薬学会

雑誌

薬学雑誌 (ISSN:00316903)

巻号頁・発行日

vol.103, no.2, pp.p165-172, 1983-02

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Ethyl 5-hydroxybenzo [α] phenazine-6-carboxylates (IIa, b) were prepared by the condensation of ethyl 1,4-dihydro-1,4-dioxo-3-methoxy-2-naphthoate (I) with o-phenylene-diamines. Acylations and alkylations of IIa, b gave the corresponding o-acyl and alkyl compounds (IIIa-k). The reaction of IIa, b with ethanolamine gave β-hydroxyethyl-carboxamides (Va, b). Compound Va was converted into β-chlorinated compound (VIa), whose chlorine was substituted by dialkylamines to give ethylenediamine-type amides (VIIa, b, c). Compounds VIId and VIIe were obtained by the reaction of IIb with dialkylalkylenediamines. Oxidation of IIa, b afforded N-oxides (IXa, b). The antimicrobial activities of all synthetic compounds were tested by paper discagar diffusion assay. Compounds IIId, e, g, VIIa and IXa showed inhibitory activities to T. interdigitale and IXa to C. albicans.

著者

林 恭子 大津 史子 矢野 玲子 榊原 仁作 後藤 伸之

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.131, no.1, pp.139-152, 2011 (Released:2011-01-01)

参考文献数

32

被引用文献数

3 3

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The present study investigated risk factors and subjective symptoms associated with drug-induced leucopenia. We selected 248 patients with drug-induced leucopenia from the Case Reports of Adverse Drug Reactions and Poisoning Information System (CARPIS) database of over 47000 case reports of adverse drug reactions and assigned them to a case group. We also randomly selected 743 cases of adverse drug reactions not associated with leucopenia as a control group. A comparison of patient characteristic data between the two groups using logistic-regression analysis revealed that female sex, autoimmune disease and renal damage were background risk factors for drug-induced leucopenia. In addition, thiamazole, ritodrine, propylthiouracil, ticlopidine, allopurinol, minocycline and captopril administration significantly increased the risk of drug-induced leucopenia. A significant association was also found for fever, chills and pharyngeal abnormalities. Based on these findings, we developed two estimated regression equations to help prevent drug-induced leucopenia in the community pharmacy setting.

著者

安江 政一 加藤 義成 林 玉美 榊原 仁作

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.88, no.6, pp.738-741, 1968-06-25

被引用文献数

1

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Dried leaves of Acanthopanax sciadophylloides FRANCH. et SAV. were extracted with methanol and the water-soluble part of the extract was treated successively with solutions of lead acetate, basic lead acetate, and ammoniacal alkaline lead salt, as shown in Chart 1. myo-inositol, scyllitol, kaempferitrin, and antoside were isolated and identified. The constituents of these leaves were somewhat different according to the district where the materials came from. Utkin had suggested the structure of antoside as quercetin 3 (7)-glucosido-7 (3)-rhamnoside. Relative positions of glucose and rhamnose in the antoside molecule were now determined by enzymatic cleavage of rhamnose to give quercetin 3-glucoside (isoquercitrin) (Chart 2).