著者

座間味 義人 相良 英憲 萱野 由佳 小山 敏広 白石 奈緒子 江角 悟 鵣川 豊世武 千堂 年昭 氏家 良人 名倉 弘哲

出版者

一般社団法人 日本臨床救急医学会

雑誌

日本臨床救急医学会雑誌 (ISSN:13450581)

巻号頁・発行日

vol.19, no.3, pp.461-465, 2016-06-30 (Released:2016-06-30)

参考文献数

9

被引用文献数

1

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エダラボンを用いた治療は患者の神経学的予後を改善する一方,急性腎障害発現のリスクがあると報告されている。本研究はエダラボン投与による急性腎障害発現を予防するために,エダラボン投与時の患者背景から危険因子を解析することを目的とした。岡山大学病院においてエダラボンが投与された患者を対象に,患者基本情報およびエダラボン投与情報,血液検査結果を電子カルテより遡及的に調査した。調査データから単変量解析を実施し,抽出した因子を用いて二項ロジスティック回帰分析を行った結果,感染症の併発が,エダラボンによる急性腎障害発現の有意な危険因子(予測因子)であることが示唆された。したがって,感染症の所見がある患者にエダラボンを投与する際は,急性腎障害発現に留意する必要がある。

著者

江角 悟 佐藤 智昭 黒田 智 河崎 陽一 名倉 弘哲 北村 佳久 千堂 年昭

出版者

一般社団法人日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.18, no.2, pp.72-80, 2016 (Released:2016-09-27)

参考文献数

15

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Objective: In drug treatment for pregnant and lactating women, pharmacists need to contribute to adequate drug treatment by collecting much information from various sources.  However, it takes much time to collect information using plural sources.  In this study, we tried to develop a database system which enables expeditiously collecting the domestic and foreign drug use criteria information in order to streamline collecting information for pregnant and lactating women.  In addition, we assessed the utility of the database by comparing the time to collect information using the database to that using each information source and the usability by questionnaires.Methods: We developed a database system that integrates drug information from the FDA Pregnancy Category, Australian categories for prescribing medicines in pregnancy, “Drugs in Pregnancy & Lactation,” and Japanese package inserts.  For assessment of the usability of the database, we assessed the time required to collect information and subjective evaluation using the five-method questionnaires.Results: The database significantly reduced the time needed for collecting criteria information and made it possible to compile the information simultaneously from various sources.  The questionnaire survey showed that over 80% of pharmacists and students were satisfied with the database.Conclusion: It is suggested that our database system is useful to efficiently collect drug use criteria information for pregnant and lactating women.

著者

小川 敦 牛尾 聡一郎 亀田 雅博 横木 梓 椋田 千晶 江角 悟 渡邊 亜津子 村川 公央 安原 隆雄 北村 佳久 伊達 勲 千堂 年昭

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.47, no.8, pp.445-451, 2021-08-10 (Released:2022-08-10)

参考文献数

22

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A female patient in her 30s developed intractable trigeminal neuralgia on the left side of her face due to a metastatic tumor in the left middle cranial fossa. Despite being treated with carbamazepine, gabapentin, pregabalin, baclofen, tramadol, lidocaine, Neurotropin, and nerve block, the trigeminal neuralgia was not resolved. After a joint discussion between pharmacists and neurosurgeons, the patient was suspected of having trigeminal neuralgia with facial numbness due to a tumor. We, therefore, administered traditional the Japanese herbal medicine Goshajinkigan, a formulation approved for pain and numbness. An MRI revealed a tumor with edema around the left trigeminal nerve, and the traditional Japanese herbal medicine Saireito was also administered to reduce edema. Her neuralgia improved markedly after Goshajinkigan and Saireito administration, i.e., the pain was confined to a narrow area on her left lower eyelid, temple, and lower jaw. Furthermore, her breakthrough pain scale score decreased from numerical rating scale (NRS) 10 to NRS 3, and her continuous pain scale score decreased from NRS 10 to NRS 0. The findings from this case suggest that Goshajinkigan and Saireito may benefit patients with intractable trigeminal neuralgia.

著者

江角 悟 河崎 陽一 猪田 宏美 北村 佳久 千堂 年昭

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.138, no.5, pp.649-653, 2018-05-01 (Released:2018-05-01)

参考文献数

5

被引用文献数

1

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Pharmacists are required to contribute to evidence-based medicine (EBM) by providing drug information, which can be collected from various sources such as books, websites, and original articles. In particular, information from original articles is needed in some situations. For example, original articles by international researchers are used to aid the management of novel in-hospital preparations on which little knowledge is available. We introduced an information evaluation program, the Okayama University Hospital EBM Model, into the clinical training of 5th-year pharmacy students. It aims to enable students to evaluate the validity of novel in-hospital preparations using original articles. This program has improved students' knowledge of EBM, and the satisfaction level of those enrolled was high. In addition, customer satisfaction analysis revealed that the overall degree of student satisfaction was related to their understanding of the necessity for EBM and the difficulty of practical training. In addition, students' achievements were evaluated using rubrics, and that method allowed the achievements of each student to be assessed appropriately. We hope to revise this program with the aim of improving students' understanding of EBM.

著者

牛尾 聡一郎 北村 佳久 江角 悟 座間味 義人

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学会年会要旨集 第95回日本薬理学会年会 (ISSN:24354953)

巻号頁・発行日

pp.1-P-062, 2022 (Released:2022-03-21)

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Hochuekkito (HET), a Kampo medicine, is used to treat post-operative and post-illness general malaise and decreased motivation. HET is known to regulate immunity and inflammation. However, the mechanism underlying the anti-anxiety effect of HET is unknown. In this study, we revealed the effect of HET on lipopolysaccharide (LPS) -induced anxiety-like behavior and examined the mechanism underlying LPS induced anxiety-like behaviors. Following the administration of LPS (300 µg/kg, i.p.), mice demonstrated inflammation-induced anxiety-like behaviors in hole-board and light-dark box tests. Systemic administration of LPS increased the serum levels of interleukin-6. Repeated administration of HET (1.0 g/kg, p.o.) once a day for 2 weeks before LPS treatment ameliorated anxiety-like behavior and reduced LPS-induced serum levels of interleukin-6 in 5 h after LPS treatment. Additionally, HET decreased LPS-induced secretion of interleukin-6 in human macrophage cell line (THP-1) and mouse macrophage cell line (RAW264.7) as in mouse models. Therefore, our findings suggest that HET may be useful in treating inflammation-induced anxiety-like behavior.