1 0 0 0 OA 透析医療を科学する臨床研究デザイン : 抄録道場
- 著者
- 長谷川 毅 佐田 憲映 柴垣 有吾 福原 俊一 秋澤 忠男
- 出版者
- 一般社団法人 日本透析医学会
- 雑誌
- 日本透析医学会雑誌 (ISSN:13403451)
- 巻号頁・発行日
- vol.44, no.3, pp.221-227, 2011-03-28 (Released:2011-04-14)
- 参考文献数
- 5
1 0 0 0 OA リンの有害な作用とその除去上の問題点
- 著者
- 秋澤 忠男 越川 昭三
- 出版者
- 日本膜学会
- 雑誌
- 膜 (ISSN:03851036)
- 巻号頁・発行日
- vol.17, no.1, pp.12-18, 1992-01-01 (Released:2011-03-04)
- 参考文献数
- 17
- 被引用文献数
- 2 2
Phosphate (P) retention, resulted from renal insufficiency directly or indirectly provides pathogenetic roles to the human body. P related signs and symptoms include osteodystrophy, metastatic calcification, central or peripheral neuropathy, anemia, cardiomyopathy, lipid and carbohydrate mal-metabolisms, immunodysfunctions and so on. From these pathological effects of P, P is regarded as one of the major uremic toxins. In spite of the small molecular weight of P, P always shows lower dialysis efficiency than urea. This result can be partially explained by the interaction between negatively charged P and dialysis membrane. Although computer simulation model represented the increase in dialysis efficiency of P across the positively charged membranes, these membranes have not been clinically available. Dialysis membrane with larger membrane pore size and increased porosity significantly stimulated the P removal, however dialysis efficiency of P remained still lower than urea. From these results, it is strongly expected that membrane technology will succeed in the development of new dialysis membrane with more effective P removal.