著者

蓮沼 英樹 市瀬 孝道 上田 佳代 小田嶋 博 金谷 久美子 清水 厚 高見 昭憲 竹内 文乃 西脇 祐司 渡部 仁成 橋爪 真弘

出版者

一般社団法人日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.74, pp.19010, 2019 (Released:2019-12-25)

参考文献数

63

被引用文献数

1

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Asian dust is a phenomenon involving the long-range transport of atmospheric pollutants originating from the desert areas of China and Mongolia. In recent years, the health effects of Asian dust have raised public concerns. Numerous studies on the health effects of Asian dust have been published since the last review in 2010. Thus, a literature review was conducted to shed light on the latest epidemiologic findings. PubMed and Science Direct databases were used for the review of epidemiologic studies published between June 2009 and April 2018. We identified 53 epidemiologic studies. Mortality, ambulance transportation, hospitalization/medical examination, changes in symptomatic, functional, and examination findings, as well as birth outcomes have been reported as outcomes. When the outcomes were categorized by disease, the effects of Asian dust on respiratory, cardiovascular, and allergic diseases raised concerns. The common evidences of causation between Asian dust and these diseases were the consistency of findings and temporal sequence of association. As results of research on dose-response relationships have become available, and the possibility that the health effects of Asian dust may vary depending on its chemical composition has been pointed out, further research using the exposure level indicators of Asian dust or its chemical composition should be conducted. Furthermore, with focus on the crucial issue of reducing exposure, research related to prevention and raising awareness should be further promoted.

著者

射場 浩介 道家 孝幸 花香 恵 金谷 久美子 阿部 恭久 山下 敏彦

出版者

日本疼痛学会

雑誌

PAIN RESEARCH (ISSN:09158588)

巻号頁・発行日

vol.31, no.4, pp.203-209, 2016-12-26 (Released:2017-01-27)

参考文献数

20

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We have recently demonstrated that pathological changes leading to increased bone resorption by osteoclast activation are related to the induction of pain–like behavior in ovariectomized (OVX)mice. In addition,we have shown that the skeletal pain accompanying osteoporosis is possibly associated with the acidic microenvironment caused by osteoclast activation under a high bone turnover state. We, therefore, hypothesize that another osteoporosis model mouse might reveal the induction of pain–like behaviors in relation with osteoporotic changes. In this study, we demonstrated that regional osteoporosis of hind limbs induced pain–like behaviors using tailsuspended mice as another osteoporosis model.The hind limbs of tail–suspended mice were unloaded for 2 weeks, during which time the mice revealed significant regional osteoporotic changes in their hind limbs accompanied by osteoclast activation. In addition, these changes were significantly recovered by the resumption of weight bearing on the hind limbs for 4 weeks. Consistent with the pathological changes in the hind limbs, pain–like behaviors in the mice were induced by tail suspension and recovered by the resumption of weight bearing. Moreover, treatment with bisphosphonate significantly prevented the triggering of the regional osteoporosis and pain–like behaviors, and antagonists of the acid–sensing nociceptors, such as transient receptor potential channel vanilloid subfamily member 1 and acid–sensing ion channels, significantly improved the painlike behaviors in the tail–suspended mice.We, therefore, believe that pathologic changes of osteoporosis due to osteo clast activation might be a trigger for the pain–like behaviors in osteoporosis patients.