著者

Tomoharu Ishikawa Muneto Tatsumoto Katuhiro Maki Minoru Mitsui Hiroshi Hasegawa Koichi Hirata

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.2206-18, (Released:2019-02-01)

参考文献数

33

被引用文献数

9

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Objectives Sound hypersensitivity is highly comorbid with migraine headaches. To elucidate the pathogenic mechanism of migraine attacks, we must first identify the types of everyday environmental sounds they perceive as unpleasant and clarify the acoustic properties of such sounds. This study aimed to clarify the true nature of "noise," i.e. everyday sounds perceived as unpleasant by migraineurs, by evaluating their subjective comfort/discomfort in response to several sounds commonly heard in everyday life. Methods Participants were presented with 20 environmental sounds they would likely hear daily. Subjects rated the pleasantness/unpleasantness of each stimulus using a nine-step scale. Patients We recruited 50 adults with migraine headaches (46 women, 4 men) and 50 healthy controls (35 women, 15 men). Results Migraineurs provided statistically significantly lower (more unpleasant) ratings to ambulance sirens, police car sirens, and railroad crossing bells than did controls. Our analysis also investigated the acoustic characteristics associated with higher rating gaps between the two groups. Greater divergence in ratings for the same stimulus was associated with less power (smaller amplitude envelope) and slower temporal variation in signals in the 400-Hz band. Conclusion We identified specific signal components associated with different subjective (un) pleasantness scores between migraineurs and healthy adults, which may lead to the elucidation of the pathogenic mechanism underlying migraine attacks triggered by sound.

著者

Natsuki SUGIYAMA Hiroshi HASEGAWA Kentaro KUDO Ryo MIYAHARA Rikizo SAITO Chikashi MARUKI Masaru TAKASE Akihide KONDO Hidenori OISHI

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.9, pp.225-230, 2022-12-31 (Released:2022-07-27)

参考文献数

18

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There are only a few case reports in which cholesterol crystals were found in the thrombus retrieved by mechanical thrombectomy for cryptogenic stroke, leading to a definitive diagnosis. We herein report a case of aortogenic embolic stroke diagnosed by the presence of rich cholesterol crystals in the retrieved thrombus and review the previously reported cases. A woman in her 80s was transferred as an emergency due to consciousness disturbance, right conjugate deviation, and severe left hemiparesis. Magnetic resonance imaging showed occlusion of the right middle cerebral artery (MCA) and acute infarction in the territory. The MCA was recanalized by thrombectomy using an aspiration catheter and stent retriever, and the symptoms improved. Although the physiological examination did not detect the embolic source during hospitalization, pathological examination of the thrombus revealed atheroma with numerous cholesterol crystal clefts and intermixing of fibrin. Contrast-enhanced computed tomography performed based on the pathological results showed atheromatous lesions in the aortic arch as the embolic source. As a subsequent treatment, medications of a strong statin and an antiplatelet agent were continued, and the patient had no recurrence. The finding that the retrieved thrombus is a simple atheroma containing cholesterol crystals with poor hemocytes suggests embolism due to plaque rupture. Pathological examination of the thrombus obtained by thrombectomy is one of the useful diagnostic approaches for stroke etiology and the determination of its treatment.

著者

Tadashi Nakajima Reika Kawabata-Iwakawa Yoshiaki Kaneko Shin-ichiro Hamano Rie Sano Shuntaro Tamura Hiroshi Hasegawa Takashi Kobari Yoshihiko Kominato Masahiko Nishiyama Masahiko Kurabayashi

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.20-203, (Released:2020-09-12)

参考文献数

19

被引用文献数

7

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While a KCND3 V392I mutation uniquely displays a mixed electrophysiological phenotype of Kv4.3, only limited clinical information on the mutation carriers is available. We report two teenage siblings exhibiting both cardiac (early repolarization syndrome and paroxysmal atrial fibrillation) and cerebral phenotypes (epilepsy and intellectual disability), in whom we identified the KCND3 V392I mutation. We propose a link between the KCND3 mutation with a mixed electrophysiological phenotype and cardiocerebral phenotypes, which may be defined as a novel cardiocerebral channelopathy.

著者

Yuka Kobara Hiroshi Hasegawa Masanori Hirose Hiroyuki Takano Yoshio Kobayashi

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.17-547, (Released:2018-10-25)

参考文献数

52

被引用文献数

2

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Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used as antidiabetic drugs. We recently reported that DPP-4 inhibition has beneficial effects on heart failure (HF) mice model. Furthermore, we confirmed that myocardial DPP-4 activity was significantly increased in HF mice compared with non-HF mice. The aim of this study was to investigate the level of myocardial CD26 (DPP-4) expression and its association to clinical parameters in HF patients.Endomyocardial biopsy (EMB) specimens (n = 33) were obtained from HF patients who were admitted to Chiba University Hospital from June 2006 to July 2012. EMB specimens were fixed in formaldehyde and stained with Masson's trichrome staining or with anti-CD26 antibody. Patients were divided into the high CD26 density (CD26-H) or low CD26 density groups (CD26-L). DPP-4 density was compared with blood brain natriuretic peptide (BNP) level and echocardiographic parameters at one year after EMB. Although there were no significant differences in echocardiographic parameters between the CD26-H group and CD26-L group, blood BNP levels were higher in the CD26-H group than in the CD26-L group at one year after EMB. Multivariate regression analysis showed that CD26 density was also an independent determinant of blood BNP levels at one year after EMB.The level of myocardial CD26 expression might be a predictive marker of prognosis in patients with HF.

著者

Maya KAMAO Yoshihisa HIROTA Yoshitomo SUHARA Naoko TSUGAWA Kimie NAKAGAWA Toshio OKANO Hiroshi HASEGAWA

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.33, no.7, pp.863-867, 2017-07-10 (Released:2017-07-10)

参考文献数

22

被引用文献数

6

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This study aimed to develop a menadione (MD) determination method employing liquid chromatography–tandem mass spectrometry (LC-MS/MS) using a pseudo multiple reaction monitoring (MRM) technique, wherein two quadrupoles are used to monitor the same ion. Detection limits of 40 and 2 pg were obtained for MD and its deuterium-labeled form, respectively, whereas MD intra- and inter-assay coefficient of variation values were determined as 5.4 – 8.2%, with the corresponding recoveries equaling 90.5 – 109.6%. The developed method enables determination of MD in urine, plasma, cell extract, and culture media, demonstrating that pseudo multiple reaction monitoring can achieve quantification of compounds forming no suitable product ions, such as MD.

著者

Yoshiaki Kaneko Tadashi Nakajima Takashi Iizuka Shuntaro Tamura Hiroshi Hasegawa Masahiko Kurabayashi

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.61, no.2, pp.380-383, 2020-03-28 (Released:2020-03-28)

参考文献数

13

被引用文献数

1 3

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We report a case of atypical slow-slow atrioventricular nodal reentrant tachycardia (AVNRT) utilizing a superior slow pathway as a retrograde limb. The standard electrophysiological criteria confirm the diagnosis of this AVNRT by successfully excluding a diagnosis of atrial tachycardia and atrioventricular reentrant tachycardia. The earliest atrial activation during tachycardia was found at the interatrial septum 17.5 mm superior to the site identified during retrograde conduction with the fast pathway. The tachycardia was not inducible after ablation at the right posterior septum, consistent with successful ablation of the typical slow pathway.

著者

Naoko TSUGAWA Akiko KUWABARA Honami OGASAWARA Mayu NISHINO Kimie NAKAGAWA Maya KAMAO Hiroshi HASEGAWA Kiyoshi TANAKA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.68, no.3, pp.172-180, 2022-06-30 (Released:2022-06-30)

参考文献数

33

被引用文献数

4

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Avoidance of sunlight and self-restraint due to the COVID-19 pandemic may contribute to reduced vitamin D status. This study provides comparable data on vitamin D status in Japanese young women and assesses the effect of lifestyle, including changes caused by the COVID-19 pandemic, on vitamin D status. In study 1, 39 young healthy Japanese women aged 21–25 y were recruited from May 2016–June 2017. Serum 25-hydroxyvitamin D (25OHD) concentration and diet and lifestyle information were obtained from participants each month (n=124). In study 2, using the same parameters as study 1, young women aged 21–23 y (n=10) were recruited in September 2020. In the results of study 1, we found the frequencies of vitamin D deficiency (25OHD<20 ng/mL) in spring, summer, fall, and winter were 90.5%, 62.5%, 81.5%, and 91.3%, respectively. The substantial difference of serum 25OHD concentration was obtained in spring (Δ3.6 ng/mL) and summer (Δ5.1 ng/mL) depending on the frequency of sunscreen use (0–2 d/wk, 3–7 d/wk). In study 2, serum 25OHD concentration in September 2020 was extremely lower than in September 2016 (13.2 ng/mL vs. 21.7 ng/mL). The number of days spent outside in 2020 decreased drastically compared with 2019. In conclusion, vitamin D deficiency was highly common in Japanese women in their early 20s, and frequent sunscreen use contributed to low vitamin D status. Moreover, because the decrease in days outside due to the COVID-19 pandemic obviously resulted in a decline in vitamin D status, both appropriate sunbathing and increased dietary vitamin D intake are recommended to young women.

著者

Kei Nakayama Mari Kondo Tomoko Okuno Nurhanani Razali Hiroshi Hasegawa

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

pp.b22-00842, (Released:2022-12-27)

参考文献数

29

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Immune suppression in elderly individuals is one of the most important hygienic problems in aged societies. The primary immune organ thymus is histologically and functionally reduced by aging, which is known as thymic involution. The thymus is also involuted by nutritional deficiency, which frequently occurs in elderly individuals. However, there is no information on the thymic changes caused by nutritional deficiency with aging. Therefore, this study was conducted to examine the histological and molecular responses of the thymus to nutritional deficiency in young and aged mice. The thymic size was significantly smaller in 16- or 18-week-old aged mice than in 7-week-old young mice. Dietary restriction for 48 h reduced the thymic size in young mice, but not in aged mice. Immunostaining with anti-keratin 5 antibody revealed that the integrity of the corticomedullary boundary was maintained in the aged thymus, whereas dietary restriction induced its disorganization in both young and aged thymus. The numbers of IgG-positive cells were increased upon dietary restriction in aged, but not in young, thymus. Dietary restriction, but not aging, upregulated the mRNA levels of Th2-related Il5, Il6, and Il10, whereas aging increased that of Th1-related Ifng. The dietary restriction–induced upregulation of prostanoid-synthesizing enzymes was clearly observed in the young thymus but attenuated in the aged thymus. Thus, nutritional deficiency and aging cause an involuted thymus with different properties. Moreover, the thymus in aged mice does not show further reduction in size by nutritional deficiency but still responds differently compared with that in young mice.

著者

Takuji TACHIBANA Yusuke HIROTA Keijiro SUZUKI Takehiro TSURITANI Hiroshi HASEGAWA

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Communications (ISSN:09168516)

巻号頁・発行日

pp.2022EBN0001, (Released:2022-10-03)

被引用文献数

4

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To accelerate research on Beyond 5G (B5G) technologies in Japan, we propose an algorithm that designs mesh-type metropolitan area network (MAN) models based on a priori Japanese regional railway information, because ground-truth communication network information is unavailable. Instead, we use the information of regional railways, which is expected to express the necessary geometric structure of our metropolitan cities while remaining strongly correlated with their population densities and demographic variations. We provide an additional compression algorithm for use in reducing a small-scale network model from the original MAN model designed using the proposed algorithm. Two Tokyo MAN models are created, and we provide day and night variants for each while highlighting the number of passengers alighting/boarding at each station and the respective population densities. The validity of the proposed algorithm is verified through comparisons with the Japan Photonic Network model and another model designed using the communication network information, which is not ground-truth. Comparison results show that our proposed algorithm is effective for designing MAN models and that our result provides a valid Tokyo MAN model.

著者

Ryuta Shigefuku Kyoko Yoshikawa Mone Tsukimoto Hirono Owa Yasuyuki Tamai Masahiko Tameda Suguru Ogura Ryosuke Sugimoto Hideaki Tanaka Akiko Eguchi Kazushi Sugimoto Hiroshi Hasegawa Motoh Iwasa Hayato Nakagawa

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.9701-22, (Released:2022-06-21)

参考文献数

14

被引用文献数

5

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A 70-year-old man was diagnosed with hepatocellular carcinoma (HCC) with portal vein invasion and lung metastases, for which atezolizumab plus bevacizumab (ATZ/BEV) was initiated. After two months, computed tomography revealed tumor growth accompanied by ascites, right ventricular invasion, exacerbation of the lung metastases, and main portal vein invasion. However, continuation of ATZ/BEV caused remarkable size reductions in all lesions, finally resulting in the disappearance of the vascular invasion and lung metastases after nine cycles of treatment. The tumor growth was considered to reflect pseudoprogression, which is difficult to distinguish from hyperprogression. We herein report a remarkable HCC case of pseudoprogression on ATZ/BEV.

著者

長谷川 博 ハセガワ ヒロシ Hiroshi HASEGAWA

雑誌

千葉商大論叢

巻号頁・発行日

vol.47, no.1, pp.65-91, 2009-09

著者

長谷川 博 Hiroshi Hasegawa

出版者

関西外国語大学・関西外国語大学短期大学部

雑誌

関西外国語大学教育研究報告 = Kansai Gaidai Educational Research and Report

巻号頁・発行日

vol.2, pp.1-14, 2001-08

著者

Ryota Nakasaki Hiroshi Hasegawa Masao Kasuga

出版者

ACOUSTICAL SOCIETY OF JAPAN

雑誌

Acoustical Science and Technology (ISSN:13463969)

巻号頁・発行日

vol.34, no.3, pp.159-165, 2013-03-01 (Released:2013-05-01)

参考文献数

11

被引用文献数

1 5

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In this paper, we investigated subjective impressions of air-conditioning sounds in a vehicle by using the psychoacoustic parameters of loudness and sharpness. First, we carried out a subjective evaluation using a rating scale method and investigated the relationships between the psychoacoustic parameters and nine evaluation words, quiet, refreshing, heavy, wide, muddy, violent, dry, warm, and cool, that represent impressions of air-conditioning sounds. As a result, we found that the impressions of ``violent'' and ``quiet'' strongly depended on the loudness, and the impressions of ``heavy,'' ``dry,'' ``warm,'' and ``cool'' strongly depended on the sharpness. Next, we performed a factor analysis. As a result, we found that the air-conditioning sounds can be explained by two factors, a volume factor and a thermal factor, which were strongly correlated with the loudness and sharpness, respectively. This result shows that the feelings of heating and cooling perceived from air-conditioning sounds are related to the sharpness. Therefore, a synergetic effect on the heating and cooling performance can be expected by improving the sharpness of air-conditioning sounds.