著者

Sakiko Itaya Zen Kobayashi Kokoro Ozaki Nozomu Sato Yoshiyuki Numasawa Kinya Ishikawa Takanori Yokota Hiroshi Matsuda Shuzo Shintani

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0068-17, (Released:2018-02-09)

参考文献数

14

被引用文献数

4

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A 58-year-old man consulted our hospital due to a 2-year history of dysarthria and a 1-month history of blepharospasm. In addition to the ataxic dysarthria and blepharospasm, a neurological examination demonstrated slight ataxia of the trunk and lower limbs. Brain MRI demonstrated atrophy of the upper portion of the cerebellar vermis. Gene analysis established a diagnosis of spinocerebellar ataxia type 31 (SCA31). SPECT with the three-dimensional stereotaxic ROI template (3DSRT) software program demonstrated hyperperfusion in the lenticular nucleus and thalamus. Although the association between SCA31 and blepharospasm in our patient remains unclear, we considered that this combination might be more than coincidental.

著者

Hiroshi Matsuda Hiroo Takaragawa

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.QH-060, (Released:2023-06-17)

被引用文献数

2

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Passion fruit (Passiflora spp.) vines, mostly indigenous to tropical highlands, although some species can be cultivated in tropical lowlands, are susceptible to high temperatures. To increase the resilience of passion fruit to the warming climate, there is an urgent need to evaluate existing genetic resources for traits suited to high temperatures and to efficiently select the superior genotypes. We investigated the genotypic variation in leaf photosynthetic reduction at high temperatures (> 30°C) as a base target trait for warming climates. Leaf photosynthesis and dark respiration were measured at 30–45°C leaf temperatures for 13 genotypes from various Passiflora spp. using a portable gas exchange system. Temperature-net and -gross photosynthetic rate curves were plotted, and the relationships between the photosynthetic rate and the transpiration rate and stomatal conductance were analyzed. The net photosynthetic rate decreased with reduced stomatal conductance and transpiration rate as the leaf temperature increased from 30°C to 40°C. Up to 45°C, the net photosynthetic rate continued decreasing with increasing dark respiration rate, whereas the gross photosynthetic rate tended to stop decreasing as the stomatal conductance and transpiration rate stopped decreasing. The respiration load of photosynthesis varied among genotypes: Alata seedling #1 (P. alata) and ‘MaQuatro’ (P. edulis f. flavicarpa) showed the lowest load, together with the smallest reduction in photosynthetic rate at high temperatures, while the Iriomote strain (P. laurifolia) showed the largest load despite the smallest reduction in photosynthetic rate. Although the trend in the physiological response to high temperatures was similar among genotypes, the rate of leaf photosynthetic reduction at high temperatures varied among passion fruit genotypes both inter- and intra-specifically. Reduction of the photosynthetic rate at high temperatures was significantly correlated with stomatal activity under non-stress conditions at 30°C leaf temperature. Stomatal length was closely correlated with photosynthetic and transpiration rates at higher leaf temperatures in the P. edulis group, whereas no correlation was detected when including the lowland relatives. We concluded that genotypes showing higher stomatal conductance and transpiration rates at 30°C leaf temperature maintained a higher leaf photosynthetic rate at temperatures > 40°C, providing potential indicators for screening.

著者

Yosuke AMAGAI Akane TANAKA Akira MATSUDA Kumiko OIDA Kyungsook JUNG Sho NISHIKAWA Hyosun JANG Saori ISHIZAKA Hiroshi MATSUDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0025, (Released:2013-02-22)

被引用文献数

1 4

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Myeloid cell leukemia sequence 1 (MCL1) is a potent antiapoptotic protein that plays a critical role in cell survival and drug resistance in various cancers. However, to the best of our knowledge, the role of MCL1 in mast cell tumors (MCTs) has not been investigated in dogs. Here, we detected increased MCL1 expression in MCT cell lines, regardless of the presence of a c-kit mutation. MCL1 expression increased when the cells were exposed to specific inhibitors of mitogen-activated protein kinase or Janus kinase-signaling pathways, thus protecting the cells from apoptosis, but not when KIT or phosphatidylinositol-3 kinase signaling cascades were inhibited. These results indicate that MCL1 expression may contribute to MCT survival and confer drug resistance.

著者

Hiroshi Matsuda Hirokazu Higuchi Naoki Miyaji Masanori Okabe

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.QH-057, (Released:2023-06-10)

被引用文献数

1

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The salak fruit (snake fruit) contains one to three seeds covered with an aril. The size of the fruit primarily depends on the number of seeds. Fruits with more seeds grow larger and attain higher commercial value in fresh markets owing to their superior appearance. In eastern Thailand, during the hot period in the early rainy season, the fruit set of salak decreases, which is empirically believed to be caused by high night temperatures. In this study, we pollinated and incubated salak spadices at various temperatures (18–36°C) to determine the optimal post-pollination temperature range needed to produce valuable fruits. Chronological pollen-tube elongation in the pistil and development of the early embryo and endosperm were then observed anatomically, followed by fruit-set estimation. At ≤ 21°C, pollen-tube elongation was limited. At 24–27°C, although elongation was slow, pollen tubes attained embryo sacs in > 60% of florets within 36 h after pollination. Pollen tubes elongated fastest at 30–33°C and attained embryo sacs within 12 h after pollination. At 36°C, the difference in the elongation speed tended to be higher among the pistils. The percentages of ovules with developing embryos were the highest at 27°C at 48 h after pollination; zygote and early embryos were observed in 10.8% and 55.9% of the ovules, respectively, and the primary endosperm nucleus, dispersing endosperm nucleoplasm, and free endosperm nuclei were observed in 8.6%, 38.7%, and 19.4%, respectively. The second highest percentage was observed at 24°C. The percentages tended to decrease at 30°C and decreased significantly at ≥ 33°C. At ≥ 30°C, shriveled embryo sacs were observed. The estimated fruit-set percentage based on embryo development as the consequent fruit set was the highest (≈80%) at 27°C, while the second highest percentage (≈75%) was at 24°C. At ≥ 30°C, the estimated percentage decreased to less than half that at 27°C. Fruits containing three seeds were expected to grow in the range of 17.6–28.0% at ≤ 27°C. One- or two-seeded fruits were expected to grow at ≥ 30°C. Limited fruit set was expected at 36°C. Our results indicate that salak prefers relatively cool temperatures of approximately 25°C for the fertilization and set of valuable fruits.

著者

松田 央 Hiroshi MATSUDA

雑誌

論集

巻号頁・発行日

vol.54, no.2, pp.35-48, 2008-01

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The author of the fourth Gospel is named John and understands Jesus Christ as the Logos. The Logos means the Word of God. John's Christology is called Christology of the Logos. Jesus is not so much a prophet who communicates to people the Word of God as the Word of God itself. Jesus, the Logos exists with God (Father) from the eternal beginning, and has the divine nature. Christian God is God of the Trinity who has three persons (personae), the Father, the Son and the Holy Spirit. Jesus, the Son and Logos was sent from the Father to the world, and born as a human being (John 1: 14, 18). This event is named the incarnation of the Logos. The glory of God approached more nearly to us through Jesus who was the incarnated Logos, and could move with Jesus' flesh. The existence of God became more familiar to people in the New Testament than in the Old Testament. We can be formed as the form of Christ and have the divine nature through Christ's person.

著者

Izumi ANDO Kaoru KARASAWA Hiroshi MATSUDA Akane TANAKA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0258, (Released:2016-07-22)

被引用文献数

8

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Serum nerve growth factor (NGF) levels are increased by the external stress in mice, humans and horses; however, similar variations have been unclear in dogs. Since dogs are usually subjected to conditions of work, exercise and activity as important partners of humans, we measured serum NGF levels post-exercise and compared them with serum cortisol levels, as a biomarker of physical stress. Serum cortisol levels were immediately elevated post-exercise and returned to basal levels within 1 hr. On the other hand, serum NGF levels were significantly increased 1 hr post-exercise and gradually returned to basal levels. Further research is necessary; nevertheless, we have demonstrated for the first time that serum NGF levels respond to exercise stress in dogs.

著者

Yosuke AMAGAI Akane TANAKA Akira MATSUDA Kumiko OIDA Kyungsook JUNG Hiroshi MATSUDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0540, (Released:2013-01-17)

被引用文献数

4 7 2

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Mast cell tumors (MCTs) are the most common tumors in dogs, accounting for 16–21% of cutaneous tumors. Although several small molecule inhibitors, including imatinib mesylate, have been used for the treatment of MCTs, the response rate remains less than 50%. In this study, the effects of different selective signal inhibitors on MCT cell growth were evaluated using 4 different cell lines derived from dogs. We found that the phosphoinositide 3-kinase (PI3K) signaling pathway is crucial for the proliferation of MCT cells in the presence or absence of c-kit gene mutations. Here, we propose a novel therapeutic strategy to target the PI3K pathway for the treatment of canine MCTs.

著者

松田 央 Hiroshi MATSUDA

雑誌

神戸女学院大学論集 = KOBE COLLEGE STUDIES

巻号頁・発行日

vol.51, no.2, pp.115-137, 2004-12-20

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Friedrich Nietzsche (1844-1900), a German philosopher designates European Nihilism (der europaische Nihilismus) which is a radical character in the western occurrence, a spiritual movement in the long-range western history, according to Heideggerian interpretation. Nietzsche thinks that Christianity is the origin of European Nihilism and it created European moral values. The Christian morality was the highest value to the European traditional culture. However according to Nietzsche's view, the aim of the Christian morality, namely kingdom of God is not yet achieved and the European morality is never improved. Accordingly there appeared atheism that denies God's existence. Nietzsche talks of 'God's death' in "The Joyful Knowledge (Die frohliche Wissenschaft)", the number 125. Nietzsche denied the Christian God and developed Perspectivism, named the eternal recurrence to endure European Nihilism. He tried to conquer himself and experience the eternal joy which was the affirmation of his life. Moreover he created a new god, named the superman (Ubermensch) which is the subject of the conquest of the self, and proclaimed 'the God's death' to revive truly human beings. However we must notice that Nietzsche's thought of the superman has its source in Christian God-man thought.

著者

Hiroshi MATSUDA Hirokazu HIGUCHI

出版者

Japanese Society for Tropical Agriculture

雑誌

Tropical Agriculture and Development (ISSN:18828450)

巻号頁・発行日

vol.63, no.2, pp.79-82, 2019 (Released:2020-03-07)

参考文献数

10

著者

Yosuke AMAGAI Akane TANAKA Akira MATSUDA Kumiko OIDA Kyungsook JUNG Sho NISHIKAWA Hyosun JANG Saori ISHIZAKA Hiroshi MATSUDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.7, pp.971-974, 2013 (Released:2013-07-31)

参考文献数

25

被引用文献数

1 4

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Myeloid cell leukemia sequence 1 (MCL1) is a potent antiapoptotic protein that plays a critical role in cell survival and drug resistance in various cancers. However, to the best of our knowledge, the role of MCL1 in mast cell tumors (MCTs) has not been investigated in dogs. Here, we detected increased MCL1 expression in MCT cell lines, regardless of the presence of a c-kit mutation. MCL1 expression increased when the cells were exposed to specific inhibitors of mitogen-activated protein kinase or Janus kinase-signaling pathways, thus protecting the cells from apoptosis, but not when KIT or phosphatidylinositol-3 kinase signaling cascades were inhibited. These results indicate that MCL1 expression may contribute to MCT survival and confer drug resistance.