- 著者
- Chih-Wei Yang Shun-Neng Hsu Jhih-Syuan Liu Dueng-Yuan Hueng
- 出版者
- 一般社団法人 日本内科学会
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.53, no.15, pp.1665-1668, 2014 (Released:2014-08-01)
- 参考文献数
- 23
- 被引用文献数
- 3 11
The formation of spinal epidural abscess following acupuncture is very rare. We herein report the case of a 54-year-old woman who presented with progressive low back pain and fever with a root sign. She underwent surgical decompression, with an immediate improvement of the low back pain. A culture of the epidural abscess grew Serratia marcescens. One year postoperatively, magnetic resonance imaging revealed the almost complete eradication of the abscess. This case is the first case of Serratia marcescens-associated spinal epidural abscess formation secondary to acupuncture. The characteristics of spinal epidural abscess that develop after acupuncture and how to prevent such complications are also discussed.
3 0 0 0 OA Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke
- 著者
- Taoping Sun Yanwei Zhang Jiawei Yin Xiaobo Peng Li Zhou Suli Huang Ying Wen Benfeng Cao Liangkai Chen Xiaoqin Li Wei Yang Aijun Tan Jinquan Cheng Liegang Liu
- 出版者
- Japan Atherosclerosis Society
- 雑誌
- Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
- 巻号頁・発行日
- pp.55962, (Released:2020-07-09)
- 参考文献数
- 37
- 被引用文献数
- 23
Aim: We aimed to investigate the relationship of trimethylamine N-oxide (TMAO) concentrations with ischemic stroke in a large-scale case–control study conducted among the hospital-based general population. Methods: We recruited 953 case–control sex- and age-matched pairs, and cases were confined to first acute ischemic stroke in this study. Fasting plasma TMAO was measured using high-performance liquid chromatography–tandem mass spectroscopy. Conditional logistic regression analysis was conducted to calculate odds ratios (OR) for the association of plasma TMAO with ischemic stroke. Results: We found that plasma TMAO concentrations in patients with ischemic stroke were significantly higher than that in the control group (median: 2.85 µmol/L vs. 2.33 µmol/L, P<0.001). In multivariable conditional logistic regression models, higher plasma TMAO concentrations were associated with increased odds of ischemic stroke [fully adjusted OR for highest vs. lowest TMAO quartile: 1.81; 95% confidence interval (CI): 1.27, 2.59; P for trend <0.001]. The multivariable-adjusted OR for ischemic stroke per 1 µmol/L increment of plasma TMAO was 1.05 (95% CI: 1.02, 1.08). Additionally, the positive association also persisted in subgroups stratified by age, sex, body mass index, smoking status, alcohol habits, history of diabetes, and history of hypertension. Conclusions: This study suggested a positive association between plasma TMAO and ischemic stroke. Further studies are required to explore the role of plasma TMAO concentrations in predicting stroke risk.
- 著者
- 畑中 駿平 Wei Yang 細見 直希 翠 輝久 山田 健太郎 杉浦 孔明
- 出版者
- 一般社団法人 人工知能学会
- 雑誌
- 人工知能学会研究会資料 知識ベースシステム研究会 126回 (2022/08) (ISSN:24364592)
- 巻号頁・発行日
- pp.34-39, 2022-08-19 (Released:2022-08-19)
- 著者
- Bang-Chieh Huang Lee-Wei Yang
- 出版者
- The Biophysical Society of Japan
- 雑誌
- Biophysics and Physicobiology (ISSN:21894779)
- 巻号頁・発行日
- vol.16, pp.473-484, 2019 (Released:2019-11-29)
- 参考文献数
- 59
- 被引用文献数
- 1 3
In this study, we provide a time-dependent mechanical model, taking advantage of molecular dynamics simulations, quasiharmonic analysis of molecular dynamics trajectories, and time-dependent linear response theories to describe vibrational energy redistribution within the protein matrix. The theoretical description explained the observed biphasic responses of specific residues in myoglobin to CO-photolysis and photoexcitation on heme. The fast responses were found to be triggered by impulsive forces and propagated mainly by principal modes <40 cm−1. The predicted fast responses for individual atoms were then used to study signal propagation within the protein matrix and signals were found to propagate ~8 times faster across helices (4076 m/s) than within the helices, suggesting the importance of tertiary packing in the sensitivity of proteins to external perturbations. We further developed a method to integrate multiple intramolecular signal pathways and discover frequent “communicators”. These communicators were found to be evolutionarily conserved including those distant from the heme.
- 著者
- Chi Cai Wei Hua Li-Gang Ding Jing Wang Ke-Ping Chen Xin-Wei Yang Zhi-Min Liu Shu Zhang
- 出版者
- 日本循環器学会
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.78, no.12, pp.2899-2907, 2014-11-25 (Released:2014-11-25)
- 参考文献数
- 24
- 被引用文献数
- 8 20
Background:The effect of adiposity on response to cardiac resynchronization therapy (CRT) and long-term outcome in patients undergoing CRT has not been previously reported. This study assessed the impact of baseline body mass index (BMI) on cardiac reverse remodeling and prognosis following CRT.Methods and Results:A total of 247 CRT patients were included and divided into 4 groups according to baseline BMI. During 6-month follow-up, overweight and obese patients (BMI, 24–28 kg/m2, ≥28 kg/m2, respectively) were inclined to have better clinical and echocardiographic improvements (P<0.05) as well as higher response rate (P<0.001) than underweight and normal weight patients (BMI, <18.5 kg/m2, 18.5–24 kg/m2, respectively). During long-term follow-up, overweight and obese patients had lower all-cause mortality (P=0.015) and combined endpoint of death or HF hospitalizations (P=0.001) than underweight and normal weight patients. Compared with normal weight patients, underweight patients had a 2.29-fold increase in risk of combined endpoint events whereas overweight and obese patients had a reduction in the risk of death (66% and 58%, respectively) and combined endpoint events (52% and 38%, respectively).Conclusions:Patients with obesity and overweight derived more benefit from CRT. Higher BMI was independently associated with better clinical outcome in CRT patients. (Circ J 2014; 78: 2899–2907)
1 0 0 0 材料の強度と破壊に関するメゾスコピックモデルの構築
- 著者
- 青木 繁 BUI Huy Duon YANG Wie KNAUSS Wolfg 北川 浩 岸本 喜久雄 YANG Wei HUY Duong BU WEI YANG WOLFGANG KNA MAIGRE H. RAVICHANDRAN ジー ROSAKIS Ares NAKAMURA Tos 天谷 賢治
- 出版者
- 東京工業大学
- 雑誌
- 国際学術研究
- 巻号頁・発行日
- 1996
本研究は,日米中仏の4ヶ国の研究者の共同研究により実施するのもので,材料の破壊プロセスにおける微視的な内部構造変化について総合的に検討するとともに,それらを踏まえたメゾスコピック材料モデルを構築することを目的とする.すなわち,本研究では,原子レベルならびにナノレベルにおける微視的アプローチ,不均質材料,材料界面,高分子材料,複合材料の損傷・破壊モデルの検討,および,衝撃荷重や環境など外因の影響を踏まえた材料モデルの考察など,種々の立場から,材料モデルの構築を進めるとともに,相互に協力,啓発を行い,それらを統合化した材料の寸法尺度,時間尺度に対する階層構造を的確に捉えたメゾスコピック材料モデルの構築を目指している.本研究において設定した調査テーマは下記の通りである.(1)分子動力学法を基礎とする材料モデルの構築,(2)材料の損傷・破壊現象のミクロとマクロメカニクス,(3)界面強度特性とミクロ・マクロ材料モデル,(4)不均質材料の特性発現機構と損傷機構のミクロ・マクロモデル,(5)複合材料の損傷過程とミクロ・マクロモデル,(6)ミクロ構造を考慮した高分子材料モデルの形成とマクロ特性,(7)破壊のプロセスゾーンの損傷モデル,(8)衝撃荷重下における材料の破壊モデル,(9)材料の環境強度に及ぼす電気化学因子のモデル化また,東京工業大学,カルフォルニア工科大学,エコールポリテクニークにおいて共同研究を実施するとともに,中国,カナダ,アイルランド,ポルトガルにおいて調査研究を実施した.それらの結果,材料の内部微細構造の変化のダイナミクスを多面的に捉えるための分子動力学法,境界要素法,有限要素法などの種々の方法に基づくモデリング手法についての知見が得られた.