著者

山口 裕貴 Yuki YAMAGUCHI 桜美林大学総合科学系 J. F. Oberlin University Division of Integrated Sciences

出版者

桜美林大学

雑誌

桜美林論考. 自然科学・総合科学研究 = The journal of J. F. Oberlin University. Natural and applied sciences (ISSN:21850712)

巻号頁・発行日

vol.3, pp.51-62, 2012-03-01

著者

Hiroyuki SHIMADA Toshiaki YAMAGUCHI Hirofumi SUMI Yuki YAMAGUCHI Katsuhiro NOMURA

出版者

The Ceramic Society of Japan

雑誌

Journal of the Ceramic Society of Japan (ISSN:18820743)

巻号頁・発行日

vol.125, no.4, pp.257-261, 2017-04-01 (Released:2017-04-03)

参考文献数

28

被引用文献数

9 10

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Perovskite-type mixed protonic and oxide ionic conductors for electrolyte material of solid oxide fuel cells were investigated, focusing on BaZr0.1Ce0.7Y0.1Yb0.1O3−δ (BZCYYb) due to its high ionic conductivity and chemical stability. BZCYYb and NiO-added BZCYYb were evaluated using electrolyte-supported cell (ESC) and anode-supported cell (ASC) samples. 2 wt.% NiO was solid solute into the BZCYYb, resulting in improvement in the sinterability and thermal-expansion behavior. The addition of NiO, however, lead to the deterioration of cell performance. Compared with the ESC, power density of the ASC was much higher due to thin electrolyte, whereas its open-circuit voltage (OCV) was lower. This is due to Ni diffusion from the NiO–BZCYYb anode into the BZCYYb electrolyte during high-temperature co-sintering process at 1350°C. From the results of OCV measurements, 0–2 wt.% NiO was considered to be dissolved in the BZCYYb electrolyte of the ASC, suggesting that controlling Ni diffusion during co-sintering process is essential to achieve higher-performance ASCs using BZCYYb.

著者

塚本 友美 山口 友希 三谷 ゆりか 伊藤 裕才 Tomomi Tsukamoto Yuki Yamaguchi Yurika Mitani Yusai Ito

雑誌

共立女子大学家政学部紀要 = Bulletin of the faculty of home economics Kyoritsu Women's University

巻号頁・発行日

vol.64, pp.73-78, 2018-01

著者

Mayako Uchida Yasuhiro Mori Kenta Akiba Moena Miyasaka Tatsuya Hirano Hiroaki Ikesue Yuki Yamaguchi Aoi Takano Nami Maegawa Yoshimitsu Shimomura Keiko Hosohata Nobuyuki Muroi Takayuki Ishikawa Tohru Hashida Tsutomu Nakamura

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.43, no.10, pp.1577-1582, 2020-10-01 (Released:2020-10-01)

参考文献数

26

被引用文献数

2

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Bendamustine plays an especially important role as a treatment for non-Hodgkin lymphoma (NHL). However, patients administered bendamustine alone or in combination with rituximab (BR) may experience drug-associated skin toxicities that can profoundly impact their health-related QOL through both physical discomfort and psychological distress. Moreover, worsening skin symptoms may lead to dose reduction or termination in the management of cancer chemotherapy. We retrospectively investigated patient backgrounds and pretreatment characteristics from medical records of NHL patients treated with bendamustine alone or BR therapy and identified predictive factors for skin toxicities at the start of chemotherapy. Patients were eligible for the study if they were 20 years older, diagnosed with NHL, and received bendamustine alone or BR therapy at the Department of Hematology, Kobe City Medical Center General Hospital, between April 1, 2011, and March 31, 2018. This study included 95 patients with newly diagnosed or refractory or relapsed NHL. Multivariate stepwise logistic regression analysis with backward selection revealed that baseline non-prior chemotherapy (odds ratio (OR), 15.72; 95% confidence interval (CI), 4.24–83.13, p < 0.001) was a significant factor influencing the occurrence of skin toxicity. Our results demonstrated that non-prior chemotherapy was a significant risk factor for skin toxicities in patients with NHL receiving bendamustine alone or BR therapy. No patient experience serious side effects of grade 3 or higher and that bendamustine is very useful as a first-line treatment.

著者

山口 裕貴 Yuki YAMAGUCHI

雑誌

桜美林論考. 自然科学・総合科学研究 = The journal of J. F. Oberlin University. Natural and applied sciences (ISSN:21850712)

巻号頁・発行日

vol.3, pp.51-62, 2012-03-01

著者

Mayako Uchida Yuki Yamaguchi Syuhei Hosomi Hiroaki Ikesue Yasuhiro Mori Nami Maegawa Aoi Takano Yuki Sato Keiko Hosohata Nobuyuki Muroi Keisuke Tomii Tohru Hashida Tsutomu Nakamura

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.43, no.8, pp.1235-1240, 2020-08-01 (Released:2020-08-01)

参考文献数

42

被引用文献数

3

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We retrospectively obtained data of patient background and pretreatment characteristics from medical records and identified the predictive factors of febrile neutropenia (FN) in patients with non-small cell lung cancer (NSCLC) treated with docetaxel alone or in combination with the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab. Patients were eligible for inclusion in the study if they were 20 years or older, diagnosed with NSCLC, and received docetaxel monotherapy alone or in combination with bevacizumab at the Department of Respiratory Medicine, Kobe City Medical Center General Hospital, between July 1, 2011, and March 31, 2018. Eighty-one patients with recurrent or advanced NSCLC were included. Multivariate stepwise logistic regression analysis with backward selection revealed that lower baseline Eastern Cooperative Oncology Group performance status (ECOG-PS) scores of 1 and 2 (odds ratio (OR), 5.098; 95% confidence interval (CI), 1.045–24.879, p = 0.021) and baseline platelet count below 18.8 × 104/µL (OR, 3.861; 95% CI, 1.211–12.311, p = 0.022) were significant factors influencing the FN occurrence rate. Our results demonstrated that ECOG-PS 1–2 and lower baseline platelet count were significant risk factors of FN in patients with NSCLC receiving docetaxel-based chemotherapy. Moreover, the combination of anti-VEGF antibodies and docetaxel might be associated with increased FN frequency. Despite the limitations of this study including its retrospective design, single-center site, and small sample size, baseline ECOG-PS score and platelet count may be regarded as important indices to identify patients for prophylactic granulocyte-colony stimulating factor (G-CSF) treatment before docetaxel-based chemotherapy.

著者

Yoshikuni Kitamura Takafumi Watanabe Yukari Kato WeiWei Teoh Keiko Kataoka Yuki Yamaguchi Tomohiro Haruta Hideo Nishioka Kiyokazu Kametani

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.UTD-003, (Released:2018-06-19)

被引用文献数

1

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Information about mechanical reinforcement of decorative organs could help development of a novel technique that would give flowers with robust floral organs and broadly contribute to postharvest flower preservation. Hydrangeas (Hydrangea spp.) exhibit remarkable characteristics in terms of mechanical reinforcement of decorative sepals. Although decorative sepals at the flowering stage shrink when they are desiccated, decorative sepals after flowering maintain their shape even after desiccation. In this study, the lignifications of the vein cells in decorative sepals were analyzed using phloroglucinol/HCl-staining. The microstructure of the cell wall was analyzed using transmission electron microscopy (TEM). The three-dimensional structure of vein cells was analyzed using serial block-face scanning electron microscopy (SBF-SEM). Tubular- and spindle-shaped dead cells with a lignified pitted secondary cell wall were observed around the vessel elements in decorative sepals after flowering. These cells were observed as living cells without a secondary cell wall in the veins of decorative sepals at flowering and in fully expanded leaves. Further, 10 hydrangea cultivars were analyzed for development of mechanical reinforcement in vein cells, and some of them were compared by desiccation testing. Decorative sepals of a cultivar lacking those cells exhibited shrinkage after flowering when they were desiccated. In conclusion, dead cells with a lignified pitted secondary cell wall contribute to the reinforcement of veins in decorative sepals of hydrangeas and become sclerified parenchyma cells. Axial parenchyma sclerifying in veins after flowering is essential for robust hydrangea floral organs and represent a new type of mechanical reinforcement tissue in plant decorative floral organs.