著者
後藤 伸之
出版者
公益社団法人 日本薬剤学会
雑誌
薬剤学 (ISSN:03727629)
巻号頁・発行日
vol.63, no.4, pp.197-200, 2003 (Released:2019-05-12)
参考文献数
11
著者
内山 進 エレナ クラユヒナ 野田 勝紀
出版者
公益社団法人 日本薬剤学会
雑誌
薬剤学 (ISSN:03727629)
巻号頁・発行日
vol.74, no.1, pp.12-18, 2014 (Released:2014-07-01)
参考文献数
10
被引用文献数
2
著者
坂本 真史
出版者
公益社団法人 日本薬剤学会
雑誌
薬剤学 (ISSN:03727629)
巻号頁・発行日
vol.76, no.3, pp.127-130, 2016 (Released:2016-11-01)
参考文献数
3
著者
大谷 道輝 山岡 由紗 松元 美香 並木 路広 山村 喜一 江藤 隆史
出版者
公益社団法人 日本薬剤学会
雑誌
薬剤学 (ISSN:03727629)
巻号頁・発行日
vol.69, no.6, pp.470-476, 2009 (Released:2019-03-31)
参考文献数
14

Topical retinoids are very important in acne treatments. Clinical experience has shown that adapalene, a new topical retinoid, has a superior cutaneous safety profile. In the guidelines of care for acne vulgaris management of our country, the combinations with adapalene gel and topical antibiotics (e.g., clindamycin nadifloxacin) are an effective acne treatment, and these combination treatments are ranked as a recommendation A. For the purpose of improvement of compliance, the mixing of ointments and/or creams is common practice. However, many of the admixtures of ointments and/or creams may lack pharmaceutical stability.To assess the pharmaceutical stability of these mixtures after mixing, we attempted to investigate the change in the appearance and contents of adapalene, clindamycin and nadifloxacin in admixtures. As a result, no lowering of the content of adapalene was noted in any admixtute. After admixtures of adapalene and clindamycin or nadifloxacin, the contents of clindamycin or nadifloxacin were constant.
著者
郡 修徳 小澤 武史 高崎 雅彦 江口 久恵 三輪 興三 沼 潤幸 阿部 信
出版者
公益社団法人 日本薬剤学会
雑誌
薬剤学 (ISSN:03727629)
巻号頁・発行日
vol.61, no.1, pp.34-45, 2001 (Released:2019-05-18)
参考文献数
19

We prepared a troche containing camostat mesilate for the prevention of the mucositis in the mouth induced by cancer chemotherapy. The troche was formed by the direct compression of a powder mixture of camostat mesilate, a flavoring agent, hydroxypropylcellulose, and magnesium stearate. A troche containing 10% or 20% hydroxypropylcellulose and a flavoring agent of coffee or green apple diminished the bitterness of camostat mesilate. It was found that the metabolising rate of camostat in saliva was much slower than that in blood, although metabolites in saliva were the same kinds as those in blood. The amounts of camostat retained in the mouth after administration of the troche to healthy subjects were much larger than those after applying a gargle which had a bitter taste. Moreover, the troche containing the flavoring agent of green apple showed smaller amounts of camostat and its metabolites retained in the mouth compared to the troche containing the flavoring agent of coffee. It is considered that the increase in the secreting volume of saliva after administration of the troche containing the flavoring agent of green apple would prevent the retaining of camostat and its metabolites in the mouth. Moreover, the administration of a troche is more convenient than that of a gargle for patients. The troche prepared in this study would be a substitute dosage form for the gargle and promote the quality of life in patients.
著者
合田 幸広
出版者
公益社団法人 日本薬剤学会
雑誌
薬剤学 (ISSN:03727629)
巻号頁・発行日
vol.75, no.3, pp.170-176, 2015 (Released:2015-11-01)
参考文献数
5
被引用文献数
2
著者
福居 篤子
出版者
公益社団法人 日本薬剤学会
雑誌
薬剤学 (ISSN:03727629)
巻号頁・発行日
vol.75, no.1, pp.42-47, 2015 (Released:2015-07-01)
参考文献数
11
被引用文献数
1
著者
矢花 直幸
出版者
公益社団法人 日本薬剤学会
雑誌
薬剤学 (ISSN:03727629)
巻号頁・発行日
vol.76, no.3, pp.167-171, 2016 (Released:2016-11-01)
参考文献数
7