著者

永井 恒司

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.77, no.1, pp.4-6, 2017 (Released:2017-01-01)

著者

永井 恒司

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.79, no.1, pp.26-30, 2019 (Released:2019-01-01)

著者

永井 恒司

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.69, no.5, pp.370-372, 2009 (Released:2019-03-31)

参考文献数

8

著者

永井 恒司

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.73, no.3, pp.144-146, 2013 (Released:2019-02-10)

著者

永井 恒司

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.2, no.2, pp.189-195, 1971-04-30 (Released:2010-06-28)

参考文献数

22

著者

永井 恒司

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.74, no.2, pp.148-149, 2014 (Released:2014-09-01)

著者

永井 恒司

雑誌

薬剤学 = The archives of practical pharmacy (ISSN:03727629)

巻号頁・発行日

vol.69, no.3, pp.217-218, 2009-05-01

被引用文献数

1

著者

高山 幸三 藤川 未来人 小幡 誉子 森下 真莉子 永井 恒司

雑誌

薬剤学 = Journal of Pharmaceutical Science and Technology, Japan (ISSN:03727629)

巻号頁・発行日

vol.64, no.1, pp.2-12, 2004-01-01

被引用文献数

3

著者

米谷 芳枝 石倉 豊昭 永井 恒司

出版者

Japan Oil Chemists' Society

雑誌

油化学 (ISSN:18842003)

巻号頁・発行日

vol.37, no.6, pp.408-415, 1988-06-20 (Released:2009-11-10)

参考文献数

29

著者

一丁田 健一 川城 巌 鈴木 郁生 名取 信策 北川 晴雄 永井 恒司

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.11, no.2, pp.97-102, 1975-02-01 (Released:2018-08-26)

著者

永井 恒司

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.64, no.1, pp.27-28, 2004 (Released:2019-05-10)

著者

永井 恒司

出版者

一般社団法人 日本生体医工学会

雑誌

BME (ISSN:09137556)

巻号頁・発行日

vol.1, no.8, pp.614-617, 1987-08-10 (Released:2011-09-21)

---

薬の副作用を抑え, その作用を最大限に発揮させるための新しい薬剤投与技術, 薬物送達システム (DDS) が最近, 注目されている. 本稿ではこのDDSについて, 薬物をターゲットに選択的に送り届ける手法, 生物学的利用能と薬物送達の制御技術についてまとめ, DDSの代表例をいくつか記述した.

著者

永井 恒司

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 = Journal of the Pharmaceutical Society of Japan (ISSN:00316903)

巻号頁・発行日

vol.123, no.3, pp.143-150, 2003-03-01

参考文献数

11

被引用文献数

4

---

In Japanese pharmaceutical community, there seems to be a lack of “Science of Science” and “Research on Research” which are to utilize unit sciences and research for the benefit of human being. In other words, pharmaceutical people in Japan should have much more pharmaceutical philosophy. The late Professor Komei Miyaki, founder Editor-in-Chief of FARUMASHIA, the monthly membership magazine of Pharmaceutical Society of Japan, under whom I worked as one of editorial board members, taught me that scientists should have their own philosophy of their sciences. Such a pharmaceutical philosophy as mentioned above should be established on the basis of complete separation of medical profession between doctors and pharmacists, which form the most important and necessary issue in safety assurance for patients with the complete zero defect (ZD action), as there is a long history for that in Europe since the separation was completed by King Friedrich II in 1240. Therefore, we have to learn the social status of European/American pharmacist practitioners who are the great No. 1 among all the professions. European pharmacists guarantee the safety of every chemical used for human body and pets, such as medicines, cosmetics, foods, tooth stuffs and so on. Regarding the pharmaceutical sciences in Japan also there seems to be a lack of pharmaceutical philosophy, as pharmaceutical scientists have no identity in research object that may be similar to basic scientists who are non-pharmacy graduates. Japanese sciences generally have developed along the lines of the Western model, reaching the current high level. We now not only should receive profits from the outside but also should embark on a mission to support pharmaceutical sciences throughout the world, especially Asian courtiers. At the present, we do not seem to be fulfilling our mission to do that, even though general activity includes significant international exchange. We have to make much more effort for international contribution/participation. For that, the most important and necessary issue is to make change in fundamental sense in Japanese pharmaceutical community, though an internationalization of technological issues is usually taken into consideration. In this connection, regarding the new drug development, we must have a change in the sense to establish pharmaceutical philosophy and jump up in conception from the existing one. Based on the above mentioned pharmaceutical philosophy, seven star pharmacists should be educated as described in 2000 FIP Statement of Policy: Good Pharmacy Education Practice, who could be a (1) care giver; (2) decision maker; (3) communicator; (4)leader; (5) manager; (6) life-long learner; (7)teacher.<br>

著者

川口 健夫 鈴木 嘉樹 南部 直樹 永井 恒司

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.33, no.7, pp.2956-2961, 1985-07-25 (Released:2008-03-31)

参考文献数

13

被引用文献数

6 8

---

Five acidic 3', 5'-diesters of 5-fluoro-2'-deoxyuridine (FUdR) including 3-carboxypropionate, 4-carboxybutyrate, 5-carboxypentanoate, 6-carboxyhexanoate and 7-carboxyheptanoate were synthesized, and their susceptibility to porcine liver, rat liver homogenate, rat intestinal homogenate and rat plasma esterase preparations was studied. The susceptibility of the derivatives to porcine liver esterase preparation increased as the number of methylene groups in the ester promoiety increased in both acidic (pH 5.0) and neutral (pH 7.0) solutions. The derivatives showed about 100 times higher reactivity to the esterase at pH 5.0 than at pH 7.0. With the rat tissue homogenates and plasma preparations, the longer the ester chain the higher the susceptibility, except for 3', 5'-bis (3-carboxypropionyl) FUdR (I) with rat liver homogenate. Though the reactivity of I was the lowest with porcine liver esterase preparation and not measurable with rat intestinal homogenate and plasma, I showed the highest reactivity with the rat liver homogenate.

著者

川口 健夫 鈴木 嘉樹 中原 葉子 南部 直樹 永井 恒司

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.33, no.1, pp.301-307, 1985-01-25 (Released:2008-03-31)

参考文献数

17

被引用文献数

13 16

---

The activity of porcine liver esterase towards diesters of 5-fluoro-2'-deoxyuridine with saturated aliphatic acids including acetic, propionic, butyric, hexanoic, octanoic, decanoic and dodecanoic acids was investigated. The susceptibility of the 3', 5'-diesters increased as the acyl chain was lengthened up to octanoyl, but further increase in the acyl chain length resulted in a sharp decrease in the susceptibility. The susceptibility of 3'-and 5'-monoesters increased as the chain was lengthened to decanoyl and slightly decreased on going to dodecanoyl. These results suggest that the higher antitumor activity of longer alkyl chain diesters of 5-fluoro-2'-deoxyuridine is partly due to their slow rates of hydrolysis by non-specific esterase.

著者

川口 健夫 斉藤 政彦 鈴木 嘉樹 南部 直樹 永井 恒司

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.33, no.4, pp.1652-1659, 1985-04-25 (Released:2008-03-31)

参考文献数

18

被引用文献数

21 24

---

The bioactivation characteristics of 3', 5'-diesters of 5-fluoro-2'-deoxyuridine (FUdR) esterified with saturated aliphatic acids, including acetic, propionic, butyric, hexanoic, octanoic, decanoic, dodecanoic and trimethylacetic acids, were studied by using rat tissue homogenates and plasma. The susceptibility of the esters to hydrolysis by the biological media increased as the acyl promoiety was lengthened up to octanoyl. Further elongation resulted in decreasing susceptibility. Antitumor activity against L1210 of the esters with a longer chain or branched acyl group administered intraperitoneally and orally to tumor-bearing mice was also examined. Both the antitumor activity and the therapeutic index (ILSmax/ILS30) of the esters improved as the acyl promoiety was lengthened from octanoyl to dodecanoyl. These results suggested that the higher antitumor activities of longer alkyl chain diesters of FUdR are due to their slow rates of FUdR regeneration with esterases.

著者

今泉 宏之 南部 直樹 永井 恒司

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.28, no.9, pp.2565-2569, 1980-09-25 (Released:2008-03-31)

参考文献数

13

被引用文献数

66 96

---

An X-ray diffraction method for determination of the degree of crystallinity of indomethacin was established, and the transition rate of indomethacin from amorphous to crystalline form was investigated. The transition of the amorphous form to crystalline form at 20°, 30°and 40°followed first-order kinetics and the Arrhenius plot showed good linearity. The amorphous form was shown to change to form I at 100% relative humidity (RH), to form I or II at 89% RH and to form I at 79% and 69% RH at 30°. The transition rate of the amorphous form to form II at 100% RH was larger than that at 89% RH. A good linear relation was observed between the maximum amount of water absorbed (log scale) and the degree of crystallinity at 100% or 89% RH at 30°. The dissolution rate of the amorphous form was higher than those of forms I and II. The amorphous form showed better tablet-forming properties than the crystalline form.

著者

永井 恒司

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.6, no.9, 1970

著者

高山 幸三 藤川 未来人 小幡 誉子 森下 真莉子 永井 恒司

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 = Journal of Pharmaceutical Science and Technology, Japan (ISSN:03727629)

巻号頁・発行日

vol.64, no.1, pp.2-12, 2004-01-01

参考文献数

71

被引用文献数

3

---

<p>A pharmaceutical formulation is composed of several formulation factors and process variables. Several responses relating to the effectiveness, usefulness and stability, as well as safety, must be optimized simultaneously. Consequently, expertise and experience are required to design acceptable pharmaceutical formulations. A response surface method (RSM) has widely been used for selecting acceptable pharmaceutical formulations. However, prediction of pharmaceutical responses based on the second-order polynomial equation commonly used in RSM is often limited to low levels, resulting in poor estimations of optimal formulations. In this review, a multi-objective simultaneous optimization method incorporating an artificial neural network (ANN) is introduced. Further, usefulness of the method is demonstrated by its application to the optimization of ketoprofen hydrogel formulations including 1-<i>O</i>-ethyl-3-<i>n</i>-butylcyclohexanol as a newly developed transdermal absorption enhancer.</p>

著者

永井 恒司

雑誌

化学と工業 = Chemistry and chemical industry (ISSN:00227684)

巻号頁・発行日

vol.45, no.7, pp.1285-1286, 1992-07-01