著者

酒井 清孝

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.14, no.1, pp.31-44, 1989-01-01 (Released:2011-03-04)

参考文献数

24

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Various materials are presently available for hollow fiber dialysis membranes which satisfy technical and medical requirements such as high permeability to uremic toxins and water, biocompatibility, resistance to sterilization, and high mechanical strength. New dialysis membranes with high permeability to β2-microglobulin and with biocompatibility leading to low complement activation have been developed for more optimal hemodialysis. Data on structure and permeability are then required to prepare the new dialysis membranes. Much attention should be paid also to the geometry of hollow fiber dialysis membranes available for chronic renal failure patients with elevated hematocrits caused by the administration of erythropoietin.

著者

岩堀 博

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.31, no.1, pp.26-27, 2006 (Released:2015-07-01)

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Membrane separation technology, applying to seawater desalination, contributes to provide a safer, more stable and less expensive alternative water supply in arid and/or highly populated regions.

著者

品川 嘉也

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.1, no.3, pp.176-183, 1976-09-10 (Released:2010-10-21)

参考文献数

21

著者

美宅 成樹 澤田 隆介 辻 敏行 横山 泰範

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.35, no.2, pp.42-49, 2010 (Released:2015-06-14)

被引用文献数

1

著者

丸山 徹

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.34, no.5, pp.246-248, 2009 (Released:2015-06-14)

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Cholesterol is a major component of cell membrane and plays a key role in maintaining membrane physiological functions and physicochemical properties. Cholesterol is absorbed by gastrointestinal tract and is synthesized by liver. 3–Hydroxy–3–methylglutaryl coenzyme A (HMG–CoA) reductase is a rate–limiting enzyme of mevalonate pathway involving cholesterol biosynthesis. So–called statin, HMG–CoA reductase inhibitor, is available in this country, and is widely applied to the patients with dyslipidemia. In this article, I would like to describe the episode of the discovery of statin in relation to the interaction between the cholesterol content and physiological functions of cell membrane in health and disease.

著者

鶴田 禎二

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.3, no.1, pp.45-58, 1978-01-01 (Released:2010-10-21)

著者

荒川 健司

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.33, no.3, pp.102-107, 2008 (Released:2015-06-18)

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Plasma glucose is continuously filtered through the glomerulus in the kidney and then reabsorbed via the transcellular transport systems. Glucose reabsorption in the kidney is mediated by a distinct class of transporters such as sodium-glucose cotransporters (SGLTs). Most of filtered glucose is reabsorbed by the low affinity/high capacity SGLT2 located in the proximal renal tubule. SGLT2 inhibitors, such as T-1095, enhance urinary glucose excretion, and consequently lower blood glucose level and control energy balance in a negative direction. The principle behind SGLT inhibition involves the amelioration of diabetic conditions without increasing body weight or the risk of hypoglycemia. A number of SGLT2 inhibitors are being developed and studies have suggested the therapeutic potential and safety of these drugs for the treatment of diabetes.

著者

藤本 豊士 大崎 雄樹 鈴木 倫毅

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.33, no.1, pp.17-23, 2008 (Released:2011-02-24)

参考文献数

40

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The lipid droplet (LD) is a ubiquitous cellular structure that is made of the core of lipid esters covered by a phospholipid monolayer. LDs have been generally assumed to form by accumulation of lipid esters between the two leaflets of the endoplasmic reticulum (ER), but rigorous evidence to support this conjecture has not been presented. PAT proteins are thought to work as a shield against cytosolic lipases, and also to facilitate budding of LD from the ER. LDs are likely to fuse each other and may divide under some circumstances, which may be augmented by the microtubule-based motility. Because of the unique structure, division of LDs should increase the chance that the lipases get access to the stored lipid esters. By this way, motility and fusion/fission of LD can be linked directly to its physiological functions.

著者

木村 啓志 酒井 康行 藤井 輝夫

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.34, no.6, pp.304-309, 2009 (Released:2015-06-14)

被引用文献数

1 1

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Conventional method of cell–based assays in life science and medical application can be difficult to duplicate in vivo situation. Microfluidics is an emerging technology with potential to provide integrated environments for cell maintenance, continuous perfusion, and monitoring. In this paper, we introduce possibility of microfluidics to become a novel cell–based assay system with its concept. Then, we show a chip–based coculture system for cytotoxicity test, as our continuous effort to develop a multi–functional micro culture system realized by integration of fluidic control and detection functionalities. The culture zone in the chip was divided into two compartments separated by a microporous membrane through which substances in culture medium can freely come-and-go to induce the mutual interactions between the cells cultured at each compartment. Performances of the chip were examined 1) monitoring of polarized transport activity of intestinal tissue models, 2) cytotoxicity model through oral intake by coculture. As a result, we conclude that microfluidics may have applications in toxicity test and drug screening.

著者

浅見 耕司

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.29, no.6, pp.350-352, 2004-11-01 (Released:2011-03-04)

参考文献数

8

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In this article I describe the application of dielectric spectroscopy to charged membranes in aqueous media. Possible mechanisms, such as interfacial polarization and counterion polarization, are discussed for dielectric relaxation in the membrane systems.

著者

笹川 滋 本田 憲治

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.6, no.5, pp.310-320, 1981-07-01 (Released:2010-10-21)

参考文献数

57

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Chemical substances having cell fusogenicity and their mechanism of cell fusion were reviewed in this article. Especially, a new concept for the chemically-induced cell fusion has been introduced on the basis of the interpolymer complex formation. Moreover, a new idea of the hybrid type of chemical fusogens has also been given according to the following order:1. Introduction2. Classification and Mechanism of Monomeric Fusogens3. New Concept of the Mechanism of Polymeric Fusogens4. Further Development

著者

後藤 雅宏 東島 弘樹 北岡 桃子

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.46, no.4, pp.226-232, 2021 (Released:2021-08-24)

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In recent years, pollinosis immunotherapy has been attracting much attention, however, the administration methods of vaccine drugs have been limited to the subcutaneous injection or the sublingual administration. In this study, we developed a transdermal vaccine administration strategy for the simple and non–invasive pollinosis immunotherapy. For the transdermal antigen delivery, the presence of stratum corneum, the hydrophobic outermost layer of the skin, is an obstacle. Another problem with current pollinosis immunotherapy is side effects of using the whole allergen molecules. To overcome these issues, we applied a solid–in–oil (S/O) nanodispersion, which is composed of hydrophilic antigen molecules coated with hydrophobic surfactants, and enables transdermal penetration of the antigen molecules into the skin. In addition, we introduced a T cell epitope peptide derived from the cedar pollen allergen (PepA : SMKVTVAFNQFGP), which had shown lower risks of the side effects. We succeeded in preparing an S/O nanodispersion containing PepA. The oil–based S/O system enhanced the skin penetration of the PepA. Antigen specific IgE levels in the murine models were significantly reduced by the S/O administration. Activations of the type–1 helper T and regulatory T cells were also confirmed, which indicates the effectiveness of the pollinosis immunotherapy using the S/O vaccine system.

著者

松方 正彦

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.31, no.5, pp.271-274, 2006 (Released:2015-06-19)

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C1 chemistry, production technologies of fuel and chemicals from syngas, includes processes that would be possible to improve their productivity, to save energy requirement, and thereby to reduce production costs by selectively removing products from syngas through membrane. In this report, the results of process simulation on methanol synthesis are introduced to discuss about efficiency of membrane reactor in this process. The process simulation demonstrated that methanol productivity was substantially improved by removing products, methanol and water, in situ from the reaction system. A key issue is to develop microporous inorganic membranes enabling us to separate products like water and alcohol at high temperatures up to 300℃ and high pressures up to 100 atm.

著者

池田 健一

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.20, no.1, pp.29-38, 1995-01-01 (Released:2011-03-04)

参考文献数

25

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Contamination of drinking water supplies by the harmful chemicals increases sharply, and it is important to remove harmful chemicals in drinking water supplies for keeping our health. The purpose of this study was to review the reverse osmosis membrane proesses available for removing harmful chemicals, such as agricultural chemicals, nitrates and trihalomethanes in ground water and river water, to acceptable limits for consumers.Reverse osmosis membrane processes are used practically in the U.S.A. for the removal of nitrates and the prevent of trihalomethane formation by the chlorine applied for disinfection of drinking water. Reverse osmosis membrane process is one of the useful methods for making the safe drinking water.

著者

金 慶子 萩原 京平 梅野 太輔 斎藤 恭一 須郷 高信

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.34, no.4, pp.233-238, 2009-07-01

参考文献数

21

被引用文献数

1 2

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An immobilized metal affinity porous membrane of a hollow-fiber form was applied to the purification of geneticallyengineered histidine (His)–tagged fusion protein. An iminodiacetate (IDA)group (–N(CH2COOH)2)was introducedinto the poly–glycidyl methacrylate chain grafted onto a polyethylene-made porous hollow–fiber membrane.Subsequently, nickel ions were bound to the IDA group before the permeation of a His–tagged green fluorescent pro-tein (GFP)solution through the porous membrane. The resultant immobilized nickel affinity porous membrane(immobilized Ni membrane)had a ligand density of 0.36 mol/kg and a phosphate buffer flux of 0.4 m/h at a perme-ation pressure of 0.1 MPa and 298 K. His–tagged GFP adsorbed to the immobilized Ni membrane was eluted by per-meating a 0.5 M imidazole solution through the porous membrane. From an SDS–PAGE analysis, the purity of theprotein was found to be improved from 35 to 97%.

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.40, no.6, pp.342-348, 2015 (Released:2016-08-19)

著者

斎藤 禎隆

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.8, no.2, pp.66-74, 1983

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Evidence in support of the active ion transport by the ciliary body epithelium as the major mechanism of aqueous humor formation (AHF) has been accumulated. This paper reviews the recent progress in research and discussion of the following topics;<BR>i) the structure of the ciliary body epithelium <BR>ii) the composition of the aqueous humor <BR>iii) the contribution of active ion transport to AHF<BR>iv) the active transport of Na, Cl and HCO<SUB>3</SUB><BR>v) the neural and humoral factors which affect AHF<BR>vi) the possible role of pigmented cells on AHF

著者

谷岡 明彦

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.35, no.3, pp.100-104, 2010 (Released:2015-06-19)

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Electrospray method (in some case called as electrospray deposition: ESD) is a versatile method for forming thin films and non-woven fabrics. This method has the following advantages: (i) applicable for various solute and molten molecules, which have a wide range of molecular weights (e.g., inorganic molecules, synthetic polymers, proteins, and DNA), (ii) polymer thin films with nano/micro–scaled structures, which range from spheres to fibers, are deposited. Electrospray-deposited thin films have recently attracted much attention for applications such as antifouling or biocompatible coatings for medical devices, high–performance filter media, drug delivery systems, biomaterial scaffolds for tissue engineering, addition of high functionality on membrane surface for water purification and biosensors and biochips (e.g., protein/DNA–microarrays and microfluidic devices).

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.31, no.1, pp.44-45, 2006 (Released:2015-07-01)

著者

斎藤 禎隆

出版者

日本膜学会

雑誌

膜 (ISSN:03851036)

巻号頁・発行日

vol.8, no.2, pp.66-74, 1983-03-01 (Released:2011-08-16)

参考文献数

92

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Evidence in support of the active ion transport by the ciliary body epithelium as the major mechanism of aqueous humor formation (AHF) has been accumulated. This paper reviews the recent progress in research and discussion of the following topics;i) the structure of the ciliary body epithelium ii) the composition of the aqueous humor iii) the contribution of active ion transport to AHFiv) the active transport of Na, Cl and HCO3v) the neural and humoral factors which affect AHFvi) the possible role of pigmented cells on AHF