著者

今村 詮

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.13, no.4, pp.164-171, 1973-07-25 (Released:2009-05-25)

参考文献数

55

著者

黒川 量雄 中野 明彦

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.56, no.4, pp.201-206, 2016 (Released:2016-07-25)

参考文献数

27

被引用文献数

1

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The Golgi apparatus plays a pivotal role in membrane traffic of eukaryotic cells. Cargo proteins synthesized in the endoplasmic reticulum (ER) are transported to the cis-face of the Golgi, processed and glycosylated, and then delivered from the trans-face of the Golgi for their final destinations. Debates exist, though, on the mechanism how proteins are transported through the Golgi apparatus. Here, we review current understanding of protein transport through the Golgi apparatus, and describe our models based on the observation of their dynamics by the 3D live imaging microscopy we developed.

著者

吉田 基治

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.56, no.5, pp.262-265, 2016 (Released:2016-09-27)

参考文献数

18

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Persistent firing is believed to support short-term (up to tens of seconds) information retention in the brain. Although recurrent synaptic excitation is widely known to support persistent firing, recent studies have established that neurons can support persistent firing through an intrinsic mechanism within individual cells. This intrinsic mechanism involves activations of cholinergic receptors and the calcium activated non-selective cationic (CAN) current, and is observed in multiple brain areas including the hippocampus. Computer simulations from my group indicate that this mechanism is crucial for persistent firing in vivo, and it underlies the transition of hippocampal activity between encoding and consolidation stages.

著者

谷本 博一 木村 健二 木村 暁

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.56, no.5, pp.271-274, 2016 (Released:2016-09-27)

参考文献数

20

被引用文献数

1 1

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The various molecules and organelles in a eukaryotic cell are suitably positioned within the cell to carry out their functions at the appropriate time. This intracellular positioning is accomplished through interplay among the active transport mechanisms, intracellular fluctuations, and physical properties of the components inside the cell. Here, we review the recent advances in research on how the nucleus moves toward, and maintains its position at, the geometrical center of the cell. This question has attracted researchers from various fields, and is a good subject for interdisciplinary collaboration.

著者

柴田 敏史

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.62, no.1, pp.32-35, 2022 (Released:2022-03-25)

参考文献数

19

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ヒトの口腔内,腸内細菌叢の主要構成細菌であるBacteroidia綱細菌はヒトの健康に大きく関わっている.これらが持つ付着装置の線毛はピリンがリポタンパク質として菌体表面に輸送され,プロテアーゼ依存性のストランド交換反応によって根本から伸長するユニークな形成機構を持ったV型線毛である.

著者

冨樫 祐一

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.56, no.4, pp.246-246, 2016 (Released:2016-07-25)

著者

伊藤 優志 井手 聖 前島 一博

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.6, pp.385-388, 2021 (Released:2021-11-25)

参考文献数

10

著者

美宅 成樹

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.28, no.6, pp.317-322, 1988-11-25 (Released:2009-05-25)

参考文献数

15

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This paper describes the analysis of amino acid sequence as well as the denaturation experiment of soluble globular and membrane proteins. The two kinds of proteins were discriminated by amino acid sequence almost completely, using only the hydrophobicity. The denaturation measurements lead to the conclusion that the hydrophobic interaction determines the form of proteins (i.e. globular or membrane proteins), while the polar interactions play major role in the tertiary structure formation.

著者

藤岡 宏子 柏木 由紀 安永 卓生

出版者

一般社団法人日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.45, no.1, 2005-10-19

著者

岩部 直之

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.31, no.2, pp.91-98, 1991-01-25 (Released:2009-05-25)

参考文献数

21

被引用文献数

1 1

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All extant organisms are thought to be classified into three primary kingdoms, eubacteria, eukaryotes, and archaebacteria. Based on the analyses of a pair of duplicated genes, elongation factors EF-Tu/l α and EF-G/2, and catalytic and noncatalytic subunits of ATPase (ATPsynthase), archaebacteria are more closely related to eukaryotes than eubacteria. While this relatedness is certified, phylogenetic relationship among several major groups of archaebacteria (extreme thermophiles, extreme halophiles, and methanogens) and eukaryotes is still unsettled because the phylOgenetic tree topologies among them vary with the genes analysed. The ambiguous situation suggests that archaebacterial major groups and eukaryotes were diverged during very short period in the long course of evolution.

著者

浅利 宏紀

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.5, pp.347-348, 2021 (Released:2021-09-28)

著者

木寺 詔紀

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.6, pp.419-420, 2021 (Released:2021-11-25)

参考文献数

4

著者

木下 正弘 永山 國昭

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.52, no.4, pp.203-205, 2012 (Released:2012-07-25)

参考文献数

8

著者

村瀬 浩司 高山 誠司

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.5, pp.321-323, 2021 (Released:2021-09-28)

参考文献数

8

著者

岩下 皇藏

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.5, pp.345-346, 2021 (Released:2021-09-28)

参考文献数

1

被引用文献数

1

著者

岡田 康志

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.60, no.3, pp.188-189, 2020 (Released:2020-05-27)

参考文献数

5

著者

加藤 和貴 三沢 計治

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.46, no.6, pp.312-317, 2006 (Released:2006-12-07)

参考文献数

25

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Multiple sequence alignment is an important tool for computational analysis of nucleotide or amino acid sequences. It is also a challenging combinatorial optimization problem in computer science. As a large amount of sequence data is becoming available from genome and other large-scale sequencing projects, efficiency, as well as accuracy, is currently required for a multiple sequence alignment program. Several new programs are being developed aiming at improving both efficiency and accuracy. We overview the algorithms and performances of new programs including that by ourselves.

著者

御手洗 菜美子

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.53, no.1, pp.015-019, 2013 (Released:2013-01-29)

参考文献数

20

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Messenger RNAs (mRNA), that code sequences of amino acids by using triplets of nucleotides (codons), are translated by multiple ribosomes. Usually more than one codon corresponds to an amino acid. The ribosome speed is known to dependent on the codon, thus there is a room to keep an amino acid sequence (protein) and change the ribosome speed. We model the ribosome traffic with codon-dependent rate estimated for E. coli and show that some wild type codon sequences can regulate “traffic jam” by placing slow codons at the begging of the mRNA. We discuss possible roles of slow codons in translation process.

著者

横田 浩章

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.4, pp.227-231, 2021 (Released:2021-07-30)

参考文献数

20

被引用文献数

1

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The Escherichia coli UvrD protein is a superfamily 1, non-hexameric DNA helicase that plays a crucial role in repair mechanisms. Previous studies suggested that wild-type UvrD has optimal activity in its oligomeric form. Nevertheless, a conflicting monomer model was proposed using a UvrD mutant lacking the C-terminal 40 amino acids (UvrDΔ40C). Here, single-molecule direct visualization of UvrDΔ40C revealed that two or three UvrDΔ40C molecules were simultaneously involved in DNA unwinding, presumably in an oligomeric form, similar to that with wild-type UvrD. Thus, single-molecule direct visualization of nucleic acid-binding proteins provides quantitative and kinetic information to address their fundamental mechanisms.

著者

宮田 隆

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.24, no.2, pp.82-90, 1984-03-25 (Released:2009-05-25)

参考文献数

46

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Some possible mechanisms of gene evolution were examined from the aspect of dynamical mode associated with drastic changes of DNA and genetic information. There is growing evidence that eukaryotic multigene families often underwent exchange of genetic information between members of each family during evolution by mechanism of either gene conversion or double unequal crossing-overs. A detail examination of many examples for such genetic information exchange reported to date revealed that they are classified into four categories. Some evolutionary implications for such genetic process were also discussed. Alternation of intron splicing mode associated with conversion of exon into intron was emphasized as a mechanism responsible for the emergence of a new gene which differs radically in structure and function from its ancestor. Gene shuffling and joining of adjacent genes by an intron would be a mechanism that is important for generating a variety of genes having diverse functions in evolution. Two major steps of evolution through such process was suggested to have occurred since the early evolution of organisms. A novel mechanism for the evolution of viral multifunctional genes was proposed; by integrating a foreign piece of DNA carrying a certain function, viruses could acquire a new function.