著者
柴田 達夫
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.46, no.4, pp.194-200, 2006 (Released:2006-07-25)
参考文献数
12
被引用文献数
1 2

Stochasticity of chemical reaction is particularly prominent in small systems, such as cells. Recent experimental and theoretical studies reveal that stochastic cellular reactions generate fluctuations, which affect the behaviors of downstream reactions. Here, I show how large each reaction generate fluctuation, and how large the fluctuation is amplified in the downstream reaction. I discuss the possibility that such propagating fluctuations convey information about reaction networks.
著者
新海 暁男
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.54, no.5, pp.247-252, 2014 (Released:2014-09-30)
参考文献数
34

Adaptive immunity is acquired when foreign substances enter the body. Interestingly, this immune system exists not only higher organisms but also many bacteria. The CRISPR-Cas systems are the bacterial adaptive immune systems against foreign DNA and RNA derived from phages or plasmids. Many bacteria can memorize the sequences of foreign DNA and RNA, and remove them by means of these systems. Structural and functional studies of these systems have dramatically progressed over the past few years. In particular, one of the CRISPR-Cas systems, Cas9, has received considerable attention as a highly efficient tool for genome editing.
著者
上田 哲男 小畠 陽之助
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.25, no.3, pp.91-99, 1985-05-25 (Released:2009-05-25)
参考文献数
17
被引用文献数
1

Biological cell is the smallest system in which energy is transformed and information is processed autonomously. This complex and fascinating system is in the far from equilibrium state, and hence can manifest self-excited oscillations. Here we will describe rhythmic locomotion in amoeboid cells, oscillatory responses to chemical stimuli and rhythmic morphogenesis. Their biological and biophysical implications are discussed.
著者
柳尾 朋洋
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.45, no.2, pp.66-71, 2005-03-25
被引用文献数
1

The so-called "falling cat" problem, which is concerned with the coupling between internal motions and rotations of a flexible body, is introduced. I give a geometric interpretation of the Eckart condition, which is frequently used for the approximate separation of rotations and internal motions of polyatomic molecules. It is shown that the separation procedure based on the Eckart condition disregards the intrinsically "curved" nature of molecular internal space (shape space). The "curved" nature of shape space is shown to have considerable effects on structural transition dynamics of polyatomic molecules.
著者
宮下 治 タマ フロハンス
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.57, no.2, pp.090-094, 2017 (Released:2017-03-30)
参考文献数
20

Hybrid approaches combine computational modeling techniques with low-resolution structural data. Such approaches have proven to be powerful tools to obtain new 3D structural and dynamical information on biological systems. Currently, major applications focus on cryo-EM data. Methods and some applications to construct atomic structural models of new functional states will be reviewed. In addition, possible extension to data from X-ray free electron laser, which currently provides low-resolution data, will be discussed.
著者
YAMADA Naohumi IGUCHI Kakeru AGENO Yasuo HUSIMI Yuzuru
出版者
一般社団法人日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.48, no.1, 2008-10-25

rights: 日本生物物理学会rights: 本文データは学協会の許諾に基づきCiNiiから複製したものであるrelation: IsVersionOf: http://ci.nii.ac.jp/naid/110007014122/

3 0 0 0 OA 研究の今昔

著者
河村 悟
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.48, no.5, pp.269-269, 2008 (Released:2008-09-25)
著者
小林 徹也 上村 淳
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.53, no.2, pp.086-089, 2013 (Released:2013-03-28)
参考文献数
20

Biological systems can operate robustly even with substantial stochasticity in their components. One possible but not yet proven mechanism to implement robust operation with noisy components is that relevant information for robust control is embedded in apparently stochastic signals. In this work, by employing Bayesian theory, we theoretically show that intracellular reactions with specific structures can implement statistically optimal dynamics to decode (extract) the relevant information embedded (encoded) within the apparently noisy signal. We also demonstrate that the decoding dynamics is related to a noise-induced transition, implying that optimal dynamics to suppress noise behaves as if exploiting noise for signal amplification.

3 0 0 0 OA No Border

著者
野地 博行
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.53, no.5, pp.233-233, 2013 (Released:2013-09-25)
著者
近藤 宗平
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.14, no.3, pp.118-126, 1974-05-25 (Released:2009-05-25)
参考文献数
45
被引用文献数
1 1

Recent knowledge of DNA repair is reviewed in perspective with emphasis on Escherichia coli. Enzymatic phtoreactivation is the simplest and the most general among the three major DNA repair systems. Excision repair is also common from microorganisms to human and yet its molecular mechanism is not universal. Tolerance repair, i.e., post-replication repair, is effective for the widest variety of DNA damage and rather different between lower and higher forms. From these characteristics, it is proposed that DNA repair mechanisms evolved in the order of photoreactivation, excision repair and tolerance repair after the primary living systems were created by solar ultraviolet.