著者

井口 利仁 岩垣 博巳 浜中 荘平 モレイラ ルイス・フエルナンド 難波 浩 岡林 孝弘 日伝 晶夫 折田 薫三

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.103, no.11, pp.1171-1176, 1991

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A case of recurrence of colon cancer with marked tumor reduction after effective chemotherapy is reported. The patient was a 27-years-old female who was admitted to the 1st department of surgery because of a giant abdominal tumor. She had undergone surgery for cecal cancer 16 months before admission. Abdominal and pelvic CT-SCAN revealed a giant tumor (21×18cm) invading the rectum and uterus. Surgical cannulation was performed into bilateral internal iliac arteries, and anti-cancer drugs (5-FU : 5000mg, ADR : 40mg, CDDP : 200mg) were administered intraarterially. The occurrence of hyperkalemia and striking rises in LDH, CEA, CA19-9 after the chemotherapy strongly suggested the tumor lysis syndrome, which to our knowledge, has not been reported as a complication of the treatment of colon carcinoma.

著者

黒田 智 磯崎 英子 松永 尚 千堂 年昭

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.121, no.3, pp.209-213, 2009-12-01 (Released:2010-01-04)

参考文献数

3

著者

伊達 洋至

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.118, no.2, pp.113-117, 2006-09-01 (Released:2011-06-03)

参考文献数

12

著者

松永 尚 千堂 年昭

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.119, no.3, pp.319-322, 2008-01-04 (Released:2008-07-04)

参考文献数

14

著者

藤原 一夫 遠藤 裕介 三宅 由晃 尾崎 敏文

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.122, no.2, pp.159-162, 2010-08-02 (Released:2010-09-01)

参考文献数

33

著者

原岡 昭一

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.74, no.1-3, pp.381-392, 1962-03-30 (Released:2009-03-30)

参考文献数

41

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By means of the lead X, Y, Z, the scalar recording of its component, a difference of the electrocardiogram was compared between the young and the old persons. They include the normal healthy and diseased ones. The former consisted of 88 elder and 32 younger persons. In this study, criteria of ventricular hypertrophy were sought.P-wave showed a positive or diphasic one in the lead X, Y, but a negative in the lead Z. QRS-wave also showed a positive one in the lead X, Y, and a diphasic or positive, in the lead Z. T. wave showed a positive one in the lead X, Y, and a negative in the lead Z.The frontal QRS axis calculated from the lead X, Y, exhibited a correlation with the Eintoven's triangle, although the normal range of the former was narrower than that of the latter.It was found that the mean spatial T-magnitude was smaller in the younger aged groups than in the elder groups. in hypertensive patients an increase of the elevational QRS-Vo was considered to be due a shift of the QRS vecthr to the left and posterior. It was also noted that the mean spatial QRS-T angle and QRS, T. magnitude were angmented. The mean spatial T-magnitude showed a decrease upon an elevation of the diastolic presure.Thus, it would seem that R×+R=≤ 20 mm is more quantitative method for criteria of the diagnosis of left ventricular hypertrophy.This leading method is found to be more quantitative method than ever before and to have fewer leading sited of the electrodes. Therefore, it may clinically be useful.

著者

福元 一男

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.70, no.7, pp.2533-2540, 1958-07-31 (Released:2009-03-30)

参考文献数

11

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1. I took 5.520 (2.740 males and 2.780 females) of the people living in the southern part of Satuma Peninsula as examples of the southern Kyushu inhabitants from among all the Japanese of Kyushu to examine the frequency of the occurrence of the four basic fingerprints. And of the four prints in the cast of males, a type is 1.5%±0.07%; r type 3.2%±0.1%; u type 54.6%±0.30%; and w type 40.7%±0.29%. And in the case of females, a type is 2.1%±0.08%, r type 2.6%±0.09%, u type 59.1%±0.29%, and w type 36.2%±0.28%.2. When the above mentioned frequency of the occurrence of each of the four basic fingerprints is compared with that of the representative one of the Japanese rase, it is found that there is a resemblance to east-share people of Koshikijima (Kagoshima Prefecture), and the Indonesians (Java) as southern race.

著者

勝井 邦彰 沖本 智昭 金澤 右

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.127, no.2, pp.155-157, 2015-08-03 (Released:2015-09-01)

参考文献数

7

著者

小野 昌也

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.72, no.2, pp.515-520, 1960-01-30 (Released:2009-03-30)

参考文献数

16

被引用文献数

2

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ダイコクネズミ脳homogenateを用い,グルタミン酸-アスパラギン酸トランスアミナーゼ(GAT)活性に及ぼす18種の向精神薬,および3種の向神経薬の影響を測定した.1. フエノチアジン系向精神薬は, Prochlorperazineを除く他の6種はいずれもGAT阻害を示し,阻害作用はChlorpromazineに最も強かつた. Chlorpromazine S-oxideはChlorpromazineに比してGAT阻害作用は著しく弱い. 2種のフエノチアジン系向神経薬はGAT活性に影響をみなかつた.2. AzacyclonolはGAT阻害を示し, LSD-25は高濃度で阻害を示したが低濃度では影響を与えなかつた.3, 中枢刺戟剤4種のうち, PipradrolとDMAEは促進, Methylphenidateは影響なく, Tofranilは阻害を示した.4. バルビツール酸系睡眠剤AmobarbitalとPhenobarbital,非バルビツール酸系睡眠剤MethyprylonとGlutethimideは,すべて阻害を示した.しかるにバルビツール酸拮抗剤BemegrideはGATに無影響であつた.抗てんかん剤Primidoneは阻害を示した.5. 実験に用いた中枢抑制剤13種のうち12種が阻害を示した.6. GATに及ぼす作用において, ImipramineとChlorpromazineの類似, DiethazineやPromethazineとChlorpromazineとの差異を,化学構造における2個のN原子間の距離の一致と相異に対応すると考えた.

著者

桑原 進

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.67, no.7, pp.1377-1382, 1955-12-31

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Reading tests were made with Ishihara's Charts (10th edition) under incandescent lamps, daylight fluorescent lamps. de luxe daylight fluorescent lamps, mixed light of daylight fluorescent lamps and incandescent lamps, and neutral daylight. The result was as follows: The reading accuracy was highest under the de luxe daylight fluorescent lamp, and neutral daylight. the daylight fluorcscent lamp, mixed light of the daylight fluorescent and the incandescent lamps followed in this order with slight differences, and the incandescent lamp was the lowest.

著者

渡辺 漸

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.70, no.12supplement, pp.53-66, 1958 (Released:2009-08-24)

参考文献数

20

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No systemic study to induce leukemia in the experimental animals with the internal irradiation with radioactive isotopes has ever been attempted. We set about experiments with this object in 1953 and succeeded in the induction of experimental leukemia in dt, ddF and ddN uniform strain mice treated with small frequent doses of P32, Sr89 and Ce144.Single dosis of the isotopes ranged from 0.03 to 0.5 μc per gram body weight twice a week was administrated to mice with the methods of intravenous injection, intraperitoneal injection, intratracheal administration and intraesophageal dripping. The total administrations of the isotopes were 7-16 times.The development of leukemia was confirmed in higher frequencies among mice which were administered with small frequent doses of P32. The highest incidence of leukemia throughout our experiments was about 42% in the experiment with P32 at 0.3-0.5 μc level.The development of leukemia remains in lower frequencies among mice which were given small frequent doses of Sr89 or Ce144. In the former cases we confirmed the higher incidence of osteogenic sarcoma. In the latter cases the aplasia of the bone marrow were easily resulted.Among the Beta-emitting radioisotopes the one which has the shorter halflife and more intensive energy such as P32 is more suitable to induce leukemia in mice so far we had experienced.The excessive and at the same time partially abnormal regeneration preceed the development of leukemia after the administrations of small frequent doses of the radioisotopes.The order of the intensity of the radioactivity in the bone after the administration of the radioisotope change from time to time. Such effect will also contribute to enforce the abnormal regeneration of the bone marrow.For the development of leukemia in mice after the administration of the frequent small doses of the radioisotope we should not overlook the most intensive regenerative hematopoietic activity in the bone marrow corresponding middle portion of the long bone such as the femur.

著者

加藤 艮六

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.52, no.5, pp.1020-1027, 1940-05-31

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Es wurde der Einfluss verschiedener Mittel auf die tum Tode führende Tetrodtoxinvergiftung bei der Maus untersucht, indem man dem Tiere diese Mittel mit der letalen Dosis von Tetrodtoxin gleichzeitig subkutan einführte. Die Versuche erstreckten sich einerseits auf Vitamin C, Omnadin und Erstin, andrerseits auf verschiedene Organpräparate, wie Thyroxin, Lienalin, Opostatin, Yakriton, Interenin, Oporenin, Antasthol, Enarmon und Ovahormon. Die Resultate sind, wie folgt, kurz zusammenzufassen. 1) Vitamin C beeinflusst den Tetrodtoxintod nicht antagonistisch. 2) Omnadin und Erstin; die zum Zwecke der unspezifischen Immuno-Therapiegebraucht werden, scheinen der Vergiftung etwas entgegenzuwirken. 3) Thyroxin, ein Schilddrusenhormon, zeigt einen viel gunstigeren Erfolg, denn sie verlangert nicht nur die Lebensdauer, sondern vermindert auch die Mortalitat der vergifteten Tiere. 4) Yakriton, Interenin, Lienalin, Opostatin, Enarmon und Ovahormon wirken der Vergiftung nicht entgegen. Im Gegenteil verkurzen Oporenin und Antasthol die Lebens dauer.

著者

高樹 正浩

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.72, no.1, pp.79-94, 1959-12-30

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In order to elucidate the stability of the occured change on the properties of the tsutsugamushi disease rickettsia by contineous action of small amount of chloramphenicol in the body of mouse, the author investigated the stability of the varied rickettsia using that rickettsia as the antigen in the complement fixation test. As the result of this investigation, the occured change on the properties of the rickettsia found to be turned back to that of the original rickettsia by serial passage through normal mouse at least 7 generations.

著者

Takahashi Yoshio

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.38, no.437, pp.611-632, 1926-06-30

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炭類ガ著明ナル吸着作用ヲ有スルコトハ甚ダ舊キ時代ヨリ知ラレタル事實ニシテ, 之レガ治療的應用ハ既ニ埃及時代ヨリ試ミラレタルガ如シ. 而シテ炭類ノ吸着作用ニ就テ, 科學的ニ藥物學的研究ヲ行ヒタルハWichowskiヲ以テ嚆矢トナス. 輓近丹村氏ハ血炭及ビ木炭ノ毒物吸着ニ關スル生物學的研究ヲ發表セリ. 余ハ摘出家兎腸管, 子宮及ビ蛙心ニ於テ, 骨炭ノ外, 白陶土, 滑石, 硫酸「バリウム」及ビ「アラビアゴム」ヲ吸着相トシ, 種々ノ毒物吸着作用ニ關スル生物學的研究ヲ行ヒ, 大要次ノ如キ結論ヲ得タリ. 物理學上吸着相トシテ知ラレタル骨炭, 白陶土, 滑石, 硫酸「バリウム」及ビ「アラビアゴム」ハ生物學的實驗ニ於テモ亦其吸着現象ニヨリ解毒作用ヲ呈スルヲ認メ, 且夫等吸着相ノ諸種毒物ニ對スル吸着ノ量的關係ヲ明ラカニスルコトヲ得タリ. 如上ノ諸吸着相ハ, 毒物ノ營養液中ニ溶解セルモノハ勿論, 既ニ臟器組織内ニ侵入セルモノヲモ尚良ク吸着脱取シテ其作用ヲ消失セシム. 而シテ其際吸着セラレ得ベキ毒物最大量ハ兩者ノ場合ニ於テ殆ンド差異ヲ呈セズ. 各吸着相ノ吸着能力ヲ比較スルニ, 骨炭ハ其力最モ顯著ニシテ白陶土, 滑石及ビ「アラビアゴム」ハ其力著シク劣リ, 硫酸「バリウム」ニ至リテハ其力微弱ニシテ骨炭ト比較ス可クモアラズ. 同一吸着相ニ吸着セラルル毒物ノ量ハ, 其種類ニヨリテ大差アルヲ認メタリ. 余ノ實驗成績ニ據レバ一定量ノ吸着相ニ吸着セラルル毒物量ハ, 濃度ヲ増スニ從ツテ比較的減少スルヲ見タリ. 之ハ物理學的實驗ト全ク一致スル所ナルガ, 例外トシテ「ビロカルビン」及ビ「ストロフアンチン」ハ之レニ反シテ濃度ヲ増セバ被吸着量ハ吸着相増加トノ比例以上ニ増加スルヲ認メタリ. 本實驗ニ於テ吸着作用ハ頗ル迅速ニ起ルヲ見, Freundlichノ凡テ吸着現象ハ極メテ迅速ニ現ハレ數秒ニシテ一定ノ平衡状態ニ達ス, ト云ヘル事實ニ一致スルヲ認メタリ. 即チ營養液中ニ第一次吸着相ヲ, 第二次毒物ヲ注加スルトキハ, 毒物ハ直チニ吸着セラレテ其作用ハ全ク表ハレザルカ, 或ハ現ハルルモ甚ダ微弱ニシテ直チニ正常ニ恢復スルヲ見ル. 之レニ反シ, 第一次毒物ヲ注加シ其作用ヲ臟器ニ及ボシタル後, 第二次吸着相ヲ加ヘ其毒物ヲ吸着脱取セシメテ臟器ノ官能ヲ恢復セシムルニハ, 毒物ノ種類ニヨリテ著シク時間的差異アルヲ見ル. 「ビロカルビン」「アドレナリン」及ビ「コカイン」等ニ對シテハ容易ニ其官能ヲ恢復セシメ得ルモ, 「ストロフアンチン」ノ如キ「デイギタリス」屬ノ通有性トシテ組織ト堅ク結合スル毒物ニ對シテハ, 臟器ノ官能ヲ恢復セシムルニ甚ダ長時間ヲ要スルヲ認メタリ. 實驗方法トシテ, 吸着相ノ器底ニ沈滯スルヲ防ギ可及的平等ニ營養液中ニ浮遊セシメンガ爲四本ノ通氣嘴管ト一個ノ攪拌器トヲ設ケタルガ, 甚好成績ヲ收メ得タリ. 上述各吸着相特ニ骨炭ノ如キ吸着作用顯著ナルモノハ, 解毒ヲ目的トスル治療的應用ニ向ツテ効果確實ナル可キハ勿論ナレドモ, 爾他ノ吸着相ノ如キ吸着能力比較的微弱ナルモノト雖モ, 之レヲ他ノ藥物ト併用スルニ際シテハ, 其作用ヲ減弱乃至遲延セシムル虞アルハ實地上看過ス可カラザル事實ナリト云フ可シ.

著者

小野 吉昭

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.68, no.10, pp.1821-1837, 1956-10-31 (Released:2009-03-30)

参考文献数

58

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“Umayado Disease” has happened in summer especially at east area of Kagawa-ken.I have studied about. what kind of Tsutsugamushi will have increased and made peak at summer.Against this purpose, I have caught rats and collected the Tsutsugamushi living upon the rats twice a month regularly extending full 2 years up, and I have determined that a lot of Trombicula tosa has appeared and made the peak at summer usually.I think Trombicula tosa should be valuable agency to contaminate the Rickettsia orientalis at Kagawa-ken.

著者

吉岡 明彦

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.120, no.3, pp.285-289, 2008-12-01 (Released:2009-01-05)

参考文献数

21

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Objective: To examine the specificity of QuantiFERON®TB-2G (QFT) in tuberculosis contact investigations of children. Methods: A schoolgirl was diagnosed with smear-positive pulmonary tuberculosis. To determine the extent of tuberculosis infection among contact schoolchildren, tuberculin skin tests were performed on 75 children enrolled in the school. All the children had been vaccinated with BCG at least once. The QFT test was then given to the 68 children who had tuberculin reactions including erythema larger than 10mm in diameter. Written informed consent was obtained from a parent of each child. Results: The number of infected subjects was 22 based on tuberculin skin test results. Of the 68 contacts, 1 was positive for QFT, 2 were doubtful positive, and the remaining 65 were negative. During the 2-year follow-up, none of the children developed tuberculosis. Specificity was 95.6%. Conclusions: It was confirmed that the additional use of QFT would reduce the number of indications for chemoprophylaxis cases. The current criteria for the indication of chemoprophylaxis based on a strong tuberculin reaction are considered unreliable, causing many subjects with strong reactions to be given unnecessary preventive medications.

著者

板谷 裕子

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.116, no.1, pp.29-38, 2004-05-31 (Released:2011-06-03)

参考文献数

48

著者

万倉 三正 野田 泰子 森 昭胤

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.124, no.1, pp.15-26, 2012-04-02 (Released:2012-04-29)

参考文献数

61

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Diabetes mellitus (DM) represents a global health and economical problem. Many patients with DM in Asia, South America, India and East Africa have traditionally used the water extract of unripe fruits of Momordica charantia (bitter melon) as some form of complementary and alternative medicine. Studies of laboratory animals have shown the beneficial blood-glucose lowering and anti-diabetic effects of this remedy. Some oral components that bring lower blood glucose level have been isolated : charantin (sterol glycosides), charantin (polypeptide) and cucurbine-type triterpenes. Part of their actions are related to AMP-activated kinase and repression of the oxidative stress that is increased in DM. Most clinical reports are not fully convincing due to the lack of randomized control studies. The present article reviews the pharmacological and clinical effects of bitter melon with special emphasis on the anti-diabetic effects, and some effects that would require caution in the context of human trials.

著者

吉井 清水

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.63, no.2, pp.56-58, 1951-03-31 (Released:2009-05-26)

参考文献数

6

被引用文献数

1

著者

高塚 住子

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.82, no.9, pp.431-434, 1970-10

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In order to know the relationship between concentration of trichloroethylne and the amount of urinary trichloroethanol or trichloroacetic acid, average concentration of trichloroethylene inhaled by the workers in an automobile parts factory was measured by Kitagawa detector tube at 20-minute's interval. And urinary trichloroethanol and trichloroacetic acid were determined by Ikeda's oxidation method of chromium trioxide and our direct colorimetricmethod. The results were as follows. 1. Straight relationship between trichloroethylene concentration in the air and trichloroethanol or trichloroacetic acid in the urine was recognized by Ikeda's method. 2. Urinary trichloroethanol and trichloroacetic acid concentrations in workers exposed to trichloroethylene were determined by both our direct colorimetric method and Ikeda's oxidation method of chromium trioxide. Correlation between urinary trichloroethanol and trichloroacetic acid determined by Ikeda's method and our direct colorimetric method was observed.泄されるのであろうと言つている.1946年,Forssman,Ahlmark(2)3))はトリクレン蒸気中で働く労働者の訴えと,その尿中三塩化酢酸濃度との関係を見い出し,その75mg/lがトリクレン中毒の警戒すべき限界であると報告した.これに対して,1950年,Frant,Westeadorp(4))は,環境に気中のトリクレン濃度100ppmのもとで働く場合,その尿中には200mg/l濃度の三塩化酢酸を含むと述べられている.現在までは,三塩化酢酸の許容濃度はFrantの成績より75mg/lであるとしている.又,トリクレンの尿中代謝産物には三塩化エタノールのグルクロン酸抱合物もあり,soucek and Vlachova(5))等は1964年に,三塩化エタノールは,三塩化酢酸より排泄量が多く,しかも,排泄速度がはやい事を報告している.著者は実際の作業場で,三塩化エタノール,三塩化酢酸の関係を調べ,気中濃度との関係を求めた.又,三酸化エタノールの定量を池田氏の方法に比べて,簡便な定量を見いだした.そして作業者の尿を用いて,著者等の方法と池田氏の方法との相関を調べた.その成績をここに報告する.