著者

出宮 一徳

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.79, no.7-8, pp.619-635, 1967-08-30 (Released:2009-03-30)

参考文献数

70

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As a link in the series of studies on the functions of the diencephalo-pituituitary adrenocortical system in endogenous psychosis, an investigation was carried out on 26 cases of schizophrenia who received the standard bilateral lobotomy, for the purpose to find out how the frontal lobe affects to the endocrine functions and autnomic nervous systems. For this purpose ACTH (25 units) was administered intramuscularly to 17 cases of them, and the m echolyltest was conducted with the other 9 cases, measuring the lelvels of corticoids in serum and urine of both groups. For the controls, ACTH was administered to 9 cases of schizophrenia who did not receive lobotomy. The results of the study may briefly be summarized as follows.1) In the control group after ACTH adiministration the serum 17-OHCS showed a tendency of a decrease in the cortical reserve capacity, and in the lobotomized group there could be seen an abnormal reaction to ACTH in addition to a decrease in the cortical reserve capacity.2) Total blood cholesterol after the ACTH stimulation decreased temporarily, showing similar changes up to 30 minutes in both groups, but in the lobotomized group an increase in cholesterol could be observed thereafter, revealing a contrasting phenomenon to the decreasing tendency of the serum 17-OHCS.3) The blood potassium decreased transiently 10 minutes after the ACTH administration in both groups and such changes were unstable in the control group while the blood potassium in the lobotomized group increased steadily. As for the fluctuations of urine potassium its excretion was decreased transiently after the ACTH administration in both groups, which later rebounded, and this recovery tendency was more marked in the lobotomized group.4) 17-KS excreted in urine on ACTH stimulation increased accompanying a marked increase in the amount of urine in the case of lobotomized group.5) The results of the mecholyl test revealed that even the lobotomized patients respond to mecholyl, but there can be observed a decline and delay in the reactivity.6) Observations on the fluctuations of serum 17-OHCS, urine 17-OHCS and 17-KS conducted simultaneouly with the mecholyl test revealed a declinining tendency in serum free 17-OHCS while total 17-OHCS in urine to be rather increased in the lobotomized group. The quantity of 17-KS excreted in urine decreased at first and then increased, and such a tendency did not parallel with the change in the total 17-OHCS excreted in urine. In the patients showing identically the same pathological conditions there could be recognized no distinct correlation between the type of response to mecholyl and the corticoid picture.7) While we can recognize a certain correlation between defect symptoms of the frontal lobe and the endocrine functions, when we investigate individual caes, we find complex features in the endocrine function and autonomic nervous system according to the constitution before the lobotomy and the postoperative pathological picture. Namely, in those patients in a quiet menthal state, though they are not completely cured, both functions maintain the balance in the state of lowered tension. On the other hand, in those who show a premonition of unrest and excitation, both functions have become unstable. Moreover, those who may have hallucination and delusion and are in the state of chronic defect, so long as there occurs no excitation, they show the levels of function close to the normal.8) Summarizing these findings, it may be said that there is a decreasing tendency of the response to the ACTH stimulation in the functions of the diencephalo-pituitary-adrenocortical system of chronic shizophrenic group, and distribution of the estimated values is larger than that of normal persons, and this tendency is still more pronounced in the lobotomized group.

著者

雑賀 隆史

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.123, no.1, pp.63-64, 2011-04-01 (Released:2011-05-02)

参考文献数

1

著者

木浦 勝行 谷本 安 田端 雅弘 金廣 有彦 上岡 博 谷本 光音 渡邊 都貴子 草野 展周 小出 典男

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.115, no.1, pp.63-68, 2003

著者

石津 日出雄 山本 雄二 守屋 文夫 宮石 智 仙波 昌三

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.103, no.3, pp.145-153, 1991-06-18 (Released:2009-08-24)

参考文献数

31

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The progress of sex identification methods for forensic materials such as dried bloodstains and others in legal medicine is reviewed.Dixson and Torr (1956) first described a scientific method to identify human sex from forensic materials by detection of X chromatin in female cell nuclei. In 1972, we introduced a method for detecting Y chromatin in the human interphase nuclei by fluorescent microscopy as a new tool for decisive male sex determination from forensic materials. This method was accepted in forensic practice as the only reliable means to identify sex. In 1983, we reported sexes were distinguishable from dried bloodstains by the ratio of sex hormones, testosterone and progesterone, determined by radioimmunoassay. Gene analytical methods to prove the human Y chromosome specific DNA sequences have been introduced in this field. We also examined the method of Witt and Erickson (1989) to detect Y and X chromosome specific sequences using the polymerase chain reaction (PCR), and we improved this technique to exhibit its ability to identify sex in forensic practice. Our improved PCR method is expected to have a broad applicability in forensic practice because of its simplicity, sensitivity and reliability.

著者

野田 知之 尾崎 敏文

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.122, no.3, pp.253-257, 2010-12-01 (Released:2011-01-04)

参考文献数

6

被引用文献数

2

著者

林 瑶子 名和 秀起 北村 佳久 千堂 年昭

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.126, no.1, pp.59-63, 2014-04-01 (Released:2014-05-01)

参考文献数

14

著者

高坂 睦年 薄井 省吾 帆秋 穐誉

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.67, no.1, pp.345-354, 1955-01-31 (Released:2009-08-24)

参考文献数

26

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1. The Heinz body formation in vitro due to the addition of hydroxylamin hydrochlorate as a blood gift was studied and compared in 71 cases of 22 normal subjects and 49 schizophrenics.2. The mean value of erythrocytes with Heinz body formation: normal group 94‰ chronic standstill group 146‰; strong excitement and confusion group 211‰, chronic progressive group 213‰; intense deterioration group 304‰. If we suppose the mean value of normal group as 100, so the rate of every schizophrenic group is calculated as follows; chronic standstill group 155; strong excitement and confusion group 224, chronic progressive group 227: intense deterioration group 324. This fact indicates that the erythrocytes of schizophrenic patients are pathological.3. The resistance of erythrocytes with Heinz body is weaker than that of normal. (by the Ribiere's method).4. We found that the erythrocytes sedimentation rate in the intense deterioration group accelsrates more than in normal, and that e. s. r. has some relation to Heinz body appearance.

著者

倉田 智子 阿部 康二

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.126, no.2, pp.155-157, 2014-08-01 (Released:2014-09-01)

参考文献数

4

著者

板野 義太郎

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.103, no.1-2, pp.117-127, 1991 (Released:2009-03-30)

参考文献数

37

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To clarify the acute-phase response in brain, we investigated the induction of metallothionein (MT) genes by administering an endotoxin (lipopolysaccharide) in rat intraperitoneum. We performed in situ hybridization on the serial brain sections to identify the cells expressing the MT genes in the acute-phase. After endotoxin administration, transcripts of MT genes were detected in the arachnoideal, ependymal cells and the Bergmann glia of the cerebellum, while no significant induction of the MT genes by zinc ion was observed in the brain. These results suggest that the acute-phase response occurs specifically in at least these three non-neuronal cells.

著者

宮村 能子

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.124, no.3, pp.255-257, 2012-12-03 (Released:2013-01-04)

参考文献数

7

著者

鵜殿 平一郎

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.125, no.1, pp.13-18, 2013-04-01 (Released:2013-05-01)

参考文献数

25

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がんワクチンによる免疫治療では,如何にCD8T細胞を感作(プライミング)しその数を増やすか(免疫増強)という点に多大の努力が払われて来た.樹状細胞への抗原デリバリーと抗原プロセシング/提示,Toll様受容体などの刺激,即ち自然免疫系の活性化の併用などはそれに該当する.しかし十分に活性化されたT細胞をもってしても癌の拒絶は容易ではない.それには癌組織という特殊な環境が禍している.T細胞は癌塊内に入り込み莫大な数の癌細胞と遭遇する.癌組織内での繰り返す抗原認識の過程でT細胞は疲弊し,次第に本来あるべき機能を喪失していく.この疲弊(exhaustion)と呼ばれる現象は,T細胞に発現する複数の免疫抑制性分子―免疫チェックポイント分子―と腫瘍に発現するそのリガンドの結合によってもたらされる.代表的なチェックポイント分子の機能を抑制し,エフェクターT細胞が疲弊することなくその機能を長く維持できれば,これからのがん免疫治療に飛躍的な進展がみられるかもしれない.

著者

柴田 直樹

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.104, no.5, pp.609-616, 1992

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The clock gene of <i>Drosophila</i> containing a hexamer repeat sequence (ACAGGC)n (period, <i>per</i>, repeat) is reported to be involved in the circadian rhythm. Young et al. (1985) cloned a mouse genomic DNA with the <i>per repeat</i> (cp2.2). In this study, temporal and spatial expression of <i>CP2.2F.</i> and <i>RB15</i> was examined in the adult rat brain by <i>in situ</i> hybridization. The former is a family of genes detected by using cp2.2 as a probe, and the latter is a gene corresponding to pRB15, one of the 11 rat brain cDNA recombinants homologous to cp2.2. Both genes were expressed in almost all neurons. Fluctuation of the genes under the light-dark cycle was apparently observed in the suprachiasmatic nucleus; an intensive hybridization signal in the middle of the day and a weak in the middle of the night (p<0.01). However, the signal stayed relatively constant in other brain regions. Expression of both genes was detected in some glial and ependymal cells in the day but few at night. The present findings suggest that <i>CP2.2F.</i> and <i>RB15</i> are involved in the circadian rhythm in the rat nervous system.

著者

柴田 直樹

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.104, no.5, pp.609-616, 1992

被引用文献数

1

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The clock gene of Drosophila containing a hexamer repeat sequence (ACAGGC)n(period, per, repeat) is reported to be involved in the circadian rhythm. Young et al. (1985) cloned a mouse genomic DNA with the per repeat (cp202). In this study, temporal and spatial expres-sion of CP2.2F. and RB15 was examined in the adult rat branin by in situ hybridization. The former is a family of genes detected by using cp2.2 as a probe, and the latter is a gene corresponding to pRB15, one of the 11 rat brain cDNA recombinants homologous to cp2.2. Both genes were expressed in almost all neurons. Fluctuation of the genes under the light-dark cycle was apparently observed in the suprachiasmatic nucleus ; an intensive hybridization signal in the middle of the day and a weak in the middle of the night (p<0.01). However, the signal stayed relatively constant in other brain regions. Expression of both genes was detected in some glial and ependymal cells in the day but few at night. The present findings suggest that CP2.2F. and RB15 are involved in the circadian rhythm in the rat nervous system.

著者

板谷 裕子

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.118, no.2, pp.149-150, 2006-09-01 (Released:2011-06-03)

参考文献数

10

著者

石川 隆紀 宮石 智 土井 裕輔 高田 智世 今林 貴代美 稲垣 幸代 吉留 敬 山本 雄二 石津 日出雄

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.114, no.3, pp.303-308, 2003-01-31 (Released:2009-03-30)

参考文献数

11

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We encountered two cases of unnatural death occurring indoors in early spring in Okayama Prefecture. The two cases were both females aged 31yearsold and 88yearsold. Autopsies revealed death from hypothermia as the cause of death. The diagnosis of death from cold was not based solely on the characteristic findings of the dead body. After confirming that there were no other accidents and diseases that may cause death, an overall evaluation should be made considering the conditions surrounding occurrence of death from cold. We describe these procedures using these two autopsy cases of death from hypothermia.

著者

井口 利仁 岩垣 博巳 浜中 荘平 モレイラ ルイスフエルナンド 難波 浩 岡林 孝弘 日伝 晶夫 折田 薫三

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.103, no.11, pp.1171-1176, 1991

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A case of recurrence of colon cancer with marked tumor reduction after effective chemotherapy is reported. The patient was a 27-years-old female who was admitted to the 1st department of surgery because of a giant abdominal tumor. She had undergone surgery for cecal cancer 16 months before admission. Abdominal and pelvic CT-SCAN revealed a giant tumor (21×18cm) invading the rectum and uterus. Surgical cannulation was performed into bilateral internal iliac arteries, and anti-cancer drugs (5-FU : 5000mg, ADR : 40mg, CDDP : 200mg) were administered intraarterially. The occurrence of hyperkalemia and striking rises in LDH, CEA, CA19-9 after the chemotherapy strongly suggested the tumor lysis syndrome, which to our knowledge, has not been reported as a complication of the treatment of colon carcinoma.

著者

白髭 郁子

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.78, no.2-3, pp.365-386, 1966-03-30 (Released:2009-02-13)

参考文献数

44

被引用文献数

1

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Two cases of the juvenile form of amaurotic family idiocy were described in the present communication. 1) Case 1 was a 11-year-10-month boy. His family history had consanguinities. He was slightly deteriorated before the onset of the disease. At the age of 5 years, the ataxia of gait was initially manifested. Later there developed the progressive mental deterioration and the “Blitz-Nick- Salaam Krämpfe”. On neurological examinations the marked cerebellar syndroms (ataxia, intention-tremor and hypotonia), the involuntary movements and the narrowing of the ocular vessels could be recognised. Case 2 was 10-year-7-month girl. Her two brothers died of amaurotic family idiocy. She had been healthy until she complained of the myoclonic contractions of the tips of the fingers. The mental deterioration, the convulsive seizures and the visual disturbances were gradually appeared. The neurological examinations showed the involuntary movements, the hypotonia, the optic atrophies and the retinal degeneration. Both patients died six years after the onset of the disease. 2) The autopsy findings of the brains in both cases revealed macroscopically the generalised atrophy and the increased consistency. Microscopically the essential changes were observed in the neuronal swelling and the lipidosis. These changes were distributed ubiquitously throughout the central nerves system and were most markedly in the cerebral cortexes, decreasing by degrees caudally. Furthermore in the case 1, the severest damage was seen in the cerebellar cortex. In the cerebellum of case 1, the entire nerve cell elements except Golgi's cells and the nerve fivers were almost completely obliterated. The swelling of axons in the the cerebral cortexes was recognised in both cases. too. 3) The findings of the organs such as liver, spleen and others in case 2 revealed no lipid accumuration as seen in Niemann-Pick's disease. There were observed the degeneration of the retinal outer layer which was characteristic of the juvenile form of the disease. 4) From the results of the histochemical observations in both cases it was concluded that the intraneuronal substances consisted of the mixture of the sphingomyelin and PAS-positive substances that might be the glycolipid. A part of them and the substances in the fat granulle cells were assumed to be combined with the protein. 5) Above mentioned results, the clinical, the histological and the histochemical findings in both cases indicated the jnvenile form of the disease. In case 1 there would be the developmental anomaly of the brain beside the essential chages of amaurotic family idiocy.

著者

原 功一

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.86, no.9-10, pp.453-464, 1974-10-30 (Released:2009-03-30)

参考文献数

41

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Folic acid contents of various foods (147 items) were estimated by the microbioassay using Lactobacillus casei as the test organism. Folic acid were abundant in vegetables, fruits, fishes and the liver of animals. Nineteen foods were examined for loss of folic acid during boiling. Leaching out into the water was also examined. 20-70% of free folate was destroyed after 5 minutes and 20-90% after 15 minutes. Destruction of total folate was less than that of free folate i.e., 30% after 5 minutes and 40-60% after 15 minutes. Pteroylglutamic acid was not destroyed by boiling for 15 minutes. So the folate destroyed during boiling was considered to be other forms of folate except pteroylglutamic acid.Folic acid contents of two hospital diet in Okayayma city was estimated. Mean daily folic acid amount in the diet of hospital A was 205μg of free folate and 839.8μg of total folate. In the diet of hospital B, 305.5μg of free folate and 738.1μg total folate were present. These amounts were much more than those reported in USA and England. As to the reason why megaloblastic anemia is rare and folic acid defi ciency is so mild in Japan, abundant folic acid intake from diets, uniformity of dietary habits i.e. boiled rice as basic food, were discussed.

著者

武本 充広 片山 敬久 勝井 邦彰 金澤 右

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.120, no.3, pp.313-320, 2008-12-01 (Released:2009-01-05)

参考文献数

14

著者

宮崎 俊明 錦織 淳美 松永 尚 千堂 年昭

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.122, no.2, pp.163-167, 2010-08-02 (Released:2010-09-01)

参考文献数

7