著者
池田 嘉一郎
出版者
岡山医学会
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.32, no.371, pp.646-666, 1920-12-31

(一)所謂人乳中毒症ニ於ケル精紳症状ハ、輕症ナルモノニ於テハ、一過性ノ興奮性充進竝ニ嗜眠状態ヲ呈スルニ過ギザルモ、重症ナルモノニ於テハ、更ニ進ミテ意識溷濁乃至無慾状顔貌ヲ呈シ、周圍ノ事情ニ對スル識別力ヲ失ヒ笑ハズ泣カズ、眼付曇ヨリシ、時トシテ舞踏病樣不隨意運動乃至不明ノ言ラ發ス、カク特異ナル精紳症状ヲ呈スルハ神經申樞ニ何等カノ病變ノ存スルモノト考ヘザルベカラズ、余ハカカル患者ニ遭遇スル毎ニ勉メテ腰椎穿刺ヲ行ヒ腦脊髓液ノ性状ヲ檢シタルニ、ソノ外觀、比重、糖反應、蛋白量、蜘蛛網状物形成ノ有無等ノ關係ハ、多クハ健康者ノモノト差異ヲ認ムルコト能ハザリシモ、「グロブリン」反應及ビ細胞數ニ於テ輕微ノ變化ノ存スルヲ認メタリ、即チ「グロブリン」反應中、ノンネーアツペルト氏反應竝ニパンヂー氏反應ハ多クハ陰性(時トシテ弱陽性ナルコトアリ)ナルモ野口氏反應ハ毎常弱陽性ヲ示セリ、而シテ淋巴球ノ數ハ通常ナルカ或ハ僅ニ増加セリ、即チ輕度ノ漿液性腦膜炎ノ腦脊髓液ニ相類似ス、カカル腦脊髓液ノ變化ハ唐澤博士ノ報告セル軟腦膜ニ於ケル解剖的變化ト相符合ス。(二)臨牀上ニ於ケル所謂人乳中毒症ト乳兒脚氣トノ主要ナル區別點ハ、伊東博士ニ依レバ血行器症状竝ニ精神症状ノ有無ニ存ス、然レドモ血行器症状ハ兩疾患ヲ鑑別スルニ向ツテ爾カク重要ナル資料トナスヲ得ズ、蓋シ血行器症状ハ乳兒脚氣ニ於ケル必要ナル症状ノ一ツナルモ而モ之ヲ伴ハザルモノ稀ナラズ、又所謂人乳中毒症ニ於テモ血行器症状ハ必ラズ缺如スベキモノニアラザルガ故ナリ、況ンヤ症例(三)ニ於ケルガ如ク、所謂人乳中毒症ニ於テ其ノ經渦中ニ突然衝心症状ヲ表ハシタル事實アルエ於テオヤ。精神症状ノ有無ニ至リテハ、吾人ハ兩疾患ニ於ケル最モ顯著ナル差異タルヲ是認セザルベカラズ、然レドモ大人脚氣ニ於テ稀ニ精神症状ヲ伴フコトアルコト竝ニ余ノ實驗例ノ如ク幼兒脚氣ニ於テ躁暴狂状乃至昏迷ヲ呈シ、而モ軟腦膜ノ病理解剖的所見ニ於テ所謂人乳中毒症ト殆ド同樣ナル病變ヲ呈セルコトアル事實ヨリ推考スル時ハ、乳兒脚氣ニアリテモ亦精神症状ノ表ハルルコトアリテ可ナル理ナリ。(三)所謂人乳中毒症ト母體脚氣トハ甚ダ密接ナル關係ヲ有スルハ余ノ統計的觀察ニ依リテ明カナリ、余ノ症例(四)及ピ(五)ハ正シクコノ事實ヲ立證セルモスト云フヲ得ベシ、即チ余ノ症例ハ哺乳ノ時期ヲ異ニスルモ、脚氣ヲ有スル同一母體ノ乳汁ヲ哺乳シタルニ依リテ、第四子ハ乳兒脚氣ヲ惹起シ、第五子ハ所謂人乳中毒症ヲ惹起セルモノトス、カカル事實ハ、所謂人乳中毒症ハ其ノ本態ニ於テ乳兒脚氣症ト同一ナルモノニアラズヤトノ疑念ヲ益々吾人ニ抱カシム。(四)以上ノ事實ヲ綜合スル時ハ、所謂人乳中毒症ハ其ノ本態ニ於テ乳兒脚氣ト同一上ニ立ツベキ疾患ニシテ、詳言セバ乳兒脚氣ノ一異型ト見做スベキモノナリト信ズ、余思ヘラク、乳兒脚氣ハ脚氣毒素ガ母體ノ乳汁ヲ介シテ小兒ニ移行スルニ依リテ起ル一種ノ中毒症ニ外ナラズ、而シテ臨牀上ニ於テ一方ニハ專ラ心臓機能ヲ障碍スル衝心型アリ又他方ニ血行器症状ヲ件ハズシテ専ラ末梢神經ヲ侵ス所ノ麻痺型ナルモノアリ、コレ等ノ事實ヨリ考フル時ハ脚氣毒素ガ主トシテ心臓ヲ侵ス時ハ衝心型トナリテ表ハレ、主トシテ末梢神經ヲ侵ス時ハ麻痺型トナリテ表ハレ、專ラ腦膜ヲ侵ス時ハ所謂人乳中毒症ノ型トナリテ表ハルルモノニアラザルカ、カカル關係ハカノ麻疹ノ例ニ於テ之ヲ見ル、即チ症状ノ劇烈ナルモノニ於テハ、多クハ肺炎ヲ合併シコレト同時ニ心臓衰弱ヲ招來スルモ、時トシテハ主トシテ中樞神經系統ニ障碍ヲ及ボシ、既ニ前驅期或ハ發疹期ノ初メニ於テ意識溷濁ヲ來シ遂ニ無慾状態ニ陷ルコトアリ、又恢復期ニ於テ稀ニ腦膜ヲ侵シ漿液性腦膜炎ヲ惹起スルモノアリ、是レ麻疹毒ハ時ニ主トシテ中樞神經系統ヲ侵スコトアルヲ意味スルモノニシテ、以上述ベタル余ノ乳兒脚氣ニ於ケル説明ト相符合スル點アルヲ以テ茲ニ之ヲ引用シタルニ過ギズ、カク觀察シ來ル時ハ精神症状ノ有無ハ敢テ問題トナスニ足ラザルナリ、余ハ所謂人乳中毒症ヲ乳兒脚氣腦型トナシ乳兒脚氣中ニ包括スルニ賛スル者ナリ。
著者
岡崎 昌一
出版者
岡山医学会
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.72, no.5, pp.1351-1357, 1960-07-30

By selecting 4 oxime compounds possessing pyridine nucleus in the molecular construction, namely, PATD, PPATD, PPAPD, and PAD, the author compared their therapeutic effects on alkylphosphate poisoning with the effect of PAM. 1. As for the therapeutic effect on alkylphosphate poisoning in mice, when administered in the maximum safety dose, PATD and PPATD are superior to PAM, but on scrutinous examinations there can be recognized not any significant difference. Effect of PPAPD is about the same as that of PAM. 2. Both PAM and PATD are most effective when administered concurrently with the intravenous administration of alkylphosphate, but as the time before or after the administration of alkylphosphate lengthens, the effect of drugs decreases proportionately. 3. Atropine used concurrently with these oxime compounds yields no better results than without it. 4. The effect of PATD is slightly more lasting than PAM, but the difference is not significant. 5. PATD has been proven to possess a reactivating action on rabbit blood cholinesterase just as PAM. Consequently it is assumed that the effective mechanism of both drugs is same. 6. When an equal dose of PAD and PAM is administered to the mice with ethylparathion poisoning, PAD is inferior to PAM in improving the mortality rate of the mice. 7. There seems to be no benefit in administering intramuscularly 15 mg/kg PAD concurrently with the administration of various oximes.
著者
大重 彌吉
出版者
岡山医学会
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.66, no.5, pp.951-957, 1954-05-31 (Released:2009-08-24)
参考文献数
13

From the data gathered by myself and other investigators up to 1954 in every district of Japan, I have chosen those of the mother population according to the law of X2-distribution and from their average value have concluded that the corrected frequency of principal psychoses in rural districts of Japan is as follows:-
著者
新井 達潤
出版者
Okayama Medical Association
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.89, no.1-2, pp.21-36, 1977-02-28 (Released:2009-03-30)
参考文献数
59

Ventricular fibrillation was induced in fifteen monkeys by electric stimulation using a bipolar intracardiac pacemaker electrode which was inserted through a femoral vein. The monkeys were defibrillated and resuscitated after several minutes. Cerebral blood flow (CBF), intracranial pressure (ICP) and EEG were monitored continuously. CBF autoregulation was checked regularly before and after ventricular fibrillation to study the relation between it and other parameters such as CBF, ICP, EEG.Fifteen monkeys were divided into two groups, a burr-hole group and a no burr-hole group. ICP was measured in the burr-hole group (10 monkeys). The purpose of having two groups was to ascertain the effect of a burr-hole (artificial injury in the skull and dura) on the parameters CBF, EEG and autoregulation. CBF was measured with electromagnetic flowmeter at internal carotid artery.The conclusion of the experiment was as follows;(1) Autoregulation was lost in all monkeys after resuscitation. In the monkeys which had had autoregulation before cardiac arrest, the autoregulation recovered in three (no burr-hole group) to five (burr-hole group) hours after resuscitation, if resuscitation took place within five minutes. In the monkeys whose autoregulation had already been lost before cardiac arrest, it did not return despite successful cardiac resuscitation.(2) Immediately after resuscitation, BP, ICP and CBF increased for 20-60 minutes. In the monkeys who had no recovery of autoregulation after resuscitation, the rate of increase of ICP was much larger than those whose autoregulation recovered, and at the peak of ICP, the CBF decreased. Impairment of autoregulation itself, indicates that the ballance of circulatory dynamics of the brain is easily impaired by noxious stimulation such as hypoxia.(3) In the monkeys with recovery of autoregulation, general status was good after resuscitation but in the monkeys without recoverey, symptomes of increased ICP were seen and the prognosis was poor.(4) Six minutes of cardiac arrest would appear to be the upper limit for monkeys to survive after resuscitation.(5) Before ventricular fibrillation, corresponding changes in the CBF and the frequency of the EEG wave recorded, but after resuscitation the frequency of the EEG wave decreased despite an increase in CBF. This is probably the same mechanism as occures in the “luxury perfusion syndrome”.There was no relation between EEG and autoregulation, but when EEG showed dominant slow or flat waves, there was no autoregulation.
著者
杉山 明
出版者
Okayama Medical Association
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.99, no.3-4, pp.251-260, 1987-04-30 (Released:2009-03-30)
参考文献数
20

The kinetics of serum ferritin were studied in 42 male patients with alcoholic liver diseases (17 with alcoholic fibrosis, 10 with alcoholic hepatitis and 15 with alcoholic cirrhosis). In addition, the chromatic reaction of biopsied liver tissue to ferritin staining (PAP method) was examined and compared with serum ferritin levels and the iron-staining data. Serum ferritin levels in patients with alcoholic liver diseases, determined immediately after abstinence, were significantly higher than those in normal controls, although no significant difference was noted in serum ferritin among the different disease types. The serum ferritin levels decreased exponentialy after abstinence regardless of the disease type. There were positive correlations between serum ferritin and the intensity of hepatic hemosiderin and between the intensity of hepatic hemosiderin and hepatic ferritin. These correlations indicate that the ferritin level changes according to the amount of hepatic iron stores. These results indicate that hyperferritinemia of patients with alcoholic liver diseases reflects an increase in hepatic iron stores and that the escape of hepatic ferritin due to hepatocellular damage and the reduced clearance of serum ferritin are also related to hyperferritinemia.
著者
高原 光弘
出版者
Okayama Medical Association
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.91, no.9-10, pp.1235-1248, 1979-10-30 (Released:2009-03-30)
参考文献数
37
被引用文献数
1 1

Persistent juvenile T wave patterns found in mass examination and in clinical cases were studied for the purpose of clarifying their significance. Persistent juvenile T wave patterns were classified into three types. Type I had negative T waves in lead V1 only, Type II in lead V1 and V2 and Type III in V1 to lead V3 or V4. During mass examinations, persistent juvenile T wave patterns were found in 243 cases (43.5%) of 558 male subjects. Of these, 15 (6.2%) were Type II, III. On the other hand they occurred in 547 (66.5%) of 823 female subjects. Of these, 86 (15.7%) were Type II, III. The incidence of each Type of persistent juvenile T wave pattern did not vary significantly with age, but Type II, III were relatively more frequent between 35 and 49 years of age. Persistnet juvenile T wave patterns were often positive in many cases in electrocardiograms (ECG) thaken from the same subjects 8 years after the first mass examination. Standard ECG's and Frank's system vectorcardiogram (VCG)'s were analysed in 116 clinical cases showing persistent juvenile T wave patterns. Transitional zone and electrical axis deviation in ECGs were almost normal in the persistent juvenile T wave pattern. The shape of the transverse T loop was mostly normal whereas the transverse QRS loop normally varied in shape. Clockwise rotation of the transverse T loop was observed in 15 of 116 clinical cases. The maximum magnitude of the T loop in VCG was significantly smaller in Type III than in Type I, II. Changes in the persistent juvenile T wave pattern on ECG and VCG were studied in 25 cases after administration of Propranolol. The negative T wave in ECG tended to become positive and the maximal T vector tended to become larger shifting towards anterior in VCG after administration of Propranolol. The persistent juvenile T wave pattern was observed more frequently in middle aged women and usually became normal after administration of Propranolol. These results suggest that increased sympathetic tone is one of the pathological mechanisms involoved in the persistent juvenile T wave pattern.
著者
水川 展吉 冨永 進 木股 敬裕 小野田 友男 野宮 重信 杉山 成史 川本 知明 山近 英樹 植野 高章 高木 慎
出版者
岡山医学会
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.119, no.3, pp.267-272, 2008-01-04 (Released:2008-07-04)
参考文献数
10
被引用文献数
2 2

There is a medical team approach used in many hospitals for oral cancer patients. The members are head & neck surgeons and plastic surgeons, or oral surgeons and plastic surgeons. However, in Japan, it is very difficult for oral surgeons to cooperate with head & neck surgeons, except in the case of extractions and oral health care, because both surgeons treat oral carcinomas and there is therefore a conflict in their scope of practice. We believe it desirable for head & neck surgeons to treat oral cancer patients with tumors extending to other regions, and oral surgeons should be in charge of occlusion in head and neck carcinomas. We treated two patients with oral carcinomas in collaboration with head and neck surgeons and plastic surgeons, with head & neck surgeons resecting the tumors, plastic surgeons reconstructing, and oral surgeons (dentists) taking charge of the occlusion for patients in the operating room. This collaboration resulted in patients having good position of the temporomandibular joint and occlusions after the operation. We therefore conclude that this collaborative team approach may be of benefit to the patients.
著者
山元 敦也
出版者
Okayama Medical Association
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.105, no.5-6, pp.629-639, 1993 (Released:2009-03-30)
参考文献数
13
被引用文献数
1 1

It was previously reported that the elevation of inorganic fluorine level in plasma after inkalation of methoxyflurane causes acute renal failure. This study investigated whether the peak concentration or the duration of the inorganic fluorine is responsible for the renal failure. Continuous infusion (5 millimols/liter and 10 millimols/liter) or a single intravenous bolus injection (720 millimols/liter) of sodium fluoride solution was administered to rabbits. The plasma concentration and the duration of the plasma fluorine was measured.There werer no signs of pathological or biochemical changes that suggested renal failure when the peak plasma concentration was less than 50 millimols/liter for over 4 hours (5 millimols/liter, 24 hours), or whether peak concentration of plasma inorganic fliorine was over 50 millimols/liter for less than 4 hours (720 millimols/liter, intravenous bolus). However when 10 millimols/liter of sodium fluoride solution was administered at a speed of 10 milliliters/hour for 24 hours, the rabbits showed a peak plasma inorganic fluorine concentration over 50 micromols/liter for more than 4 hours and signs of renal failure developed ata plasma concentration of 65.8 micromols/liter 24 hours after the beginning of infusion. renal failure was mainly inthe form of edema of the tubular cells in both the cortex and medulla and abnormal biochemical changes (blood urea nitrogen 55.8±12.5 milligrams/deciliter, plasma creatinine 1.2±0.1 milligrams/deciliter).Inorganic fluorine can cause renal changes when its paek plasma concentration reaches more than 50 micromols/liter and lasts for more than 4 hours.
著者
片山 昭
出版者
Okayama Medical Association
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.91, no.7-8, pp.847-860, 1979-08-30 (Released:2009-03-30)
参考文献数
12

In order to study the fundamental touch in piano playing, the physiological mechanics of the player and the kinetic mechanics of the swing-stroke system in the piano need to be studied.Equipment for analyzing and measuring the intensity of the swing-strokes has been developed to study the fundamental touch in piano playing. This equipment measures the velocity of the hammer and indicates the relationship of the intensity and the velocity of the swing-strokes.The tone-volume depends on the amount of kinetic energy which the player spends in striking the key. The kinetic energy is in direct proportion to the mass set in motion and is the square of the velocity.The mass set is always constant and the energy depends only upon the velocity of the hammer. Thus it is possible to analyze the tone-volume by measuring the velocity of the hammer.Two methods of swing-strokes were set up to analyze the movement of the swing-stroke. Two experiments were performed: (a) static swing-stroke in which the height of the swingstroke was fixed and the weight was changed and (b) dynamic swing-stroke in which the weight of the swing-stroke was fixed and the height was changed.Experiments with the swing-stroke were made by a skilled pianist. The control system of the intensity of the swing-strokes is discussed.
著者
平木 潔 太田 善介 入野 昭三 三好 勇夫 瀬崎 達雄 原田 英雄 鈴木 信也 大里 尚司 永森 俤一郎 守屋 純一郎 六車 昌士 高杉 潔 駄場崎 浩 池田 一彦
出版者
Okayama Medical Association
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.77, no.5-6, pp.795-835, 1965-06-30 (Released:2009-03-30)
参考文献数
229

Morphologic characteristics of most of known oncogenic viruses, some of which were investigated by us, were described in relation to their oncogenicity and their localizations in tumor tissues.Oncogenic viruses were classified into six groups: type A, B, C, D, E and F. Viruses pertaining to type A were presumably not mature virus particles. Some of them could, however, be immature form or incomplete form of oncogenic virus particles. Viruses belonging to type B, C, D, E, and F were represented by mammary tumor virus of mice, leukemia viruses of mice and chickens, polyoma virus, Shope fibroma virus and Lucké renal adenocarcinoma virus, respectively. They were different in size and shape, and in the mode of development.It was presumed that type B and C viruses were members of the Myxovisus group and type D viruses belonged to Adenovirus and the Papova virus group. It was also believed that type E and F viruses had in general the feature of the Pox virus group and Herpes virus group, respectively.
著者
三宅 進 宮村 能子
出版者
岡山医学会
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.124, no.3, pp.239-241, 2012-12-03 (Released:2013-01-04)
参考文献数
5

We herein report a case of bilateral frontal horn cysts. The infant was delivered with a low birth weight (1,710g) at 31 weeks, 0 days by emergency Cesarean section. She was severely asphyxiated and exhibited respiratory distress syndrome. Surfactant was administered, and mechanical ventilation was required until 21 days of age. Brain computed tomography (CT) at 45 days of age revealed bilateral cysts adjacent to the frontal horns of the lateral ventricles. Her growth and development were normal. At 1 and a half- years of age, she underwent brain CT again and the above-mentioned cystic abnormality had disappeared. No dilatation or irregularity of the lateral ventricles was found. Normal development and transient abnormal cystic findings in brain CT suggested a diagnosis of frontal horn cysts. Frontal horn cysts should be considered as the causes of cystic lesions of the brain.
著者
高橋 義雄 難波 祐三郎 岸本 晃司 光嶋 勲
出版者
Okayama Medical Association
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.113, no.3, pp.279-284, 2001-12-31 (Released:2009-03-30)
参考文献数
9

GENDER IDENTITY DISORDER (GID) is a unique human condition that is classified behaviorally and treated medically with hormones and surgery in the severe form. This condition has been and still somewhat remains controversial by religious beliefs, social institutions and health care delivery systems. We described the surgical management of transsexuals, so called SEX REASSGINMENT SURGERY (SRS) and showed the team for gender treatment, GENDER CLINIC. A gender treatment team composing staff members from the Psychiatric, Plastic Surgery, Urology, Obstetric/Gynecological Surgery, and the Social Service, was established at the Hospital of Okayama University Medical schools in 1999. Female-to-Male procedures include mastectomy, phalloplasty, Phalloplasty are completion and an appurtenance, something pleasing to others. Male-to-Female program includes the genital surgery. The genital change surgery consists of the penile inversion, orchiectomy, vaginoplasty. Other procedures include reduction thyroid chondroplasty, hair transplant, voice change, laryngeal surgery, epilation with the laser.SRS is the only effective treatment available today in the management of GID. The aesthetic and functional results achievable from various procedures are generally satisfactory and are acceptable to the patients. On the other hand, we should remember that the numerous steps of information for SRS will be required.
著者
池口 豪泉
出版者
岡山医学会
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.119, no.2, pp.153-163, 2007-09-03 (Released:2008-07-04)
参考文献数
35
被引用文献数
1

The purpose of this study is to analyze the background factors relating to opinions on organ donation through factorial and structural comparisons between Japanese and Americans. The data were obtained from responses to a questionnaire (371 Japanese and 41 Americans).The main findings are as follows:1. Most of the factors, ‘a will for organ donation depending on a recipient’, ‘view of remains’, ‘understanding of brain death’ and so on showed significant differences between Japanese and Americans.2. Japanese had a better understanding of brain death. On the other hand, the ratio of Americans who were willing to donate an organ was higher than that of Japanese.3. It was revealed that “the approval of organ donation for the third person, not only for one's family” had an impact for having donor card showing the approval for organ donation. Furthermore, as underlying factors generating differences on organ transplant opinions, differences were found among Japanese between “approval of organ transplant” and the attitude assuming that oneself or a member of one's family was the person concerned with organ transplantation. There were also differences between Japanese and Americans on ideas about a view for life and death such as soul existence or view of remains.The argument for transplantation in Japan should consider these structural differences.