3 0 0 0 OA 薬物相互作用(17―脂質異常症治療薬の相互作用)
3 0 0 0 OA 死体および保存臓器におけるアルコール産生とその機序に関する研究
- 著者
- 長島 洋
- 出版者
- Okayama Medical Association
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.98, no.7-8, pp.669-685, 1986-08-30 (Released:2009-03-30)
- 参考文献数
- 28
The purpose of the present study was to investigate experimentally the formation of ethanol in corpses and stored biological samples important in medicolegal examination, and to study the mechanism of ethanol formation.In the tissues and bodily fluids of corpses, ethanol, n-propanol, iso-propanol, acetaldehyde, acetone and others may be formed to various degrees according to the post-mortem conditions. The criteria of post-mortem ethanol formation are 20°C and 24 hours of post-mortem time, and a significant amount of ethanol can be formed at higher temperatures and longer times. The presence of n-propanol in samples may be useful for ascertaining post-mortem ethanol formation. The amount of ethanol formed post-mortemly may be presumed to be under 20 times of the amount of n-propanol simultaneously detected.Post-mortem ethanol formation is not increased by ante-mortem ethanol intake. Ethanol may be produced in biological samples including cadaveric blood. Fresh aseptic blood is not conducive to ethanol formation within five days.The formation of n-propanol due to yeast in the stomach of corpses is lower than that due to bacteria in other organs and bodily fluids. The addition of antibiotics, which suppress the bacterial growth in the samples, and the addition of chemical inhibitors of ADH and ALDH contained in bacteria comletely blocked ethanol formation.It may be considered that ADH and ALDH in the bacteria in corpses produce ethanol from carbohydrates such as glucose and pyruvic acid through the reverse pathway of ethanol metabolism in living subjects.
3 0 0 0 OA 頚椎症性脊髄症の診療ガイドライン
3 0 0 0 OA 腱の癒着に関する実験的研究
- 著者
- 水野 一郎
- 出版者
- Okayama Medical Association
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.71, no.8-2, pp.5221-5229, 1959-08-15 (Released:2009-03-30)
- 参考文献数
- 16
Several experiments on the adhesion of tenden were performed with adult rabbits, and following results were obtained.1). Adhesion of tendon seen after removal of the paratenon was most intensive in two to three weeks.2). The adhesion was less in the tendon preserved paratenon, which was thought to be a factor affecting the adhesion of tendon.3). Although the adhesion was slight in the crushed tendon, for the paratenon was preserved, the fixation of two to three weeks' duration was necessary for restoration of the tendon.4). On the prevention of adhesion the effect of wrapping tendon in living fascia or polyethylene membrane was studied comparatively. The result was better in polyethylene membrane, which prevented the adhesion perfectly.5). It was undesirable to wrap tendon in polyethylene membrane immediately after suture or transplantation, because of its complete interception of cell permeation disadvantageous to repair of the tendon.6). Repair of the tendon were thought to be incompatible with prevention of adhesion. It was, therefor, reasonable to intend prevention of readhesion after separation of adhesion, and best result was obtained with polyethylene membrane.
3 0 0 0 GID(性同一性障害)学会第22回研究大会報告
- 著者
- 難波 祐三郎
- 出版者
- 岡山医学会
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.131, no.2, pp.109-110, 2019-08-01 (Released:2019-09-02)
3 0 0 0 IR 1979年岡山県下における蚊の出現状態と 日本脳炎発生状況について
- 著者
- 稲臣 成一 板野 一男 村主 節雄 頓宮 廉正 安治 敏樹 原田 正和 頼 俊雄 何 黎星 山本 友子
- 出版者
- 岡山医学会
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.93, no.1, pp.29-43, 1981-02-28
県下9ヶ所の定点において,light-trapによる蚊の終夜採集を,4月より9月迄行った。1. 本年の平均気温が平年より上回ったのは6月に入ってからで,4月の降雨量は,平年より少なく,県南では,平年の50%以下であった。6月6日梅雨入りし,7月25日に明けた。8月に台風11号,9月に台風12号,16号が岡山附近を通った。本年の平均気温が,本格的に25℃を越えたのは,7月19日~8月28日の40日間で,昨年より20日間も短くなっている。2. アカイエカの採集総数が,昨年より増えたのは,岡山(保)で1.5倍,瀬戸で1.3倍,成羽で1.6倍,津山で3.4倍であった。一方倉敷,新見では,1/2に減少している。3. コガタイエカの採集総数が,昨年より増えたのは,笠岡で3.5倍,瀬戸で2.9倍,成羽で1.3倍,新見で5倍であった。一方減ったのは,倉敷で1/1.1,岡山(保)で1/1.6に減少している。4. シナハマダラカの採集総数が昨年より減ったのは,倉敷で1/2,瀬戸で1/1.5に,減少した。また岡山(保)では,雌3羽,雄3羽と少なく,西大寺保健所では,雌1羽だけで,岡大・医学部構内では,全然採集されなかった。5. 本年は新たに,岡山市西大寺保健所が定点に加えられ,一方岡大・医学部構内でも採集を行ったが,高い塀で囲まれている関係で,採集数も少なかった。6. 本年の採集蚊数で,アカイエカ,コガタイエカ,シナハマダラカ共に,昨年より増えたのは,笠岡,成羽,津山で共に昨年より減ったのは,倉敷のみであった。瀬戸では,アカイエカ,コガタイエカの増加がみられた。7. 本年は,日本脳炎患者の発生は,疑似患者のみで真性患者の発生は見られなかった。Mosquito collections were done at nine spots in Okayama Prefecture twice a week from April till September in 1979. The day-light type light-trap was used for the mosquito collection and the trap was set all night long. 1. The mean temperature of the day became higher than the average one after June and was higher than 25℃ for 40 days from July 19 till August 28. The term was 20 days shorter than that of last year. The rainly season lasted from June 6 till July 25. Typhoon No. 11passed bv Okayama Prefecture in August and No.12 & No. 16 in September. 2. The numbers of collected Culex pipiens pallens were more than those of last year at Okayama (1.5 times). Seto (1.3 times). Nariwa (1.6 times) and Tsuyama (3.4 times) respectively. While the numbers decreased at Kurashiki and Niimi (1/2 time). 3. The numbers of collected Culex tritaeniorhynchus increased comparing to those of last year at Kasaoka (3.5 times). Seto (2.9 times), Nariwa (1.3 times) and Niimi (5 times). While they decreased at Kurashiki (1/1.1 time) and Okayama (1/1.6 time). 4. In Anopheles sinensis the collected numbers decreased comparing to those of last year at Kurashiki (1/2 time) and Seto (1/1.5 time). Only three femal and three male mosquitoes were caught at Okayama, one female at Saidaiji, and no Anopheles sinensis was caught at the compus of Okayama University Medical School. 5. The numbers of collected mosquitoes were very few at Saidaiji (where mosquito collection was started newly from 1979) and Okayama University Medical School. 6. The collected numbers in all Culex pipiens pallens. Culex tritaeniorhynchus and Anopheles sinensis increased at Kasaoka, Nariwa and Tsuyama. While the numbers in all these three species decreased at Kurashiki. At Seto the numbers of collected mosquitoes increased only in Culex pipiens pallens and Culex tritaeniorhynchus. 7. There was no human case of Japanese B encephalitis in 1979.
3 0 0 0 IR 河豚毒中毒死ニ對スル二三藥物ノ影響
- 著者
- 今橋 鐵三
- 出版者
- 岡山医学会
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.40, no.12, pp.2451-2464, 1928-12-31
Es wurde der Einfluss verschiedener Mittel auf die zum Tode führende Tetrodotoxinvergiftung bei der Maus untersucht, indem man dem Tiere diese Mittel mit der letalen Dosis von Tetrodotoxin gleichzeitig subkutan einführte. Die Versuche erstreckten sich einerseits auf die vorwiegend zentral erregenden, andrerseits auf die die peripheren motorischen Apparate erregenden Gifte und ferner auf die Substanzen mit keiner spezifischen Wirkung, wie Traubenzucker und Alkalien, welch letztere in vitro das betreffende Gift entgiften sollen. Die Ergebnisse sind, wie folgt, kurz zusammenzufassen. 1. Pikrotoxin, Physostigmin, Guanidin und Adrenalin beeinflussen nicht nur den Tetrodotoxintod antagonistisch, sondern verstärken auch die Toxizität. 2. Kaffein, Hexeton und Coramin wirken der Vergiftung entgegen, indem sie die Lebensdauer der Tiere mässig zu verlängern vermögen. Cardiazol und Traubenzucker sind auch wirksam, scheinen aber diesen genannten etwas nachzustehen. 3. Lobelin und Natriumkarbonat zeigen einen viel günstigeren Erfolg, denn sie verlängern nicht nur die Lebensdauer, sondern vermindern auch die Mortalität der vergifteten Tiere. Besonders ist Natriumkarbonat am stärksten wirksam. Daraus geht hervor, dass bei der tödlichen Vergiftung durch Fugugift die atmungserregenden Mitiel mit mehr Erfolg lebensrettend sind, als die Mittel, welche auf die peripheren motorischen Apparate erregend wirken, und dass Alkalien, die das Gift chemisch zerstören können, den besten Erfolg haben.
2 0 0 0 OA 高温湿環境下,重筋労働に関する衛生学的研究
- 著者
- 康 逸雄
- 出版者
- Okayama Medical Association
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.78, no.1, pp.159-170, 1966-01-30 (Released:2009-02-13)
- 参考文献数
- 24
In this experiment, the author investigated the changes of blood and urine of the rescue team workers engaging in heavy tasks in high thermal conditions, in addition to the reaffirmation of the previous results. Further, he encountered several cases of heat stroke occasionally. The followings were the results obtained: 1. Change of pulse pressure which the results were obtained previously was affirmed statistically by increasing the number of the cases. 2. The cases of heat stroke suggested that the threshold limit of the increase of pulse pressure seemed to exist around the rate of 150%. 3. The threshold limit of body temperature (under tongue) was around 39°C. 4. By remarkable sweating after the task, blood was concentrated, resulting the increase of specific gravity of the total blood, proteine in plasma, hematocrit value and hemoglobin content. 5. The group of heat stroke showed higher pulse pressure, higher pulse rate, higher temperature under the tongue and has a tendency of a higher rate of blood concentration. 6. Life-saving mask type 4 produced heat when soda lime absorbed CO2 expired in the circulaing air. But the influence of the high temperature and high humidity of the environment was greater than the heated air-input of the mask. 7. The limitation of the continuity of the task in such a high thermal condition seemed to be around 30 minutes. The resting time was needed at least 90 minutes for adequate recovery.
2 0 0 0 OA 失神の診断と治療
- 著者
- 西井 伸洋
- 出版者
- 岡山医学会
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.124, no.2, pp.161-163, 2012-08-01 (Released:2012-09-03)
- 参考文献数
- 10
2 0 0 0 OA 低用量経口避妊薬の使用に関するガイドライン
2 0 0 0 OA 直腸癌根治手術における膀胱ならびに性機能障害の防止に関する臨床的研究
- 著者
- 小松原 正吉
- 出版者
- Okayama Medical Association
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.90, no.1-2, pp.101-119, 1978-02-28 (Released:2009-03-30)
- 参考文献数
- 37
A pertinent procedure for preserving postoperative urinary and sexual functions was searched in the radical surgery for rectal cancer, from a neuroanatomical point of view, and the clinical status about disturbances of these functions was analized in relation with a mode of preservation of the lower hypogastric and/or the pelvic nerve among the patinet undergone the surgery applied this procedure. The result of the operation was also evaluated as for the influence of this procedure on the curability of the cancer.Results obtained were as follows:1. In the anatomical study with 17 necropsy cases, it was found that the most preferable mean for identifying the lower hypogastric nerve, pelvic plexus and pelvic nerve was to begin with isolating the upper hypogastric nerve dividing the posterior peritoneum along the lower abdominal aorta, and to follow the bilateral lower hypogastric nerves on the inner surface of the pelvic cavity down to the pelvic plexus, from which the pelvic nerves were able to explore by the retrograde approach to the sacral foramina. Since this procedure was able to be progressed in accordance with that of the radical operation by Miles, technical troubles were of eliminable.2. Urinary functions were examined on 47 cases out of 60 patients received the surgery with the nerve-saving procedure above.a) The period before the spontaneous urination occurred after the surgery was prolonged significantly by the bilateral injury to the pelvic nerve and this was not observed in the patient whose pelvic nerve was unilaterally injured, as well as in the patient whose lower hypogastric nerve was uni- or bilaterally injured.b) The result of cystometry and catheterization study showed that cystic hypotonia and urinary retention prolonged as long as 40 days or more, and 23 days in average in the patient with injury to the bilateral pelvic nerves, as compared to 8 days in average in the patient with bilateral denervation of the lower hypogastric nerve and also in the patient with unilateral injury to the pelvic nerve. Duration of sensation as to urinary retention was quite accorded with these results.3. Sexual function was surveyed making inquiries by the letter to 48 subjects and was summarized on 43 including 19 female with satisfactorily recorded answers.a) Ability of the erection was preserved in about 60 to 70% of the patient regardless of presence or absence of the denervation of the lower hypogastric nerve. However, it was impaired in all patients with bilateral injury to the pelvic nerve, although even the unilateral preservation saved the ability in all.b) Ability of the ejaculation was satisfactorily kept only in the subjects whose lower hypogastric nerve was bilaterally saved. Among those who had injury to bilateral pelvic nerve, only the patient whose lower hypogastric nerve was bilaterally saved preserved the ability, suggesting a close participation of the hypogastric nerve to the ejaculation.4. The decrease in the curability of the cancer under this procedure was not observed, compared with that in patients undergone the surgery performed without the positive intention to save the nerve but with the aim to eradicate the cancer.
2 0 0 0 OA 成人期に達したDravet症候群の長期経過に関する研究
2 0 0 0 OA 正常脳組織の加温限界の検討
- 著者
- 松海 信彦
- 出版者
- Okayama Medical Association
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.101, no.11-12, pp.1049-1061, 1989 (Released:2009-03-30)
- 参考文献数
- 44
- 被引用文献数
- 1
The thermal damage threshold of brain tissue was estimated from the immediate and delayed histological changes caused by 2450 MHz microwave antenna and an antenna cooling system of a device used for interstitial hyperthermia treatment. An antenna within a cooling system was inserted through the small cranietomy under general anesthesia. The temperature at a reference point, 4 mm radially away from the surface of the cooling system, was maintained at 42 °C, 43 °C, 44 °C, 45 °C or 46 °C for 60 minutes. In a non-survival experiment, 18 animals were used and sacrificed immediately after the treatment. In a survival experiment, 9 animals were used and sacrificed seven days after the treatment. The histological changes were evaluated by microscopic examination with hematoxylin and eosin, Klüver-Barrera, or Bodian stainings. In the non-survival experiment, areas heated below 44 °C showed no obvious irreversible change. In the survival experiment, areas heated at 44 °C or above showed coagulative necrosis. Those histological findings indicate that the thermal damage occurs in normal brain tissue after heating at 44 °C or above for 60 minutes, and suggest that the safety limit for brain hyperthermia is 43 °C for 60 minutes.
2 0 0 0 OA 薬物相互作用 (35―オピオイド鎮痛薬の薬物相互作用)
2 0 0 0 OA ソニック・ヘッジホッグ (Sonic hedgehog) を用いた新たな心筋組織の修復
- 著者
- 草野 研吾
- 出版者
- 岡山医学会
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.119, no.2, pp.137-139, 2007-09-03 (Released:2008-07-04)
- 参考文献数
- 10
2 0 0 0 OA トロンビン点滴静注による事故死の一剖検例
- 著者
- 石津 日出雄 宮石 智 山本 雄二 高田 真吾
- 出版者
- Okayama Medical Association
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.105, no.9-10, pp.839-845, 1993 (Released:2009-03-30)
- 参考文献数
- 5
A 63-year-old male died in the hospital from erroneous drip infusion of thrombin, a local hemostatic, after polypectomy for intestinal polyposis. At autopsy, thromboses were observed in the cutaneous veins of the right arm, the right axillary vein and the right subclavian vein, and soft fibrin clots in the superior vena cava, the right atrium, the right ventricle and the pulmonary arteries. Thrombi were also found in the rami of the arteries in both lungs under the microscope. Leucocyte infiltration was recognized in the thrombus, but no organization. This finding shows that the thrombi were fresh. The remainder (150ml) of the drip solution was analyzed for thrombin activity and 8 to 16 units of thrombin activity per ml were demonstrated. From these results, the cause of death was considered pulmonary thrombosis due to intravenous administration of thrombin.
2 0 0 0 OA 電子レンジによるおしぼり付着菌の殺菌効果
- 著者
- 国府島 泉 山本 洋 山本 マリリア明美 中村 知明 長町 栄子 寺坂 昌子 金政 泰弘
- 出版者
- Okayama Medical Association
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.96, no.3-4, pp.385-389, 1984-04-30 (Released:2009-03-30)
- 参考文献数
- 11
電子レンジによるおしぼり付着菌の殺菌効果について検討した.菌付着おしぼりを1本ずつ照射する実験ではE. coli, S. aureus, P. aeruginosaの細菌類は2分間程度のマイクロ波照射で殺菌された.真菌類のC. albicansも3分で殺菌された.しかしB. subtilisの芽胞は5分間のマイクロ波照射でも10%の生残が認められた.実際面を考慮しておしぼり10本程度を同時に行なう場合は,効率的にやや長時間を要するが,芽胞以外のものを対照にする限り5分照射で充分である.電子レンジによるおしぼりの殺菌は手軽に短時間にしかも効果的になされることが判明し,自家処理おしぼりの殺菌にはもちろんのこと業者処理おしぼりの追加殺菌にも有用であると考えられる.
2 0 0 0 水素水は怪しい水でしょうか?
2 0 0 0 OA 耳管閉開機序に関する考察
- 著者
- 牧山 宏志
- 出版者
- Okayama Medical Association
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.71, no.6-1, pp.3077-3084, 1959-05-01 (Released:2009-03-30)
- 参考文献数
- 18
On the basis of the findings on the relationship between tubal muscles and the Eustachian tube as described in the previous report, the actions of various tubal muscles on the Eustachian tube are discussed, and the observations carried out by the methods described below on the movements in vivo of the naso-haryngeal orifice at the time of phonation and of swallowing reveaied the following results.1. Observations were carried out with the use of a nasopharyngoscope.2. Observations were done on the patients who underwent the radical operation for the cancer of maxillar sinus. As the inferior nasal concha was already removed at the time of the operation, it was possible to insert a small nasal mirror into the posterior nasal cavity of the operated side to catch the whole view around the tubal orifice of healty side.3. For the children over 5-6 years old with cleft palate, observations were carried out directly on the pharyngeal orifice through the mouth cavity (motion pictures were taken in this instance).At a result it has been found that the nasopharyngeal orifice of the tube is widened because the posterior lip and the mucous membrane of the base of the Eustachian tube move slightly outward at the time of swallowing. In anatomically summarizing these observations the author arrived at the following conclusions.At the time of swallowing the tensor muscle of the palate dilates the Eustachian tube at the points near the middle part and the anterior part of the tube. The levator palatini muscle assists the opening action of the tensor muscle by fixing or by drawing the base of the tube slightly toward the inferior-interior side. The salpingopharyngeus muscle or the salpingopharyngeal fold, being drawn inward by the cephalopharyngeal muscle and pahryngopalatine muscle and widening the nasopharygeal orified, assists the dilatating action of the tensor muscles.When the muscles are relaxed, the Eustachian tube is closed probably by the elasticity of the lateral cartilaginous lamina and by the pressure of the tissues surrounding the tube.