著者
池田 苗夫
出版者
社団法人 日本感染症学会
雑誌
日本傳染病學會雜誌 (ISSN:00214817)
巻号頁・発行日
vol.42, no.5, pp.125-130, 1968-08-20 (Released:2011-11-25)

As mentioned in previous reports, it was clear that the epidemic hemorrhagic fever (EHG) could be induced to quite healthy persons by inoculation of the blood specimens collected from the patients with genuine EHF. Therefore, the agents of EHF were certainly considered to exist in the blood of patients in acute stage of EHF.Dr. Masaji KITANO found a specific species of tick, ‘Togedani’, attaching to rat and playing an important role as a carrier of the disease, and so he insisted that the togedani inhabiting the areas where, EHF was prevelent, might be a natural possessor of the agents. In addition, it was supposed that in such circumstances, other insects such as vermin, fleas, bed-bugs, flies, or mosquitoes might be also reservor of the agents at least transiently. However, because no soarlling blood-sucking insects could remain being active in serious cold of winter in the noreheastern part of China where EHF had been prevalent still in this season, these kinds of insects could be excluded from the object of investigation. The author examined the infectivity of fleas and lice isolated from patients, and acquisition of infectivity on the artificially incubated unstained louse line by stinging the patients with EHF. Thus, it was confirmed that the healthy persons would develop the disease by stinging of poisoning louse.It is not clear whether lice in the epidemic area naturally possess the agents of EHF, but it is doubtless that the poisoning lice which have sucked the blood from a healthy person, may cause him an infection of EHF. Therefore, it is concluded that a louse must be looked upon as a carrier of EHF.On the other hand, as to the flea, the author failed to confirm whether flea had infectivity of EHF to man, in consequence of several biological experiments.
著者
池田 苗夫
出版者
社団法人 日本感染症学会
雑誌
日本傳染病學會雜誌 (ISSN:00214817)
巻号頁・発行日
vol.42, no.4, pp.75-77, 1968-07-20 (Released:2011-11-25)

Several serlogical experiments were carried out to establish a serum reaction specific to epidemic hemorrhagic fever in man.The results were as follows:1. Unchanging low precipitating antibody titers in patient sera against supernatant fluid of emulsion of liver released from deceased patient by autopsy, suggested that the reactiossn failed to be a useful method for the diagnosis.2. The Weil-Felix antibodies in sera from patients in pyrexial stage, to the Proteus vulgaris OX-19, OX-2, and OX-K strains, were also so low that the Weil-Felix reaction was not specific for the disease.3. Finally, a skin test with antigenic materials prepared by filtrating the liver emulsion in physiological saline solution (as well Ringer's solution or Tyrode's solution) with Chamberland filter, was performed and it was demonstrated that this reaction was useful to differentiate the patients from the controls with other diseases after 24 hours and therefore available for the diagnostic purposes.
著者
池田 苗夫
出版者
社団法人 日本感染症学会
雑誌
日本傳染病學會雜誌 (ISSN:00214817)
巻号頁・発行日
vol.41, no.9, pp.337-346, 1967-12-20 (Released:2011-11-25)
参考文献数
5

Tamura reported that there has fairly long been existing epidemic haemorrhagic fever (EHF) in Osaka City in the form of an endemic and there is likely to be a great possibility of its spreading to other parts of this country. This motivated the author to make public his experience with this disease in northern and eastern Manchuria at the time when he was a member of the special medical team of the then Japanese Imperial Army.Since 1938, Japanese army had begun stricken by a hitherto unknow disease in northern and eastern Manchuria. At an outbreak in Songo and Sanchinfu, northern Manchuria, in winter of 1941, the number of patients including soldiers and villagers counted as many as 500. Mortality rate of this epidemic was. aboto. the recuthout 15%. Later, in 1942, the special medical team, before mentioned, was set up and dispatched epidemic areas. The discovery of EHF was thus brought about by them in that year. The firstognition of its viral and infectious nature was made through an experiment carried out by the ar
著者
三輪 清三 上野 高次 桜井 稔 小林 章男 鈴木 重一
出版者
社団法人 日本感染症学会
雑誌
日本傳染病學會雜誌 (ISSN:00214817)
巻号頁・発行日
vol.38, no.1, pp.10-20, 1964-04-20 (Released:2011-11-25)
参考文献数
32

Tularemia in Izu Peninsula in Shizuoka Prefecture was investigated epidemiologically and1. All the tularemia cases collected by us occurred locally in the southern parts of Izu Peninsula; 25 cases in Minamiizumachi of them 20 cases infected each by separate hares, 7 cases in Shimoda-machi 6 infected each by separate hares, and 1 case in Matsuzaki machi.2. Among these cases, the first case occurred in 1932 and the majority of cases occurred in 1949. Thereafter occurrences of a few cases continued to 1962.3. Most cases occurred from December to March.4. Almost all the cases were infected from skinning and processing the meat of hares found dead or weak.5. The rate of inapparent infection of hunters group in each region in Izu area was as follows; South coast of the Peninsula 20.2%, Central part 19.4%, West coast 9.7%, and North part 8.3%, paralleing the number of the tularemia cases in each region of Izu Peninsula.6. In retrospect, agglutination test that is positive above 1: 32 was advisable for the diagnosis.7. Characteristics of the prevalence of tularemia in Japan was discussed.
著者
落合 国太郎 上床 博 内藤 晶之助 川端 純一 川辺 亘
出版者
The Japanese Association for Infectious Diseases
雑誌
日本傳染病學會雜誌 (ISSN:00214817)
巻号頁・発行日
vol.32, no.10, pp.721-729, 1959

A mass incidence of bacillary dysentery broke out in March, 1957 among 728 students and 29 teachers on an educational trip to Shikoku and Chugoku districts. Afterreturning to Nagoya, the feces of not only the students who travelled but also those who did not travel and their family members were examined for dysentery bacilli.<BR>Of 54 positive cases 28 were diagnosed as bacillary dyentery and 26 as bacillary carriers. The isolated strains were serologically classified into Sh. flexneri 2a, 3a, 4a, var. Y and Sh. sonnei, the most numerous being Sh. flexneri 2a, i. e. 45 strains.<BR>Fourty nine strains were examined for resistance against various antibiotics and sulfonamides. Out of 40 2a strains isolated from those travelling and regarded as causative agent of the mass incidence, 32 demonstrated 250 γ/cc resistance against oxytetracycline (Terramycin), 100 γ/cc against tetracycline, 50 γ/cc to aureomycin, 0.5 γ/cc against chloromycetin, 10 γ/cc to streptomycin and 100 mg/dl against sulfathiazol.<BR>The clinical symptoms disappeared rapidly by the application of antibiotics, particularly chloromycetin. Out of 12 cases treated with terramycin, 11 reexcreted the bacilli in their feces after the medication, and out of 38 cases including carriers the reexcretion was detected after having left the hospital. The source of infection could not be discoverd.
著者
池田 苗夫
出版者
社団法人 日本感染症学会
雑誌
日本傳染病學會雜誌 (ISSN:00214817)
巻号頁・発行日
vol.42, no.6, pp.157-160, 1968-09-20 (Released:2011-11-25)
参考文献数
6

The author described some results of ecological studies on body lice, which he hadartificially bred and incubated. Namely, he observed their life cycle and several important habits, established unstained louse strains, and using them, determined the optimum coditions, especially temperature of incubation or blood-stinging intervals, to breed and maintain them.
著者
高橋 良二
出版者
The Japanese Association for Infectious Diseases
雑誌
日本傳染病學會雜誌 (ISSN:00214817)
巻号頁・発行日
vol.39, no.8, pp.298-303, 1965

It has been pointed out by Dr. Abe that the rate of isolation of sh. Sonnei from the dysentery patients had increased, as did the multi-drug resistant strains. The majority of sh. strains isolated from the inpatients was found to be drug-resistant.<BR>In this time, it was demonstrated that a new chemotherapeutic agent, Chlor-Acetoxylin-Qinidin. (CAQ), had strong antibacterial activity against sh. flexneri and vibrio parahamolyticus, but moderate activity to sh. sonnei.<BR>CAQ concentration in the blood following the oral administration of this medicine was sometimes. very low, wheras the concentration in the intestinal fluid was very high. This phenomenon is intergreted by malabsorption of CAQ from the intertine In such a case, the study showed that the medicine was found in the rectum within very short time following the administration of this medicine, due to frequent peristalsis of the intertioe. On the treatment of dysentery good clinical effects were obtained, woan the causative bacteria was sh. flexnari, but only fair clinical effects against sh. sonnei because of less sensitive bacteria to CAQ than the former. Furthermore it shout be emphasixzd that CAQ was very effective to the so-called drug-resistant straics without any side effects. Thorefore it might be conluded that CAQ is a valuable drug on cliniaal and prophylactic use prophylactic use for dysemery.