著者

山本 直樹 茶谷 絵理

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.4, pp.236-239, 2021 (Released:2021-07-30)

参考文献数

13

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Understanding the mechanism of the amyloid fibril formation is crucial for the development of therapeutic methods of amyloidoses and neurodegenerative diseases. We focused on the role of prefibrillar intermediates that accumulate prior to the fibril formation by using a model peptide derived from insulin. Using circular dichroism spectroscopy, nuclear magnetic resonance, dynamic light scattering, and small-angle X-ray scattering, we found that the fibril formation occurred via specific prefibrillar intermediates. We also found that a plasma protein, fibrinogen, prohibited the fibril formation. It was suggested that the inhibition was exhibited by the specific and strong interaction of fibrinogen with the surface of the prefibrillar intermediates.

著者

下村 拓史 入江 克雅

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.4, pp.223-226, 2021 (Released:2021-07-30)

参考文献数

10

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Voltage-dependent Ca2+ channels (Cavs) are indispensable for coupling action potentials with Ca2+ signaling. We report the first identification of a native prokaryotic Cav, CavMr, whose selectivity filter contains a smaller number of negatively charged residues than that of artificial prokaryotic Cavs. A relative mutant whose selectivity filter was replaced with that of CavMr exhibits high Ca2+ selectivity. The glycine residue of the CavMr selectivity filter is a determinant for Ca2+ selectivity. This glycine residue is well conserved among subdomains I and III of eukaryotic Cavs, which provide new insight into Ca2+ selectivity mechanism conserved from prokaryotes to eukaryotes.

著者

秦野 節司

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.13, no.3, pp.119-130, 1973-05-25 (Released:2009-05-25)

参考文献数

59

著者

Ueda Keisuke Kimura-Sakiyama Chieko Miki Masao Arata Toshiaki

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.48, 2008

著者

舘野 高

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.58, no.3, pp.139-143, 2018 (Released:2018-05-31)

参考文献数

19

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In this review, the recent advances in neural control engineering are described in terms of three hierarchical levels. In the lowest level, the microelectrode recording and electromagnetic stimulation technique are particularly addressed. In the middle level, two types of neural stimulation and their evoked responses in the rodent auditory cortex are explained on our experimental results using flavoprotein autofluorescence imaging. In the highest level, finally, one of our computational models for the auditory cortex is introduced to simulate auditory induction phenomenon and the associated sound-driven responses.

著者

庄村 康人 樋口 芳樹

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.53, no.2, pp.082-085, 2013 (Released:2013-03-28)

参考文献数

14

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Hydrogenases play crucial roles in the hydrogen metabolism by catalyzing the production and decomposition of H2. The membrane-bound [NiFe]-hydrogenase is a representative member of O2-tolerant hydrogenases, but the mechanism of which is poorly understood. Recently, we and other groups have reported the crystal structures of membrane-bound [NiFe]-hydrogenases, which revealed an unprecedented structure of one of three iron-sulfur clusters in the enzyme. Together with the spectroscopic study that shows the unique iron-sulfur cluster takes three oxidation states under physiological redox potentials, we concluded that the iron-sulfur cluster plays a key role in the O2-tolerant mechanism of the membrane-bound [NiFe]-hydrogenase.

著者

高田 彰二

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.3, pp.144-151, 2021 (Released:2021-05-28)

参考文献数

27

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Towards cellular-scale structural modeling, multiscale biomolecular simulation is gaining much attention. Here, I review methodological aspects of coarse-grained (CG) biomolecular simulations. I begin with conceptual argument of coarse graining for proteins where the idea behind Gō models is discussed. Then, statistical physics and theories of coarse graining are described. I then exemplify a class of CG models for proteins, nucleic acids, and lipids, where about 10 non-hydrogen atoms are grouped into one CG particles. Finally, I discuss three sources of speeding up by coarse graining.

著者

竹谷 浩介 高橋 正行 加藤 剛志 矢沢 道生

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.44, 2004

著者

箕浦 逸史 武藤 悦子

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.52, no.1, pp.010-013, 2012 (Released:2012-01-31)

参考文献数

9

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To understand the mechanism underlying the one-dimensional (1D) Brownian motion of proteins, we analyzed the behaviors of counterions along microtubules using the electroorientation method and compared these with the 1D Brownian motion of charged nanoparticles. Both results demonstrated that during 1D Brownian motion, each positively charged nanoparticle behaves as a polycation constrained within the electrostatic field around the microtubules. Owing to the polyelectrolytic nature of microtubules, nanoparticles can move along microtubules with a diffusion constant independent of the charge density of the microtubules. The study highlights the possibility that 1D Brownian motion of proteins is based on a similar, nonspecific charge-dependent mechanism.

著者

中村 秀樹

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.3, pp.166-170, 2021 (Released:2021-05-28)

参考文献数

20

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In a previous report, the author developed a synthetic biology molecular tool, iPOLYMER, which produces hydrogel condensates consisting of two polypeptide chains in living cells, in a stimulus-dependent manner. Functionalizing the iPOLYMER polypeptides with an RNA-binding domain successfully reconstituted a typical example of biomolecular condensates, stress granules, in living cells under a stress-free condition. In the current review, achievements made possible by iPOLYMER are summarized, with reference to a brief history of biomolecular condensate research. Future prospects, as well as technical challenges, of synthetic biological approaches to the novel class of intracellular structures are also described.

著者

伴野 詢太

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.3, pp.201-202, 2021 (Released:2021-05-28)

著者

飛田 武幸

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.21, no.3, pp.135-144, 1981-05-25 (Released:2009-05-25)

参考文献数

7

著者

三村 昌泰

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.18, no.3, pp.130-136, 1978-05-25 (Released:2009-05-25)

参考文献数

8

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It has been observed that plankton displays spatial heterogeneity (patchiness) even though its environment appears homogeneous. As a model mechanism to explain this phenomenon, an interaction model is proposed which is in a prey-predator relationship. The model considered here is a generalized Lotka-Volterra system with diffusion. The results show that perturbations caused by fluctuations give rise to patchiness after long time: it depends on certain biological factors.A mathematical tool is the theory of bifurcation for partial differential equations.

著者

植木 紘史 河岡 義裕

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.2, pp.090-094, 2021 (Released:2021-03-25)

参考文献数

18

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Influenza virus is a respiratory pathogen that causes pandemics and seasonal epidemics. The pathophysiological changes and in vivo dynamics of immune cells in influenza virus-infected lungs are poorly understood. Here, we established an in vivo imaging system that combines two-photon excitation microscopy and fluorescent influenza viruses of different pathogenicity. This approach allowed us to monitor and correlate several parameters and pathophysiological changes in the lungs of live mice. Our findings demonstrate the potential of this in vivo imaging system, which we termed two-photon IMPRESS (IMaging Pathophysiology RESearch System), to provide novel information about the pathophysiological consequences of influenza virus infection.

著者

教誓 祐太 伊藤 悦朗

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.2, pp.107-109, 2021 (Released:2021-03-25)

参考文献数

9

著者

稲葉 謙次

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.2, pp.121-123, 2021 (Released:2021-03-25)

著者

岡田 康志

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.60, no.3, pp.188-189, 2020

著者

郷 通子

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.60, no.2, pp.125-126, 2020

被引用文献数

1

著者

竹田 哲也

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.56, no.1, pp.013-017, 2016 (Released:2016-01-27)

参考文献数

15

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Cytokinesis is the final step in cell division essential for cell proliferation, tissue differentiation and animal reproduction. Cytokinesis is featured by its dramatic changes in cell shape by which a cell divides into two nascent cells with equal genomic background. The cell morphogenesis during cytokinesis is mainly driven by extensive reorganization of cytoskeleton. However, recent studies demonstrated that various membrane dynamics such as membrane trafficking and membrane remodeling also play essential roles during cytokinesis. In this review, I will overview function and regulation of the membrane dynamics during cytokinesis and discuss about its future perspectives.

著者

前仲 勝実 福原 秀雄 橋口 隆生 CAAVEIRO Jose M. M. 長門石 曉 黒田 大祐 津本 浩平

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.2, pp.082-089, 2021 (Released:2021-03-25)

参考文献数

29

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Recent virological researches using biophysical methods, termed as virus biophysics or virophysics, largely contribute to the development of anti-viral drugs and vaccines. In this review, examples of structural and physicochemical analyses for representative viruses to develop drug modalities such as small compounds, antibodies, and vaccines are explained, and future direction of biophysical research for virus research is also discussed.