著者

龍野 正実

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.47, no.6, pp.368-377, 2007 (Released:2007-11-30)

参考文献数

50

被引用文献数

1 1

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The replay of behaviorally induced multi-neuronal activity patterns during subsequent sleep or quiet waking is conjectured to play an important role in the consolidation process of certain types of memory. During the early stages of memory consolidation, the hippocampus appears to be critical; however, over time the involvement of the hippocampus decreases as the memories become gradually consolidated in the neocortex. In this article, we review how temporal spike patterns are replayed during sleep and the possible interactions of the hippocampus and neocortex through these patterns.

著者

東條 正 青木 大輔 木脇 圭一 イスカンダル シルヴィア 多田隈 尚史 石渡 信一 船津 高志

出版者

一般社団法人日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.42, no.2, 2002-10-10

著者

田中 正太郎 小橋川 敬博 三浦 和紀 西宮 佳志 三浦 愛 津田 栄

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.43, no.3, pp.130-135, 2003 (Released:2003-05-23)

被引用文献数

3 1

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In 1969, the first antifreeze protein (AFP) was discovered from the blood plasma of Antarctic Nototheniids. In the past thirty years, different types of AFP have been found in many life forms that exhibit freezing tolerance, such as bacteria, fungi, plants, insects, and vertebrates. These discoveries have evoked us many questions regarding to the antifreeze mechanism and its biological significance for preventing their tissues from freezing damage. At present, ice physicist, biologist, chemist, biochemist, molecular biologist, physiologist, and NMR and X-ray structural biologists are subjecting AFP, which greatly improves our understandings about AFP and accelerates its applicability to various cryo-industries. In the present review we will describe an updated biophysical aspects of AFP to highlight the interests of this research field.

著者

大西 武雄

出版者

The Biophysical Society of Japan General Incorporated Association

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.26, no.1, pp.11-19, 1986

被引用文献数

3

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Most of the investigations of ultraviolet(UV)-radiation effects on organisms have been made with 254nm from a germicidal lamp. The specific DNA lesion, pyrimidine dimers, caused by UV irradiation have been shown to be toxic, mutagenic and carcinogenic. In contrast, knowledge of the biological effects of far UV(UV-C) radiation may not be relevant to the carcinogenic, mutagenic and lethal effects of UV in sunlight. Recently, since it has been indicated that the DNA lesions caused by mid-UV(280-320nm, UV-B) and nearUV(320-400nm, UV-A) is harmful to a wide variety of organisms, the studies of mid-UV and near-UV effects are considered to be important. The possible DNA damages caused by mid-UV and near-UV are summarized in the present review. In mid-UV range, both the pyrimidine dimers and other photoproducts such as 5-hydroxy-methyl cytosine may be responsible for the observed biological effects and they are repairable by excision repair systems or T4 endonuclease. Several DNA damages of near-UV are indicated to be DNA strand breaks dependent on pol<SUP>+</SUP> and nur<SUP>+</SUP> repair systems, DNA-protein cross-links and a small amount of pyrimidine dimers which are responsible to repair deficint mutants including human patients. In addition, other kinds of photodamages in tRNA carrying cytidine 13 and thiouridine 8 link than DNA damage are indicated to also interact to repair processes.

著者

河野 敬一 相沢 智康

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.39, no.2, pp.109-112, 1999-03-25 (Released:2000-04-12)

参考文献数

8

著者

岡田 公太郎 神崎 亮平

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.43, no.2, pp.101-104, 2003 (Released:2003-03-25)

著者

山田 聡一郎 Scot C. Kuo

出版者

一般社団法人日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.43, no.4, pp.180-185, 2003-07-25

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生細胞の細胞質は細胞の形とその運動性を司っている細胞骨格繊維のネットワークで満たされている.細胞骨格ネットワークのダイナミクスと不均一性は最近可視化されているが,生細胞の細胞質への接近の難しさからその物理的な性質の測定には難しい点がある,そこで,小粒子のブラウン運動の観察からその周囲の力学的環境を調べることができるという簡単な観察をもとに,マイクロレオロジーという新規の方法が考案され,生細胞への応用にも成功している.本稿では,このマイクロレオロジー法の最近の進歩を紹介し,この方法が生物学における細胞より下のレベルでの諸過程の理解にどのように役立つかについて述べる.

著者

立花 政夫

出版者

一般社団法人日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.47, no.6, pp.355-361, 2007-11-25

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Oscillatory synchronized activities are generated among visual neurons in a manner that depends on certain key features of light stimulation. Although these activities are assumed to play an important role in perceptual integration, their functional significance has yet to be elucidated. We performed behavioral tests and multi-electrode recordings from retinas isolated from the frog. Pharmacological manipulation of the oscillatory synchronized activities in a class of retinal ganglion cells (dimming detectors) induced correlated changes in escape behavior. The retinal oscillatory synchronized activities are likely to encode escape-related information in frogs.

著者

中野 修一 杉本 直己

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.46, no.5, pp.251-256, 2006 (Released:2006-09-25)

参考文献数

29

被引用文献数

1

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The medium of biomolecules in a living cell differs remarkably from a dilute solution, and many properties of biomolecules that are not observed in vitro are emerged as a result of such intracellular environments. Molecular crowding which is one of the important intracellular environments changes equilibria and rates of biomolecular interactions. Studies with solutions containing high concentration of water-soluble inert cosolutes reveal influences of the molecular crowding on the structures and interactions of proteins and nucleic acids, providing significant insights not only into traditional biology but also bionanotechnology.

著者

林 重彦

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.46, no.2, pp.76-81, 2006 (Released:2006-03-25)

参考文献数

15

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Chemical reactions play important roles in biological functions. In order to elucidate molecular mechanism of the chemical reactions in biosystems, so-called hybrid quantum mechanical/molecular mechanical (QM/MM) methods have been developed and applied to many biochemical reactions recently. The methods permit one to calculate electronic states of reaction substrate molecules in protein binding pockets by taking into account molecular interactions with the surrounding protein environment. In this review, we survey our QM/MM studies for chemical reactions in rhodopsin photoreceptor proteins and F1-ATP synthase along with a brief introduction of the methodology.

著者

奥田 隆 渡邊 匡彦 黄川田 隆洋

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.44, no.4, pp.172-175, 2004 (Released:2004-07-22)

被引用文献数

1 1

著者

青野 真士 原 正彦

出版者

一般社団法人日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.44, no.1, 2004-11-10

著者

右田 たい子 吉田 匡

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.44, no.2, pp.81-86, 2004 (Released:2004-03-23)

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Plant heme oxygenase (HO), which catalyzes conversion of heme to biliverdin, being further converted to photo-receptive phycobilins, had been known only in the cell extracts of primitive red algae and cyanobacteria for these twenty years. Recent development of gene analysis, however, has shown that HO is ubiquitously contained in variety of living species. We have succeeded for the first time in obtaining recombinant HO protein of cyanobacteria and in characterizing the HO protein and its heme complex by spectroscopic analyses. Here, we review the existence, role, and characteristics of cyanobacterial and plant HOs in comparison with those of mammalian and bacterial HOs.

著者

川端 猛 西川 建

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.40, no.1, pp.52-56, 2000-01-25 (Released:2000-04-12)

参考文献数

7

被引用文献数

1 1 1