著者
荒谷 剛史
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.59, no.3, pp.169-170, 2019 (Released:2019-05-25)
被引用文献数
1
著者
篠原 康雄 寺田 弘
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.28, no.3, pp.131-134, 1988-05-25 (Released:2009-05-25)
参考文献数
19

This paper deals with why the Pβ0-Pγ bond is cleaved specifically in the enzymic hydrolysis of ATP mediated by Mg2+. Mg2+ coordinates with the β-and γ-phosphoryl groups in such a way that it binds more strongly to the former. This asymmetric coordination weakens the bond where specific cleavage takes place in the enzyme catalyzed hydrolysis.
著者
木下 正弘 原野 雄一
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.46, no.4, pp.214-219, 2006 (Released:2006-07-25)
参考文献数
19
被引用文献数
2 1

In the biological system, various processes of the self-assembly and formation of ordered structure (e.g., protein folding, molecular recognition, association of protein molecules, and protein-membrane association) occur to sustain life. By referring to our results of analyses using statistical-mechanical theories, we argue that the entropic gain originating from the translational movement of water molecules play crucially important roles in these processes.
著者
土井 光暢 石田 寿昌
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.30, no.3, pp.120-126, 1990-05-25 (Released:2010-01-07)
参考文献数
20

Enkephalin is a morphine-like pentapeptide: Tyr-Gly-Gly-Phe-Xxx, Xxx=Met or Leu. To consider the relationship between the enkephalin conformation and the opioid receptor, the crystal structures of enkephalin analogues were analyzed by the X-ray diffraction method, and two characteristic forms were observed as the fundamental conformation of enkephalin, One is the β-turn structllre and the other the antiparallelly extended dimer (ED) structure. From the NMR and CD spectral studies, it was suggested that the β-turn and ED structures of enkephalin are the most probable conformations for the binding to μ-and δ-receptors, respectively. Further, the molecular-dynamics simulations indicated that these conformation are both advantageous in energetical term. Based on the insight of the enkephalin conformation, it was attempted to convert the μ-selective morphine toward δ-affinitive ligand by the dimerization.
著者
下澤 東吾 小比類巻 生 大山 廣太郎 照井 貴子 福田 紀男
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.59, no.1, pp.009-013, 2019 (Released:2019-01-26)
参考文献数
20

In vivo nano-imaging is today’s key technology for understanding cellular and molecular functions on a real-time basis in living organisms. In mammals, including humans, the heart sends blood to the lungs and to the rest of the body each time it beats, only under the in vivo conditions. However, to date, sarcomeric contractions, which are the basis of myocardial dynamic behavior, have not been directly observed in vivo due to technical hurdles. In this article, we describe our newly developed in vivo cardiac nano-imaging microscope for mice, and discuss recent, novel findings obtained under true physiologic conditions by using this cutting-edge technology.

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出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.54, no.1, pp.057-058, 2014 (Released:2014-01-29)
被引用文献数
1