文献一覧: SCIENTIFIC REPORTS (雑誌)

2 0 0 0 OA Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes

著者: Mashimo Tomoji Kaneko Takehito Sakuma Tetsushi Kobayashi Junya Kunihiro Yayoi Voigt Birger Yamamoto Takashi Serikawa Tadao
出版者: Nature Publishing Group
雑誌: Scientific Reports
巻号頁・発行日: vol.3, 2013-02-13
被引用文献数: 71

TALエフェクターヌクレアーゼ(TALEN)を用いた効率的な遺伝子改変ラットの作製技術. 京都大学プレスリリース. 2013-02-13.

2015-03-13 01:07:47
1 CiteULike
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2 0 0 0 OA Prenatal regression of the trophotaenial placenta in a viviparous fish, Xenotoca eiseni.

著者: Iida Atsuo Nishimaki Toshiyuki Sehara-Fujisawa Atsuko
出版者: Nature Publishing Group
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.5, 2015-01-19
被引用文献数: 16

魚類が「胎生」になるために獲得した仕組みの一端を解明京都大学プレスリリース. 2015-01-20.

2015-01-21 15:28:42
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2 0 0 0 OA Mothers' multimodal information processing is modulated by multimodal interactions with their infants.

著者: Tanaka Yukari Fukushima Hirokata Okanoya Kazuo Myowa-Yamakoshi Masako
出版者: Nature Publishing Group
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.4, 2014-10-17
被引用文献数: 4

「子どもが育つ、親も育つ」-養育経験が脳の働きに与える影響-. 京都大学プレスリリース. 2014-10-20.

2014-11-01 18:33:46
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2 0 0 0 OA Alloparenting for chimpanzee twins.

著者: Kishimoto Takeshi Ando Juko Tatara Seiki Yamada Nobuhiro Konishi Katsuya Kimura Natsuko Fukumori Akira Tomonaga Masaki
出版者: Nature Publishing Group
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.4, 2014-09-09
被引用文献数: 7

2歳のふたごチンパンジーに対して、母親以外のおとなも世話行動. 京都大学プレスリリース. 2014-09-12.

2014-09-16 14:25:48
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2 0 0 0 OA A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

著者: Nakagawa Masato Taniguchi Yukimasa Senda Sho Takizawa Nanako Ichisaka Tomoko Asano Kanako Morizane Asuka Doi Daisuke Takahashi Jun Nishizawa Masatoshi Yoshida Yoshinori Toyoda Taro Osafune Kenji Sekiguchi Kiyotoshi Yamanaka Shinya
出版者: Nature Publishing Group
雑誌: Scientific Reports (ISSN:20452322)
巻号頁・発行日: vol.4, 2014-01-08
被引用文献数: 487

細胞移植に適した新しいヒトiPS細胞の樹立・維持培養法を確立. 京都大学プレスリリース. 2014-01-08.

2014-01-15 12:00:14
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2 0 0 0 OA APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells

著者: Shinohara Masanobu Io Katsuhiro Shindo Keisuke Matsui Masashi Sakamoto Takashi Tada Kohei Kobayashi Masayuki Kadowaki Norimitsu Takaori-Kondo Akifumi
出版者: Nature Publishing Group
雑誌: Scientific Reports (ISSN:20452322)
巻号頁・発行日: vol.2, 2012-11-13
被引用文献数: 86

新規発癌遺伝子アポベック3による新たな発癌機構. 京都大学プレスリリース. 2012-11-14.

2013-05-14 08:41:20
1 CiteULike
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1 0 0 0 IR Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation

著者: 松本忠彦白川康太郎横山勝福田寛文サルカアナマリアダニエラ小藪助直山崎寛章数馬安浩松井宏行丸山亙永田佳代子田邊史子小林正行新堂啓祐森下了佐藤裕徳髙折晃史
出版者: Springer Science and Business Media LLC
雑誌: Scientific Reports (ISSN:20452322)
巻号頁・発行日: no.9, 2019-06-05

がんに遺伝子変異を導入する酵素の分子スイッチを発見 --リン酸化によるDNAシトシン脱アミノ化酵素の活性制御機構--. 京都大学プレスリリース. 2019-06-07.

2021-11-13 14:44:27
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https://ci.nii.ac.jp/naid/120006644044

1 0 0 0 OA Lazy workers are necessary for long-term sustainability in insect societies

著者: Hasegawa Eisuke Ishii Yasunori Tada Koichiro Kobayashi Kazuya Yoshimura Jin
出版者: Nature Publishing Group
雑誌: Scientific Reports (ISSN:20452322)
巻号頁・発行日: vol.6, pp.20846, 2016
被引用文献数: 41

Optimality theory predicts the maximization of productivity in social insect colonies, but many inactive workers are found in ant colonies. Indeed, the low short-term productivity of ant colonies is often the consequence of high variation among workers in the threshold to respond to task-related stimuli. Why is such an inefficient strategy among colonies maintained by natural selection? Here, we show that inactive workers are necessary for the long-term sustainability of a colony. Our simulation shows that colonies with variable thresholds persist longer than those with invariable thresholds because inactive workers perform the critical function of replacing active workers when they become fatigued. Evidence of the replacement of active workers by inactive workers has been found in ant colonies. Thus, the presence of inactive workers increases the long-term persistence of the colony at the expense of decreasing short-term productivity. Inactive workers may represent a bet-hedging strategy in response to environmental stochasticity.

2021-06-30 11:23:09
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1 0 0 0 IR Positron Annihilation Studies on Chemically Synthesized FeCo Alloy

著者: Rajesh P. Sellaiyan S. Uedono A. Arun T. Joseyphus R. Justin セライヤンセルバクマー上殿明良
出版者: Nature Publishing Group
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: no.8, 2018-06

Equiatomic flower-like FeCo magnetic nanoparticles are synthesized through a modified one-pot polyol technique. The as-prepared samples are annealed at 700 and 800 °C under reducing atmosphere. The saturation magnetization and coercivity of the flower-like FeCo are found to be 198 (1) emu/g and 243 (10) Oe respectively. The magnetic properties of FeCo approach the bulk behavior with annealing. Positron lifetime studies on the chemically synthesized equiatomic FeCo magnetic nanoparticles with flower-like morphology are reported and compared with Fe, Co and FeCo annealed at various temperatures. The FeCo is characterized by different lifetime components corresponding to positron annihilation events in vacancies and various open volume defects due to their unique morphology. The studies suggest defects arising out of cluster vacancies and interpetal gap that reduce on annealing. The average pore size obtained from positron annihilation studies closely matches with the interpetal distance obtained from the electron microscopic analysis for the flower-like FeCo.

2020-11-09 16:15:06
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https://ci.nii.ac.jp/naid/120006496522

1 0 0 0 Discovery of a new mode of oviparous reproduction in sharks and its evolutionary implications

著者: Nakaya Kazuhiro White William T. Ho Hsuan-Ching
出版者: Nature Publishing Group
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.10, pp.12280, 2020-07-23
被引用文献数: 11

Two modes of oviparity are known in cartilaginous fishes, (1) single oviparity where one egg case is retained in an oviduct for a short period and then deposited, quickly followed by another egg case, and (2) multiple oviparity where multiple egg cases are retained in an oviduct for a substantial period and deposited later when the embryo has developed to a large size in each case. Sarawak swellshark Cephaloscyllium sarawakensis of the family Scyliorhinidae from the South China Sea performs a new mode of oviparity, which is named "sustained single oviparity", characterized by a lengthy retention of a single egg case in an oviduct until the embryo attains a sizable length. The resulting fecundity of the Sarawak swellshark within a season is quite low, but this disadvantage is balanced by smaller body, larger neonates and quicker maturation. The Sarawak swellshark is further uniquely characterized by having glassy transparent egg cases, and this is correlated with a vivid polka-dot pattern of the embryos. Five modes of lecithotrophic (yolk-dependent) reproduction, i.e. short single oviparity, sustained single oviparity, multiple oviparity, yolk-sac viviparity of single pregnancy and yolk-sac viviparity of multiple pregnancy were discussed from an evolutionary point of view.

2020-10-19 10:05:20
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1 0 0 0 OA Individual Apostichopus japonicus fecal microbiome reveals a link with polyhydroxybutyrate producers in host growth gaps

著者: Yamazaki Yohei Meirelles Pedro Milet Mino Sayaka Suda Wataru Oshima Kenshiro Hattori Masahira Thompson Fabiano L. Sakai Yuichi Sawabe Toko Sawabe Tomoo
出版者: Nature Publishing Group
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.6, 2016-02-25
被引用文献数: 75

Gut microbiome shapes various aspects of a host's physiology, but these functions in aquatic animal hosts have yet to be fully investigated. The sea cucumber Apostichopus japonicus Selenka is one such example. The large growth gap in their body size has delayed the development of intensive aquaculture, nevertheless the species is in urgent need of conservation. To understand possible contributions of the gut microbiome to its host's growth, individual fecal microbiome comparisons were performed. High-throughput 16S rRNA sequencing revealed significantly different microbiota in larger and smaller individuals; Rhodobacterales in particular was the most significantly abundant bacterial group in the larger specimens. Further shotgun metagenome of representative samples revealed a significant abundance of microbiome retaining polyhydroxybutyrate (PHB) metabolism genes in the largest individual. The PHB metabolism reads were potentially derived from Rhodobacterales. These results imply a possible link between microbial PHB producers and potential growth promotion in Deuterostomia marine invertebrates.

2020-07-26 08:23:22
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1 0 0 0 IR Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

著者: Yoshimaru Tetsuro Aihara Keisuke Komatsu Masato Matsushita Yosuke Okazaki Yasumasa Toyokuni Shinya Honda Junko Sasa Mitsunori Miyoshi Yasuo Otaka Akira Katagiri Toyomasa
出版者: Springer Nature
雑誌: Scientific Reports (ISSN:20452322)
巻号頁・発行日: vol.7, 2017-05-12
被引用文献数: 11

Estradiol (E2) and the oestrogen receptor-alpha (ERα) signalling pathway play pivotal roles in the proliferative activity of breast cancer cells. Recent findings show that the brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-PHB2) complex plays a crucial role in E2/ERα signalling modulation in breast cancer cells. Moreover, specific inhibition of the BIG3-PHB2 interaction using the ERα activity-regulator synthetic peptide (ERAP: 165–177 amino acids), derived from α-helical BIG3 sequence, resulted in a significant anti-tumour effect. However, the duration of this effect was very short for viable clinical application. We developed the chemically modified ERAP using stapling methods (stapledERAP) to improve the duration of its antitumour effects. The stapledERAP specifically inhibited the BIG3-PHB2 interaction and exhibited long-lasting suppressive activity. Its intracellular localization without the membrane-permeable polyarginine sequence was possible via the formation of a stable α-helix structure by stapling. Tumour bearing-mice treated daily or weekly with stapledERAP effectively prevented the BIG3-PHB2 interaction, leading to complete regression of E2-dependent tumours in vivo. Most importantly, combination of stapledERAP with tamoxifen, fulvestrant, and everolimus caused synergistic inhibitory effects on growth of breast cancer cells. Our findings suggested that the stapled ERAP may be a promising anti-tumour drug to suppress luminal-type breast cancer growth.

2019-07-11 05:45:14
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1 0 0 0 IR Pandemic HIV-1 Vpu overcomes intrinsic herd immunity mediated by tetherin

著者: Iwami Shingo Sato Kei Morita Satoru Inaba Hisashi Kobayashi Tomoko Takeuchi Junko S. Kimura Yuichi Misawa Naoko Ren Fengrong Iwasa Yoh Aihara Kazuyuki Koyanagi Yoshio
出版者: Nature Publishing Group
雑誌: Scientific Reports (ISSN:20452322)
巻号頁・発行日: vol.5, 2015-07-17
被引用文献数: 14

Among the four groups of HIV-1 (M ,N, O, and P), HIV-1M alone is pandemic and has rapidly expanded across the world. However, why HIV-1M has caused a devastating pandemic while the other groups remain contained is unclear. Interestingly, only HIV-1M Vpu, a viral protein, can robustly counteract human tetherin, which tethers budding virions. Therefore, we hypothesize that this property of HIV-1M Vpu facilitates human-to-human viral transmission. Adopting a multilayered experimental-mathematical approach, we demonstrate that HIV-1M Vpu confers a 2.38-fold increase in the prevalence of HIV-1 transmission. When Vpu activity is lost, protected human populations emerge (i.e., intrinsic herd immunity develops) through the anti-viral effect of tetherin. We also reveal that all Vpus of transmitted/founder HIV-1M viruses maintain anti-tetherin activity. These findings indicate that tetherin plays the role of a host restriction factor, providing 'intrinsic herd immunity', whereas Vpu has evolved in HIV-1M as a tetherin antagonist.

2017-08-14 02:00:12
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1 0 0 0 OA Environmental DNA metabarcoding reveals local fish communities in a species-rich coastal sea

著者: Yamamoto Satoshi Masuda Reiji Sato Yukuto Sado Tetsuya Araki Hitoshi Kondoh Michio Minamoto Toshifumi Miya Masaki
出版者: Springer Nature
雑誌: Scientific Reports
巻号頁・発行日: vol.7, 2017-01-12
被引用文献数: 310

わずか1日の調査で魚種の8割を検出 : 海水からのDNA解析法で. 京都大学プレスリリース. 2017-01-13.

2017-01-13 13:18:26
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1 0 0 0 OA High maltose sensitivity of sweet taste receptors in the Japanese macaque (Macaca fuscata).

著者: Nishi Emiko Tsutsui Kei Imai Hiroo
出版者: Springer Nature
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.6, 2016-12-16
被引用文献数: 8

ニホンザルの甘味受容体がすごい : ヒトが感じられない麦芽糖の甘みにも敏感. 京都大学プレスリリース. 2016-12-26.

2016-12-26 15:33:34
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1 0 0 0 OA Gas-generated thermal oxidation of a coordination cluster for an anion-doped mesoporous metal oxide

著者: Hirai Kenji Isobe Shigehito Sada Kazuki
出版者: Nature Publishing Group
雑誌: Scientific reports (ISSN:20452322)
巻号頁・発行日: vol.5, 2015-12-18
被引用文献数: 2

Central in material design of metal oxides is the increase of surface area and control of intrinsic electronic and optical properties, because of potential applications for energy storage, photocatalysis and photovoltaics. Here, we disclose a facile method, inspired by geochemical process, which gives rise to mesoporous anion-doped metal oxides. As a model system, we demonstrate that simple calcination of a multinuclear coordination cluster results in synchronic chemical reactions: thermal oxidation of Ti8O10(4-aminobenzoate)(12) and generation of gases including amino-group fragments. The gas generation during the thermal oxidation of Ti8O10(4-aminobenzoate)(12) creates mesoporosity in TiO2. Concurrently, nitrogen atoms contained in the gases are doped into TiO2, thus leading to the formation of mesoporous N-doped TiO2. The mesoporous N-doped TiO2 can be easily synthesized by calcination of the multinuclear coordination cluster, but shows better photocatalytic activity than the one prepared by a conventional sol-gel method. Owing to an intrinsic designability of coordination compounds, this facile synthetic will be applicable to a wide range of metal oxides and anion dopants.