著者

KOIKE Akira NAGAYAMA Osamu GODA Ayumi HOSHIMOTO Masayo YAMAGUCHI Kaori TAJIMA Akihiko UEJIMA Tokuhisa ITOH Haruki AIZAWA Tadanori

出版者

社団法人日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.71, no.9, pp.1418-1423, 2007-08-20

被引用文献数

1 5

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<b>Background</b> It has been recently reported that cerebral oxyhemoglobin (O₂Hb) decreases during exercise in nearly 50% of patients with dilated cardiomyopathy. The present study evaluated whether the inhalation of supplemental O₂ diminishes the decrease in cerebral O₂Hb during exercise. <b>Methods and Results</b> Ten patients with a left ventricular ejection fraction <50% and a clearly observable decrease in cerebral O₂Hb during preliminary exercise testing underwent 2 additional symptom-limited incremental exercise tests: 1 while breathing room air (control) and the other while breathing 50% O₂. In the latter test, the switch from room air to 50% O₂ was performed, on average, at 43.0±14.2 W. Cerebral O₂Hb was continuously monitored during exercise using near-infrared spectroscopy. In the control exercise test, cerebral O₂Hb gradually decreased as the work rate increased in all the subjects. When the subjects breathed 50% O₂, this decrease in cerebral O₂Hb was diminished. The change in cerebral O₂Hb from rest to peak exercise during the test under 50% O₂ was significantly higher than that during the control test (-0.23 ±1.89 vs -2.47±1.57 μmol/L, p=0.002). Similarly, the change in the cerebral tissue oxygenation index was significantly higher in the test under 50% O₂ (0.45 ±4.46 vs -3.33±3.06%, p=0.023). <b>Conclusions</b> Impaired cerebral oxygenation during moderate to heavy intensity exercise in patients with left ventricular dysfunction can be offset by breathing supplemental O₂. (<i>Circ J</i> 2007; <b>71:</b> 1418 - 1423)<br>

著者

飯塚 積 平澤 進武 早川 和夫 大竹 眞一郎 阿良田 慶次郎 岡田 義春 山中 昭男

出版者

社団法人日本循環器学会

雑誌

日本循環器學誌 (ISSN:00471828)

巻号頁・発行日

vol.21, no.3, pp.135-136, 1957-06-20

著者

廣瀬 恒夫

出版者

社団法人日本循環器学会

雑誌

日本循環器病學

巻号頁・発行日

vol.5, no.12, pp.531-534, 1940-03-01

著者

Nagasaka Shiro Katoh Hideki Niu Chim Feng Matsui Saori Urushida Tsuyoshi Satoh Hiroshi Watanabe Yasuhide Hayashi Hideharu

出版者

社団法人日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.71, no.3, pp.429-436, 2007-02-20

被引用文献数

2 22

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Background The identification of protein kinase A(PKA) anchoring proteins on mitochondria implies a direct effect of PKA on mitochondrial function. However, little is known about the relationship between PKA and mitochondrial metabolism. Methods and Results The effects of PKA on the mitochondrial redox state(flavin adenine dinucleotide(FAD)), mitochondrial membrane potential(ΔΨ_m) and reactive oxygen species(ROS) production were investigated in saponin-permeabilized rat cardiomyocytes. The PKA catalytic subunit(PKA_<cat>; 50 unit/ml) increased FAD intensities by 56.6±7.9%(p<0.01), 2'7'-dichlorofluorescin diacetate(DCF) intensities by 10.5±3.3 fold(p<0.01) and depolarized ΔΨ_m to 48.1±9.5% of the control(p<0.01). Trolox(a ROS scavenger; 100μmol/L) inhibited PKA_<cat>-induced ΔΨ_m, FAD and DCF alteration. PKA_<cat>-induced ΔΨ_m depolarization was inhibited by an inhibitor of the inner membrane anion channel(IMAC), 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid(DIDS: 1μmol/L) but not by an inhibitor of mitochondrial permeability transition pore(mPTP), cyclosporine A(lOOnmol/L). Conclusions PKA_<cat> alters FAD and ΔΨ_m via mitochodrial ROS generation, and PKAcat-induced ΔΨ_m depolarization was not caused by mPTP but rather by DIDS-sensitive mechanisms, which could be caused by opening of the IMAC. The effects of PKA on mitochondrial function could be related to myocardial function under the condition of extensive β-adrenergic stimulation.

著者

Toyama Takuji Hoshizaki Hiroshi Isobe Naoki Adachi Hitoshi Naito Shigeto Oshima Shigeru Taniguchi Koichi

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.64, no.12, pp.937-942, 2000-11-20

被引用文献数

6 6

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To identify and quantify the amount of viable hibernating myocardium in patients with chronic coronary artery disease, resting ^<201>Tl single photon emission computed tomography(SPECT) was compared with ^<99m>Tc-methoxy-isobutyl isonitrile(MIBI) SPECT after nitrate infusion (nitrate-^<99m>Tc-MIBI) and ^<201>Tl SPECT after ^<201>Tl with glucose-insulin-potassium infusion (^<201>Tl-GIK) in 25 patients. Twenty-one patients also underwent completely left ventriculography beforehand and 5±4 months afterwards. SPECT images were divided into 9 segments and scored visually from 0 (normal uptake) to 3 (absent). The defect score was calculated as the summation of the total scores(TDS) in each patient. The TDS of nitrate-^<99m>Tc-MIBI images (6.3±4.3) and ^<201>Tl-GIK images (5.8±4.2) were significantly lower than the 7.4±4.3 of resting ^<201>Tl images (p<0.01). Based on the improvement of wall motion after coronary revascularization, the sensitivity of ^<201>Tl-GIK imaging (85%) was significantly higher (p<0.05), and that of nitrate-^<99m>Tc-MIBI imaging (79%) also tended to be higher (p=0.08), than that of ^<201>Tl imaging (62%) in detecting viable myocardium. The specificity of the 3 methods was almost the same. The nitrate-^<99m>Tc-MIBI and ^<201>Tl-GIK methods were more useful than the resting ^<201>Tl method for evaluating viable hibernating myocardium. Furthermore, the ^<201>Tl-GIK method may provide a more accurate estimate of the amount of viable myocardium than the nitrate-^<99m>Tc-MIBI method.

著者

御幡 千里 中川 泰洋 古出 隆士 大柳 光正 河崎 久美 津田 義三 石田 純一郎 小西池 篤 小正 尚裕 安藤 博信 岩崎 忠昭

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.46, 1982-11-01

著者

三谷 頼永 大柳 光正 毛笠 隆夫 山本 茂宏 石田 純一郎 寺脇 一江 羽崎 理恵子 河合 喜孝 岩崎 忠昭

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.48, 1985-04-10

著者

星 光 殿岡 一郎 佐藤 聡 金谷 透 山口 佳子 目黒 光彦 立木 楷 安井 昭二 駒谷 昭夫

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.51, 1988-02-10

著者

飴谷 由佳 清川 裕明 中林 智之 井内 和幸 石川 忠夫 本道 洋昭 西谷 泰 藤村 光夫 神田 享勉

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.59, 1996-02-20

著者

Hirota Hisao Izumi Masahiro Irie Hirofumi Masaki Mitsuru Sugiyama Shoko Kuroda Tadashi Terai Kazuo

出版者

社団法人日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.69, 2005-03-01

著者

北村 和正 村上 渉 木村 登

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.25, no.10, 1961-10-15

著者

Aoyagi Shigeaki Akashi Hidetoshi Kawara Takemi Ishihara Kenji Tanaka Atsuhisa Kanaya Seiji Koga Yoshinori Ishikawa Ritsuko

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.62, no.1, pp.64-68, 1997-12-20

被引用文献数

2

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A 26-year-old man was admitted for treatment of congestive heart failure resulting from aortic regurgitation. The patient had been on medical treatment for ulcerative colitis(UC)since he was 14 years old and for ankylosing spondylitis(AS)since he was 20 years old. On admission, gradients of blood pressure among the extremities were observed. Echocardiography revealed marked dilation of the left ventricle(LV), hypokinetic wall motion of the LV, slightly prolapsed aortic cusps with annular dilatation, and severe aortic regurgitation. Camputed tomographic scans demonstrated an aneurysmal dilation of the ascending aorta and thickening of the descending and abdominal aortic wall. Digital subtraction angiography demonstrated an aneurysmal dilation of the ascending aorta;however, there was no clear evidence of steno-occlusive lesions in the brachiocephalic vessels. Blood studies showed positive inflammatory signs and negative rheumatoid factor. HLA typing showed A2, 24(9), B27, 67, Cw1, 7, and DR1, 2. Based on these data, the diagnosis of Takayasu arteritis associated with UC and AS was made. Aortic root replacement was performed. Steroid therapy was restarted immediately after surgery. Histologic studies of the aortic wall showed findings compatible with Takayasu arteritis. The combination of these rare diseases suggests that they have a common pathophysiologic background.

著者

依藤 進

出版者

社団法人日本循環器学会

雑誌

日本循環器學誌 (ISSN:00471828)

巻号頁・発行日

vol.22, no.6, pp.393-396, 1958-09-20

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The author reported the value of stroke-volume and momentum of cardiac ejection of normal subjects obtained by ballistocardiogram, and at the same time these methods of measurement were critically examined. As ballistocardiogram showes, as previously reported, the impulse wave of circulation which is mediated by human body, the values obtained by it inevitably contain some degree of inexactness. In quantitative investigation by ballistocardiogram if we want to get the minimum error of it, it is better to use the value of momentum of cardiac ejection, where survey of the relation of it to other physiologic functions is sacrificed. In order to supplement this weak point, one needs deducing stroke-volume from ballistocardiogram, though its value is not so exact. In the latter it is advisable to investigate the relative changes in same subject.