著者

大関 道薫 松浦 啓 河田 正仁 足立 和正 平山 恭孝 河 良崇 植田 勲人 伊集院 真一 坂本 丞

出版者

社団法人日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.72, 2008-04-20

著者

丹羽 良子 本荘 晴朗 児玉 逸雄 佐久間 一郎 柴田 仁太郎

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.62, 1998-02-28

著者

児玉 逸雄 丹羽 良子 山本 充 本荘 晴朗 柴田 仁太郎 佐久間 一郎

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.62, 1998-02-28

著者

小坂 利幸 伊藤 厚士 児玉 逸雄

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.62, 1998-02-28

著者

劉 蔚然 安井 健二 加田 賢治 北条 真弓 仁瓶 宗樹 辻 幸臣 竹内 進 李 鐘国 神谷 香一郎 児玉 逸雄 林 秀晴

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.63, no.3, 1999-10-20

著者

深田 靖久 松居 喜郎 山内 英智 Dudra Jan 椎谷 紀彦 村下 十志文 佐々木 重幸 安田 慶秀

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.64, 2000-04-20

著者

Nozawa Takashi Inoue Hiroshi Iwasa Atsushi Okumura Ken Lee Jong-dae Shimizu Akihiko Hayano Motonobu Yano Katsusuke

出版者

社団法人日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.68, no.1, pp.29-34, 2003-12-20

被引用文献数

11 41

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Background Elevation of hemostatic markers may account for the increased risk of ischemic stroke in patients with non-valvular atrial fibrillation (NVAF). The aim of this study was to determine the effects of anticoagulation intensity on hemostatic markers in patients with NVAF. Methods and Results In 509 patients with NVAF, comprising 263 patients treated with warfarin and 246 patients without warfarin, the hemostatic markers of prothrombin fragment F1.2 (F1.2), fibrin D-dimer, platelet factor 4 (PF4), and β-thromboglobulin were determined and compared with those in 111 patients with sinus rhythm. F1.2 was inversely related with anticoagulation intensity and D-dimer increased with age. All hemostatic markers, except F1.2, were greater in patients with NVAF than in patients with sinus rhythm. F1.2 and D-dimer were significantly lower in patients with international normalized ratio (INR) ≥ 1.5 than in NVAF patients without warfarin and were not different between NVAF patients with INR of 1.5-1.9 and with INR ≥ 2.0. Conclusions Low intensity of anticoagulation (INR 1.5-1.9) suppresses the elevated concentration of F1.2 and D-dimer in patients with NVAF, and might be favorable in Japanese patients with NVAF in view of the balance between prevention of thromboembolism and the adverse effect by warfarin (ie, bleeding).

著者

田中 慎司 齋藤 滋 細川 丈志 秋満 忠郁 金田 秀昭 廣江 吉隆

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.63, no.1, 1999-03-01

著者

Fukuda Kazuya KUCHII MASATO HANO TAKUZO MOHARA OSAMU MIYAMOTO YASUMASA NISHIO ICHIRO MASUYAMA YOSHIAKI

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.47, no.10, pp.1221-1226, 1983-10-20

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α_2-Adrenoceptors were studied in renal membrane fractions from spontaneously hypertensive (SHR), two-kidney, one clip hypertensive (2K, 1C HT) and DOCA-salt hypertensive (DOCA-salt HT) rats, using radioligand binding method. α_2-Adrenoceptor concentration in the kidney measured by [^3H] yohimbine binding was significantly increased in SHR at 4 weeks old (41.5±2.8 fmol/mg protein, mean ±SEM, p<0.01), 12 weeks old (54.9±2.5 fmol/mg protein, p<0.01) and 35 weeks old (59.8±3.4 fmol/mg protein, p<0.01) as compared with age-matched Wistar-Kyoto rats (WKY, 31.5±2.5, 40.9±1.8, 47.8±2.0 fmol/mg protein, respectively). There were no significant differences in binding affinity and 5'-nucleotidase activity (plasma membrane marker enzyme) between SHR and WKY at any age. In 2K, 1C HT rats, α_2-Adrenoceptor concentration in the clipped kidney was higher than that of control rats, but α_2-Adrenoceptor concentration in the unclipped kidney was unchanged. binding affinity and 5'-nucleotidase activity showed no significant changes in renal hypertensive rats. In DOCA-salt HT rats, no significant change was found in concentration and affinity of renal α_2-Adrenoceptor. The observed increase in renal α_2-Adrenoceptor concentration in SHR may contribute to the pathogenesis and maintenance of hypertension through increased sodium and water reabsorption in the kidney.

著者

小野寺 幸男 中川 誠 大矢内 幹 中山 恵輔 伊勢 忠男

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.64, 2000-10-20

著者

計良 夏哉 辰巳 哲也 山中 聡 白石 淳 明石 加都子 的場 聖明 小原 幸 中川 雅夫 盛 俊一郎 朝山 純

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.64, 2000-03-01

著者

辰巳 哲也 明石 加都子 計良 夏哉 白石 淳 的場 聖明 小原 幸 河原 聡 鶴山 幸喜 田中 哲也 片村 真紀 中川 千明 太田 凡 中川 雅夫 朝山 純

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.63, no.1, 1999-03-01

著者

梅村 敏 平和 伸仁 安田 元 石井 當男 W. A. Pettinger

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.56, 1992-03-01

著者

柏田 和子 木田 博和 佐一木 康人 染谷 一彦 増原 慶壮 篠崎 公一 荒井 栄 佐藤 あけみ

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.46, pp.292-293, 1982-08-01

著者

田中 保則 佐々木 紀仁 広江 晃 ギアス Uアーメド 坪井 麻理子 山本 康孝 真鍋 一郎 太田原 顕 井川 修 久留 一郎 重政 千秋

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.61, 1998-03-20

著者

先田 信哉 岸 幸夫 渡辺 智幸 渡辺 良治 足利 貴志 丸山 義明 角田 恒和 橋本 裕二 沼野 藤夫

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.60, 1996-02-20

著者

Nakazato Yuji Yasuda Masayuki Sasaki Akitoshi Iida Youji Kawano Yasunobu Nakazato Kaoru Tokano Takashi Mineda Yoriaki Sumiyoshi Masataka Nakata Yasuro Daida Hiroyuki

出版者

社団法人日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.69, no.1, pp.44-48, 2004-12-20

被引用文献数

39 60

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Background Bepridil has multiple ion-channel blocking effects similar to armodarone and is expected to have anti-arrhythmic effects that are useful for the management of atrial fibrillation (AF). The aim of this study was to clarify the conversion of persistent AF and maintenance of sinus rhythm (SR) by oral bepridil. Methods and Results Oral bepridil was administered to 112 patients (83 males, 29 females; age: 59.0±10.8 years) with persistent AF lasting an average of 5 months. The conversion effects and maintenance of SR after pharmacological or direct current (DC) cardioversion, as well as the incidence of adverse complications, were evaluated. In 65 of 112 (58%) patients, SR was restored within 6 months (average: 2.1 months) following bepridil administration. DC cardioversion was carried out for 21 of the remaining 47 patients with unsuccessful pharmacological conversion, and all had restoration of SR. Eventually, of the 86 patients in total who were restored to SR by either bepridil or DC cardioversion, 70 (81%) patients maintained SR after a mean follow-up of 18 months. No serious adverse complications were observed, except for marked QT prolongation in 2 cases. Conclusion Bepridil showed favorable conversion effects in patients with persistent AF and was highly effective for maintaining SR after pharmacological or electrical cardioversion. However, careful follow-up is necessary for the prevention of torsade de pointes caused by QT prolongation.

著者

Yamashita Takeshi Ogawa Satoshi Aizawa Yoshifusa Atarashi Hirotsugu Inoue Hiroshi Ohe Tohru Okumura Ken Kato Takao Kamakura Shiro Kumagai Koichiro Kurachi Yoshihisa Kodama Itsuo Koretsune Yukihiro Saikawa Tetsunori Sakurai Masayuki Sugi Kaoru Nakaya Haruaki Nakayama Toshio Hirai Makoto Fukatani Masahiko Mitamura Hideo Yamazaki Tsutomu

出版者

社団法人日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.67, no.9, pp.738-741, 2003-08-20

被引用文献数

22 50

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The Japanese Rhythm Management Trial for Atrial Fibrillation (J-RHYTHM study) is a randomized comparative evaluation of rate control and rhythm control, both combined with antithrombotic therapy, as therapeutic strategies for the treatment of atrial fibrillation (AF). This study differs from the earlier AFFIRM and RACE studies in that it has a composite primary end-point representing mortality and also physical/psychological disablement (total mortality, symptomatic cerebral infarction, systemic embolism, major bleeding, hospitalization for heart failure requiring intravenous administration of diuretics, and patient disablement). Patients' will to change the therapeutic strategy to the other is also considered as an end-point representing disablement under the assigned strategy. The secondary end-point includes quality of life scores and the efficacy and safety of drugs used in treating AF. The J-RHYTHM study emphasizes patient-reported experience and perception of AF-specific disablement, and the safety of antiarrhythmics available in Japan; it will follow 2,600 patients treated at more than 150 sites in Japan for a 3-year period. (Circ J 2003; 67: 738-741)

著者

山田 道治 佐藤 文明 松山 敏 松井 義親 柴田 哲男

出版者

社団法人日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.69, 2005-10-20

著者

Koike Akira Hoshimoto Masayo Tajima Akihiko Nagayama Osamu Yamaguchi Kaori Goda Ayumi Yamashita Takeshi Sagara Koichi Itoh Haruki Aizawa Tadanori

出版者

社団法人日本循環器学会

雑誌

Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)

巻号頁・発行日

vol.70, no.11, pp.1457-1461, 2006-10-20

被引用文献数

6 20

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Background In a recent study the indexes of cerebral oxygenation decreased during maximal exercise in nearly half of all patients with left ventricular dysfunction. Whether these levels decrease severely enough to influence mental status or level of consciousness was evaluated in the present study. Methods and Results Forty-two patients with idiopathic dilated cardiomyopathy (IDC) and 29 healthy subjects underwent a symptom-limited maximal exercise test. The cerebral oxyhemoglobin (O_2Hb) and tissue oxygenation index (TOI) were continuously monitored using near-infrared spectroscopy. The changes in O_2Hb and TOI were also measured in 7 subjects: 2 who experienced episodes of reduced consciousness caused by sudden decreases in blood pressure during exercise recovery and 5 who exhibited sustained ventricular tachycardia during an electrophysiological study. The change in cerebral O_2Hb during exercise in patients with IDC averaged 0.38±3.39μmol/L, significantly lower than in the normal subjects (4.30±4.47μmol/L, p<0.0001). The cerebral O_2Hb decreased during exercise in 18 of 42 patients with IDC. The change in cerebral TOI in the IDC patients during exercise was significantly less than that in the normal subjects (-2.0±4.7 vs 2.1±5.8%, p=0.002). The mean decreases in cerebral O_2Hb and TOI were -5.34μmol/L and -9.7%, respectively, in the patients with reduced consciousness during exercise recovery, and -2.52μmol/L and -16.5%, respectively, in those with ventricular tachycardia. Conclusion The indexes of cerebral oxygenation may drop severely enough during maximal exercise in some patients with severe IDC that consciousness is affected.