著者
江頭 かの子 北原 隆志 柏木 香 樋口 則英 中嶋 幹郎 一川 暢宏 佐々木 均
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.126, no.11, pp.1155-1161, 2006-11-01 (Released:2006-11-01)
参考文献数
13
被引用文献数
5 5

Antimicrobial agents sometimes cause the adverse effects of diarrhea and loose stool. Antibiotic-resistant lactic acid bacteria are used to prevent these adverse effects. The bacteria are not resistant to several antimicrobial agents, although the bacterium preparations are sometimes prescribed the antimicrobial agents concomitantly. Therefore this paper reports that the minimal inhibitory concentration of three new antimicrobial agents against antibiotic-resistant lactic acid bacteria were determined using a microdilution method with cation-adjusted Mueller-Hinton broth. Furthermore, we investigated antimicrobial agents that are prescribed concomitantly with antibiotic-resistant lactic acid bacterium preparations or a clostridium butyricum preparation. The bacteria were susceptible to the three new antimicrobial agents. Approximately 50% of the bacterium preparations were prescribed alone, and 30% were prescribed concomitantly with antimicrobial agents that show antimicrobial activity against the bacteria. Consequently, we suggest that pharmacists need to confirm prescriptions and to provide more drug information on antibiotic-resistant lactic acid bacterium preparations.
著者
植木 哲也 宮野 佳子 坂本 佳子 長井 惠子 橋口 靖 中嶋 弥穂子 中嶋 幹郎
出版者
一般社団法人日本医薬品情報学会
雑誌
医薬品情報学 (ISSN:13451464)
巻号頁・発行日
vol.17, no.1, pp.39-44, 2015 (Released:2015-06-28)
参考文献数
22

Objective: Information on medicines brought to hospital by inpatients is essential to optimize drug use and patient safety.  However, the actual situation and usefulness of identifying such medicines on the emergent admission of patients remain to be clarified.  The objective of this study was to examine the usefulness of identifying the medicines patients bring to the hospital on emergent admission.Methods: We compared the source of information on identifying medicines between two groups of patient: emergent admissions (N=276) and elective admissions (N=50), and also investigated intervention by pharmacists regarding the medicines patients had brought with them.Results: Regarding the source of information to identify the medicines, the rate of utilizing medicine notebooks on emergent admission was significantly lower than on elective admission, and the rate of inquiring with community pharmacies on emergent admission was significantly higher than on elective admission.  The frequencies of intervention by pharmacists in the two groups were similar, and, therefore, the usefulness of identifying the medicines patients brought was noted regardless of the admission course.Conclusion: Identifying the medicines patients bring to the hospital might be useful on emergent admission.  Hospital pharmacists should promote an increase in the medicine notebook utilization rate and reinforce cooperation with community pharmacies.
著者
樋口 則英 一川 暢宏 嶺 豊春 中嶋 幹郎 平井 正巳 佐々木 均
出版者
日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.30, no.6, pp.382-388, 2004-06-10
被引用文献数
1 2

In recent years, computerized prescription order entry systems have played an increasingly important role in medical risk management as such systems have become more sophisticated. Though prescription order entry systems enable us to access huge amounts of information in drug information databases on drug interactions, adverse reactions and so forth, it is very difficult to manage such large amounts of information. Prescription order entry systems have a prescription checking function but the master maintenance must be done properly for it to work well. With this in mind, we developed an improved system using a commercially available program, PC-ORDERING 2000 (NEC Corp.), to make it easier to use the master maintenance screen of the order entry system. In order to investigate the resulting improvements we did the following : 1) measured the improvement in input efficiency, 2) evaluated the improvement in reference functions, 3) evaluated the improvement in file output functions and 4) made a comparison with the existing system. As a result, we found that the required maintenance time with the improved system was reduced to 66% and considered this to be very important to risk management since the prescription checking function in the order entry system had been enhanced.
著者
中嶋 幹郎 大山 要
出版者
公益社団法人 日本薬学会
雑誌
ファルマシア (ISSN:00148601)
巻号頁・発行日
vol.53, no.8, pp.787-789, 2017 (Released:2017-08-01)
参考文献数
10

ジェネリック医薬品は先発医薬品と治療学的に同等であることが保証された医薬品であるが、医療関係者や患者からは、副作用による安全性への懸念の声があげられる。そこで、副作用の一つである薬剤性肝障害を評価するため、臨床試験とは異なるアプローチでヒト肝細胞キメラマウスとトキシコゲノミクスの手法を用いた新しい手法を開発し、様々な先発医薬品とジェネリック医薬品の薬剤性ヒト肝障害リスクの同等性を評価した。
著者
中嶋 幹郎 佐々木 均 中嶋 弥穂子
出版者
長崎大学
雑誌
基盤研究(C)
巻号頁・発行日
2008

本研究では、注射薬の後発医薬品の安全性と毒性に関する品質試験を培養細胞や実験動物を用いて行うとともに、医薬品の心毒性をオンチップ心筋細胞集団ネットワーク計測法により評価する実験法の開発を試みた。その結果、心筋細胞集団ネットワークの拍動リズムに対する影響を観察することで、医薬品が作用するイオンチャネルの違いを区別できることを明らかにし、心毒性評価法としての本法の可能性を示した。また被験注射薬の中でその先発医薬品と比較し安全性や毒性に関する品質面において問題のある後発医薬品はなかった。