著者

松下 幸生

出版者

公益財団法人 パブリックヘルスリサーチセンター

雑誌

ストレス科学研究 (ISSN:13419986)

巻号頁・発行日

vol.33, pp.3-9, 2018 (Released:2019-02-23)

参考文献数

28

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Gambling in Japan is considered to be unique because of pachinko, a legal mechanical gambling device. In 2016, the estimated size of the pachinko market was 197 billion US dollars, far exceeding other types of legal gambling in Japan. The most recent epidemiological study in Japan revealed that prevalence of gambling disorder (GD) was 3.6% for lifetime and 0.8% in the previous 12 months. That study also revealed that only 10% of the participants with a lifetime GD and 17% with a present GD had ever asked for help with gambling, and hardly any of the participants had sought treatment. These results clearly showed a serious treatment gap for participants with GD, as has frequently been reported in other countries. Cognitive behavioral therapy is a standard treatment for GD and a six-session treatment program is conducted at the Kurihama Medical and Addiction Center.Impulsivity is one of the major risk factors for the development of GD. Genetic and environmental factors and their interactions have also been shown to be involved in the development of GD. Stressful life-events are also risk factors for GD. A positive correlation between violence and gambling has only been observed in men and a previous study reported that women tended to gamble to cope with anxiety and negative feelings. Therefore, the relationship between stress and GD might differ by gender.

著者

尾崎 米厚 金城 文 松下 幸生 樋口 進

出版者

日本アルコール・薬物医学会

雑誌

日本アルコール・薬物医学会雑誌 (ISSN:13418963)

巻号頁・発行日

vol.52, no.2, pp.73-86, 2017-04

著者

鈴木 健二 村上 優 杠 岳文 藤林 武史 武田 綾 松下 幸生 白倉 克之

雑誌

日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence (ISSN:13418963)

巻号頁・発行日

vol.34, no.5, pp.465-474, 1999-10-28

被引用文献数

20

著者

松下 幸生 加藤 元一郎 樋口 進 鹿島 晴雄

雑誌

日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence (ISSN:13418963)

巻号頁・発行日

vol.44, no.4, pp.266-267, 2009-08-28

著者

鈴木 健二 武田 綾 松下 幸生

雑誌

日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence (ISSN:13418963)

巻号頁・発行日

vol.40, no.6, pp.559-571, 2005-12-28

参考文献数

39

被引用文献数

4

著者

鈴木 健二 木村 充 武田 綾 松下 幸生

雑誌

日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence (ISSN:13418963)

巻号頁・発行日

vol.43, no.1, pp.44-53, 2008-02-28

参考文献数

29

被引用文献数

1

著者

松井 敏史 櫻井 秀樹 遠山 朋海 吉村 淳 松下 幸生 樋口 進

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.86, no.11, pp.630-635, 2012

参考文献数

20

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Wernicke's encephalopathy (WE) is the best known acute neurologic complication of vitamin B_1 (B_1) deficiency and often occurs in chronic alcoholism. The plausible causes of B_1 deficiency in alcoholics depend on the underlying mechanisms, such as a low dietary intake of B_1, inadequate absorption of B_1 from the intestine due to the gastrointestinal tract damage, and coexistent alcoholic liver disease altering the capacity of B_1 storage and the metabolism of biologically important nutrients. Because the use of the classic triad of WE may overlook a mild form of WE that can be detected as inactive WE pathology, Caine and colleagues have proposed the clinical criteria for diagnosis of WE in chronic alcoholics based on the clinical-neuropathological correction. The Caine criteria include dietary deficiency, oculomotor abnormalities, cerebellar dysfunction and either altered mental status or mild memory impairment, two of which are required for diagnosis of clinical WE. In our cohort, 13 alcoholic patients who fulfilled the Caine criteria were followed up and CSF-tau levels increased at the acute stage of the disease and then decreased at the chronic stage, suggesting that the patients have a transient neuronal damage. The Caine criteria enabled an immediate intravenous administration of B_1 and provided a favorable prognosis. For the therapy of WE, parenteral treatment with a high dose of B_1 is now recommended. A typical regimen is that 500 mg of B_1 is intravenously administered three times daily for two consecutive days and 500 mg of B_1 is intravenously administered once daily for additional five days, in combination with other B vitamins. After establishment of a sufficiently low threshold for parenteral B_1 treatment, the B_1 treatment should be conducted in all alcoholic patients with altered mental status, oculomotor disorders or ataxia.

著者

松本 俊彦 松下 幸生 奥平 謙一 成瀬 暢也 長 徹二 武藤 岳夫 芦沢 健 小沼 杏坪 森田 展彰 猪野 亜朗

雑誌

日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence (ISSN:13418963)

巻号頁・発行日

vol.45, no.6, pp.530-542, 2010-12-28

参考文献数

33

被引用文献数

3

著者

尾崎 米厚 松下 幸生 白坂 知信 廣 尚典 樋口 進

雑誌

日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence (ISSN:13418963)

巻号頁・発行日

vol.40, no.5, pp.455-470, 2005-10-28

被引用文献数

22