著者

小山 善之 熊取 敏之 澁谷 敏三 新谷 和夫 福田 龍三 今村 幸雄 佐野 一郎 鴫谷 亮一 古屋 曉一 河野 實 日野 佳弘 渡邊 孝 武正 勇造 中村 なをゑ 小澤 義光 林 康之 平島 信子 早船 喬一 濱口 榮祐 木村 信良 神田 清 岡本 十二郎 濱田 政彦 大橋 成一 橋本 敬祐 小酒 井望 石井 暢 天木 一太 深澤 義明 貴船 トミ子 松村 義寛 中野 巖 種田 強一郎 林 義次 村田 貢

出版者

Japanese Society of National Medical Services

雑誌

医療 (ISSN:00211699)

巻号頁・発行日

vol.9, no.1, pp.5-45, 1955

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This paper is an intermediate report of the clinical observations and various investigations made upon the 16 patients of the radiation sickness caused by BIKINI ashes on. 1st March 1934. The patients were admitted to the First Tokyo National Hospital on March 28th, and this report shall be for the period of the 5 months from March 28th to the end of August, 1964. Later, a thorough and complete report will be given, in which some amendments may be added to the present paper.<br>INTRODUCTION: At 3.50 a. m. on 1st March 1954, the 5th Lucky Dragon, a fishing boat, with a crew of twenty three on board, was located at about 100 miles east of BIKINI. The boat was under grey-white ash-fall for more than 5 hours. The crew was exposed to the ash-fall for 1.5 to 5 hours. The evening of that day they suffered from headache, anorexia, conjunctivitis and later nausea, vomiting, exhaustion and diarrehea, Several days later they suffered from itching, pain, rash, and erosion on the exposed skin areas. One week later two of the crew had hemorrhage of gingiva and some of the crew suffered from depilation. On March 19th, the boat returned to its base at Yaizu. On March 16th, the crew was admitted to the Kyoritsu Yaizu Hospital and on March 28th, 16 patients out of 23 were transfered to our hospital (the First Tokyo National Hospital).<br>On March 26th, Prof. Kimura's laboratory of Tokyo University made the analysis of the ashes taken from the 5th Lucky Dragon and found the following radioactive substances: Sr-89, Sr-90, Y-90, Y-91, Zr-96, Nb-95m, Nb-95, Ru-103, Ru-106, Te-129m, Te-129, Te-132, I-131, I-132, Ba-140, La-140, Ce-141, Ce-144, Pr-143, Pr-194, Nd-147, Pm-147, S-35, Ca-45, U-237, and Pu-239. The remaining radiation of the boat was investigated by Dr. Kakei et al. of March 17th and found it to be around 100mr/hr. Upon this data the total radiation was estimated at a count of 270 to 440γ. on the crew. In addition to the external exposure of such radiation, internal exposure, such as respiration of contaminated air, drinking of contaminated water and taking of contaminated food, shall be taken into consideration in the present cases. Radioactivity was found in the bile and urine taken from the patients.<br>GENERAL REMARKS: The 16 cases were strong young men but their body weight began to decrease from the middle of May and high or slight fever, anorexia, feeling of exhaustion, diarrhea and headache continued.<br>Skin and Hair: Irregular depilation, depigmentation, pigmentation with rain and itching, and erosion was observed. Some cases had folliculitis with pustules in April, while others recovered from erosions and at the end of May, regeneration of hair began. In July, hair condition was almost normal.<br>Blood and Bone-marrow: At the middle of April, the lowest peripheral leucocyte count was less than 2, 000. Two cases who had lower leucocyte count recovered earlier, i. e., their leucocytes increased to around 5, 000 at the middle of May. Meanu hile, the other cases had from 3, 033 to 4.000 count during the entire period. The former cases had also moderate anemia while the latter had only slight anemia. Blood platelet count of the former cases was less than 20, 000 and the recovery was slower than that of the leucocyte count. Reticulocyte count kept pace with that of leucocyte. In the former cases, myelocyte and other immature blood cells appeared temporarily in the circulated blood and eosinophile cells increased. The count of bone-marrow cells decreased remarkably (8, 000), i. e. panmyelophthisis, which later recovered slowly. In the latter cases, peripheral leucocyte findings and myelogram had almost no changes from the beginning of our observation and count of bone marrow cells was remarkably different by the sites of bone-marrow puncture. Vacuole and toxic granula appeared in the neutrophile cells in the circulated blood and vacuoles also appeared in lymphocyte and monocyte.

著者

中村 皖一 中川 明彦 田中 実 増田 裕 林 康之 西園 寺克

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.83, no.2, pp.183-191, 1984 (Released:2007-03-07)

参考文献数

33

被引用文献数

11 7

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3位にmethyltetrazolylthiomethyl基を有するセフェム系抗生物質によるジスルフィラム様作用の発現機構を追求するために以下の実験を行った.1)cefetazole(CMZ),cefoperazone(CPZ),latamoxef(LMOX)をヒト,サル,イヌ,ラットに静脈内投与後の原薬物ならびに3位置換基由来のmercaptomethyltetrazole(Me-TZ)の累積尿中排泄率(0~24時間)を求めた.ヒトにおけるMe-TZの尿中排泄率はCPZ(39%)>LMOX(14%)>CMZ(3% of dose)となり,同様の傾向はラット,サルでも見られた.2)ラットにCMZ,CPZ,LMOX,Me-TZを静脈内に単回投与し,一定時間後ethanolを経口負荷したところ,血中アセトアルデヒド値は用量依存的に上昇した.その傾向はMe-TZの尿中排泄率に比例し,CPZ>LMOX>CMZとなった.またサルの2回静脈内投与群においてもCPZ>CMZの傾向が見られた.以上の結果からMe-TZがジスルフィラム様作用の原因物質と推測できたが,本作用発現の強弱に種差,抗生物質問の差異が見られた.それらはこれまでに報告されている各抗生物質の胆汁移行率の大小および組織液中での安定性に起因していると考えられた.

著者

宮川 道夫 小林 康之 鳥羽 啓 石井 望

出版者

一般社団法人電子情報通信学会

雑誌

電子情報通信学会論文誌. D-II, 情報・システム, II-パターン処理 (ISSN:09151923)

巻号頁・発行日

vol.83, no.12, pp.2810-2821, 2000-12-25

被引用文献数

10

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注視位置情報を利用したヒトとコンピュータとの円滑な情報伝達を目的とし, 無拘束で自由な体の動きを許容した注視点検出手法を開発した.PSDカメラにより眼球回転中心を, またCCDカメラにより角膜の曲率中心をステレオ計測し, ビデオ信号処理と推定演算により注視点を求める.無拘束状態で注視点を検出するため, カメラと眼球間の距離に応じて眼球反射光が広がりをもち輝度値も低下する.検出精度が低下しないよう, AGC回路や輝点の中心座標を算出するパルス中心位置計測回路を備え, 精度の高い注視点検出を可能としている.また, コンピュータ使用時の頭部変動量をPSDカメラで測定・評価し, 頭部の最大移動量を算出した.その結果, コンピュータ使用時の頭部変動は本システムの計測範囲内に収まることを確認した.