著者
飯野 美穂 井上 進 二上 由紀 小林 洋紀 加藤 尚美 森田 庄治 石島 あや子 柴田 洋一 溝口 秀昭 南 陸彦
出版者
一般社団法人 日本輸血・細胞治療学会
雑誌
日本輸血細胞治療学会誌 (ISSN:18813011)
巻号頁・発行日
vol.56, no.4, pp.508-514, 2010 (Released:2010-09-10)
参考文献数
18

日本血小板・顆粒球型ワークショップの参加施設の協力を得て2007年4月から2009年3月までの2年間に各依頼施設に検査依頼があり,血小板数が15×104/μl未満であった66症例を対象とし,集計調査を行った.新生児溶血性疾患と異なり,初回妊娠から発症した症例が多くみられた.母親の妊娠回数,輸血歴,既往歴における血小板抗体陽性率に有意差はみられなかった.患児の頭蓋内出血の有無別にみた在胎週数,出生時体重,患児血小板数に有意差はみられなかった.抗体特異性はHLA抗体単独例が33.3%,HPA抗体が21.2%,陰性が40.9%で,HPA抗体陽性例の血小板交差適合試験は全て陽性であった.HPA抗体の特異性はHPA-4b抗体が最も多く,次いでHPA-5b抗体が多かった.
著者
稲葉 頌一 大戸 斉 柴田 洋一 坂本 久浩 高橋 孝喜 十字 猛夫 前田 義章
出版者
一般社団法人 日本輸血・細胞治療学会
雑誌
日本輸血学会雑誌 (ISSN:05461448)
巻号頁・発行日
vol.40, no.1, pp.1-13, 1994-01-25 (Released:2010-03-12)
参考文献数
9

Sixty-six patients who succeeded in storing a sufficient volume of autologous blood (mean±SD; 1097±452ml) using KL-3R3 solution contained in blood bags before elective surgery were included in this study, a five week phase 3 clinical trial of the whole blood preservative solution KL-3R3, commonly known as CPDA-1 (citrate phosphate dextrose adenine) solution. The mean time required for sufficient storage of autologous blood was 23.4±6.9 days, with 40 of the 66 (60.6%) requiring more than 21 days, a period of time that would have resulted in time expiration had we used the citrate-phosphate-dextrose (CPD) or acid-citrate-dextrose (ACD) solution bags which are presently commercially available. Sixty of the 66 patients (90.9%) completed their operations using only autologous blood units. After eliminating three patients who were administered recombinant erythropoietin, the efficacy of KL-3R3 was evaluated as effective in 61 (96.8%) of the 63 patients evaluated (markedly effective 57 (86.4%) and effective 4 (6.1%). Furthermore, in 48 of 56 patients (85.7%), in whom we were able to measure the autologous blood recovery rate after 24 hours of transfusion were estimated effective (markedly effective 29 (51.8%) and effective 19 (33.9%)). In sixty-three patients who had hematological and biochemical laboratory data, vital signs, and urinary data recorded both before and after receiving autologous blood units. RBC counts and hemoglobin levels and platelets counts decreased, and WBC counts increased after returning autologous blood at operation, changes observed commonly under surgical stress. Hemolysis markers such as GPT, indirect bilirubin, and LDH were slightly increased the day after operation, but returned to normal the second day after operation. Other data moved within normal limits expect urine occult blood. Hematuria was observed immediately after transfusion of autologous blood units, but this finding was observed transiently (the first day after transfusion 45.7% and the second day 13.3%). The safety was evaluated in sixty-five patients' blood bags by sight observations and bacterial culture tests, and no abnormal findings or bacterial propagation were detected. One patient was excluded from the safety evaluation because he was operated on within a week of initial predeposition. Two-hundred-thirty-eight KL-3R3 preserved blood bags were transfused in the 66 patients, in one (1/238, 0.4%) which had be discarded because of a large clot formation. In sixty-one patients, both the efficacy and the safety tests of KL-3R3 were rated for usefulness, with all 61 confirmed useful. The laboratory data of the 26 patients whose autologous blood were used within 21 days and the 40 patients whose autologous blood contained at least one unit that exceeded 21 days preservation was compared, with no significant differences observed.Our results confirmed that, in clinical trial of KL-3R3 preserved autologous blood units, all the criteria of effectiveness, safety and usefulness were satisfied.
著者
柴田 洋一 高松 竹男 Yoichi Shibata Takeo Takamatsu 小山工業高等専門学校一般物理 小山工業高等専門学校技術室
出版者
小山工業高等専門学校
雑誌
小山工業高等専門学校研究紀要 = The research reports of Oyama Technical College (ISSN:02882825)
巻号頁・発行日
vol.37, pp.23-27, 2005-03-10

ペットボトルロケットの工作上、翼部分は最も精度が要求されやっかいである。しかし翼は実はもっと単純な構造で同様の効果が得られる。形状と同時に翼の取り付け位置も変え、どのように飛行が変化するか実証実験を行った結果を報告する。またこれらの実験を通して、翼の働きについても考察をおこなった。