著者

吉田 和佳奈 齋藤 栄 酒向 孫市 野田 政充 川口 諭 新井 一也 安齋 沙織 久保田 聡 渋谷 清 町田 充 堀野 忠夫 青木 学一 尾鳥 勝也

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.8, pp.893-900, 2022-08-01 (Released:2022-08-01)

参考文献数

12

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“Leukerin® powder 10%” containing mercaptopurine (6-MP) is an oral anticancer drug that requires careful handling. As a powder formulation, there are risks of exposure due to scattering during dispensing and possible 6-MP contamination to other drugs due to adhesion to the packaging machine. We previously reported that wiping with an alcohol-containing towel is useful for removing scattered powder after dispensing. However, it is recommended to wipe disk-type powder-packaging machines with water instead of cleaning with the alcohol-containing towel. Hence, we scattered 6-MP powder 100 mg (total amount of 6-MP: 10 mg), and then wiped with water three times using different types of cloth each time. We confirmed that third time wiping cloth did not have any 6-MP. Furthermore, we confirmed that the adhering 6-MP could be removed by wipe-cleaning (water-wiping twice and dry-wiping once) after dispensing 6-MP powder at two pharmacies that routinely dispensed 6-MP powder using a disk-type powder-packaging machine. In addition, we confirmed the adhesion of 6-MP in parts of the machine not cleaned by wipe-cleaning and also in parts that were washed only with water, in both the pharmacies. Based on the above observations, we recommend the following steps for cleaning disk-type powder-packaging machines after dispensing 6-MP powder: (1) wipe-cleaning that includes water-wiping twice and then dry-wiping once, (2) cleaning all areas of the packaging machine, and (3) wipe-cleaning with water before washing with water.

著者

青木 学一 小田 さつき 久保田 聡 齋藤 栄 横田 訓男 柴﨑 淳 渋谷 清 酒向 孫市 尾鳥 勝也

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.141, no.1, pp.125-133, 2021-01-01 (Released:2021-01-01)

参考文献数

15

被引用文献数

1

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The immunosuppressant azathioprine (AZA) is classified as a hazardous drug. AZA contamination during tablet-splitting increases exposure risk. However, there is no study on contamination and exposure during AZA tablet splitting and dispensing. AZA tablet splitting and dispensing methods were classified based on whether tweezers are used during splitting and packaging. In Dispensing Method (1), no tweezers were used in either step. In Dispensing Method (2), no tweezers were used during tablet splitting, but were used during packaging. In Dispensing Method (3), tweezers were used in both steps. After AZA half-tablet split-dispensing, we quantified the adherent AZA removed from the tools, packaging machines, and dispensing counters by three consecutive wipings with water-dampened polypropylene cloths. A large amount of AZA adhered to the gloves used in Dispensing Methods (1) and (2), wherein tablets were placed with gloved hands, compared with Dispensing Method (3), wherein tablets were held with tweezers. Thus, the gloves must be replaced before touching the packaging paper during the final step. After three consecutive wipings, AZA was not detected at most of the sites in the third round. Thus, we recommend that (1) AZA tablet splitting should be performed while wearing gloves, (2) the gloves should be changed before packaging the half tablets, and (3) the tools, packaging machines, and dispensing counters should be wiped twice or thrice with a water-dampened cloth after dispensing.

著者

服部 明徳 大内 綾子 渋谷 清子 佐藤 和子 細谷 潤子 中原 賢一 西永 正典 亀田 典佳 土持 英嗣 松下 哲 折茂 肇

出版者

一般社団法人 日本老年医学会

雑誌

日本老年医学会雑誌 (ISSN:03009173)

巻号頁・発行日

vol.38, no.3, pp.360-365, 2001-05-25 (Released:2009-11-24)

参考文献数

7

被引用文献数

3 4

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介護負担度に影響する因子を明らかにする目的で, 老年者の問題行動の有無や介護者自身の要因と介護負担度との関連をバーンアウト・スケールを用いて検討した. 対象は当院総合内科に入院した65歳以上の患者のうち, 家族が何らかの介護をしていた73例 (男性31例女性42例, 平均年齢82.7±6.9歳) で, 主たる介護者へのアンケートにより, 患者・介護者の属性や一日の介護時間, 徘徊などの問題行動の有無などを調査した. また, アンケートには Pines のバーンアウト質問項目が含まれ, 計算式からバーンアウト・スコアを算出した. 介護者の属性では, 約3割が配偶者であり, 介護者が高齢であるとバーンアウト・スコアは有意に高値となった (p<0.01). これに加えて介護者自身の健康状態に基づき介護負担を重く感じるほどバーンアウト・スコアは高値となった (p<0.001). 老年者の問題行動のうち, 夜間の介護が必要 (p<0.05), 監視が必要 (p<0.01), そして介護拒否 (p<0.01) があるとバーンアウト・スコアは有意に高値となった. バーンアウト・スコアを説明変数とする重回帰分析では, 老年者の Basic ADL・問題行動・介護者自身の要因のうち介護者自身の健康状態による介護負担, 夜間の介護そして排泄の介助が独立した因子でバーンアウト・スコアの約4割を説明し得た (R2=040: p<0.0001). 介護保険サービスの導入によって, 上記の家族の介護負担を重くしている要因が改善され, バーンアウト・スコアを低下させるか検討することが今後必要である.

著者

片岡 章勝 鈴木 斎 門間 正彦 渋谷 清和 栗田 勲 高橋 潤一郎 伊知地 宏志

出版者

公益社団法人日本放射線技術学会

雑誌

日本放射線技術學會雜誌 (ISSN:03694305)

巻号頁・発行日

vol.51, no.10, 1995-10-01

著者

西川 龍也 渋谷 清 大畑幸恵

出版者

福山市立大学

雑誌

福山市立女子短期大学研究教育公開センター年報 (ISSN:13485113)

巻号頁・発行日

vol.9, pp.11-18, 2012

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In Japan we can find two rooms designed by JamesTurrell, famous contemporary artist. One is "Open Sky"; belong to The Chichu Art Museum in Naoshima. And another one is "Blue Planet Sky", belong to the 21st Century Museum of Contemporary Art in Kanazawa.Like twins, two rooms were designed very similar.But visitors will face very different situations in each room. The atmosphere of "Open Sky" may enforce ceremonious behavior to the visitors. The visitors of "Blue Planet Sky" should be able to take cozy spaces. The difference of the ideals of the museums caused the situations.The Chichu Art Museum anticipates the enthusiast of contemporary art.But the 21st Century Museum of Contemporary Art aims to be the contemporary art evangelist.The difference had been shaped by the situation of the museums and the industrial policy of local governments.So If we would make the room designed by Turrell in Fukuyama, We should have to choose the way of Kanazawa.

著者

渋谷 清見

出版者

公益社団法人日本航海学会

雑誌

航海 (ISSN:0450660X)

巻号頁・発行日

no.11, pp.47-52, 1959-12-31