著者
乾 あやの 小松 陽樹 日衛嶋 栄太郎 十河 剛 永井 敏郎 藤澤 知雄
出版者
一般社団法人 日本肝臓学会
雑誌
肝臓 (ISSN:04514203)
巻号頁・発行日
vol.51, no.8, pp.457-459, 2010 (Released:2010-09-02)
参考文献数
5
被引用文献数
1

Since the national program of immunoprophylaxis against perinatal transmission of hepatitis B virus (HBV) was started in 1986, the HBV carrier rate in children was dramatically decreased. However, the cases of failure of the prevention still exist. In this study, we retrospectively analyzed the reasons of 56 cases of the failure of the prevention after the initiation of national program. Seventeen (31%) were not received the immunoprophylaxis of the national program by mistake. Seven (12%) were received the inappropriate doses of schedule. Our national program is relatively complicated compared to the method adopted by almost all other countries. Because of the universal vaccination program is easy to finish the schedule, we should consider converting our prevention schedule to the universal vaccination program.
著者
小松 陽樹 乾 あやの 十河 剛 藤澤 知雄
出版者
一般社団法人 日本肝臓学会
雑誌
肝臓 (ISSN:04514203)
巻号頁・発行日
vol.51, no.2, pp.92-94, 2010-02-25
参考文献数
5
被引用文献数
1 1

We compared the international HB vaccine program with the Japanese HB vaccine program. A good responder was defined as having 100 mIU/m<i>l</i> or more of serum HBs antibodies. Eighty-one children were protected according to the international schedule and 60 children were treated with the Japanese schedule. The levels of serum HBs antibodies in children treated with the Japanese schedule were significantly higher than that in children treated with the international schedule one month after the 3<sup>rd</sup> vaccination and one year after birth. However, there was no significant difference in the proportion of good responders between the two schedules. In conclusion, the international HB vaccine program was as effective as the Japanese HB vaccine program.<br>