著者

平賀 幸弘 黄 淳一 霜村 真一

出版者

一般社団法人 日本耳鼻咽喉科頭頸部外科学会

雑誌

日本耳鼻咽喉科学会会報 (ISSN:00306622)

巻号頁・発行日

vol.116, no.10, pp.1114-1119, 2013-10-20 (Released:2013-11-26)

参考文献数

12

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血管免疫芽球性T細胞リンパ腫 (angioimmunoblastic T-cell lymphoma: AITL) の1症例を経験した. 患者は33歳女性で, 前頸部に単発の腫瘤を認め, 手術にて摘出された. 病期診断はStage IAで, CHOP3コースと頸部へのX線照射40Gyが施行され, 経過観察中であるが再発を認めない. AITLは, 非ホジキンリンパ腫の1.2~2.5%にみられるまれな疾患で, 耳鼻咽喉科領域での報告は認めない. 全身リンパ節腫脹, 肝脾腫, 皮疹, 貧血, 高ガンマグロブリン血症などを症状とする. 治療は多剤併用の化学療法が一般的であるが, 5年生存率20~50%と高悪性に分類されている.

著者

岸保 鉄也 霜村 真一 久松 健一 中澤 勉 中島 司 野沢 出 村上 嘉彦

出版者

日本耳科学会

雑誌

Otology Japan (ISSN:09172025)

巻号頁・発行日

vol.4, no.1, pp.90-94, 1994

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In middle ear diseases including otitis media with effusion (OME), there are various lipids mediators such as leukotoriene C<SUB>4</SUB>, D<SUB>4</SUB> (LTC<SUB>4</SUB>, LTD<SUB>4</SUB>) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) in the effusion of the tympanic cavity. Therefore, it is important to examine the effect of these mediators on middle ear clearance. We studied on the effect of LTC<SUB>4</SUB>, LTD<SUB>4</SUB> and PGE<SUB>2</SUB> on mucociliary transport of the eustachian tube both in vitro and in vivo. Healthy guinea pigs with normal Preyer's reflexes were used in vitro study. Normal ciliated epithelium was carefully obtained from the tubotympanium and incubated with RPMI solution in the from of tissue culture. The epithelial specimens were incubated with LTC<SUB>4</SUB>, LTD<SUB>4</SUB> and PGE<SUB>2</SUB> respectively, ranged at the concentrations of 10<SUP>-8</SUP>M and 10<SUP>-6</SUP>M. Ciliated cells of the specimens were observed under an inverted microscope. Ciliary activity of each ciliated cell was photo-electrically measured on a TV monitor. LTC<SUB>4</SUB> and LTD<SUB>4</SUB> inhibited ciliary activity at the concentrations of 10<SUP>-8</SUP>M and 10<SUP>-6</SUP>M in vitro. PGE<SUB>2</SUB> promoted ciliary activity at the concentrations of 10<SUP>-8</SUP>M and 10<SUP>-6</SUP>M. Healthy chinchillas were used in vivo study. The animals were free of middle ear infection and hearing loss as determined by otomicroscopy, tympanometry and auditory brainstem response (ABR). One ml each of 10<SUP>-5</SUP>M LTC<SUB>4</SUB>, LTD<SUB>4</SUB>, PGE<SUB>2</SUB> and the control solution (10<SUP>-3</SUP> ethanol/saline) was directly injected into the tympanic bulla with a 27-gauge syringe under anesthetization. The middle ears were examined by otomicroscopy, tympanometry and ABR across time. LTC<SUB>4</SUB> and LTD<SUB>4</SUB> inhibited mucociliary transport of the eustachian tube. However, there was no significant difference between PGE<SUB>2</SUB> and the control.

著者

野沢 出 中山 久代 霜村 真一 橋本 かおり 今村 俊一 久松 建一 村上 嘉彦

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.52, no.4, pp.577-583, 1993 (Released:2009-06-05)

参考文献数

22

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We carried out a questionnaire. survey on orthostatic dysregulation (abbreviated OD) in 63 young female subjects aged 18-19 years. Ten of them were judged to have confirmed OD, 8 had suspected OD, and the remaining 45 were regarded as normal. Schellong test results showed some difference in three items between the confirmed OD group and normal subjects, but the positive rate of the Schellong test in itself was not significantly different among these three groups. It was our impression that a more detailed analysis of this test is needed to increase its diagnostic validity in determining OD.The Cornell Medical Index-Health Questionnaire (abbreviated CMI) which was modified for the Japanese population with emotional disturbances by Fukamachi was given to these subjects to obtain information about their underlying psychological and emotional status. According to Fukamachi's classification Type III or IV patterns, suggestive of suspicious (III) or probable (IV) neurosis were found in 5 (11.1%) of the normal subjects, in 3 (30.3%) of the subjects with confirmed OD, and in 4 (50.0%) of those with suspected OD. These data suggest a correlation between OD and emotional and/or psychogenic disturbances.Subjects with OD and patients with vertigo or dizziness who visited our clinic were noted to have similar results on CMI. This does not, however, necessarily mean that some subjects with OD are abnormal or sick, since the CMI itself is intended only as an adjunct to, and not as a substitute for, medical interviews and physical examinations.