文献一覧: 村上嘉彦 (著者)

1 0 0 0 ロイコトリエンC4,D4及びプロスタグランジンE2の耳管粘液線毛輸送能に与える影響

著者: 岸保鉄也霜村真一久松健一中澤勉中島司野沢出村上嘉彦
出版者: 日本耳科学会
雑誌: Otology Japan (ISSN:09172025)
巻号頁・発行日: vol.4, no.1, pp.90-94, 1994

In middle ear diseases including otitis media with effusion (OME), there are various lipids mediators such as leukotoriene C4, D4 (LTC4, LTD4) and prostaglandin E2 (PGE2) in the effusion of the tympanic cavity. Therefore, it is important to examine the effect of these mediators on middle ear clearance. We studied on the effect of LTC4, LTD4 and PGE2 on mucociliary transport of the eustachian tube both in vitro and in vivo. Healthy guinea pigs with normal Preyer's reflexes were used in vitro study. Normal ciliated epithelium was carefully obtained from the tubotympanium and incubated with RPMI solution in the from of tissue culture. The epithelial specimens were incubated with LTC4, LTD4 and PGE2 respectively, ranged at the concentrations of 10-8M and 10-6M. Ciliated cells of the specimens were observed under an inverted microscope. Ciliary activity of each ciliated cell was photo-electrically measured on a TV monitor. LTC4 and LTD4 inhibited ciliary activity at the concentrations of 10-8M and 10-6M in vitro. PGE2 promoted ciliary activity at the concentrations of 10-8M and 10-6M. Healthy chinchillas were used in vivo study. The animals were free of middle ear infection and hearing loss as determined by otomicroscopy, tympanometry and auditory brainstem response (ABR). One ml each of 10-5M LTC4, LTD4, PGE2 and the control solution (10-3 ethanol/saline) was directly injected into the tympanic bulla with a 27-gauge syringe under anesthetization. The middle ears were examined by otomicroscopy, tympanometry and ABR across time. LTC4 and LTD4 inhibited mucociliary transport of the eustachian tube. However, there was no significant difference between PGE2 and the control.

2021-08-21 13:00:34
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1 0 0 0 OA 起立性調節障害へのメトリジン®の効果

著者: 中山久代今村俊一野沢出橋本かおり村上嘉彦
出版者: 耳鼻咽喉科臨床学会
雑誌: 耳鼻咽喉科臨床 (ISSN:00326313)
巻号頁・発行日: vol.89, no.11, pp.1407-1413, 1996-11-01 (Released:2011-11-04)
参考文献数: 15
被引用文献数: 1

The effectiveness of midodrine administration for the treatment of dizziness in patients with orthostatic dysregulation (OD) was investigated. Midodrine (4mg/day) was administered for 8 weeks to 42 patients with dizziness who were confirmed to have orthostatic dysregulation based on a questionnaire. The patients were subdivided into 3 groups on the basis of blood pressure and Schellong test results. Twenty patients had low systolic pressure, less than 100mmHg at rest in the supine position, twelve patients had orthostatic hypotension, and the other ten patients were diagnosed to have orthostatic dysregulation without low systolic pressure or orthostatic hypotension.The effects of the drug were evaluated objectively on the basis of improvement in the Schellong test results, and subjectively on the basis of the patient's perception of symptoms as described in the OD questionnaire results at 4 and 8 weeks after midodrine administration. In general, the symptoms tended to decrease after treatment in most of the patients. In patients with hypotension or orthostatic hypotension, in particular, excellent improvement was achieved. Improvement occurred not only in the patients symptoms, but also in low blood pressure at bed rest and Schellong test results. These observations suggest that administration of midodrine was efficacious in the treatment of dizziness in patients with orthostatic dysregulation as a probable consequence of poor cir culatory function due to autonomic imbalance.

2020-12-03 09:08:42
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1 0 0 0 OA KW-4679 (Olopatadine hydrochloride) の通年性アレルギー性鼻炎に対する臨床評価

著者: 奥田稔高坂知節三宅浩郷原田康夫石川哮犬山征夫間口四郎新川秀一池野敬一松原篤稲村直樹中林成一郎後藤了小野寺亮遠藤里見亀井民雄室井昌彦馬場廣太郎島田均舩坂宗太郎大橋伸也鄭正舟小澤実佳八木聰明大久保公裕後藤穣服部康夫上野則之柏戸泉大塚博邦山口潤佃守池間陽子坂井真新川敦小林良弘佐藤むつみ山崎充代藤井一省福里博寺田多恵小川裕加賀達美渡辺行雄中川肇島岳彦齋藤等森繁人村上嘉彦久松建一岩田重信井畑克朗坂倉康夫鵜飼幸太郎竹内万彦増田佐和子村上泰竹中洋松永喬上田隆志天津睦郎石田春彦生駒尚秋鈴木健男涌谷忠雄宮國泰明夜陣紘治森直樹田頭宣治宮脇浩紀青木正則小林優子高橋正紘沖中芳彦遠藤史郎池田卓生関谷透奥園達也進武幹前山忠嗣恒冨今日子増山敬祐浅井栄敏土生健二郎中崎孝志吹上忠祐角田憲昭渡辺隆野口聡隈上秀伯吉見龍一郎茂木五郎鈴木正志大橋和史
出版者: 耳鼻と臨床会
雑誌: 耳鼻と臨床 (ISSN:04477227)
巻号頁・発行日: vol.42, no.5, pp.633-658, 1996-09-20 (Released:2013-05-10)
参考文献数: 21

通年性アレルギー性鼻炎患者211例を対象に, KW-467910mg/日 (KW群) の有効性, 安全性および有用性をoxatomide 60mg/日 (OX群) を対照薬として多施設二重盲検群間比較試験により検討した.最終全般改善度の「改善」以上は, KW群61-6%, OX群57.6%で, 両群間に有意差は認められなかつたが, 同等性の検証を行った結果, KW群はOX群と比較して同等ないしそれ以上と考えられた. 概括安全度の「安全性に問題なし」と評価された症例は, KW群68.0%, OX群61.4%で, 両群間に有意差は認められなかった. 主な副作用症状は両群とも眠気であった. 有用度の「有用」以上は, KW群54.9%, OX群50.5%であり両群間に有意差はなかったが, KW群の方がやや有用率が高かった.以上の成績より, KW-4679は通年性アレルギー性鼻炎に対して, 臨床的に有用性の高い薬剤であると考えられた.

2019-02-28 18:27:48
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1 0 0 0 OA 若年女性における起立性調節障害の検討

著者: 野沢出中山久代霜村真一橋本かおり今村俊一久松建一村上嘉彦
出版者: 一般社団法人日本めまい平衡医学会
雑誌: Equilibrium Research (ISSN:03855716)
巻号頁・発行日: vol.52, no.4, pp.577-583, 1993 (Released:2009-06-05)
参考文献数: 22

We carried out a questionnaire. survey on orthostatic dysregulation (abbreviated OD) in 63 young female subjects aged 18-19 years. Ten of them were judged to have confirmed OD, 8 had suspected OD, and the remaining 45 were regarded as normal. Schellong test results showed some difference in three items between the confirmed OD group and normal subjects, but the positive rate of the Schellong test in itself was not significantly different among these three groups. It was our impression that a more detailed analysis of this test is needed to increase its diagnostic validity in determining OD.The Cornell Medical Index-Health Questionnaire (abbreviated CMI) which was modified for the Japanese population with emotional disturbances by Fukamachi was given to these subjects to obtain information about their underlying psychological and emotional status. According to Fukamachi's classification Type III or IV patterns, suggestive of suspicious (III) or probable (IV) neurosis were found in 5 (11.1%) of the normal subjects, in 3 (30.3%) of the subjects with confirmed OD, and in 4 (50.0%) of those with suspected OD. These data suggest a correlation between OD and emotional and/or psychogenic disturbances.Subjects with OD and patients with vertigo or dizziness who visited our clinic were noted to have similar results on CMI. This does not, however, necessarily mean that some subjects with OD are abnormal or sick, since the CMI itself is intended only as an adjunct to, and not as a substitute for, medical interviews and physical examinations.

2018-02-02 17:34:06
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