著者

三輪 芳弘 山路 昭 中浜 肇 折田 義正 福原 吉典 鎌田 武信 石橋 道男 市川 靖二 高原 史郎 園田 孝夫

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.108, no.11, pp.1087-1092, 1988-11-25 (Released:2008-05-30)

参考文献数

15

被引用文献数

1 1

---

A method of high performance liquid chromatography for the determination of unchanged furosemide and its metabolites in the plasma and urine of human subjects is reported. A reversed phase Hibar Lichrosorb RP-8 column was applied to the present method. Furosemide from samples was extracted with diethylether. Beta-glucronidate of furosemide was determined after the addition of beta-glucronidase. 4-Chloro-5-sulfamoyl-anthranilic acid (CSA) was determined by the supernatant obtained from ten minutes centrifugation of the urine with ethanol. In the plasma and urine concentrations of unchanged furosemide of healthy volunteers, there were recognized differences among individuals. In patients with chronic renal failure, urine concentration of beta-glucronidate of furosemide increased in response to impairment of creatinine clearance. CSA could be detected only in the urine of patients receiving renal transplantation under a large dose administration of furosemide (above 200mg/d during rejection). And CSA does not seem to be an artifact product by the procedures of extraction. No interference could be observed by the drugs co-administered with furosemide. The present method can be utilized for a routine drug monitoring system of furosemide. Mechanism of formation of metabolites of furosemide should be further studied.

著者

岡 一雅 星田 義彦 吉村 英雄 内藤 賢郎 川嶋 真由美 高原 史郎 中塚 伸一 冨田 裕彦 青笹 克之

出版者

特定非営利活動法人日本臨床細胞学会

雑誌

週刊文春 (ISSN:03871193)

巻号頁・発行日

vol.45, no.27, 2003-07-10

著者

瀬戸 加奈子 松本 邦愛 高橋 絹代 藤田 民夫 高原 史郎 相川 厚 篠崎 尚史 長谷川 友紀

出版者

一般社団法人 日本移植学会

雑誌

移植 (ISSN:05787947)

巻号頁・発行日

vol.52, no.4-5, pp.346-351, 2017-09-30 (Released:2017-11-24)

参考文献数

10

---

Although public opinion polls reported that over 40% of Japanese people want to donate their organs at death, the number of organs remains low (=< 1 donor/million population). This low donation rate is supposed to be due to the lack of an in-hospital system to confirm patient desires to donate organs to patients at hospitals. The purpose of this study is to develop and evaluate the educational program to improve the quality of terminal care at acute care hospitals in the form of a QM (quality management) seminar at emergency departments, focusing on management methods and quality management to facilitate and establish an in-hospital system. From 2013 to 2015, there were 94 participants. Pre- and post-program test showed that the improvement rate was 15.9% for transplantation medical care, 6.9% for skills, and 10.5% for the management method. By the educational method, the improvement rate was 10.1% for lecture and 10.2% for group-work exercise (+ lecture). Compared with doctors, nurses had a lower improvement rate in the domain of management methods. A questionnaire survey showed that the participants evaluated that management method was difficult and their understanding level was low, but they highly recommended participation. To improve the quality terminal care, the role of nurses is important because they are the major players in patient care, and revision to improve the educational program is necessary to provide outcomes similar to those doctors produce. Other supporting methods, such as the provision of educational tools and sharing success cases, should be considered to facilitate in-hospital system development.

著者

小角 幸人 江 宏思 ムタバリクアプデルハキム 高野 右嗣 亀岡 博 高原 史郎 石橋 道男 奥山 明彦

出版者

社団法人日本泌尿器科学会

雑誌

日本泌尿器科學會雜誌 (ISSN:00215287)

巻号頁・発行日

vol.84, no.1, pp.158-159, 1993-01-20

著者

松本 充弘 難波 行臣 矢澤 浩治 市丸 直嗣 宮川 康 高原 史郎 奥山 明彦 金 眞理子 児島 康行 小角 幸人 京 昌弘

出版者

社団法人日本泌尿器科学会

雑誌

日本泌尿器科學會雜誌 (ISSN:00215287)

巻号頁・発行日

vol.94, no.7, pp.685-688, 2003-11-20

---

症例は29歳女性,血液型はO型Rh(+).2000年にB型Rh(+)の父親をドナーとしてABO不適合移植術を受けた.移植後血清クレアチニン(s-Cr)値は1.1〜1.2mg/dlまで改善し第53病日に退院した.しかし,第460病日頃より徐々に腎機能悪化を認めたため,第520病日に腎生検術を施行し「間質性腎炎を伴う慢性移植腎症」と診断した.その後,免疫抑制療法を強化するも腎機能の改善は得られず,第630病日に再度腎生検を施行した.光顕所見では,同質性腎炎と腫大した尿細管上皮細胞を認めたため,BKウイルス腎症を疑った.抗SV40抗体による免疫染色およびPCR法によるBKウイルス血症を確認し,「BKウイルス腎症」と確定診断した.腎移植後,拒絶反応治療に抵抗性を示す症例に対しては,BKウイルス腎症の検索を行う必要がある.