著者

Tae Woo Yoo Ki Chul Sung Hun Sub Shin Byung Jin Kim Bum Soo Kim Jin Ho Kang Man Ho Lee Jung Ro Park Hyang Kim Eun Jung Rhee Won Young Lee Sun Woo Kim Seung Ho Ryu Dong Geuk Keum

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.69, no.8, pp.928-933, 2005 (Released:2005-07-25)

参考文献数

29

被引用文献数

215 267

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Background Associations between hyperuricemia, cardiovascular diseases and diabetes have been reported, but few of the studies have been conducted in the Korean population. The present study examined a Korean adult population with respect to the relationships between serum uric acid concentrations and hypertension, insulin resistance, and the risk factors of metabolic syndrome. Methods and Results A total of 53,477 subjects were divided into 4 groups according to serum uric acid quartiles. The incidence of hypertension in all subjects was higher in the first quartile than in the third plus fourth quartile (odds ratio (OR) 1.192, p<0.001). Homeostasis model assessment index was found to be associated with serum uric acid concentration in all subjects (OR 1.193, p<0.001), and the serum uric acid concentration was positively correlated with the risk factors of metabolic syndrome. In addition, the number of metabolic syndrome variables increased as serum uric acid concentration increased. Conclusions Serum uric acid concentration was found to be independently correlated with hypertension, insulin resistance and the risk factors of metabolic syndrome. In addition, even those with a serum uric acid concentration in the normal range showed an increased risk of metabolic syndrome as serum uric acid concentration increased. (Circ J 2005; 69: 928 -933)

著者

Yeong-Deok Choi Jung-Ho Lee

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.11, pp.3084-3087, 2016 (Released:2016-11-29)

参考文献数

12

被引用文献数

12

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[Purpose] The purpose of this study was to investigate the impact on the edema and pain when applying transcutaneous electrical nerve stimulation. [Subjects and Methods] Eleven patients who were diagnosed with lymphedema were selected as the subjects of the study. The experimental group received transcutaneous electrical nerve stimulation treatment on edema regions three times per week for four weeks. Surface tape measurement was used to measure changes in lower extremity edema. Pain intensity was measured using the visual analog scale. [Results] The edema decrements in the experimental group were significantly larger than those in the control group. The pain decrements in the experimental group were significantly larger than those in the control group. [Conclusion] In conclusion, application of transcutaneous electrical nerve stimulation was confirmed to be effective in reducing edema and pain.

著者

Yong-Kyu Choi Young-Han Park Jung-Ho Lee

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.4, pp.1166-1169, 2016 (Released:2016-04-28)

参考文献数

17

被引用文献数

9

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[Purpose] The aim of this study was to evaluate the overlap effect of the PNF following the application of Kinesio taping and the McConnell taping, and also the impact of the taping application method on the balance and walking speed of the patients with stroke. [Subjects and Methods] Thirty-six patients who were diagnosed with hemiplegia due to stroke were selected as subjects of this study. They were randomly and evenly divided into experiment group 1 (Kinesio taping group), experiment group 2 (McConnell taping group), and the control group; each group had 12 patients. [Results] The Berg balance scale (BBS) was used to evaluate balance, and the ability in this study. A 10 m walking test (10MWT) was performed to measure the walking speed. Experiment group 1 showed a statistically significant improvement in balance and walking speed compared to experiment group 2, and the control group in week 4 and week 8. [Conclusion] Application of Kinesio taping had a more beneficial effect on the balance and walking speed than joint-fixation taping of the patients with stroke.

著者

Junho Chae Jun-Gi Lee Jun-Ho Lee Sam-Kyu Kim

出版者

Arachnological Society of Japan

雑誌

Acta Arachnologica (ISSN:00015202)

巻号頁・発行日

vol.72, no.1, pp.29-37, 2023-06-20 (Released:2023-07-01)

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A poorly known nursery web spider species, Dolomedes nigrimaculatus (Araneae: Pisauridae), is redescribed on the basis of Korean specimens, with a new junior synonym, Dolomedes jirisanensis which has been treated wrongly as a nomen nudum. Dolomedes nigrimaculatus is considered a sister species of D. zatsun from Okinawa Island, Japan, which have several morphological characteristics in common. Detailed description and remarks on the synonymy and intraspecific variation in its body coloration and shape of copulatory organs of D. nigrimaculatus are provided, with a key to all Korean Dolomedes species.

著者

Ho Lee Tatsuya Suzuki Yohei Okada Hiromu Tanaka Satoshi Okamori Hirofumi Kamata Makoto Ishii Masahiro Jinzaki Koichi Fukunaga

出版者

The Keio Journal of Medicine

雑誌

The Keio Journal of Medicine (ISSN:00229717)

巻号頁・発行日

pp.2021-0012-OA, (Released:2021-11-11)

参考文献数

23

被引用文献数

2

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Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in December 2019 as an outbreak of pneumonia of unknown origin. Previous studies have suggested the utility of chest computed tomography (CT) in the diagnosis of COVID-19 because of its high sensitivity (93%–97%), relatively simple procedure, and rapid test results. This study, performed in Japan early in the epidemic when COVID-19 prevalence was low, evaluated the diagnostic accuracy of chest CT in a population presenting with lung diseases having CT findings similar to those of COVID-19. We retrospectively included all consecutive patients (≥18 years old) presenting to the outpatient department of Keio University Hospital between March 1 and May 31, 2020, with fever and respiratory symptoms. We evaluated the performance of diagnostic CT for COVID-19 by using polymerase chain reaction (PCR) results as the reference standard. We determined the numbers of false-positive (FP) results and assessed the clinical utility using decision curve analysis. Of the 175 patients, 22 were PCR-positive. CT had a sensitivity of 68% and a specificity of 57%. Patients with FP results on CT diagnosis were mainly diagnosed with diseases mimicking COVID-19, e.g., interstitial lung disease. Decision curve analysis indicated that the clinical utility of CT imaging was limited. The diagnostic performance of CT for COVID-19 was inadequate in an area with low COVID-19 prevalence and a high prevalence of other lung diseases with chest CT findings similar to those of COVID-19. Considering this insufficient diagnostic performance, CT findings should be evaluated in the context of additional medical information to diagnose COVID-19.

著者

Jung-Ho Lee Soo-Jin Park Sang-Su Na

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.25, no.6, pp.713-716, 2013-06-25 (Released:2013-07-23)

参考文献数

23

被引用文献数

18 26

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[Purpose] The present study examined the effects of treatment using PNF extension techniques on the pain, pressure pain, and neck and shoulder functions of the upper trapezius muscles of myofascial pain syndrome (MPS) patients. [Subjects] Thirty-two patients with MPS in the upper trapezius muscle were divided into two groups: a PNF group (n=16), and a control group (n=16) [Methods] The PNF group received upper trapezius muscle relaxation therapy and shoulder joint stabilizing exercises. Subjects in the control group received only the general physical therapies for the upper trapezius muscles. Subjects were measured for pain on a visual analog scale (VAS), pressure pain threshold (PPT), the neck disability index (NDI), and the Constant-Murley scale (CMS). [Results] None of the VAS, PPT, and NDI results showed significant differences between the groups, while performing postures, internal rotation, and external rotation among the CMS items showed significant differences between the groups. [Conclusion] Exercise programs that apply PNF techniques can be said to be effective at improving the function of MPS patients.

著者

Young-Han Park Jung-Ho Lee

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.9, pp.1680-1683, 2017 (Released:2017-09-15)

参考文献数

18

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[Purpose] The purpose of this study was to investigate the effects of interferential current therapy on the waist circumference and visceral fat length in obese women. [Subjects and Methods] In this study, we selected 30 patients whose body mass index was over 25 kg/m2. The subjects were randomly assigned to receive interferential current therapy three times a week for four weeks (n=15) and transcutaneous electrical nerve stimulation three times a week for four weeks (n=15). Waist circumference was measured in cm using a tape measure with the participant in an upright posture, and the length of visceral fat was measured using a high-resolution, B-mode ultrasound machine. [Results] There was a statistically significant difference between the group of waist circumference and visceral fat length. The change of waist circumference and visceral fat length was larger the experimental group than the control group. [Conclusion] These results can be used as a basis for reducing the risk factors that increase mortality due to diseases and can prevent cardiovascular and other adult diseases caused by obesity.

著者

Tien-Yu Chen Wen-Jung Chung Chien-Ho Lee Po-Jui Wu Shu-Kai Hsueh Tzu-Hsien Tsai Chien-Jen Chen Chiung-Jen Wu Cheng-I Cheng

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.18-377, (Released:2019-04-25)

参考文献数

19

被引用文献数

1

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We investigated the accuracy of various bleeding risk scores to estimate the bleeding risk in patients with acute myocardial infarction (AMI) managed with percutaneous coronary intervention (PCI) access via the radial artery.We retrospectively enrolled 1,651 patients who were definitively diagnosed with ST-elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI). We assessed the predictive validities of 30-day bleeding events in various scoring systems using receiver operating characteristic curves.Overall, ACUITY-HORIZONS exhibited the highest area under the curve to predict 30-day bleeding, followed by ACTION and CRUSADE; HAS-BLED displayed the lowest score. With a cut-off of 17, ACUITY-HORIZONS demonstrated the best discrimination for the Thrombolysis in Myocardial Infarction (TIMI) 30-day serious bleeding rate. We observed significant differences among all-cause death, cardiovascular death, and major adverse cardiac events between the ACUITY-HORIZONS groups with a score of ≤ 17 and > 17. ACUITY-HORIZONS score > 17, initial systolic blood pressure (SBP) < 90 mmHg, and Killip III and IV upon admission positively predicted the 30-day bleeding risk, whereas myocardial infarction (MI) and TIMI major bleeding within 30 days, heart failure at admission, and initial SBP < 90 mmHg positively predicted the 30-day mortality.Comparatively, ACUITY-HORIZON is the most reliable system in predicting 30-day bleeding for patients with AMI via transradial PCI. In the transradial scenario, bleeding and MI within 30 days are substantially related to 30-day mortality.

著者

Hyukchan Kwon Kiwoong Kim Yong-Ho Lee Jin-Mok Kim Kwon Kyu Yu Namsik Chung Young-Guk Ko

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.74, no.7, pp.1424-1430, 2010 (Released:2010-06-25)

参考文献数

25

被引用文献数

14 26

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Background: Accurate identification of patients with acute coronary syndrome (ACS) is often difficult especially when an electrocardiogram (ECG) does not show typical elevation of ST segment. The aim of the present study was therefore to evaluate the efficacy of magnetocardiography (MCG) for diagnosis of ACS in patients with acute chest pain presenting without ST segment elevation. Methods and Results: In the present retrospective study 364 patients with the suspected ACS without ST segment elevation were selected. Significant coronary artery disease (CAD) was defined as a stenosis ≥50% in at least one of 16 segments of the 3 major coronary arteries and their branches. The MCG recordings were obtained at resting state using a 64-channel MCG system in a magnetically shielded room. The patients were classified on the basis of the probability distribution. The presence of significant CAD was identified with a sensitivity of 84.0% and a specificity of 85.0%, compared to 44.7% and 89.8% on ECG. In the subgroup of patients without specific findings on ECG or biomarker test, MCG had a sensitivity of 73.5% and a specificity of 82.3%. Conclusions: MCG was acceptably sensitive and specific in identifying patients with ACS even in the absence of specific findings on ECG and positive biomarker tests. Thus, MCG seems beneficial for the early triage of patients with acute chest pain.  (Circ J 2010; 74: 1424 - 1430)

著者

Jung-Ho Lee Eun-Yeong Han

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.25, no.3, pp.341-344, 2013-03-25 (Released:2013-05-10)

参考文献数

18

被引用文献数

3 15

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[Purpose] The study aims to examines the effects of proprioceptive neuromuscular facilitation (PNF), extracorporeal shockwave therapy (ESWT), and trigger point injection (TPI) on pain reduction and functional improvement in patients with Myofascial pain syndrome (MPS) of the upper trapezius muscle and compares their treatment effects, thereby presenting precise and efficient treatment methods. [Subjects] Thirty-three patients with MPS in the upper trapezius muscle were divided into three groups: a PNF group (n=11), ESWT group (n=11), and a TPI group (n=11). [Methods] The degree of pain was measured using the visual analog scale (VAS). Pressure pain threshold (PPT) was measured at trigger points in the upper trapezius muscle by using a pressure algometer, and the Constant-Murley scale (CMS) and neck disability index (NDI) was applied for functional evaluation. [Results] A comparison of the effects of the different treatment methods revealed no significant differences among the groups in terms of PPT, but CMS (pain, range, and activities of daily living) and NDI showed significant differences among groups. [Conclusion] PNF treatment enhanced neck function, range of motion in the shoulder joint, and activities of daily living relative to the other methods; ESWT reduced degree of pain and improved functioning. TPI treatment reduced pain, but had limited effects in enhancing functional activities.

著者

Young-Shin Cho Soo-Jin Park Sang-Hun Jang Young-Chul Choi Jung-Ho Lee Jin-Sang Kim

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.24, no.12, pp.1319-1323, 2012 (Released:2013-01-17)

参考文献数

18

被引用文献数

7 30

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[Purpose] In order to develop a more effective treatment method for pain and function in myofascial pain syndrome, we examined the effects of ESWT, stability exercises, and combined treatment. [Subjects] The subjects were randomly divided into a stabilization exercise group (n=12), an ESWT (Extracorporeal Shock Wave Therapy) group (n=12), and a combined treatment group (n=12). [Methods] The stabilization exercise group performed shoulder joint stabilization exercises. The ESWT group received ESWT for the upper trapezius. The combined treatment group received a combined treatment of shoulder joint stabilization exercises and ESWT. Pain and function were measured using the visual analog scale (VAS), pressure pain threshold (PPT), neck disability index (NDI), and the Constant Murley Scale (CMS). [Results] The VAS Score showed statistically significant improvements in all of the groups. All of the CMS evaluation items except muscle strength in the stabilization exercise group, and all of the CMS items in the ESWT group and the combined treatment group, exhibited statistically significant improvements. The combined treatment group of ESWT and stabilization exercises showed statistically significant improvements in all VAS of CMS evaluation items, and the NDI test after the four-week intervention. [Conclusion] The combined treatment was more effective at reducing pain than ESWT, and stabilization exercise would be useful for physical therapists treating myofascial pain syndrome in a clinical setting.

著者

Chang Hee Kwon Sung Ho Lee Jong-Young Lee Seungho Ryu Ki-Chul Sung

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0748, (Released:2018-09-19)

参考文献数

44

被引用文献数

14

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Background: Increased serum uric acid is associated with prevalence and incidence of atrial fibrillation (AF), but there is a lack of studies on the association between serum uric acid and risk of AF in the general population. Methods and Results: We used the data from the Kangbuk Samsung Hospital health screening cohort recorded between 2002 and 2015. The primary outcome was incidence of AF diagnosed on 12-lead electrocardiography. We analyzed and compared the hazard ratios (HR) according to baseline serum uric acid quartiles. The present study involved 282,473 subjects without baseline AF. Mean follow-up was 5.4±3.6 years. During follow-up, AF was identified in 365 subjects (cumulative incidence, 0.13%). After multivariable adjustment, including that for C-reactive protein, the risk of AF was significantly higher in the upper 2 quartiles than in the lowest quartile in men (upper third quartile: adjusted HR, 1.53; 95% confidence interval [CI]: 1.11–2.89; highest quartile: HR, 1.60; 95% CI: 1.13–2.25). In women, even though AF incidence rate was very low (0.6 of 10,000 person-years), the risk of AF in the highest quartile was 6.93-fold that in the lowest quartile (95% CI: 1.53–31.29). Conclusions: Serum uric acid is significantly and positively associated with incident AF in the Korean general population.

著者

Doo-Ho Lee Ji-Su Park Seung-Woong Lee Jong-Bae Choi

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.3, pp.556-557, 2017 (Released:2017-03-22)

参考文献数

7

被引用文献数

2

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[Purpose] The purpose of the present study was to investigate the effects of dysphagia therapy in an old man with difficulty swallowing in the oral and pharyngeal phases. [Subjects and Methods] The subject was a 72-year-old man with no history of neurological disorders. He was admitted to local hospital because of the complaint of swallowing difficulty. The interventions performed were electrical stimulation and conventional dysphagia therapy. We assessed the tongue and lip muscle strengths. Swallowing function was evaluated by using the videofluoroscopic dysphagia and penetration-aspiration scales. [Results] After the intervention, the tongue and lip muscle strengths increased from 35 to 39 kPa and from 18 to 23 kPa, respectively. Moreover, the oral and pharyngeal phases of the videofluoroscopic dysphagia scale were improved. Furthermore, aspiration decreased from 4 to 2 points in the penetration-aspiration scale. [Conclusion] Our results suggest that electrical stimulation and conventional dysphagia therapy were effective in improving the swallowing function in an elderly individual with dysphagia.

著者

Ho LEE Bongseok YOO Kibaek JANG Youngsoo KIM Wooksu LEE

出版者

Eastern Asia Society for Transportation Studies

雑誌

Journal of the Eastern Asia Society for Transportation Studies (ISSN:18811124)

巻号頁・発行日

vol.11, pp.2519-2527, 2015 (Released:2015-12-26)

参考文献数

10

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The necessity of shifting the policy focus from supply-side initiatives such as physical-capacity expansion to demand-side initiatives including ease of congestion is newly rising as a compelling method of improving the general ride quality of the metro users. In an effort to catch up with such shifting trend, a system schematic that will update the congestion status of the metro lines via mobile devices is suggested through this study, along with the development of a smartphone application to realize this service idea. The developed smartphone application allows the metro passengers to identify the congested area of each station platform and to receive information on the congestion level of each train and car. Through such assistance, the metro congestion information system can improve the overall convenience of the metro passengers by helping them identify the congestion level across the metro lines.

著者

李 忠澔 Chung-Ho LEE

出版者

総合研究大学院大学文化科学研究科

雑誌

総研大文化科学研究 = Sokendai review of cultural and social studies (ISSN:1883096X)

巻号頁・発行日

no.8, pp.27-42, 2012-03-30

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『太平記』に登場する正成は、智仁勇の三徳を兼備した武将で、天皇のために命を捧げた英雄として広く知られているが、近世期以降はその教訓的な側面が正成伝説の普及を支える肝要な要素となっていく。 『太平記』において正行の母は、父正成の戦死を悲しみ自ら命を絶とうとする正行を諌め、正成の遺訓の意味を再度教え諭す。このエピソードが端緒となり、その後正成の妻は良妻賢母として顕彰されていくことになる。 一方、近世前期に流行した「太平記読み」のテクストであった『理尽鈔』は、兵学中心の合戦談という性格から、正成の妻が正行に父の遺訓を教え諭す場面を省略し、その代わりに正成の首をめぐって足利直義と楠家の家臣間で繰り広げられた駆け引きに関するエピソードを挿入している。これは、合戦談の中では女性の存在が副次的にしか認識されないことから、『太平記』における正成の妻の情緒性豊かな描写が省略された結果と見られる。 このような『理尽鈔』における扱いとは別に、正成の妻は近世の早い時期から啓蒙目的の女訓書に登場している。仮名草子女訓書『本朝女鑑』では、『太平記』原典の正成の妻に関するエピソードが簡略な形で引かれており教訓を主眼とする女訓書の性質に即して、母として息子の誤りを戒める内容が中心になっている。 さらに、時代浄瑠璃においてはそれ以前とはやや異なる正成の妻のイメージが形成される。近松門左衛門の『吉野都女楠』において、正成の妻「菊水」は従来と同様に夫の遺志を継ぎ、息子を訓戒する良妻賢母として登場するが、その上に大力という性質をも兼ね備えた逞しい女性として描かれる。ここでは、男性のために自己を犠牲にする時代浄瑠璃の典型的な女性とは異なる、戦乱という苦難を生き抜く強い女性像が正成の妻に付与されていると言える。 一方、西沢一風・田中千柳の『南北軍問答』においては新しい趣向が設定され、正成の妻は女色に溺れる正行を訓戒する。正行の誤った行動を戒めるという点では、『太平記』と軌を一にするものの、正行が好色者として描かれる点に加えて、「泣男」杉本佐兵衛が正成の妻に代わって訓戒の内容を伝えるという点が新しい構想となっている。 このように、正成の妻は『太平記』から時代浄瑠璃に至るまで、良妻賢母としてのイメージを保ちながらも、その上に新たな趣向を取り入れつつ受容されていくことになる。

著者

Ji-Young Kim Tae-Heon Oh Byeong Jin Kim Sang-Suk Kim Nam Ho Lee Chang-Gu Hyun

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.57, no.11, pp.623-628, 2008 (Released:2008-10-04)

参考文献数

20

被引用文献数

10 35

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In this study, the chemical composition and anti-inflammatory activities of hydrodistilled essential oil from Farfugium japonicum were investigated for the first time. The chemical constituents of the essential oil were further analyzed by GC-MS and included 1-undecene (22.43%), 1-nonene (19.83%), β-caryophyllene (12.26%), α-copaene (3.70%), γ-curcumene (2.86%), germacrene D (2.69%), and 1-decene (2.08%). The effects of the essential oil on nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. The results indicate that the F. japonicum essential oil is an effective inhibitor of LPS-induced NO and PGE2 production in RAW 264.7 cells. These inhibitory effects of the F. japonicum essential oil were accompanied by dose-dependent decreases in the iNOS and COX-2 mRNA expression. In order to determine whether F. japonicum essential oil can safely be applied to human skin, the cytotoxic effects of F. japonicum essential oil were determined by colorimetric MTT assays in human dermal fibroblast and keratinocyte HaCaT cells. F. japonicum essential oil exhibited low cytotoxicity at 100 μg/mL. Based on these results, we suggest that F. japonicum essential oil may be considered a potential anti-inflammatory candidate for topical application.

著者

JI-SOOK HWANG KYUNG-SIK SONG WON-OON KIM TAE-HO LEE HIROYUKI KOSHINO ICK-DONG YOO

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.50, no.9, pp.773-777, 1997-09-25 (Released:2006-11-25)

参考文献数

22

被引用文献数

21 35

著者

Quan Feng Liu Jang Ho Lee Young-Mi Kim Soojin Lee Yoon Ki Hong Soojin Hwang Youngje Oh Kyungho Lee Hye Sup Yun Im-Soon Lee Songhee Jeon Young-Won Chin Byung-Soo Koo Kyoung Sang Cho

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

pp.b15-00459, (Released:2015-10-10)

参考文献数

58

被引用文献数

3 37

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder, characterized by progressive neuronal loss with amyloid β-peptide (Aβ) plaques. Despite several drugs currently used to treat AD, their beneficial effects on AD progress remains under debate. Here, we established a rapid in vivo screening system using Drosophila AD models to assess the neuroprotective activities of medicinal plants that have been used in traditional Chinese medicine. Among 23 medicinal plants tested, the extracts from five plants, Coriandrum sativum, Nardostachys jatamansi, Polygonum multiflorum (P. multiflorum), Rehmannia glutinosa, and Sorbus commixta (S. commixta), showed protective effects against the Aβ42 neurotoxicity. We further characterized the neuroprotective activity of ethanol extracts from P. multiflorum and S. commixta. Aβ42-expressing flies that we used showed AD neurological phenotypes, such as decreased survival and motility and increased cell death and reactive oxygen species level. However, feeding these flies extracts from P. multiflorum or S. commixta showed strong suppression of such phenotypes. Similar results were observed in human cells, so that the treatment of P. multiflorum and S. commixta extracts increased the viability of Aβ-treated SH-SY5Y cells. Moreover, 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside, one of the main constituents of P. multiflorum, also showed similar protective activity against Aβ42 cytotoxicity in both Drosophila and human cells. Taken together, our results suggest that both P. multiflorum and S. commixta have therapeutic potential for the treatment of neurodegenerative diseases, such as AD.

著者

Kyung-Ah Jung Tae-Chul Song Daeseok Han In-Ho Kim Young-Eon Kim Chang-Ho Lee

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.28, no.9, pp.1782-1785, 2005 (Released:2005-09-01)

参考文献数

27

被引用文献数

43 88

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It is currently accepted that the consumption of fruit-derived antioxidants such as vitamin C, carotenoids, and flavonoids provides a preventive effect against cardiovascular disease. The purpose of the present study was to investigate potential cardiovascular protective properties of aqueous and 70% ethanol extracts from kiwifruit by analyzing the antioxidative, antihypertensive, hypocholesterolemic, and fibrinolytic activities in vitro. Aqueous and 70% ethanol extracts at 50 mg/ml showed DPPH-radical scavenging activities of 72.31% and 70.75%, respectively. Total antioxidant activity in linoleic acid emulsion was 85—88% at 10 mg/ml and 96—98% at 50 mg/ml of kiwifruit extract. Inhibitory activities against angiogensin I-converting enzyme of kiwifruit extracts were 21—26% at 10 mg/ml and 46—49% at 50 mg/ml, and inhibitory activities on HMG-CoA reductase were 13—14% at 10 mg/ml and 19—30% at 50 mg/ml. Fibrinolytic activity of kiwifruit was also observed at a high concentration of 100 mg/ml in both aqueous and 70% EtOH extracts. Based on our results, kiwifruit have potential cardiovascular protective properties in vitro.

著者

Youn-Bum Sung Jung-Ho Lee Young-Han Park

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.11, pp.1711-1714, 2014 (Released:2014-11-13)

参考文献数

18

被引用文献数

2 20

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[Purpose] The aim of this study was to evaluate the changes in function and mental state after thoracic mobilization and manipulation in patients with chronic lower back pain (LBP). [Subjects and Methods] Thirty-six subjects were randomly divided into mobilization group (group A), manipulation group (group B) and control group (group C). The Oswestry disability index (ODI) was used to measure the functional impairment of patients with LBP. A multiple spinal diagnosis was used to measure the range of motion (ROM) of vertebra segments. The Fear-avoidance beliefs questionnaire (FABQ) was used to investigate the mental state of LBP patients. [Results] Group A and group B were significantly different from group C in terms of the ODI. Between groups, there was no difference in ROM during trunk flexion. Group A and group B were also significantly different from the control group in extension ROM. The FABQ of group B was significantly different from that of group A. [Conclusion] Application of mobilization or manipulation to thoracic lumbar vertebrae has a positive effect on function, mental state, and ROM in patients with lower back pain.