著者

渡邉 一弘 ワタナベ カズヒロ Kazuhiro WATANABE

出版者

総合研究大学院大学

巻号頁・発行日

2014-03-20

著者

Kazuhiro WATANABE Kotaro IMAMURA Akiomi INOUE Yasumasa OTSUKA Akihito SHIMAZU Hisashi EGUCHI Hidehiko ADACHI Asuka SAKURAYA Yuka KOBAYASHI Hideaki ARIMA Norito KAWAKAMI

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.58, no.2, pp.107-131, 2020 (Released:2020-04-02)

参考文献数

58

被引用文献数

5 9

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Although the eudemonic perspective seems to be a promising in considering vocational identity among working population, well-being at work has been discussed primarily in terms of subjective/hedonic well-being. This study aimed to develop a new tool to measure eudemonic well-being at work (The University of Tokyo Occupational Mental Health [TOMH] well-being 24 scale)and investigate its validity in a collectivist culture. Two online surveys were conducted with a total of 1,760 workers in Japan. We created 89 potential items from existing scales. An exploratory factor analysis indicated eight factors for the dimensions of measurement. After item selection based on item response theory, the factor structure with three items from each of the eight dimensions indicated an excellent fit for another sample. Cronbach’s α and intra-class coefficients ranged from 0.671 to 0.845. The scores of the tool were more strongly associated with subjective well-being in the work context rather than well-being in general. In addition, the participants in the group demonstrating a higher risk for mental illness and a more stressful work environment indicated significantly lower scores, even after adjusting for general eudemonic well-being. The new measurement may be useful both for academic and practical applications for measuring eudemonic well-being at work, independent from general eudemonic well-being.

著者

Kazuhiro WATANABE Syun TAHARA Hiroyuki KOYAMA Mamu SHIMIZU Mifumi KAWABE Shingo MIYAWAKI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.84, no.1, pp.64-68, 2022 (Released:2022-01-07)

参考文献数

27

被引用文献数

1

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The standard procedure to treat oronasal fistula in dogs requires tooth extraction to close the fistula; hence, the subject would lose its tooth. In this study, trafermin was applied to four dog models with oronasal fistula to investigate the periodontal tissue regenerative effects of trafermin in the treatment without tooth extraction. A fistula was created along the palatal side of each upper canine tooth. One of the fistulae was filled with trafermin, whereas that on the contralateral side was left unfilled as a control. The results showed a significant decrease in the non-calcified periodontal tissue volume on the trafermin side after the fourth week. In addition, oronasal fistula closure was visually and histologically confirmed at the eighth week on the trafermin side of all four models.

著者

Kotaro Imamura Yumi Asai Kazuhiro Watanabe Akizumi Tsutsumi Akihito Shimazu Akiomi Inoue Hisanori Hiro Yuko Odagiri Toru Yoshikawa Etsuko Yoshikawa Norito Kawakami

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.60, no.4, pp.298-306, 2018-07-20 (Released:2018-07-25)

参考文献数

29

被引用文献数

16

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Objectives: This retrospective cohort study evaluated the impact of the Stress Check Program, a recently introduced national policy and program aimed at reducing psychological distress among Japanese workers. Methods: A baseline survey was conducted from November 2015 to February 2016, the period when Japan began enforcing the Stress Check Program. A one-year follow-up survey was conducted in December 2016. In the follow-up survey, two exposure variables were collected: having taken the annual stress survey, and experiencing an improvement in the psychosocial work environment. Psychological distress was assessed using the Brief Job Stress Questionnaire (BJSQ) at baseline and 1-year follow-up. The two exposure variables were used to define four groups: "Neither", "Stress survey (SS) only", "Psychosocial work environment improvement (WI) only", and "Both". BJSQ results were analyzed using repeated measures general linear modeling (GLM). Results: The study included 2,492 participants: 1,342 in the "Neither" group, 1,009 in the "SS only" group, 76 in the "WI only" group, and 65 in the "Both" group. Overall time-group interaction effects were not significant. The "Both" group showed significantly greater improvements in psychological distress than the "Neither" group (p = 0.02) at the 1-year follow-up, although the effect size was small (d = -0.14). Conclusions: Combination of the annual stress survey and improvement in psychosocial work environment may have been effective in reducing psychological distress in workers, although the effect size was small.

著者

Akihito SHIMAZU Ko MATSUDAIRA Jan DE JONGE Naoya TOSAKA Kazuhiro WATANABE Masaya TAKAHASHI

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.54, no.3, pp.282-292, 2016-05-31 (Released:2016-06-10)

参考文献数

54

被引用文献数

32 35

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This study examined whether a higher level of psychological detachment during non-work time is associated with better employee mental health (Hypothesis 1), and examined whether psychological detachment has a curvilinear relation (inverted U-shaped pattern) with work engagement (Hypothesis 2). A large cross-sectional Internet survey was conducted among registered monitors of an Internet survey company in Japan. The questionnaire included scales for psychological detachment, employee mental health, and work engagement as well as for job characteristics and demographic variables as potential confounders. The hypothesized model was tested with moderated structural equation modeling techniques among 2,234 respondents working in the tertiary industries with regular employment. Results showed that psychological detachment had curvilinear relations with mental health as well as with work engagement. Mental health improved when psychological detachment increased from a low to higher levels but did not benefit any further from extremely high levels of psychological detachment. Work engagement showed the highest level at an intermediate level of detachment (inverted U-shaped pattern). Although high psychological detachment may enhance employee mental health, moderate levels of psychological detachment are most beneficial for his or her work engagement.

著者

Yu Komase Kazuhiro Watanabe Natsu Sasaki Norito Kawakami

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.62, no.1, pp.e12185, 2020 (Released:2021-01-25)

参考文献数

44

被引用文献数

7

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Objectives: Workplace gratitude is important for improving work-related outcomes and individual well-being. Although the gratitude at work scale (GAWS) was developed in the United States, it has not been corroborated in Asian countries with interdependent cultures. This study aimed to develop and validate the GAWS among Japanese workers.Method: Japanese workers completed online surveys at baseline (N = 206) and 2 weeks later (N = 103). The Japanese GAWS was developed according to the international guidelines. We measured (a) trait gratitude as comparison for the criterion-related validity, (b) work-related outcomes/factors (eg, work engagement), and (c) well-being (eg, eudemonic well-being at work) as comparisons for convergent validity. Cronbach's alpha, intra-class correlation coefficients (ICCs), and measurement errors were calculated to assess reliability; measurement validity was evaluated by correlational analyses and confirmatory factor analysis (CFA).Results: A total of 206 and 93 workers were included for baseline and follow-up analyses, respectively. Cronbach's alpha and ICCs of the Japanese GAWS ranged from 0.81 to 0.91. CFA showed that the 2-factor model (ie, gratitude for (a) a supportive work environment and (b) meaningful work) demonstrated a good fit (χ2 (34) = 67.58, CFI = 0.967, TLI = 0.956, RMSEA = 0.069, SRMR = 0.037), similar to the original version. As we had hypothesized, overall GAWS and the two domains were significantly correlated with trait gratitude, work-related outcomes/factors, and well-being.Conclusions: The Japanese GAWS demonstrated good reliability and validity. Future research should explore mechanisms related to workplace gratitude and further intervention studies among workers.

著者

Katsuyoshi Kudoh Chikashi Shibata Yuji Funayama Kouhei Fukushima Kenichi Takahashi Munenori Nagao Sho Haneda Kazuhiro Watanabe Takeshi Naitoh Michiaki Unno

出版者

The Japan Society of Coloproctology

雑誌

Journal of the Anus, Rectum and Colon (ISSN:24323853)

巻号頁・発行日

vol.1, no.3, pp.78-83, 2017-07-27 (Released:2018-05-25)

参考文献数

22

被引用文献数

2

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Objectives: The possible effects and benefits of oral rehydration solution (ORS) on chronic dehydration after total proctocolectomy. Methods: To evaluate the effect of ORS on the renin-angiotensin system after remnant proctocolectomy in patients with ulcerative colitis (UC), we selected 20 patients after remnant proctocolectomy, ileal J pouch-anal anastomosis, and construction of a diverting ileostomy for UC. Patients were randomly divided into two groups, A (n=9) or B (n=11), 2 weeks after the surgery. In group A, ORS (1000 mL/day) was given for the first 7 days and mineral water (1000 mL/day) for the next 7 days. In group B, mineral water (1000 mL/day) was given for the first 7 days and ORS (1000 mL/day) for next 7 days. Plasma levels of renin, aldosterone and excretion of sodium in urine were evaluated at days 0, 7, and 14. We defined day 0 as the day of beginning this study. Results: Mean plasma renin levels on day 0 were six to eight times greater than the upper normal limit. In group A, ORS lowered plasma renin levels. In group B, plasma levels of renin and aldosterone after ORS were lower than those at days 0 and 7. Conclusions: ORS corrected increased plasma levels of renin and aldosterone to within the normal range in patients after proctocolectomy.

著者

瀧澤 俊也 成田 紘一 渡邉 一弘 阿部 秀樹 加藤 正 タキザワ トシヤ ナリタ コウイチ ワタナベ カズヒロ アベ ヒデキ カトウ タダシ Toshiya TAKIZAWA Koichi NARITA Kazuhiro WATANABE Hideki ABE Tadashi KATOH

雑誌

東北薬科大学研究誌

巻号頁・発行日

vol.54, pp.33-47, 2007-12

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Spiruchostatin A (1), isolated from a culture broth of Pseudomonas sp., has been shown to be a potent histone deacetylase (HDAC) inhibitor. HDAC inhibitors can suppress the growth of human tumor xenografts, this natural product, therefore, is expected to be a promising candidate for novel molecular-targeted anticancer agents. We envisioned that 1 would be synthesized through twofold macrolactam/macrolactone cyclization of the fully elaborated acyclic disulfide 2. The key segments 3 and 4, required for the preparation of the advanced key intermediate 2, were initially synthesized, and the two segments were subsequently subjected to the critical cross S-S coupling reaction to produce the desired key intermediate 11 (synthetically equivalent to 2). Upon deprotection of the N-Boc and the methyl ester groups in 11, the crucial cyclization formation was achieved using PyBOP to provide the desired macrolactam 16, a potential key precursor for 1. Further investigations concerning the transformation of 16 to the target molecule 1 were also described.

著者

Kazuhiro WATANABE Ryota IWASAKI Syun KONDO Tomohiro OHUCHI Sanae SHIBATA Hiroki SAKAI Kazuaki YAMAZOE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.5, pp.784-789, 2018 (Released:2018-05-18)

参考文献数

13

被引用文献数

3

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We present a case of an intact 14-year-old male dog with a prostate B-cell lymphoma recognized in the contents of an irreducible perineal hernia. The enlarged prostate was replaced after reducing its size by partial excision, and the perineal hernia was repaired using the tunica vaginalis communis. However, the pelvic cavity was largely occupied by the replaced prostate, and urinary retention developed. The prostate was resected on the next day via abdominal median incision, and a bladder-urethra anastomosis was performed. Lymphoma has rarely been demonstrated to develop in the prostate, with the lesion comprising the hernia contents. The present study suggests the necessity of early treatment for perineal hernias and the possibility that lymphoma may be present in the hernia contents.

著者

Kazuhiro WATANABE Ryota IWASAKI Syun KONDO Tomohiro OHUCHI Sanae SHIBATA Hiroki SAKAI Kazuaki YAMAZOE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0597, (Released:2018-03-20)

被引用文献数

3

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We present a case of an intact 14-year-old male dog with a prostate B-cell lymphoma recognized in the contents of an irreducible perineal hernia. The enlarged prostate was replaced after reducing its size by partial excision, and the perineal hernia was repaired using the tunica vaginalis communis. However, the pelvic cavity was largely occupied by the replaced prostate, and urinary retention developed. The prostate was resected on the next day via abdominal median incision, and a bladder-urethra anastomosis was performed. Lymphoma has rarely been demonstrated to develop in the prostate, with the lesion comprising the hernia contents. The present study suggests the necessity of early treatment for perineal hernias and the possibility that lymphoma may be present in the hernia contents.

著者

Kazuhiro WATANABE Saku KIJIMA Chie NONAKA Yuki MATSUKAWA Kazuaki YAMAZOE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0277, (Released:2016-04-09)

被引用文献数

7

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To investigate inhibitory effect for oral bacterial proliferation, we divided 12 dogs into 3 groups; scaling alone (C; control group), brushing (B) and application of toothpaste (P). Before scaling (Pre) and at 0 to 8 weeks after scaling (0–8 w), we collected oral bacteria from the dental surface every week and counted them using a bacterial counter. The results demonstrated a significant reduction in the number of oral bacteria for group B relative to Pre and group C, as well as for group P relative to group C at 5–7 w. Consequently, brushing may inhibit an increase in the number of oral bacteria,and toothpaste may be effective at a certain level, although not more than that of brushing.

著者

Kazuhiro WATANABE Kotaro HAYASHI Saku KIJIMA Chie NONAKA Kazuaki YAMAZOE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0193, (Released:2015-05-21)

被引用文献数

1 8

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In this study, scaling, polishing and daily tooth brushing were performed in 20 beagle dogs, and the number of oral bacteria was determined using a bacterial counter. The dogs were randomized into the scaling (S), scaling + polishing (SP), scaling + tooth daily brushing (SB) and scaling + polishing + tooth daily brushing (SPB) groups. Samples were collected from the buccal surface of the maxillary fourth premolars of the dogs immediately after scaling and every week thereafter from weeks 1 to 8. Throughout the study, the number of bacteria was significantly lower in the SB and SPB groups compared with the S group. The findings suggest that daily tooth brushing inhibited oral bacterial growth in the dogs.

著者

Shingo MIYAWAKI Makoto WASHIZU Sadatoshi MAEDA Sanae SHIBATA Kazuhiro WATANABE Kazuaki YAMAZOE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1191-1193, 2012 (Released:2012-10-01)

参考文献数

12

被引用文献数

1

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Portal vein aneurysm (PVA) is a rare abnormal dilatation of the portal vein, which has not been reported in dogs. We describe the findings of ultrasound and computed tomography in a case of PVA in a young male toy poodle, with the final diagnosis established by explorative surgical observation. The dog had an aneurysmal fusiform dilatation in the extrahepatic portal vein with portal hypertension and multiple portsystemic shunts. This is the first report of canine PVA.

著者

Shingo MIYAWAKI Makoto WASHIZU Sadatoshi MAEDA Sanae SHIBATA Kazuhiro WATANABE Kazuaki YAMAZOE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1204230818, (Released:2012-04-27)

被引用文献数

1 1

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Portal vein aneurysm (PVA) is a rare abnormal dilatation of the portal vein, which has not been reported in dogs. We describe the findings of ultrasound and computed tomography in a case of PVA in a young male toy poodle, with the final diagnosis established by explorative surgical observation. The dog had an aneurysmal fusiform dilatation in the extrahepatic portal vein with portal hypertension and multiple portsystemic shunts. This is the first report of canine PVA.

著者

Kazuhiro WATANABE Shingo MIYAWAKI Muneki KANAYAMA Mitsuru TAKAGI Mami MURAKAMI Yasuki SUGIKATA Kazuaki YAMAZOE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.1, pp.71-74, 2012 (Released:2012-02-01)

参考文献数

11

被引用文献数

3 6

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We found a case of salivary mucocele that originated in the minor salivary gland (palatine gland) of the soft palate in a dog. At first admission, the soft palate swelled remarkably. Computed tomography (CT) revealed cystic radiolucency inside a large quantity of liquid in the soft palate, and most of the airway was occupied. Marsupialization was performed, but since a recurrence was observed one month later, the salivary mucocele was removed. There has been no report of salivary mucocele arising from the minor salivary gland of the soft palate in dogs. To our knowledge, this case is the first. Complete removal, including minor salivary glands surrounding the lesion, is necessary for treatment of salivary mucocele in dogs.