文献一覧: Kei YAMAMOTO (著者)

10 0 0 0 OA COVID-19 can suddenly become severe: a case series from Tokyo, Japan

著者: Keiji Nakamura Satoshi Ide Sho Saito Noriko Kinoshita Satoshi Kutsuna Yuki Moriyama Tetsuya Suzuki Masayuki Ota Hidetoshi Nomoto Tetsuya Mizoue Masayuki Hojo Jin Takasaki Yusuke Asai Mari Terada Yutaro Akiyama Yusuke Miyazato Takato Nakamoto Yuji Wakimoto Mugen Ujiie Kei Yamamoto Masahiro Ishikane Shinichiro Morioka Kayoko Hayakawa Haruhito Sugiyama Norio Ohmagari
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: vol.2, no.3, pp.174-177, 2020-06-30 (Released:2020-07-04)
参考文献数: 8
被引用文献数: 7

Since the initial report of coronavirus disease (COVID-19) from the City of Wuhan, China in December 2019, there have been multiple cases globally. Reported here are 11 cases of COVID-19 at this hospital; all of the patients in question presented with relative bradycardia. The severity of the disease was classified into four grades. Of the patients studied, 3 with mild COVID-19 and 3 with moderate COVID-19 improved spontaneously. Lopinavir/ritonavir was administered to 3 patients with severe COVID-19 and 2 with critical COVID-19. Both patients with critical COVID-19 required mechanical ventilation and extracorporeal membrane oxygenation. Both patients with critical COVID-19 had a higher fever that persisted for longer than patients with milder COVID-19. The respiratory status of patients with critical COVID-19 worsened rapidly 7 days after the onset of symptoms. Relative bradycardia may be useful in distinguishing between COVID-19 and bacterial community-acquired pneumonia. In patients who have had a fever for > 7 days, the condition might worsen suddenly.

2022-01-20 20:31:39
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5 0 0 0 OA SARS-CoV-2 infection among returnees on charter flights to Japan from Hubei, China: a report from National Center for Global Health and Medicine

著者: Kayoko Hayakawa Satoshi Kutsuna Takeo Kawamata Yuko Sugiki Chiharu Nonaka Keiko Tanaka Michi Shoji Masaki Nagai Shunsuke Tezuka Kazuyuki Shinya Hiroki Saito Takahiro Harada Nin Moriya Motoyuki Tsuboi Masataro Norizuki Yasuo Sugiura Yasuyo Osanai Masaya Sugiyama Ayako Okuhama Kohei Kanda Yuji Wakimoto Mugen Ujiie Shinichiro Morioka Kei Yamamoto Noriko Kinoshita Masahiro Ishikane Sho Saito Yuki Moriyama Masayuki Ota Keiji Nakamura Takato Nakamoto Satoshi Ide Hidetoshi Nomoto Yutaro Akiyama Tetsuya Suzuki Yusuke Miyazato Yoshiaki Gu Nobuaki Matsunaga Shinya Tsuzuki Yumiko Fujitomo Yoshiki Kusama Hiroyuki Shichino Masao Kaneshige Junko Yamanaka Miki Saito Masayuki Hojo Masao Hashimoto Shinyu Izumi Jin Takasaki Manabu Suzuki Keita Sakamoto Yukio Hiroi Sakurako Emoto Makoto Tokuhara Toshiaki Kobayashi Koichiro Tomiyama Fumihiko Nakamura Norio Ohmagari Haruhito Sugiyama
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: vol.2, no.2, pp.107-111, 2020-04-30 (Released:2020-05-10)
参考文献数: 11
被引用文献数: 25

Due to the significant spread of a new type of coronavirus (SARS-CoV-2) infection (COVID-19) in China, the Chinese government blockaded several cities in Hubei Province. Japanese citizens lost a means of transportation to return back to Japan. The National Center for Global Health and Medicine (NCGM) helped the operation of charter flights for evacuation of Japanese residents from Hubei Province, and this article outlines our experiences. A total of five charter flights were dispatched, and the majority of returnees (793/829 [95.7%]) were handled at NCGM. A large number of personnel from various departments participated in this operation; 107 physicians, 115 nurses, 110 clerical staff, and 45 laboratory technicians in total. Several medical translators were also involved. In this operation, we conducted airborne precautions in addition to contact precautions. Eye shields were also used. The doctors collecting the pharyngeal swab used a coverall to minimize the risk of body surface contamination from secretions and droplets. Enhanced hand hygiene using alcohol hand sanitizer was performed. Forty-eight persons were ultimately hospitalized after the triage at NCGM operation, which was more than the number of persons triaged at the airport (n = 34). Of those hospitalized after NCGM triage, 8.3% (4/48 patients) ultimately tested positive for SARS-CoV-2, significantly higher than the positive rate among subjects not triaged (4/48 [8.3%] vs. 9/745 [1.2%]: p = 0.0057). NCGM participated in a large-scale operation to evacuate Japanese nationals from the COVID-19 epidemic area. We were able to establish a scheme through this experience that can be used in the future.

2022-01-20 20:31:41
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4 0 0 0 OA A novel protocol for de-isolating moderately and severely immunocompromised COVID-19 patients

著者: Kohei Kamegai Noriko Iwamoto Masahiro Ishikane Kei Yamamoto Kumi Horii Shiho Kubota Akira Hangaishi Hiroshi Shimazu Tomiteru Togano Hiroyuki Yamashita Yasuhide Yamada Norio Ohmagari
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: pp.2023.01053, (Released:2023-11-15)
参考文献数: 27

Immunocompromised coronavirus disease 2019 patients are at a higher risk of prolonged viral shedding than immunocompetent patients. However, as of August 2023, there is no clear international standard for de-isolating vulnerable patients. A comprehensive assessment is advisable based on various information, such as the increase in immune escape of specific mutant strains as well as the patient's innate immunity and vaccination status; therefore, consultation with an infectious disease specialist is recommended. The patient population defined as moderately or severely immunocompromised by the Centers for Disease Control and Prevention and the European Centre for Disease Prevention and Control is significantly broad. A boundary between the two remains to be delineated, and the existing protocols allow the release of patients based on their symptoms alone. This may lead to an unnecessary extension or premature termination of isolation. In this study, we searched for studies, particularly those that used real-world data, discussed the results with experts in our hospital, and proposed new isolation criteria based on both testing and clinical symptoms. We classified patients into three groups namely severely, moderately, and mildly immunocompromised, defined by their background and the administration of immunosuppressive drugs. A separate flowchart for ending isolation is indicated for each group. This standard may be a useful support material, especially for non-specialists. Nevertheless, our criteria must be revised and added continuously; accumulating real-world data to support revision of and addition to the list is becoming increasingly important.

2023-11-15 22:59:36
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3 0 0 0 OA Safety of Diphtheria and Tetanus Toxoids and Acellular Pertussis (DTaP) Vaccine in Adults in Japan

著者: Mugen Ujiie Shinya Tsuzuki Michiyo Suzuki Masayuki Ota Tetsuya Suzuki Hidetoshi Nomoto Kei Yamamoto Sho Saito Akatsuki Kokaze Noriko Kinoshita
出版者: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌: Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日: vol.74, no.5, pp.399-404, 2021-09-30 (Released:2021-09-22)
参考文献数: 18
被引用文献数: 6

Tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is generally used for booster vaccination of infants in Europe and the United States to avoid increased reactogenicity after diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccination. However, Japan has extended the use of additional DTaP vaccination without reducing the antigen dose for diphtheria and pertussis in adolescents and adults, despite limited reports on its safety in adults. This prospective, observational, questionnaire-based study investigated the occurrence of adverse events (AEs) following DTaP vaccination between June 2018 and June 2019 in participants aged 10 years or older. Of the 250 eligible participants, 235 (94%) responded regarding AEs. Among them, 133 (56.6%) reported AEs, of which 39 reported systemic AEs (16.6%) and 120 reported local AEs (51.1%) attributed to DTaP vaccination. The incidence of local AEs was markedly higher with DTaP vaccination than with non-DTaP vaccination (51.1% vs. 10.5%), and AEs appeared later (P < 0.01) and lasted longer (P < 0.01) with DTaP vaccination. However, more than 75% of these AEs resolved within 7 days. DTaP vaccination was not associated with any serious AEs. These results indicate that the DTaP vaccine can be widely used as a booster in adults as an alternative to the Tdap vaccine.

2021-09-23 06:25:14
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3 0 0 0 OA Safety of diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine in adults in Japan

著者: Mugen Ujiie Shinya Tsuzuki Michiyo Suzuki Masayuki Ota Tetsuya Suzuki Hidetoshi Nomoto Kei Yamamoto Sho Saito Akatsuki Kokaze Noriko Kinoshita
出版者: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌: Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日: pp.JJID.2020.947, (Released:2021-01-29)
参考文献数: 18
被引用文献数: 6

Tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is generally used for booster vaccination in Europe and the United States to avoid increased reactogenicity after diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccination in infants. However, Japan has extended the use of additional DTaP vaccination without reducing the antigen dose for diphtheria and pertussis to adolescents and adults despite limited reports on its safety in adults. This prospective observational questionnaire-based study investigated the occurrence of adverse events (AEs) following DTaP vaccination between June 2018 and June 2019 in participants aged 10 years or older. Of 250 eligible participants, 235 (94%) responded regarding AEs. Of these 235 participants, 133 (56.6%) reported AEs, with 39 reporting systemic AEs (16.6%) and 120 reporting local AEs (51.1%) attributed to DTaP vaccination. The incidence of local AEs was much higher with DTaP than with non-DTaP vaccinations (51.1% vs. 10.2%), and the AEs appeared later (p<0.01) and lasted longer (p<0.01) with DTaP vaccination. However, more than 75% of these AEs resolved within 7 days. DTaP vaccination was not associated with any serious AEs. These results indicate that the DTaP vaccine can be widely used as a booster in adults as an alternative to the Tdap vaccine.

2021-03-10 08:44:58
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3 0 0 0 OA Non-COVID-19 Patients with Life-threatening Diseases Who Visited a Fever Clinic: A Single-Center, Observational Study in Tokyo, Japan

著者: Yutaro Akiyama Shinichiro Morioka Yuji Wakimoto Akira Kawashima Kohei Kanda Ayako Okuhama Tetsuya Suzuki Yusuke Miyazato Hidetoshi Nomoto Satoshi Ide Takato Nakamoto Keiji Nakamura Masayuki Ota Yuki Moriyama Saho Takaya Kota Yamada Maho Taguchi Erika Sugito Shinji Izuka Kenji Ishiguro Toshiaki Kobayashi Wataru Miyake Shuji Kubota Masahiro Ishikane Noriko Kinoshita Kei Yamamoto Mugen Ujiie Satoshi Kutsuna Kayoko Hayakawa Sho Saito Norio Ohmagari
出版者: The Japanese Society of Internal Medicine
雑誌: Internal Medicine (ISSN:09182918)
巻号頁・発行日: pp.5614-20, (Released:2020-11-02)
参考文献数: 7
被引用文献数: 2

Objective In fever clinics screening coronavirus disease (COVID-19), there could be patients with life-threatening diseases that physicians should not overlook. We exploratorily investigated the final diagnosis among non-COVID-19 hospitalized patients who visited the fever clinic. Methods This was a retrospective, observational, and single-centered study conducted in the National Center for Global Health and Medicine (NCGM), Tokyo, Japan. We conducted a retrospective chart review of patients who visited the fever clinic in the NCGM from 11 March 2020 to 24 April 2020. Patients Patients who met the following clinical criteria visited the fever clinic in the NCGM: (1) body temperature >37.5°C, (2) any symptoms consistent with COVID-19 or (3) referral from local healthcare facilities. In the fever clinic, all patients who met the above criteria had severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test with nasopharyngeal swab specimens. Patients with severe symptoms or an unstable condition were sent to an outpatient clinic for infectious diseases for further evaluation and treatment. Results Among 1,470 patients who visited the fever clinic, 84 patients were hospitalized, and 45 of them were diagnosed as having COVID-19. Among the remaining 39 non-COVID-19 patients, there were nine patients with life-threatening diseases. The life-threatening diseases included acute heart failure, septic shock, pneumocystis pneumonia, peritonsillar abscess, and necrotizing fasciitis. Conclusion Physicians should evaluate each patient carefully while considering other life-threatening conditions even in such a COVID-19 pandemic era.

2020-11-06 07:02:23
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2 0 0 0 OA SARS-CoV-2 infection among returnees on charter flights to Japan from Hubei, China: a report from National Center for Global Health and Medicine

著者: Kayoko Hayakawa Satoshi Kutsuna Takeo Kawamata Yuko Sugiki Chiharu Nonaka Keiko Tanaka Michi Shoji Masaki Nagai Shunsuke Tezuka Kazuyuki Shinya Hiroki Saito Takahiro Harada Nin Moriya Motoyuki Tsuboi Masataro Norizuki Yasuo Sugiura Yasuyo Osanai Masaya Sugiyama Ayako Okuhama Kohei Kanda Yuji Wakimoto Mugen Ujiie Shinichiro Morioka Kei Yamamoto Noriko Kinoshita Masahiro Ishikane Sho Saito Yuki Moriyama Masayuki Ota Keiji Nakamura Takato Nakamoto Satoshi Ide Hidetoshi Nomoto Yutaro Akiyama Tetsuya Suzuki Yusuke Miyazato Yoshiaki Gu Nobuaki Matsunaga Shinya Tsuzuki Yumiko Fujitomo Yoshiki Kusama Hiroyuki Shichino Masao Kaneshige Junko Yamanaka Miki Saito Masayuki Hojo Masao Hashimoto Shinyu Izumi Jin Takasaki Manabu Suzuki Keita Sakamoto Yukio Hiroi Sakurako Emoto Makoto Tokuhara Toshiaki Kobayashi Koichiro Tomiyama Fumihiko Nakamura Norio Ohmagari Haruhito Sugiyama
出版者: National Center for Global Health and Medicine
雑誌: Global Health & Medicine (ISSN:24349186)
巻号頁・発行日: pp.2020.01036, (Released:2020-04-29)
参考文献数: 11
被引用文献数: 25

2020-05-04 10:57:25
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2 0 0 0 OA A case of imported dengue fever from Burkina Faso to Japan in October 2016

著者: Takehiro Hashimoto Satoshi Kutsuna Takahiro Maeki Shigeru Tajima Saho Takaya Yuichi Katanami Kei Yamamoto Nozomi Takeshita Kayoko Hayakawa Yasuyuki Kato Shuzo Kanagawa Norio Ohmagari
出版者: 国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌: Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日: pp.JJID.2017.181, (Released:2017-09-11)
参考文献数: 14
被引用文献数: 4

Dengue fever remains underreported in Africa due to lack of awareness among healthcare providers, the presence of other febrile illnesses, and insufficient laboratory testing. We present a case of imported dengue fever from Burkina Faso to Japan, where an outbreak of dengue was reported on October 18, 2016. The phylogenetic analysis revealed that the isolate from our patient belonged to a distinct of sylvatic dengue viruses, suggesting that dengue viruses have been maintained in the mosquitoes and human cycles in Burkina Faso for more than 30 years.

2017-09-17 03:47:34
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1 0 0 0 OA Bacterial Tracheitis Caused by Haemophilus influenzae after Influenza

著者: Kei Yamamoto Norio Ohmagari
出版者: The Japanese Society of Internal Medicine
雑誌: Internal Medicine (ISSN:09182918)
巻号頁・発行日: vol.55, no.8, pp.1031, 2016 (Released:2016-04-15)
参考文献数: 1
被引用文献数: 2 2

2022-09-06 00:47:15
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1 0 0 0 OA Microbiological Testing for Coronavirus Disease 2019

著者: Kei Yamamoto Norio Ohmagari
出版者: Japan Medical Association / The Japanese Associaiton of Medical Sciences
雑誌: JMA Journal (ISSN:2433328X)
巻号頁・発行日: vol.4, no.2, pp.67-75, 2021-04-15 (Released:2021-05-07)
参考文献数: 50
被引用文献数: 8

Microbiological diagnosis of coronavirus disease 2019 (COVID-19) is mainly performed through nucleic acid amplification test (NAAT) and antigen test. Although NAAT is the standard diagnostic test, its use is limited by insufficient laboratory resources and long turnaround time. Point-of-care NAAT tests have been introduced to address these shortcomings, but their varied sensitivity and resource constraints remain a concern. Antigen tests require fewer resources but have low sensitivity. Nevertheless, low-sensitivity tests may be useful depending on the situation. In contrast, in some clinical phases of COVID-19, high-sensitivity tests may provide false-negative results. Therefore, the right testing strategy is needed for an accurate diagnosis. In this review, the characteristics and clinical applications of microbiological tests available in Japan (NAAT, antigen test, and antibody test) are discussed. The clinical diagnosis of COVID-19 is slightly complicated, and cases in which the infection spreads from asymptomatic infected individuals are many; hence, laboratory diagnosis is essential to prevent further transmission.

2021-07-25 16:15:00
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1 0 0 0 OA Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway

著者: Izumi Tsukayama Keisuke Toda Yasunori Takeda Takuto Mega Mitsuki Tanaka Yuki Kawakami Yoshitaka Takahashi Masumi Kimoto Kei Yamamoto Yoshimi Miki Makoto Murakami Toshiko Suzuki-Yamamoto
出版者: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
雑誌: Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)
巻号頁・発行日: vol.62, no.2, pp.139-147, 2018 (Released:2018-03-01)
参考文献数: 41
被引用文献数: 6

Hyperproduced prostaglandin E2 by cyclooxygenase-2 and microsomal prostaglandin E synthase-1 evokes several pathophysiological responses such as inflammation and carcinogenesis. Our recent study demonstrated that Dioscorea japonica extract suppressed the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 and induced apoptosis in lung carcinoma A549 cells. In the present study, we investigated the effects of Dioscorea japonica on squamous cell carcinoma of mouse skin. Dioscorea japonica feeding and Dioscorea japonica extract topical application suppressed the expression of cyclooxygenase-2, microsomal prostaglandin E synthase-1, interleukin-1β and interleukin-6 and inhibited tumor formation, hyperplasia and inflammatory cell infiltration. Immunohistochemical analyses showed the immunoreactivities of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in tumor keratinocytes and stronger immunoreactivities of cyclooxygenase-2 and hematopoietic prostaglandin D synthase in epidermal dendritic cells (Langerhans cells). Treatment with Dioscorea japonica decreased the immunoreactivity of cyclooxygenase-2 and microsomal prostaglandin E synthase-1. These results indicate that Dioscorea japonica may have inhibitory effects on inflammation and carcinogenesis via suppression of the prostaglandin E2 synthetic pathway.

2018-04-09 21:24:06
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1 0 0 0 OA Meningococcemia due to the 2000 Hajj-Associated Outbreak Strain (Serogroup W-135 ST-11) with Immunoreactive Complications

著者: Kei Yamamoto Yasuyuki Kato Takuma Shindo Mugen Ujiie Nozomi Takeshita Shuzo Kanagawa Junwa Kunimatsu Yuiichi Tamori Toshikazu Kano Rumi Okuno Hideyuki Takahashi Norio Ohmagari
出版者: 国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌: Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日: vol.66, no.5, pp.443-445, 2013 (Released:2013-09-19)
参考文献数: 10
被引用文献数: 1 5

We present the first reported case of systemic infection with Neisseria meningitidis serogroup W-135 sequence type (ST)-11 in Japan. A 44-year-old woman presented with high fever, sore throat, and fatigue and was diagnosed with N. meningitidis bacteremia. The causative strain was identified as serogroup W-135 ST-11 by polymerase chain reaction and multilocus sequence typing. Approximately 1 month after treatment, she developed high fever, dyspnea, chest pain, and shoulder pain due to pericarditis, polyarthritis, and tenosynovitis, which are all relatively common immunoreactive complications of W-135 ST-11 meningococcal infections. This causative strain was the same as that responsible for an outbreak of meningitis among Hajj pilgrims in 2000. The strain is now found worldwide because it can attain a high carriage rate and has a long duration of carriage. We suspect that our patient's infection was acquired from an imported chronic carrier.

2013-09-19 14:03:09
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1 0 0 0 OA Transglutaminase 2: A Novel Autoantigen in Canine Idiopathic Central Nervous System Inflammatory Diseases

著者: Miho TANAKA Akiko INOUE Kei YAMAMOTO Satoshi TAMAHARA Naoaki MATSUKI
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: vol.74, no.6, pp.733-737, 2012 (Released:2012-07-04)
参考文献数: 29
被引用文献数: 2 5

Necrotizing meningoencephalitis (NME), necrotizing leukoencephalitis (NLE) and granulomatous meningoencephalomyelitis (GME) are common idiopathic inflammatory central nervous system (CNS) diseases with unknown etiology in dogs. We previously showed that IgG autoantibodies in the cerebrospinal fluid (CSF) of NME cases reacted to unknown brain proteins as well as to glial fibrillary acidic protein (GFAP). In the present report, we evaluated the autoantibodies against transglutaminase2 (TG2) in the canine CNS diseases. CSF samples obtained from dogs with NME (n=19), NLE (n=7), GME (n=11) and miscellaneous CNS diseases (n=12) were subjected. CSFs from 20 healthy dogs were used as controls. Indirect fluorescent antibody test on the canine cerebrum revealed astrocyte-binding IgG in the CSF of NME. After absorption of the CSF with bovine GFAP, the CSF still possessed the reactivity to astrocytes. Double-color staining showed clear colocalization of the autoantibodies and anti-human TG2 rabbit polyclonal IgG. An immunoblot assay against human recombinant TG2 revealed anti-TG2 IgG in the CSF from dogs with NME, NLE and GME. The CSF of canine idiopathic encephalitis cases, notably of NME, tended to show high ELISA OD values against human recombinant TG2 compared to healthy controls. The presence of anti-TG2 autoantibodies in the CSF may contribute to the elucidation of the etiology of canine NME, NLE and GME.

2012-07-09 21:52:58
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1 0 0 0 OA Transglutaminase 2: A Novel Autoantigen in Canine Idiopathic Central Nervous System Inflammatory Diseases

著者: Miho TANAKA Akiko INOUE Kei YAMAMOTO Satoshi TAMAHARA Naoaki MATSUKI
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.1201050751, (Released:2012-01-10)
被引用文献数: 3 5

2012-01-21 02:45:06
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