著者
Jun Chen Mieko Sadakata Mayumi Ishida Naoto Sekizuka Mitsuko Sayama
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.223, no.2, pp.97-102, 2011 (Released:2011-01-20)
参考文献数
15
被引用文献数
12 19

Neonatal jaundice is a common physiological problem affecting over half of all full term and most preterm infants. Thus, newborn infants must be monitored for signs of hyperbilirubinemia to prevent acute bilirubin encephalopathy or kernicterus. Evidence exists supporting the benefits of baby massage as a form of mild hand to skin contact, to increase neonatal physical and mental development. In the present study, the effects of gentle baby massage on neonatal jaundice in full term newborn infants were evaluated by a controlled clinical trial. The inclusion criteria of newborn neonates were as follows: (1) gestational age of 37 ~ 41 weeks, (2) birth weight of 2,800 ~ 3,600 g, (3) Apgar score at birth of 8 ~ 10, and (4) being a healthy neonate without neonatal asphyxia and hemolytic condition. Breastfed newborns without phototherapy were included: 20 in the massage group and 22 in the control group. We found the mean stool frequency of the massaged infants on day 1 and day 2 (4.6 and 4.3) was significantly higher than that of the control group (3.3 and 2.6) (p < 0.05). The transcutaneous bilirubin levels on the second to fifth day and serum total bilirubin levels on fourth day were significantly decreased in the massage group, compared to the control group. In conclusion, baby massage at an early stage after birth could reduce neonatal bilirubin levels. We suggest baby massage is beneficial for ameliorating neonatal jaundice.
著者
Shinichi Okamura Yoshie Sawada Teturou Satoh Hironosuke Sakamoto Yuichiro Saito Hiroyuki Sumino Takako Takizawa Toshiaki Kogure Chiayo Chaichantipyuth Yoshihiro Higuchi Tsutomu Ishikawa Tetsuo Sakamaki
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.216, no.4, pp.341-351, 2008 (Released:2008-12-06)
参考文献数
34
被引用文献数
11 18

Impaired lipid metabolism is an important health problem in postmenopausal women with insufficient estrogens, because dyslipidemia is a risk factor for development of atherosclerosis and the incidence of cardiovascular disease markedly increases after menopause. Pueraria mirifica (PM), a Thai herb, has been noticed as a source of phytoestrogens, estrogen-mimicking plant compounds. However, the clinical effects of PM on lipid metabolism and the underlying molecular mechanisms remain undetermined. Therefore, we examined the effects of PM on serum lipid parameters in a randomized, double-blind, placebo-controlled clinical trial. Nineteen postmenopausal women were randomly assigned to receive oral administration of PM powder or placebo. After 2 months of treatment, the PM group showed a significant increase in serum concentrations of high-density lipoprotein (HDL) cholesterol and apolipoprotein (apo) A-1 (34% and 40%, respectively), and a significant decrease in low-density lipoprotein (LDL) cholesterol and apo B (17% and 9%, respectively), compared with baseline measurements. Moreover, significant decreases were observed in the ratios of LDL cholesterol to HDL cholesterol (37%) and apo B to apo A-1 (35%). Next, we determined the effects of PM phytoestrogens on the activation of estrogen receptor (ER)-mediated transactivation by transient expression assays of a reporter gene in cultured cells. Among PM phytoestrogens, miroestrol and coumestrol enhanced both ERα- and ERβ-mediated transactivation, whereas other phytoestrogens, including daidzein and genistein, preferentially enhanced ERβ-mediated transactivation. In conclusion, PM has a beneficial effect on lipid metabolism in postmenopausal women, which may result from the activation of gene transcription through selective binding of phytoestrogens to ERα and ERβ.
著者
Ahmet Ak Cemile Oztin Ogun Aysegul Bayir Seyit Ali Kayis Ramazan Koylu
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.210, no.4, pp.285-290, 2006 (Released:2006-12-05)
参考文献数
18
被引用文献数
23 43

Arterial blood gas (ABG) analysis has an important role in the clinical assessment of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, arterial puncture or insertion of an arterial catheter has many drawbacks. The aim of this study was to evaluate whether venous blood gas (VBG) values of pH, partial pressure of carbon dioxide (PCO2) and oxygen (PO2), bicarbonate (HCO3), and oxygen saturation (SO2) can reliably predict ABG levels in patients with AECOPD. One hundred and thirty-two patients with a prior diagnosis of COPD presenting with acute exacerbation according to AECOPD criteria were included in this prospective study. AECOPD is defined as a recent increase in cough, wheezing, the volume and purulence of sputum or shortness of breath necessitating a change in regular medication, including corticosteroids or antibiotics. ABG samples were taken immediately after venous sampling, and both were analyzed. Linear regression analysis was performed and equations were established for the estimation of arterial values. The Pearson correlation coefficients for pH, PCO2, HCO3, PO2, and SO2 were 0.934, 0.908, 0.927, 0.252, and 0.296, respectively. There was a significant correlation between ABG and VBG values of pH, PCO2, and HCO3 (p < 0.001). Linear regression equations for the estimation of pH, PCO2, and HCO3 were as follows: arterial pH = 1.004 × venous pH; arterial PCO2 = 0.873 × venous PCO2; and arterial HCO3 = 0.951 × venous HCO3. VBG analysis can reliably predict the ABG values of pH, PCO2 and HCO3 in patients with AECOPD.
著者
Yuji Hatakeyama Naohisa Miyakoshi Yuji Kasukawa Arata Watanabe Masashi Hirayama Seietsu Senma Iwao Ono Yoichi Shimada
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.227, no.4, pp.263-267, 2012 (Released:2012-07-14)
参考文献数
16
被引用文献数
1 1

Vertebral fractures are an under-recognized problem in children with glucocorticoid-induced osteoporosis (GIO). They cause severe back pain and spinal column deformity with a decrease of quality of life. For evaluating the bone mass, bone mineral density measurements have been widely carried out using dual energy X-ray absorptiometry. However, bone histomorphometric analyses of GIO in children are scarce. Bone histomorphometric analyses of vertebral bodies have not been reported. Our aim is to report the first bone histomorphometric data for vertebrae from an autopsied child with GIO. A 15-year-old girl with systemic lupus erythematosus was started on a daily oral dose of 10 mg of prednisolone at 6 years of age. She presented with back pain from 12 years of age. Magnetic resonance imaging at 14 years of age showed a compression fracture of the first lumbar (L1) vertebral body. At 15 years of age, she died of heart failure owing to pulmonary hypertension. Collapsed (L1) and non-collapsed (seventh thoracic vertebrae; T7) vertebral bodies were autopsied for bone histomorphometry and compared. T7 showed severe osteoporosis (bone volume, 4.99%; trabecular thickness, 59 μm; trabecular separation, 1,134 μm). Compared with T7, L1 showed increased bone volume (33.9%) and trabecular thickness (77 μm), and decreased trabecular separation (156 μm) owing to the impact of the vertebral fracture. The bone formation and bone resorption parameters were comparable between the two vertebrae. These histological findings suggest that severe osteoporosis developed after long-term glucocorticoid administration, and that the remodeling activities were similar in the fractured and non-fractured vertebrae.
著者
Kim Junghoon Tanabe Kai Yoshizawa Yasuyo Yokoyama Noriko Suga Yoko Kuno Shinya
出版者
Tohoku University Medical Press
雑誌
Tohoku journal of experimental medicine (ISSN:00408727)
巻号頁・発行日
vol.229, no.1, pp.11-17, 2013
被引用文献数
16 5

Regular physical activity is associated with improvements of metabolic syndrome (MetS) risk factors. Furthermore, recent physical activity guidelines for health promotion recommend that moderate to vigorous physical activity should be performed in bouts lasting ≥ 10 min. Brisk walking is a popular and readily attainable form of moderate intensity physical activity and is suitable for the majority of individuals. However, it is unclear whether brisk walking lasting ≥ 10 min is associated with improvement in MetS. This study aimed to determine the effects of a 1-year lifestyle-based physical activity intervention with brisk walking of ≥ 10 min using a pedometer on the improvement in MetS. Three hundred and seventy-six overweight male employees with ≥ 1 MetS component(s) participated in this intervention study from 2008 to 2009 (age, 30-62 years; body mass index, 23.0-45.5 kg/m2). Overall, 316 participants (84%) completed the 1-year intervention. MetS was defined according to the Japanese criteria at baseline and after 1 year. Brisk walking lasting ≥ 10 min was significantly associated with the decrease in waist circumference (β = −1.479) and triglyceride (β = −31.260), and the increase in high-density lipoprotein cholesterol (β = 2.117). The brisk walking step counts were also significantly associated with higher odds for an improvement in MetS (OR, 1.48; 95% CI, 1.05-2.09) and abdominal obesity (OR, 1.45; 95% CI, 1.12-1.87). In conclusion, the lifestyle-based intervention with brisk walking of ≥ 10 min is an effective strategy to improve MetS in overweight male employees.
著者
Sebnem Bicakci Fahrettin Over Kezban Aslan Nafiz Bozdemir Esra Saatci Yakup Sarica
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.213, no.3, pp.277-282, 2007 (Released:2007-11-05)
参考文献数
16
被引用文献数
3 3

Headache is one of the most common neurological complaints of the young population and it affects the quality of life due to limitation of daily activities. In this study, our main goal was to appraise the general headache characteristics in senior medical students just before graduation and to determine the impact of headache on the quality of life, as well as the general attitude of students about their headaches. The study group consisted of 141 senior students. As the first step, the question about “having headache within the past one year period” was asked. Of the 141 students, 127 students answering “yes” were invited to a face-to-face interview. Of these, 67 students (52.8%) participated in the second evaluation. The second evaluation consisted of history taking and neurological and physical examination. All subjects were classified according to the International Classification of Headache Disorders (2nd edition) criteria. Validated Turkish version of Migraine Disability Assessment questionnaire was given to the subjects to evaluate the socio-economical impact of headache. Tension-type headache, which is the most common form of primary headaches, was identified in 34 students (50.7%) out of 67 students. Migraine was detected in 31 students (46.3%). This is the first study performed on a face-to-face interview basis with medical students using the new classification criteria in Turkey. Astonishingly, most of the students (n:65) ignored their headaches and did not seek medication, despite the negative impact of headache on daily functioning and overall quality of life.
著者
本川 弘一 三田 俊定
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.40, no.3-4, pp.298-320, 1941-07-31 (Released:2008-11-28)
参考文献数
25
被引用文献数
1 1 6

Bei der Elektrenkephalographie des Menschen lässt sich eine von den eigentlichen Hirnströmen sicher unterscheidbare langsame Schwankung auf Augenbelichtung hin nachweisen. Da sie detn bei Tieren gefundenen “On”-Effekt der optischen Hirnrinde etwas ähnlich ist, wurde sie ohne weiteres der Grosshirnrinde zugeschrieben. Angesichts ihres mit dem cerebralen “On”-Effekt bei Tieren nicht ganz übereinstimmenden Verhaltens wurde ihre vermeintliche Herkunft in Zweifel gezogen und folgende Untersuchung angestellt, um das Wesen dieser Potentialschwankung aufzuklären: 1. Sie ist von Lid- und Augenbewegungen unabhängig, was mit der elektrischen Registriermethode der Lid- und Augenbewegungen einwandfrei nachgewiesen wurde. 2. Ein rotes Licht ist weniger wirksam als ein weisses oder ein blaues, um diese Schwankung hervorzurufen. 3. Durch Untersuchungen über die Potentialverteilung auf dem Kopf wurde festgestellt, dass diese Schwankung von den Augen oder wenigstens von ihrer Nähe herruhrt. 4. Der naturgetreue Verlauf dieser Schwankung wurde mittels eines Gleichstromverstärkers und eines Oszillographen registriert, um festzustellen, dass sie in jeder Hinsicht mit dem Elektroretinogramm des Menschen iibereinstimmt. 5. Auf rhythmische optische Reize lassen sich in Bestätigung des Adrian schen Befunds periodische Schwankungen des Potentials nachweisen. Das Bild and andere Eigenschaften dieser Flickerantwort sind auf der vorderen and der hinteren Hälfte des Kopfes sehr verschieden, indem Netzhautprozess beim ersteren Fall eine überwiegende Rolle spielt. Es sei nachdrücklich betont, lass sich der Belichtungsstrom der Netzhaut bei der Elektrenkephalographie unter Umständen geltend macht, um eine Konfusion mit Hirnströmen hervorzurufen, besonders wenn eine Elektrode in der Nähe der Augen liegt.
著者
Shiro Oguma Itiro Ando Takuo Hirose Kazuhito Totsune Hiroshi Sekino Hiroshi Sato Yutaka Imai Masako Fujiwara
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.227, no.3, pp.217-223, 2012 (Released:2012-07-07)
参考文献数
27
被引用文献数
5 6

Patients with renal failure undergoing hemodialysis often have muscle cramps during and after the dialysis therapy. Muscle cramps are defined as the sudden onset of a prolonged involuntary muscle contraction accompanied with severe pain, resulting in early termination of a HD session and inadequate dialysis. The etiology of the cramps is unknown and effective anti-cramp medicine is not available. We have hypothesized that water-soluble vitamins are deficient in HD patients. Accordingly, we administrated biotin to 14 patients who had frequent muscle cramps during HD sessions. Oral administration of 1 mg/day biotin promptly reduced the onset and the severity of cramps in 12 patients both during and after HD. Then, the plasma biotin levels were measured by an enzyme-linked immunosorbent assay method (ELISA) in HD patients, including 14 patients with cramps and 13 patients without cramps, and 11 healthy volunteers. Plasma biotin levels were elevated in 27 HD patients at baseline compared with healthy volunteers [451 (377 - 649) vs. 224 (148 - 308) ng/l, median (lower-upper quartiles); p < 0.0001]. Unexpectedly, among the 14 cramp patients, the biotin levels were significantly higher in biotin-ineffective 7 patients than biotin-effective 7 patients [1,064 (710 - 1,187) vs. 445 (359 - 476) ng/l; p < 0.001]. Thus, the biotins measured by ELISA may consist of not only intact biotin but also its metabolites that do not function as a vitamin. In conclusion, biotin administration is one choice to relieve HD patients from muscle cramps regardless of their elevated plasma biotin levels.
著者
Kiyohisa Sekizawa
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.184, no.2, pp.73-84, 1998 (Released:2005-12-13)
参考文献数
75
被引用文献数
4 3

Pneumonia is not only a major cause of death for elderly persons, but also imposes substantial personal morbidity and burdens on the health care system. An understanding of the pathogenesis of this serious illness could allow us to devise methods for curbing the incidence and severity of the disease. Pathophysiological issues and preventative measures are the subject of this review.
著者
Jae-Woo Jung Hye-Ryun Kang Jae-Woo Kwon Tae-Eun Kim So-Hee Lee Kyoung Sup Hong Kyung-Sang Yu Sang-Heon Cho
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.224, no.4, pp.293-300, 2011 (Released:2011-07-29)
参考文献数
28
被引用文献数
4 4

Revaprazan is the first acid pump antagonist with a function similar to that of proton pump inhibitors (PPIs). It has a dual action, active suppression of gastric acid secretion and gastric mucosa protection. While PPIs are known to enhance the prolongation of prothrombin time by warfarin, no research has been done on the drug interaction between revaprazan and warfarin. This study was conducted in order to verify the potential drug interaction between revaprazan and warfarin. Omeprazole, a representative PPI, was used as the control for revaprazan. We searched for patients who were given either revaprazan or omeprazole along with warfarin using the medical record database of Seoul National University Hospital between July 2007 and June 2010. Among the 15 patients who took revaprazan and warfarin together, 73.3% (11/15) showed more than 30% reduction of anticoagulation effect by warfarin after revaprazan was added. The revaprazan group showed a significant shortening of prothrombin time during revaprazan administration compared to pre- and post-revaprazan medication (P < 0.05) while the omeprazole group did not show such difference. Revaprazan seems to have cumulative dose-dependent anti-warfarin or anti-coagulation effect, as judged from the fact that the longer medication with revaprazan showed correlation with the shortening of prothrombin time (R = −0.632, P < 0.05). This study shows a possible interaction between revaprazan and warfarin and suggests that revaprazan can cause shortening of prothrombin time. Therefore, when revaprazan is prescribed to patients on warfarin therapy, prothrombin time should be frequently monitored.
著者
Eul-Sang Kim Yang-Sook Ko Junghun Kim Naoko Matsuda-Inoguchi Haruo Nakatsuka Takao Watanabe Shinichiro Shimbo Masayuki Ikeda
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.200, no.1, pp.7-15, 2003 (Released:2004-10-01)
参考文献数
29
被引用文献数
10 13

This study was initiated to examine the accuracy of conventional food composition table-based estimation of intakes of energy, protein, lipid and carbohydrate, in comparison with chemical analysis. For this purpose, 66 women (at the ages of 29 to 54 years) in three locations in Jeju Island, Republic of Korea, volunteered to offer 24-hour food duplicate samples. A half of them were house-wives, and the remaining half were farmers or fishers. The duplicate samples were subjected 1) to the chemical analysis for daily intake of energy, protein, lipid and carbohydrate after official methods in Korea (measured values), and 2) to the estimation of intakes of the same items taking advantage of Korean Food Composition Tables (estimated values). The two sets of the results, i.e., the measured and estimated values, were compared by paired and unpaired t-test, and linear regression analysis. The estimated values correlated closely with the measured values, irrespective of energy or the three major nutrients. A close agreement was observed for energy intake (the estimated/measured ratio of >98%), and it was also the case for protein intake (101%). Under- and over-estimation was observed, however, in regard to carbohydrate (by −8%) and lipid intake (by +24%), respectively. It was concluded that the Korean Food Composition Tables are sufficiently accurate when applied for estimation of total energy intake as well as protein intake. Cares should be taken, however, in applying the tables for estimation of lipid and carbohydrate intake, because there may be the risk of over- and under-estimation for the former and the latter, respectively.
著者
Gunilla Wieslander Nina Fabjan Maja Vogrincic Ivan Kreft Christer Janson Ulrike Spetz-Nyström Blanka Vombergar Christer Tagesson Per Leanderson Dan Norbäck
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.225, no.2, pp.123-130, 2011 (Released:2011-09-17)
参考文献数
35
被引用文献数
21 30

Buckwheat food is a good source of antioxidants, e.g. rutin, and other beneficial substances. Here we investigated the effects of the intake of common buckwheat (low rutin content) and tartary buckwheat cookies (high rutin content) on selected clinical markers. A double blind crossover study was performed among female day-care centre staffs (N = 62) from five day-care centres. Participants were randomly divided into two groups. The first group initially consumed four common buckwheat cookies per day (16.5 mg rutin equivalents/day) for two weeks, while the second group consumed four tartary buckwheat cookies per day (359.7 mg rutin equivalents/day). Then the groups switched their type of cookies and consumed them for another two weeks. We monitored selected clinical markers related to cardiovascular disease and lower airway inflammation, lung function, and subjective breathing difficulties in the staffs. Intake of tartary buckwheat cookies reduced the serum level of myeloperoxidase (MPO) by a factor 0.84 (p = 0.02). When grouping the two types of buckwheat cookies together, there was a reduction of total serum cholesterol (p < 0.001) and HDL-cholesterol (p < 0.001) during the study period, with improved lung vital capacity (p < 0.001). The degree of reduction in total and HDL cholesterol levels was similar in staffs with low and high body mass index (cut off 25). In conclusion, intake of tartary buckwheat cookies with high level of the antioxidant rutin may reduce levels of MPO, an indicator of inflammation. Moreover, intake of both types of buckwheat cookies may lower cholesterol levels.
著者
Mio Ishibashi Hideki Tonori Takeo Miki Eriko Miyajima Yasushi Kudo Masashi Tsunoda Kou Sakabe Yoshiharu Aizawa
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.211, no.3, pp.223-233, 2007 (Released:2007-03-09)
参考文献数
26
被引用文献数
6 7

Sick house syndrome (SHS) is a Japanese concept derived from sick building syndrome (SBS), however SHS includes a broader scope of sickness than does SBS. Symptoms of SHS/SBS disappear after leaving the sick house/building, while symptoms of multiple chemical sensitivity (MCS) are elicited by the chance of chemical exposure after leaving the sick house/building. To establish the concept of SHS, we propose to introduce a new classification for SHS. A total of 214 patients complaining of SHS and/or MCS were independently classified using a new classification by clinical ecologists who are experienced physicians with expert knowledge of clinical ecology and general physicians according to disease pathogenesis from clinical records. The classification is as follows: type 1 (symptoms of chemical intoxication), type 2 (symptoms developed possibly due to chemical exposure), type 3 (symptoms developed not because of chemical exposure but rather because of psychological or mental factors), and type 4 (symptoms developed due to allergies or other diseases). The agreements on the classification made by clinical ecologists and general physicians reached 77.1% (Cohen's kappa = 0.631), suggesting that this new classification was both apt and accurate. Relations between SHS and allergy/MCS were also studied. The cases classified as SHS type 4 more frequently had allergic past histories than did other types. The proportion of possible MCS cases was higher in the chemical induced SHS group (types 1 and 2) than in other types among male patients. For the universal use in clinical practice, it is necessary to prepare helpful diagnostic criteria of this SHS classification based on pathogenesis and carry our study forward all over the country.