著者

Seiichi Mokuyasu Risa Oshitanai Toru Morioka Yuki Saito Yasuhiro Suzuki

出版者

Japanese Society of Laboratory Medicine

雑誌

Laboratory Medicine International (ISSN:24368660)

巻号頁・発行日

vol.2, no.3, pp.50-59, 2023 (Released:2023-12-29)

参考文献数

30

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Background: Absolute lymphocyte count (ALC) and neutrophil lymphocyte rate (NLR) as immune system and inflammatory markers have been suggested as prognostic factors in eribulin treatment. However, the respective cut-off values have not been determined. Hence, we investigated the relationship between overall survival (OS) and baseline ALC (bALC) and baseline NLR (bNLR) in eribulin-treated patients with human epidermal growth factor receptor 2 (HER2)-negative breast cancer (BC) by using 2 types of cut-off values for each. Methods: Univariate and multivariate analyses were performed to investigate the association of bALC and bNLR with OS among 114 female patients with HER2-negative BC treated with eribulin. Results: The OS of patients with HER2-negative BC was compared based on bALC (cut-off value: 1,200/μL and 1,500/μL) and bNLR (cut-off values: 2 and 3). A significant difference was observed in median OS between patients with bALC of ≥ 1,200/μL and those with bALC of < 1,200/μL (hazard ratio [HR]: 0.596 [0.395, 0.889], p = 0.014). For bNLR (cut-off value: 2), the median OS was significantly higher in patients with a bNLR of < 2 than in those with a bNLR of ≥ 2 (HR: 0.629 [0.406, 0.974], p = 0.038). Conclusions: Patients with HER2-negative BC with a bALC of ≥ 1,200/μL showed a longer OS than patients with a bALC of < 1,200/μL, thus suggesting that survival prediction using bALC was effective for eribulin-treated patients with recurrent HER2-negative BC. It should be noted that the optimal cut-off value for ALC may change depending on the target patient group.

著者

Keiji KIMURA Tatsuto AOKI Shigeki SANO Yasuhiro SUZUKI

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.78, no.5, pp.276-288, 2005-04-01 (Released:2008-12-25)

参考文献数

30

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The relationships between successional vegetation change and geomorphic conditions were analyzed by using a high-resolution digital terrain model (DTM) and a time series of converted digital vegetation maps combined within a geographical information system (GIS). The results of the analysis confirmed that the pattern of vegetation change is a function of geomorphic conditions (measured in terms of spatio-statistical values of various parameters and time series of those values). Current geoecological studies are usually carried out by means of detailed field observations with high spatial resolution, and the results of our study suggest that a GIS can easily deal with such data over a large area and long time period. In the study area, unforested sites were reforested using Japanese red pine (Pinus densiflora) as part of the forest rehabilitation work that occurred in the early 1950s. After that, two main patterns of vegetation change from pine forest to deciduous broadleaved forest occurred. In one type, the deciduous broadleaved forest reappeared quickly. In the other, the pine forests remained for a long time. Stands that underwent relatively rapid succession were found on north-facing gentle slopes close to large bodies of water. Stands that did not undergo rapid succession were found on steeper, warmer, and drier slopes (often south-facing slopes farther from bodies of water). The rate of forest succession towards deciduous broadleaved forest is a function of these geomorphic conditions. This suggests that forest succession is influenced by intermediate factors controlling by geomorphic conditions of site, such as soil moisture and soil thickness.

著者

Andros Theo Tracy Masebe Yasuhiro Suzuki Haruhisa Kikuchi Shoko Wada Chikwelu Larry Obi Pascal Obong Bessong Motoki Usuzawa Yoshiteru Oshima Toshio Hattori

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.217, no.2, pp.93-99, 2009 (Released:2009-02-11)

参考文献数

38

被引用文献数

35 42

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The biodiversity of medicinal plants in South Africa makes them rich sources of leading compounds for the development of novel drugs. Peltophorum africanum (Fabaceae) is a deciduous tree widespread in South Africa. The stem bark has been traditionally employed to treat diarrhoea, dysentery, sore throat, wounds, human immunodeficiency virus/ acquired immune deficiency syndrome (HIV/AIDS), venereal diseases and infertility. To evaluate these ethnobotanical clues and isolate lead compounds, butanol and ethyl acetate extracts of the stem bark were screened for their inhibitory activities against HIV-1 using MAGI CCR5+ cells, which are derived from HeLa cervical cancer cells and express HIV receptor CD4, a chemokine receptor CCR5 and HIV-LTR-β- galactosidase. Bioassay-guided fractionation using silica gel chromatography was also conducted. The ethyl acetate and butanol extracts of the stem bark of Peltophorum africanum showed inhibitory activity against HIV-1, CXCR4 (X4) and CCR5 (R5) tropic viruses. The ethyl acetate and butanol extracts yielded previously reported anti-HIV compounds, (+)-catechin, a flavonoid, and bergenin, a C-galloylglycoside, respectively. Furthermore, we identified betulinic acid from the ethyl acetate fraction for the first time. The fractions, which contained betulinic acid, showed the highest selective index. We therefore describe the presence of betulinic acid, a not well-known anti-HIV compound, in an African medicinal herb, which has been used for therapy, and claim that betulinic acid is the predominant anti-HIV-1 constituent of Peltophorum africanum. These data suggest that betulinic acid and its analogues could be used as potential therapeutics for HIV-1 infection.

著者

石井 祥子 奈良 由美子 鈴木 康弘 稲村 哲也 バトトルガ スヘー ナラマンダハ ビャンバジャブ Shoko ISHII Yumiko NARA Yasuhiro SUZUKI Tetsuya INAMURA Sukhee BATTULGA Byambajav NARMANDAHK

出版者

放送大学

雑誌

放送大学研究年報 = Journal of The Open University of Japan (ISSN:09114505)

巻号頁・発行日

vol.40, pp.19-33, 2023-03-25

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筆者らは、2017年10月から、JICA草の根技術協力事業(パートナー型)「モンゴル・ホブド県における地球環境変動に伴う大規模自然災害への防災啓発プロジェクト」を実施してきた。当初計画では、2022年9月までの5年間を予定していたが、COVID-19感染症流行のため、それ以後は現地での実践活動が継続不可能となった。幸い、これまでの成果と今後の活動の可能性が認められ、約1年半をめどにプロジェクト延長が承認された。そこで、筆者らは、2022年8-10月にウランバートル市とホブド市を訪問し、約2年半ぶりに本格的に活動を再開することができた。 本稿では、感染症流行により活動が制限された状況下における持続的な取り組みと、渡航が再開された2022年後半の活動をまとめる。主な内容は、防災カルタ大会の開催、市民を主体とする防災ワークショップの開催、そして映像コンテンツの制作と評価・活用についてである。

著者

Arata NAGAI Yasuhiro SUZUKI Tomohisa ISHIDA Yoshimichi SATO Tomoo INOUE Teiji TOMINAGA

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2022-0155, (Released:2022-10-13)

参考文献数

31

被引用文献数

1

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Delayed cerebral vasospasms after subarachnoid hemorrhage (SAH) are a risk factor for poor prognosis after successful treatment of ruptured intracranial aneurysms. Different strategies to remove clots from the subarachnoid space and prevent vasospasms have different outcomes. Intrathecal urokinase infusion therapy combined with endovascular treatment (EVT) can reduce the incidence of symptomatic vasospasms. To analyze the relationship between symptomatic vasospasms and residual SAHs after urokinase infusion therapy, we retrospectively reviewed the records of 348 consecutive patients managed with EVT and intrathecal urokinase infusion therapy for aneurysmal SAH at our institution between 2010 and 2021. Among them, 163 patients met the study criteria and were classified into two groups according to the presence of residual SAH in the cisterns, Sylvian fissures, and frontal interhemispheric fissure. The incidence of symptomatic vasospasms and the clinical outcomes were assessed. In total, eight (5.0%) patients developed symptomatic vasospasms. Patients with symptomatic vasospasms had a significantly higher incidence of residual SAH in the Sylvian or frontal interhemispheric fissures than those without (P <.0001). No patient with SAHs resolved by urokinase infusion therapy developed symptomatic vasospasms. However, the two groups did not differ significantly in terms of modified Rankin scale scores at discharge. Treatment with intrathecal urokinase infusion after EVT for aneurysmal SAH can substantially reduce the risk of clinically evident vasospasms.

著者

Norio Sato Yasuhiro Suzuki Qinglian Guo Kyoko Kato

出版者

The Society for Art and Science

雑誌

芸術科学会論文誌 (ISSN:13472267)

巻号頁・発行日

vol.4, no.4, pp.159-167, 2005 (Released:2008-07-30)

参考文献数

13

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We have developed a simulation program that presents the process of fastening band-shaped cloth objects. These objects are twisted in 3D space to mimic the movements of tying garments such as Kimono sash. Even using extensive collision handling, this simulation is tough. The difficulty lies in the complex object contacts: The movements of different parts of a long contiguous deformable object conflict with each other causing numerous collisions during fastening process; Such collisions cause implausible deformations; Moreover, the collisions in different angles are prone to fatal penetrations that are not simple to remove. We propose three schemes to solve these problems. One is a pre-step mechanical scheme for calculating fastening force to move the object smoothly. Other two are a post-step geometrical correction scheme to smooth deformations and a set of schemes to remove penetrations. These schemes proved to enable robust and visually realistic simulations with low cost.

著者

神事 努 桜井 伸二 清水 卓也 鈴木 康博 Tsutomu JINJI Shinji SAKURAI Takuya SHIMIZU Yasuhiro SUZUKI

雑誌

中京大学体育学論叢 = Research journal of physical education Chukyo University (ISSN:02887339)

巻号頁・発行日

vol.49, no.1, pp.21-27, 2008-01-01

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It has been reported that the spin axis of a pitched baseball differs between adult pitchers and youth pitchers (Tezuka and Himeno 2001). However, that information was based on visual observation, and has not been determined quantitatively. The purpose of this study was to investigate the ball spin orientation and spin rate of youth pitchers compared with those for adult pitchers. In addition, the development of the throwing motion and factors in the determination of spin rate were discussed. Fourteen youth baseball pitchers (13.9±1.2 years) and nine collegiate baseball pitchers (20.1± 0.8 years) were selected as subjects. All of them were classified as over-hand style pitchers. The baseball was filmed immediately after the ball release using a high-speed video camera (250 Hz). The direction of spin axis and the spin rate were calculated using positional changes of drawn marks on the ball surface. The direction of the spin axis was defined by two angles, θ(azimuth) and φ(elevation). The angle between spin axis and pitching direction (α) was also obtained (Jinji and Sakurai 2006). Mean values of the angles of the spin axis showed no significant differences between youth pitchers and collegiate pitchers. As for variations within each trial, however, youth pitchers were significantly more inconsistent than collegiate pitchers. Although youth pitchers have acquired similar pitching motion to adults on average, their motion was often unstable with large variations. There was a significant difference in the mean values of spin rate between the youth pitchers and collegiate pitchers (p<0.001). Moreover, the spin rate correlated significantly with the initial ball velocity (p<0.001). Pitchers with a higher initial velocity achieved a notably higher spin rate. It was concluded that a pitching motion that increased the ball velocity consequently increased spin rate.

著者

Kunihiko ENDO Itsuki NAKABAYASHI Mitsuhisa WATANABE Fumio TSUNODA Hidehiko KAZAMA Jun-ichi YOSHINO Yasuhiro SUZUKI Hiroyuki SAKAUE Minoru SHIMIZU Hiroshi UNE

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.79, no.12, pp.738-743, 2006-10-01 (Released:2008-12-25)

被引用文献数

1 1

著者

Yasuhiro SUZUKI Hiroshi UNE Kunihiko ENDO Takehiko SUZUKI Itsuki NAKABAYASHI Kotaro YAMAGATA Ikuo SUZUKI Takashi SHIMURA Yoshiyuki MURAYAMA Takashi TODOKORO Itsuki NAKABAYASHI P. Hiroshi SATO Mitsuhisa WATANABE Yohta KUMAKI

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.78, no.12, pp.867-872, 2005-10-01 (Released:2008-12-25)

著者

Tokihiko MATSUDA Yasuhiro SUZUKI Takashi NAKATA Takashi KUMAMOTO Hiroshi UNE Kiyomine TERUMOTO Yoshiyuki MURAYAMA Takayuki NISHIYAMA Masaru YAMAGUCHI

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.77, no.12, pp.883-886, 2004-10-01 (Released:2008-12-25)

被引用文献数

1 1

著者

Yasuhiro SUZUKI Satoru TSUKAMOTO Takekazu AKAGIRI Takahiko FURUYA Yohta KUMAKI Itsuki NAKABAYASHI Yuichi FURUSE Hiroyuki SAKAUE Yoshihisa HOSHINO Seiji ICHIKAWA Masaharu TSUZAWA Teruko USUI

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.76, no.12, pp.924-930, 2003-10-01 (Released:2008-12-25)

被引用文献数

1 2

著者

石井 祥子 奈良 由美子 稲村 哲也 高橋 博文 スヘー バトトルガ 鈴木 康弘 Shoko Ishii Yumiko Nara Tetsuya Inamura Hirofumi Takahashi Battulga Sukhee Yasuhiro Suzuki

雑誌

放送大学研究年報 = Journal of The Open University of Japan

巻号頁・発行日

vol.36, pp.93-111, 2019-03-25

著者

Kaoru TANIGUCHI Mitsuhisa WATANABE Yasuhiro SUZUKI Hiroshi SAWA

出版者

SEISMOLOGICAL SOCIETY OF JAPAN

雑誌

Zisin (Journal of the Seismological Society of Japan. 2nd ser.) (ISSN:00371114)

巻号頁・発行日

vol.64, no.1, pp.11-21, 2011-08-25 (Released:2011-10-18)

参考文献数

28

被引用文献数

1 2

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The 150 km long Itoigawa-Shizuoka Tectonic Line Active Fault System (ISTL) in central Japan is one of the most active fault systems in Japan. Paleoseismologcal studies 1980s have revealed that the most recent event and the average recurence interval of the ISTL. The approximately 7 km long portion of the fault system between Matsumoto and Okaya has been regarded as a gap without any active fault trace. The gap namely the “Shiojiri Pass Gap” has long been taken as a segment boundary owing to the geometric discontinuity. Recent geomorphological analyses of the gap have demonstrated a through-going left-lateral slip assocaited with recent earthquakes in this area, based on aerial photograph interpretation and excavation studies. Excavation study on this portion revealed that the latest faulting event occurred between 1,700 cal. B.P. to 1,310 cal. B.P. (255 A.D. -645 A.D.). The timing of the last faulting event at this study area coincides with the timing in the Gofukuji fault and Okaya fault. The active faults extending from the Matsumoto basin as far as the northwestern margin of the Suwa basin display the evidence for its recent reactivation at the same time.