著者

安藤 晴弘 森田 衛 土居 重之進 漆戸 利夫

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.34, no.5, pp.419-424_1, 1958-08-20 (Released:2012-09-24)

参考文献数

31

著者

鈴木 安恒 尾嶋 禮子

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.19, no.10, pp.614-620, 1943-11-20 (Released:2012-09-24)

参考文献数

5

著者

田原 重志 服部 裕次郎 石坂 栄太郎 鈴木 幸二 寺本 紳一郎 福田 いずみ 杉原 仁 寺本 明 森田 明夫

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.97, no.S.HPT, pp.32-35, 2021-09-20 (Released:2021-09-22)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.98, no.S.July, pp.1-142, 2022-07-01 (Released:2022-07-05)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.91, no.Suppl.September, pp.59-72, 2015-09-20 (Released:2016-02-16)

著者

大國 皓平 竹下 彰 五嶋 由紀子 辰島 啓太 福原 紀章 岡田 満夫 西岡 宏 山田 正三 竹内 靖博

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.98, no.S.HPT, pp.47-50, 2022-08-20 (Released:2022-08-04)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.85, no.Supplement-1, pp.7-55, 2009-08-20 (Released:2013-11-13)

被引用文献数

1 1

著者

山辺 晋吾 片山 和明 望月 眞人

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.65, no.5, pp.497-511, 1989-05-20 (Released:2012-09-24)

参考文献数

21

被引用文献数

1 1

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In order to investigate the role of progesterone in the maintenance of pregnancy, an anti-progesterone agent, RU486 (RU) was injected subcutaneously into pregnant rats on day12 (D12), and morphological changes of the uterus as well as endocrinological changes were observed.In all rats injected with RU, abortion occurred with macroscopic and microscopic intrauterine hemorrhage and degeneration or delivery of conceptuses. Endocrinologically, the levels of progesterone decreased rapidly 48 hours after the injection, while the levels of estradiol showed a tendency to increase.As progesterone is mainly produced by the corpus luteum but not by the placenta in rats, the decrease in progesterone is suspected to be due to luteolysis. Then in order to clarify the mechanism of luteolysis induced by RU and the effects of progesterone on this phenomenon, the dynamics of the luteotrophic factors (estradiol, LH, PRL) and specific binding capacity of the ovaries to LH/hCG were investigated in D7 pregnant rats treated with RU 1 mg/kg alone (RU group) or with both RU 1mg/kg and progesterone 50mg/kg (RU+P group).The serum levels of progesterone in the RU group decreased significantly after 72 hours of administration, while those in the RU+P group remained within the levels of the control group. However, serum levels of luteotrophic factors in the RU group did not de-crease, and some of them were even higher than those in the control group. In the RU+P group, luteotrophic factors remained within control levels.On the other hand, the specific bindings of LH/hCG to ovarian homogenates decreased significantly after 72 hours in the RU group. But in the RU+P group, the specific bindings were kept at the same levels as the controls. Scatchard analysis of these results disclosed that in the RU group, both affinity and numbers of receptors decreased compared to the controls, and that in the RU+P group only affinity decreased transiently and afterwards recovered quickly.From these results, it is concluded that deterioration of affinity and numbers of ovarian LH/hCG receptors seems to be one of the factors which induce luteolysis in pregnant rats treated with RU, and that progesterone can spare the effect of RU on the corpus luteum during pregnancy.

著者

田村 功 田村 博史 城崎 舞 藤村 大志 白蓋 雄一郎 三原 由美子 竹谷 俊明 杉野 法広

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.98, no.S.Update, pp.67-73, 2022-07-20 (Released:2022-07-12)

著者

類家 裕太郎 鈴木 佐和子 石渡 一樹 横手 幸太郎

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.98, no.S.Update, pp.39-41, 2022-07-20 (Released:2022-07-12)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.90, no.Suppl.HPT, pp.45-48, 2014-09-20 (Released:2014-10-07)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.91, no.Suppl.HPT, pp.21-34, 2016-02-20 (Released:2016-04-19)

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.86, no.Supplement-1, pp.25-29, 2010-06-20 (Released:2013-11-13)

被引用文献数

1

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.97, no.S.October, pp.1-55, 2021-10-25 (Released:2021-10-25)

著者

伴 良雄

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.48, no.4, pp.268-281,232, 1972

被引用文献数

1

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血中甲状腺ホルモンの日内変動を詳細に検討した.正常人では夜間, 臥位, 睡眠時にT3 RSUが高値を示すのが認められた.このT3 RSU高値の原因は, TPで補正するとT3 RSU高値が消失し, 同時刻にT<SUB>4</SUB>, FT<SUB>4</SUB>, T7が上昇傾向を示すところから, 主として血液稀釈によるものであり, 一部甲状腺ホルモンの増加によるものと考えられる.未治療甲状腺機能充進症患者, 運動量の少ない回復期の他疾患患者では未補正値, 補正値共に日内変動はわずかであつた.

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.95, no.S.Update, pp.73-99, 2019-06-20 (Released:2019-07-17)

著者

玉城 敦子 中山 良朗 益崎 裕章 久高 将太 照屋 理子 本間 健一郎 屋比久 賢光 照屋 太輝 吉村 蘭 上原 盛幸 山城 清人

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.97, pp.56-58, 2021

著者

森 昭裕 梶田 和男 山北 宜由 森田 浩之 村井 敏博 安田 圭吾 杉浦 正彦 三浦 清

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.67, no.10, pp.1147-1161, 1991-10-20 (Released:2012-09-24)

参考文献数

23

被引用文献数

1 1

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Recently several types of anti-pituitary-antibodies (APA) have been found in patients with pituitary disorders including hypopituitarism and diabetes incipidus, and in postpartum women. However, the pathophysiological role(s) of APA still remains unknown. In order to elucidate the clinical significance of APA, longitudinal follow-up and family study of APA in patients with hypopituitarism were performed.APA in serum was examined in a total of 11 patients with various types of hypopituitarism (7 of isolated ACTH deficiency, 1 of partial hypopituitarism, 3 of Sheehan's syndrome, 6 males and 5 females). Chronic thyroiditis was associated in 3 out of 7 patients with isolated ACTH deficiency, and empty sella was found in each one patient with isolated ACTH deficiency and partial hypopituitarism, and in 3 patients with Sheehan's syndrome. APA was examined on 2 or 3 occasions at more than a 6 month interval (longitudinal study). In 5 patients, their 16 family members were examined for the presence of APA, and pituitary functions were evaluated in 3 out of 7 family members with positive APA (family study). For pituitary function tests, arginine infusion test, TRH, LH-RH or CRH test and insulin tolerance test were performed. APA reacting to rat pituitary cytoplasmic antigens (pituitary cell antibodies: PCA) and APA reacting to rat GH3 cells and/or mouse AtT20 cells surface antigens (pituitary cell surface antibodies: PCSA) were assayed with indirect immunofluorescence method.At the initial examination, 6 out of 11 patients (55%) showed positive APA. Thepatients were divided into 3 subgroups according to the longitudinal study: the group with disappearance of initially positive APA (3 patients), the group with altered titers or types of initially positive APA (3 patients), and the group with sustained initially negative APA (4 patients). No effects of replacement therapy on the alterations of APA were observed.In 16 family members of 5 patients (each 1 with partial hypopituitarism and isolated ACTH deficiency syndrome, and 3 with Sheehan's syndrome), APA in their sera were investigated. Seven out of 16 members (44%) showed positive APA. Among 6 first-degree relatives of 16 family members, both or either one of APA and PCSA were positive in 4 (67%). Out of 10 of their second- or third-degree relatives, 3 (30%) were positive for PCA or PCSA. All of 3 relatives with positive APA studied showed mild pituitary hypofunction without any clinical manifestations.These results suggest the possibility that autoimmune mechanism-induced hypofunction as well as hereditary background might participate in the pathogenesis of some hypopituitarism, and that APA might have a causative role in such disorders.

著者

森 崇英 福岡 正恒

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.68, no.11, pp.1151-1157, 1992-11-20 (Released:2012-09-24)

参考文献数

20

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Although it is well established that the pituitary gonadotropins and prolactin are the primary regulators of ovarian function, steroidal and nonsteroidal molecules produced locally in the ovary have been implicated in the modulation of gonadotropin action as autocrine or paracrine regulators. Recent studies suggest that the cells of the immune system play important roles in regulating ovarian function, and the immune regulation of ovarian function has become one of the topics in the field of ovarian physiology. Since it has become clear that the immune factors, cytokines, show a wide range of biological functions, not only on immune cells but also on nonimmune cells, the physiological significance of the resident immune cells, the widespread distribution of which in mammalian ovaries has been known for a long time, has reattracted attention as a third kind of regulator of ovarian function. In this article, current knowledge of the regulatory roles of immune cells as well as the cytokines in ovarian physiology is reviewed.

著者

須田 立雄

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.63, no.12, pp.1418-1428, 1987-12-20 (Released:2012-09-24)

参考文献数

28