著者

伊藤 公一

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.2, pp.68-78, 2008-08-01 (Released:2010-06-08)

参考文献数

16

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Gingival hyperplasia (overgrowth) is a well-documented unwanted effect, associated with phenytoin, the calcium channel blockers, and cyclosporin. The pathogenesis of drug-induced gingival hyperplasia is uncertain. However, the identification of risk factors associated with both the prevalence and severity of drug-induced gingival hyperplasia is important for all parties involved with this unwanted effect. Prevalence of gingival hyperplasia with phenytoin, the calcium channel blockers, and cyclosporin is approximately 50%, 10-20%, and 8-70%, respectively. The inflammatory components of drug-induced gingival hyperplasia can be managed effectively for the majority of patients with a plaque control program and nonsurgical periodontal therapy including oral hygiene instruction, scaling and root planing coupled with continued periodontal maintenance procedures. After reevaluation, some patients may need surgical periodontal therapy and maintenance procedures. Maintenance therapy including appropriate oral home care appear to be effective in controlling the drug-induced gingival hyperplasia and in maintaining clinical improvements for a long time.

著者

竹味 利晃 岩瀬 正泰 上條 竜太郎 倉地 洋一 水野 隆 南雲 正男

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.15, no.1, pp.8-11, 1996-04-01 (Released:2010-06-08)

参考文献数

15

被引用文献数

1

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A study was carried out to evaluate the efficacy of allopurinol mouthwash on mucositis induced by chemotherapy or/and radiotherapy in patients with oral cancer. The effect of allopurinol mouthwash was judged according to the World Health Organization grading system. Eight of the nine patients (89%) were reduced clinical status on mucositis. Treatment with allopurinol mouthwash was well tolerated in all patients. There were no adverse effects in trial of allopurinol mouthwash. Allopurinol mouthwash was considerably effective against mucositis induced by chemo- and radiotherapy.

著者

山下 知巳 鈴木 邦明 出山 義昭 山岡 真茂 北田 秀昭 福田 博

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.21, no.1, pp.4-12, 2002-04-01 (Released:2010-06-08)

参考文献数

19

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Nedaplatin (NDP), an anticancer platinum complex, is supposed to have stronger action on malignant tumor and less nephrotoxicity than cisplatin. As details of the nephrotoxicity of NDP are not known, we studied the effect of NDP on pig kidney Na+, K+-ATPase activity and human renal proximal tubule epithelial cells (HRPTE cells) . The pig kidney Na+, K+-ATPase activity was inhibited by NDP, and the inhibition depended on the incubation time and the concentration of NDP, and the activity was recovered by sulfides. NDP decreased Na+, K+-ATPase and acid phosphatase activities of HRPTE cells, and the decrease was partially inhibited by addition of 2-mercaptoethanol (2ME) . HRPTE cell death by apoptosis was observed in the presence of NDP, and it was also partially inhibited by 2ME. These results suggest that the inhibition of enzyme activities by NDP may be related to nephrotoxicity, and that some sulfides can recover the activities and may reduce nephrotoxicity.

著者

郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.29, no.1, pp.1-8, 2010-04-01

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Many epidemiological studies have shown that the prevention of dental caries by fluoride is a basic and indispensable method to maintain and improve dental health. However, the countermeasures for maintenance of dental health and implementation of preventive programs for caries are still not satisfactory in Japan. In developed countries, it is thought that the prevalence of water fluoridation and use of fluoride-containing dentifrices are the primary factors responsible for the remarkable decrease in the prevalence of dental caries in children. Topical application of fluorides, especially fluoride mouth rinsing, has an extremely important role in Japan as compared with various other countries, because systemic application of fluorides, such as water fluoridation and use of fluoride tablets are not yet available in Japan. However, fluoride mouth rinsing has not become prevalent on a nationwide scale. Therefore, it is hoped that fluoride mouth rinsing will be enforced in more kindergartens, elementary schools, and junior high schools to contribute to the improvement of dental health in the future.

著者

牛山 美奈 池田 龍二 新田 哲也 田實 裕介 宮脇 昭彦 山口 辰哉 下堂薗 権洋 牛之濱 風見 松井 竜太郎 杉原 一正 中村 典史 山田 勝士

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.27, no.3, pp.143-150, 2008

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In our hospital, hospital preparations of Azunol Saline Gargle (AS, saline solution containing 0.006% sodium gualenate hydrate), and Azunol Lidocaine Saline Gargle (ALS, AS with lidocaine) are used as a treatment for oral cancer with oral mucositis. However, little is known about the stability and microbiological safety of AS and ALS. In this study, the stability and microbiological safety of AS and ALS were assessed as the pH and the percent of sodium gualenate hydrate remaining in both preparations after exposure to various light and temperature conditions and the colony formation, respectively. As a result, we found that under fluorescent lamp lighting, AS and ALS were stable for 7 days at 4°C compared with 25t or room temperature. Furthermore, by light shielding, they were stable for at least 14 days at 4°C. Bacterial contamination of AS was prevented by preserving at 4°C for 14 days.<BR>We have demonstrated the stability and microbiological safety of AS and ALS and established an appropriate preservation method. This study provides useful information regarding the management of oral mucositis in oral cancer patients.

著者

櫻井 賢 小野 徹 天内 孝昌 篠原 治征 戸谷 収二 田中 彰 又賀 泉

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.24, no.1, pp.7-12, 2005-04-01 (Released:2010-06-08)

参考文献数

10

被引用文献数

1

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Pseudomonas aeruginosa has been frequently detected from sputa around tracheostomy stuma with a high frequency of nosocomial infection among patients with an opportunistic infection. It is also reported to be difficult to treat lower respiratory infections when resistance to antibiotics for Pseudomonas aeyuginosa has developed. We discuss 15 patients, (8 males and 7 females) who underwent tracheostomy and in whom Pseudomonas aeyuginosa was isolated for 10 years from April 1993 to March 2003. Average age was 62.0 years old. All subjects were oral cancer patients. Pseudomonas aeyuginosa was detected from cultures in 15 of 19 patients (78.9%) . It was isolated from and had colonized the lower respiratory tract by 34.6 days on average after tracheostomy. Gradual change of sensitivity to antiobiotics and increase of drug tolerance were recognized. As drug tolerance may be affected by long-term administration of antibiotics, selection of antibiotics and period should be carefully considered to avoid the development of tolerance.

著者

則武 正基 神谷 博昭 横井 基夫

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.20, no.3, pp.125-129, 2001-12-01 (Released:2010-06-08)

参考文献数

20

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We often worry about oral lichen planus (OLP) with chronic inflammation, which is an intractable disease in the treatment. A study was carried out to evaluate the efficacy of allopurinol mouthwash (ALP) on OLP.We studied 9 cases (1 male and 8 females) of OLP that were clinically diagnosed in our ambulatory practice during the period from July 1996 to July 1997. The average age was 58.7, ranging from 23 to 82 years. The effect measurement was carried out after 4 weeks of administration, and there were 3 complete responses, 4 partial responses, and 2 minor responses.ALP was reported to be effective for prevention and treatment of the stomatitis, which develops during cancer chemotherapy. ALP can be easily used by gargling only, and no side effects were seen, so it seemed to be a useful drug.