著者

松原 一志

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.99, no.3-4, pp.287-301, 1987-04-30 (Released:2009-03-30)

参考文献数

23

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The infuluence of 2 stout build on the body surface electrocardiogram was studied by comparing the body surface isopotential maps of 93 normal men and 107 obese men without cardiovascular abnormalities. There were no clear differences in the mean map patterns between these groups, although the position of the peak maximum positive potential shifted slightly leftward in the obese group. The maximum positive potentials of the QRS wave (Rmax V) and T wave (Tmax V) at 87 lead points on the left anterior chest and back surface were significantly greater in the obese group. However, on the lower anterior chest surface, the values of Rmax V were smaller in the obese group. The correlations between the Rmax V of the lead points where significant differences between the groups were found and the relative body weight, skinfold thickness, chest configuration, mean frontal QRS axis of ECG, age and respiratory function (% VC, FEV 1.0%) were studied statistically. There were good correlations between Rmax V and the QRS axis and relative body weight. However, there were no apparent correlations between Rmax V and the chest configuration and skinfold thickness. These results suggest that obesity might lead to an increase in abdominal grith and elevation of the diaphragma that produces a mechanical effect on the heart, causing a left-axis shift.

著者

古元 順子

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.77, no.5-6, pp.773-794, 1965-06-30 (Released:2009-03-30)

参考文献数

54

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16才女子高校生にみられた約2ヵ月間にわたる全生活史健忘例の発端および経過として,1. 長期間に準備された不安・葛藤状態があり2. 健忘発端の一日前に偶発的な一酸化炭素中毒に罹患し3. ついで驚愕体験にひき続く意識障碍より覚醒した時に全生活史健忘が始まり,4. 自発性催眠様状態で過去の生活を継時的に追体験し遂に一酸化炭素に罹る直前の状態で覚醒し健忘の回復をみたが,5. 健忘回復後もなお情緒の動揺に関連し,癲癇自動症を疑わせる発作および頭痛が頻発し,これらは精神療法により情緒の安定が得られるまで持続した.検査所見としては1. 一酸化炭素中毒以前より存在したと思われる脳室拡大,頭蓋骨指圧痕,髄液圧亢進が認められ,2. 発端となつた意識障碍とも或程度の関係が推定され,その後の自動症と発作の相関は確実と思われる脳波異常として,後頭側頭部優位の同期性,間歇性のirregular slow wave burstおよび散発性のsharp waveないしはspiky waveが全径過を通じ安静時記録で認められたが睡眠誘発で賦活されず,情緒動揺の著明な時期に一致して上記所見が増強し,とくに右側々頭部で6 c/s positive spikeが繰り返し出現するのが確められ,3. ロールシャッハテストでも不安・神経症徴候および重篤な現実との接触喪失徴候とならんで,癲癇徴候がことに健忘回復後に増強するのが認められた.以上の経過,所見により,本例において健忘の発端となつた意識障碍に対する一酸化炭素および癲癇(とくに情動により誘発される癲癇)の関与如何につき,文献的に比較検討,綜合的に考察し,一酸化炭素の関与は完全には否定し難いが比較的に少く,ごく軽度の意識水準低下として発生準備状態の一要素を形成はていたと推定されるにとどまり,一方癲癇の関与は,発端の意識障宮が情動により誘発された癲癇それ自身であつたか,原始反応としての意識障害を惹起する準備状態の器質的主要因であつたかは別として,相当大きな比重をもつものと推定されることを述べ,併せて全生活史健忘というヒステリー反応が器質的意識障害の機構を利用しても起り得ることを推論した.

著者

谷崎 勝朗 高橋 清 上田 暢男 斉藤 勝剛 細川 正雄 小野 波津子 石橋 健 合田 吉徳 中村 之信 佐々木 良英 守谷 欣明 木村 郁郎

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.89, no.9-10, pp.1261-1265, 1977-10-30 (Released:2009-08-24)

参考文献数

8

被引用文献数

1 1

---

A skin test using buckwheat extract was performed on 182 cases of bronchial asthma. Thirty-three of them showed a positive skin test to buckwheat extract.Buckwheat allergy (bronchial asthma, urticaria, allergic rhinitis, allergic gastroenteropathy and allergic conjunctivities) was found in 19 (57.6%) of the 33 cases showing a positive skin test to buckwheat extract.Basophils from 8 cases of buckwheat asthma showed a strong response to buckwheat extract, although basophils from 10 cases with a postive skin test only, without buckwheat allergy, did not response to buckwheat extract.Bronchial asthma induced by buckwheat (16 of the 19 cases) had some special features. Their asthma attack was induced by the introduction into the body through either mouth or airway and started in childhood. Buckwheat pillows were used in 13 of the 19 cases. Ten of the 13 cases obtained alleviation of asthma upon discontinuation of buckwheat pillows. Most of the buckwheat asthma patients showed a high serum IgE level and had a hereditary factor. The results showed that cases of buckwheat asthma might be sensitized in their childhood.

著者

出井 清雄

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.70, no.8, pp.2829-2884, 1958-08-31 (Released:2009-03-30)

参考文献数

167

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By the use of trypan blue, i.e. lipoid insoluble acid stain, in order to make observation of absorption activity of the oral mucosa, animals' mucosa with rapid absorption activity, its location, absorbing process, and absorbing conditions were investigated. Then clinical and biological observation on absorption of hormone of the salivary gland was tried.I. Mixture containing equal parts of 1 per cent solution of trypan blue and saturated sodium bicarbonate solution was dropped and painted over the normal oral mucosa of various kinds of animals, such as dog, cat, hamster, albino rat, chicken, elaphis virgatus, lizard, rana esculenta, eft, and crusian and absorption of the solution was observed.The results obtained were as follows:1) Absorption varied according to the kinds of animals.2) In general absorption of the lower verbetrata was more remarkable than that of mammals and birds.3) In mammals that of dogs was more marked than that of cat, hamster and albino rat.4) In dogs marked absorption was seen in buccal and sublingual mucosa, particularly at the sublingual and parotid salivary papillae and their surrounding areas.5) In albino rats absorption was made at the hard palate corresponding to the tip of the tongue.II. In premature dogs it was equal to that of mature dogs.III. No absorption was seen in the oral mucosa of the dog's and rabbit's fetus, while slight one was seen around the erupted teeth of the guinea-pig's fetus.IV. T. B. was not introduced into the ep. cells of rabbit's oral mucosa in case of vital staining.V. The effects of various factors on T. B. absorption of the oral mucosa in dogs' experiments were as follows:Absorption-stimulating factors are, local thermal stimulation, Grace helio lamp irradiation. roentgen irradiation of amount of 60 r to 100 r, radium irradiation of amount of 33 mg. h, to 66 mg. h., intracranial amputation of maxillary and mandibular divisions of trigeminal nerve just after the procedure. and local injection of Teabrom (T. E. A. B.), in the early stage of injection, while absorption-inhibiting factor was local cold stimulation and no absorption was stimulated in case of anemia of the head following ligation of the common carotid artery.VI. Parotin and Saliva-parotin, i.e. hormone of the salivary gland was painted over the oral mucosa of man, dog and rabbit. The results obtained were as follows:1) Leucocytosis was noticed in cases of dog (1.2-5.0 mg./kg. of Parotin administered) and man (0.2-0.4 mg./kg. of Parotin or 0.1-0.2 mg./kg. of Saliva-parotin administered), 2) decrease of serum Ca. and leucocytosis in case of rabbit (1.0-5.0 mg./kg. of Parotin and Saliva-parotin administered), and 3) stimulated calcification of dentine in case of rabbit (5 mg./kg. of Parotin administered).These results will suggest us the following factors as those effecting on absorbing mechanism of the oral mucosa, especially of the epithelium: 1) resistance, 2) intensity of surface tension, 3) intercellular density, 4) characteristics of chemical substances and solvent, and 5) special vital function of the cells.

著者

玉井 守

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.104, no.11-12, pp.1007-1014, 1992 (Released:2009-03-30)

参考文献数

29

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C3H mice were subcutaneously (s. c.) injected with a tumorigenic dose (1mg/mouse) of 3-methylcholanthrene (MC) and tumor development was observed for 18 weeks. OK-432 or Ge-132 was intraperitoneally administered either after MC injection (post-treatment) or both before and after MC injection (pre- and post-treatment).Pre- and post-treatment with OK-432 significantly inhibited the development of tumors from 10 to 12 weeks after MC injection as compared with a control group. In all of the groups, the incidence of tumors was 100 percent 18 weeks after MC injection. With respect to Ge-132, both post-treatment and pre- and post-treatment administration reduced tumor growth in a similar manner to pre- and post-treatment of OK-432.After pre-treatment with OK-432 or Ge-132 for two weeks, the percentage of large granular lymphocytes in peripheral blood and the natural killer activity of splenic cells in mice were increased.These results suggest that the immune status plays an important role in the defense mechanisms against chemically-induced tumors.

著者

堀江 正司

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.104, no.1-2, pp.57-62, 1992 (Released:2009-03-30)

参考文献数

11

被引用文献数

1 1

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A well-developed nervous branch supplying the upper lateral cutanea of the arm, which arose from the suprascapular nerve, ran beneath the acromio-clavicular joint and penetrated the deltoid muscle, is described. In usual cases, this branch is thin and sometimes referred to as the accessory upper lateral cutaneous branch of the arm (Murakami) (or subacromial cutaneous nerve, Yamada). Some unusual supraclavicular nerves, which penetrated the clavicular bone or ran under this bone, are also described.

著者

出宮 一徳

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.79, no.7-8, pp.619-635, 1967-08-30 (Released:2009-03-30)

参考文献数

70

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As a link in the series of studies on the functions of the diencephalo-pituituitary adrenocortical system in endogenous psychosis, an investigation was carried out on 26 cases of schizophrenia who received the standard bilateral lobotomy, for the purpose to find out how the frontal lobe affects to the endocrine functions and autnomic nervous systems. For this purpose ACTH (25 units) was administered intramuscularly to 17 cases of them, and the m echolyltest was conducted with the other 9 cases, measuring the lelvels of corticoids in serum and urine of both groups. For the controls, ACTH was administered to 9 cases of schizophrenia who did not receive lobotomy. The results of the study may briefly be summarized as follows.1) In the control group after ACTH adiministration the serum 17-OHCS showed a tendency of a decrease in the cortical reserve capacity, and in the lobotomized group there could be seen an abnormal reaction to ACTH in addition to a decrease in the cortical reserve capacity.2) Total blood cholesterol after the ACTH stimulation decreased temporarily, showing similar changes up to 30 minutes in both groups, but in the lobotomized group an increase in cholesterol could be observed thereafter, revealing a contrasting phenomenon to the decreasing tendency of the serum 17-OHCS.3) The blood potassium decreased transiently 10 minutes after the ACTH administration in both groups and such changes were unstable in the control group while the blood potassium in the lobotomized group increased steadily. As for the fluctuations of urine potassium its excretion was decreased transiently after the ACTH administration in both groups, which later rebounded, and this recovery tendency was more marked in the lobotomized group.4) 17-KS excreted in urine on ACTH stimulation increased accompanying a marked increase in the amount of urine in the case of lobotomized group.5) The results of the mecholyl test revealed that even the lobotomized patients respond to mecholyl, but there can be observed a decline and delay in the reactivity.6) Observations on the fluctuations of serum 17-OHCS, urine 17-OHCS and 17-KS conducted simultaneouly with the mecholyl test revealed a declinining tendency in serum free 17-OHCS while total 17-OHCS in urine to be rather increased in the lobotomized group. The quantity of 17-KS excreted in urine decreased at first and then increased, and such a tendency did not parallel with the change in the total 17-OHCS excreted in urine. In the patients showing identically the same pathological conditions there could be recognized no distinct correlation between the type of response to mecholyl and the corticoid picture.7) While we can recognize a certain correlation between defect symptoms of the frontal lobe and the endocrine functions, when we investigate individual caes, we find complex features in the endocrine function and autonomic nervous system according to the constitution before the lobotomy and the postoperative pathological picture. Namely, in those patients in a quiet menthal state, though they are not completely cured, both functions maintain the balance in the state of lowered tension. On the other hand, in those who show a premonition of unrest and excitation, both functions have become unstable. Moreover, those who may have hallucination and delusion and are in the state of chronic defect, so long as there occurs no excitation, they show the levels of function close to the normal.8) Summarizing these findings, it may be said that there is a decreasing tendency of the response to the ACTH stimulation in the functions of the diencephalo-pituitary-adrenocortical system of chronic shizophrenic group, and distribution of the estimated values is larger than that of normal persons, and this tendency is still more pronounced in the lobotomized group.

著者

石津 日出雄 山本 雄二 守屋 文夫 宮石 智 仙波 昌三

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.103, no.3, pp.145-153, 1991-06-18 (Released:2009-08-24)

参考文献数

31

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The progress of sex identification methods for forensic materials such as dried bloodstains and others in legal medicine is reviewed.Dixson and Torr (1956) first described a scientific method to identify human sex from forensic materials by detection of X chromatin in female cell nuclei. In 1972, we introduced a method for detecting Y chromatin in the human interphase nuclei by fluorescent microscopy as a new tool for decisive male sex determination from forensic materials. This method was accepted in forensic practice as the only reliable means to identify sex. In 1983, we reported sexes were distinguishable from dried bloodstains by the ratio of sex hormones, testosterone and progesterone, determined by radioimmunoassay. Gene analytical methods to prove the human Y chromosome specific DNA sequences have been introduced in this field. We also examined the method of Witt and Erickson (1989) to detect Y and X chromosome specific sequences using the polymerase chain reaction (PCR), and we improved this technique to exhibit its ability to identify sex in forensic practice. Our improved PCR method is expected to have a broad applicability in forensic practice because of its simplicity, sensitivity and reliability.

著者

高坂 睦年 薄井 省吾 帆秋 穐誉

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.67, no.1, pp.345-354, 1955-01-31 (Released:2009-08-24)

参考文献数

26

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1. The Heinz body formation in vitro due to the addition of hydroxylamin hydrochlorate as a blood gift was studied and compared in 71 cases of 22 normal subjects and 49 schizophrenics.2. The mean value of erythrocytes with Heinz body formation: normal group 94‰ chronic standstill group 146‰; strong excitement and confusion group 211‰, chronic progressive group 213‰; intense deterioration group 304‰. If we suppose the mean value of normal group as 100, so the rate of every schizophrenic group is calculated as follows; chronic standstill group 155; strong excitement and confusion group 224, chronic progressive group 227: intense deterioration group 324. This fact indicates that the erythrocytes of schizophrenic patients are pathological.3. The resistance of erythrocytes with Heinz body is weaker than that of normal. (by the Ribiere's method).4. We found that the erythrocytes sedimentation rate in the intense deterioration group accelsrates more than in normal, and that e. s. r. has some relation to Heinz body appearance.

著者

板野 義太郎

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.103, no.1-2, pp.117-127, 1991 (Released:2009-03-30)

参考文献数

37

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To clarify the acute-phase response in brain, we investigated the induction of metallothionein (MT) genes by administering an endotoxin (lipopolysaccharide) in rat intraperitoneum. We performed in situ hybridization on the serial brain sections to identify the cells expressing the MT genes in the acute-phase. After endotoxin administration, transcripts of MT genes were detected in the arachnoideal, ependymal cells and the Bergmann glia of the cerebellum, while no significant induction of the MT genes by zinc ion was observed in the brain. These results suggest that the acute-phase response occurs specifically in at least these three non-neuronal cells.

著者

石川 隆紀 宮石 智 土井 裕輔 高田 智世 今林 貴代美 稲垣 幸代 吉留 敬 山本 雄二 石津 日出雄

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.114, no.3, pp.303-308, 2003-01-31 (Released:2009-03-30)

参考文献数

11

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We encountered two cases of unnatural death occurring indoors in early spring in Okayama Prefecture. The two cases were both females aged 31yearsold and 88yearsold. Autopsies revealed death from hypothermia as the cause of death. The diagnosis of death from cold was not based solely on the characteristic findings of the dead body. After confirming that there were no other accidents and diseases that may cause death, an overall evaluation should be made considering the conditions surrounding occurrence of death from cold. We describe these procedures using these two autopsy cases of death from hypothermia.

著者

白髭 郁子

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.78, no.2-3, pp.365-386, 1966-03-30 (Released:2009-02-13)

参考文献数

44

被引用文献数

1

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Two cases of the juvenile form of amaurotic family idiocy were described in the present communication. 1) Case 1 was a 11-year-10-month boy. His family history had consanguinities. He was slightly deteriorated before the onset of the disease. At the age of 5 years, the ataxia of gait was initially manifested. Later there developed the progressive mental deterioration and the “Blitz-Nick- Salaam Krämpfe”. On neurological examinations the marked cerebellar syndroms (ataxia, intention-tremor and hypotonia), the involuntary movements and the narrowing of the ocular vessels could be recognised. Case 2 was 10-year-7-month girl. Her two brothers died of amaurotic family idiocy. She had been healthy until she complained of the myoclonic contractions of the tips of the fingers. The mental deterioration, the convulsive seizures and the visual disturbances were gradually appeared. The neurological examinations showed the involuntary movements, the hypotonia, the optic atrophies and the retinal degeneration. Both patients died six years after the onset of the disease. 2) The autopsy findings of the brains in both cases revealed macroscopically the generalised atrophy and the increased consistency. Microscopically the essential changes were observed in the neuronal swelling and the lipidosis. These changes were distributed ubiquitously throughout the central nerves system and were most markedly in the cerebral cortexes, decreasing by degrees caudally. Furthermore in the case 1, the severest damage was seen in the cerebellar cortex. In the cerebellum of case 1, the entire nerve cell elements except Golgi's cells and the nerve fivers were almost completely obliterated. The swelling of axons in the the cerebral cortexes was recognised in both cases. too. 3) The findings of the organs such as liver, spleen and others in case 2 revealed no lipid accumuration as seen in Niemann-Pick's disease. There were observed the degeneration of the retinal outer layer which was characteristic of the juvenile form of the disease. 4) From the results of the histochemical observations in both cases it was concluded that the intraneuronal substances consisted of the mixture of the sphingomyelin and PAS-positive substances that might be the glycolipid. A part of them and the substances in the fat granulle cells were assumed to be combined with the protein. 5) Above mentioned results, the clinical, the histological and the histochemical findings in both cases indicated the jnvenile form of the disease. In case 1 there would be the developmental anomaly of the brain beside the essential chages of amaurotic family idiocy.

著者

原 功一

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.86, no.9-10, pp.453-464, 1974-10-30 (Released:2009-03-30)

参考文献数

41

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Folic acid contents of various foods (147 items) were estimated by the microbioassay using Lactobacillus casei as the test organism. Folic acid were abundant in vegetables, fruits, fishes and the liver of animals. Nineteen foods were examined for loss of folic acid during boiling. Leaching out into the water was also examined. 20-70% of free folate was destroyed after 5 minutes and 20-90% after 15 minutes. Destruction of total folate was less than that of free folate i.e., 30% after 5 minutes and 40-60% after 15 minutes. Pteroylglutamic acid was not destroyed by boiling for 15 minutes. So the folate destroyed during boiling was considered to be other forms of folate except pteroylglutamic acid.Folic acid contents of two hospital diet in Okayayma city was estimated. Mean daily folic acid amount in the diet of hospital A was 205μg of free folate and 839.8μg of total folate. In the diet of hospital B, 305.5μg of free folate and 738.1μg total folate were present. These amounts were much more than those reported in USA and England. As to the reason why megaloblastic anemia is rare and folic acid defi ciency is so mild in Japan, abundant folic acid intake from diets, uniformity of dietary habits i.e. boiled rice as basic food, were discussed.

著者

伊達 洋至

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.118, no.2, pp.113-117, 2006-09-01 (Released:2011-06-03)

参考文献数

12

著者

渡辺 漸

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.70, no.12supplement, pp.53-66, 1958 (Released:2009-08-24)

参考文献数

20

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No systemic study to induce leukemia in the experimental animals with the internal irradiation with radioactive isotopes has ever been attempted. We set about experiments with this object in 1953 and succeeded in the induction of experimental leukemia in dt, ddF and ddN uniform strain mice treated with small frequent doses of P32, Sr89 and Ce144.Single dosis of the isotopes ranged from 0.03 to 0.5 μc per gram body weight twice a week was administrated to mice with the methods of intravenous injection, intraperitoneal injection, intratracheal administration and intraesophageal dripping. The total administrations of the isotopes were 7-16 times.The development of leukemia was confirmed in higher frequencies among mice which were administered with small frequent doses of P32. The highest incidence of leukemia throughout our experiments was about 42% in the experiment with P32 at 0.3-0.5 μc level.The development of leukemia remains in lower frequencies among mice which were given small frequent doses of Sr89 or Ce144. In the former cases we confirmed the higher incidence of osteogenic sarcoma. In the latter cases the aplasia of the bone marrow were easily resulted.Among the Beta-emitting radioisotopes the one which has the shorter halflife and more intensive energy such as P32 is more suitable to induce leukemia in mice so far we had experienced.The excessive and at the same time partially abnormal regeneration preceed the development of leukemia after the administrations of small frequent doses of the radioisotopes.The order of the intensity of the radioactivity in the bone after the administration of the radioisotope change from time to time. Such effect will also contribute to enforce the abnormal regeneration of the bone marrow.For the development of leukemia in mice after the administration of the frequent small doses of the radioisotope we should not overlook the most intensive regenerative hematopoietic activity in the bone marrow corresponding middle portion of the long bone such as the femur.

著者

渡部 昌実

出版者

Okayama Medical Association

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.119, no.1, pp.1-5, 2007